Everybody did you know that energizes ultimate lithium, doubling batteries last up to twenty years in storage, I'll, give you the confidence that you'll have superior power when you need it most and long lasting power means you have one last thing to worry about: energize or batteries are the Senate and forget it choice in the battery world. You have to think about your devices like kids. Toys are remote, your game controllers and wonder if it's going to work the next time you need to use it. That's why energize her ultimate lithium as the number one longest lasting double a battery? This year's crazy enough take reply in batteries off your plate within a joiner. I'm danish warts host of Hayley would a new. I heard a regional policy has what happened when the world's biggest movie star took over a tiny old mining town it detail. People close to Bruce Willis have never been keen on telling, but it's a story. The people of highly are recounting

in detail for the very first time, listen daily would on the eye heart, radio, apt apple pie casts or wherever you find your favorite chance. Welcome to stop. You should know a production of Iheart Radio Pay and work under the podcast. I'm Josh clerk in their choice of each Brian over their juries persona non grata nets. That stuff is just the usual here, that's so step. We should not stop you shouldn't regular. So can I say a couple of things here: oh a preamble from Charles was here, so we're gonna, be tough today about the covert vaccines specifically

M in are I'm stuck. I avoided the alarm and am RNA vaccines. A MR now how I like to call him hadn't picked up on that. For now I can't unseated well, this is the aim is little yeah there, but still now I see it clearly the MR no vaccine just quickly. I want to see- Josh put this together from whole cloth from about eighty thousand sources, and he did agree. This is a complicated thing that you did what your wonders on and you're really good at this. Is that what you wanted to say there. I wanted to say that, and also our hopes here or there. You can understand this and are working to preach into the choir, but with our are listener ship, not not fully. There's plenty of people there's a lot of varying opinions among stuff you should know is absolutely, but I think when it comes to vaccine hesitancy

most of our listeners, are on board and in our hope is that you can understand this a little bit before thanks living with your weird uncle, so maybe you and say: hey, you know enough. things work and it's not something to be feared, is something to be like to stand up from this turkey and this table and like applied here with full no reservation and full like what in the world his science done. It's using yet really is committed it's unbelievable that science has figured this stuff out and they did it that quickly enough and that accurately- and now it is it's a triumph of modern science. for sure one of that one of the biggest and we're gonna, You know you it's an it's impossible to talk about the M Rna vaccines without talking about how it differs from traditional vaccines, and it is a huge step forward in vaccine research and vaccine production like it's the future of vaccines. It's amazing what what's just happened, but

it's not to throw any shade whatsoever on traditional vaccines, which we still need, which we still use land vaccines, yes, without which there were power. Billy, be a great many of us who would not be here here because we hadn't arrived, are parenthood survived. Our grandparents had survived some disease that a vaccine was developed to combat, throw hats off to traditional vaccines, but M, RNA vaccines are are pretty astounding and in what what science has managed to come up with yeah? So we hope to clear up some myths about what, he covered? Vaccines are and are not an fully by the end of this. You will agree that its. We would like. There are some serious Nobel prizes coming in the outer towards these people for sure, at the very least. We hope that you hear this episode and are able to go so that's what's in me. Yes, exactly

Well, it's not any. Any more will learn that do that's true chuck nice, nice foreshadowing. So it is really it's. It's really hard to kind of overstate to tell big of a breakthrough. It was fruit for a more and a vaccine and that they do kind of red represent like this now path forward, but the kind of understand how the whole thing works and what makes it so magnificent. As far as medical breakthroughs go, you can have the first Then what am RNA actually is and in what it does? Don't you agree ye I mean all That is really knew. I mean that the quickest version of the history is that the stuff was then, if a messenger organise we're talking about yes identified it nineteen, sixties and then a nineteen eighty four, the very first day, and of em are in a and then a say in our eyes, so many die. You know that their m stuff, the embassy, Mr Na,

The first strand of MR now was artificially produced in a lab in nineteen, eighty four, which in terms of size, not that long ago, and since then they have made leaps and bounds to the point where they now can and did produce a covert vaccine on a computer yeah. I mean that basically, what they're doing these days? Is there saying? Oh, I want. I want a vaccine that produces this little viral protein. I know the genomic code of this about little viral proteins from the tap tap, tap, tap, tap, tap and then press enter basically in the computer sets off some desktop machines that produce that that's exact version of em RNA, that is really really simplified version of what's going on. But in a nutshell basically, where we ve arrived. Now in, like your thing, that's that's in the last thirty five years that we first very far.

Time we ever synthesize marinade and as easy as it sounds now chuck. There were a lot of obstacles between nineteen, eighty, five and twenty twenty, when the very first time or vaccines ever in the history of humanity came out just in time for the that covered pen, Mank yeah me there were a couple of big hurdles, actually turn that, like the region, miracle into boys, but gets a religious into fish to feed the masses, while I would have gone with water into wine. Ok, no ay ay! That was a good deal a couple of them being and we're gonna get more into this. You know as we go on, but they learned how you don't you know I am RNA is really fragile. So they learn how to protect it. By putting it in these little tiny fat capsules, called limpid nanoparticles and so now they ve got a little sort of a little vehicle. The travel in that help them get into a cell

and then no. We talked about cider kind storms before when the when the human body has a really were blown reaction, over blown immune response to the point. Where can actually kill somebody, yet those sight o king stirs is kept smack and down MRI, nay, research over and over again, because even when they finally did manage to come up with a keep the fragile mri, nay from falling apart in the body. The body would be like what is this get this out of here. I'm I'm going to just over blow so hard against this, this weird for invader them gonna, threatened to kill I human though it is not at all what you want and they finally figured out there if you use some different nucleotides in place of other nuclear tides, which are the building blocks of life, if, when you're, building this mri, nay and they-

really purify you get like no slop whatsoever. You have a chance of making something. That is, that appears natural, not to fool nature, the tried and were able to really clean that stuff up, because it's not alive virus. Yes it's not a living thing and we'll get more into that nets and other way how it differs from other vaccines, but I virus. So you can even just dump. Bleach on it basically is essential, he will say in a nutshell, but yes, it maybe cuts down on any type of contamination that you mean get yet, and we have to thank for all this really the Human genome project, because, if not for that which star in the ninety. Nine is thanks to the: U S: government funding of that We would have had any these breakthroughs to begin with as far as reading the genetic code. Yes, it was a huge

ass. Men are really is paid. Often, a multiple ways in just one of them is a marinade vaccines. The the whole thing that is just major, some amazing, an astounding and just firms that we are living in some sort of simulation that the breakthroughs that pushed this this- research for em RNA vaccines from basically a pipe dream, that we had no idea how we are ever going to get there too. Ok we're ready to actually create a marinade vaccines vaccine just in time for this pandemic, that's coming along. They all just kind of came together in part, because people were already working on corona virus vaccines. In what's really cool now I M Rna vaccines is you can plug in play different stuff

so the human genome project we ve learned to kind of reed the genetic codes stuff and to write it an produce it, and because of that, because we can do that on computers. Now you can say I've got a template for a quota virus. Let me get specific with it and make it as Sars Covey to Corona VI. Now that we ve got the genetic code, we can deploy a vaccine against it and that's how they are able to do it so quickly that right and they estimate as of July this year and twenty twenty one that vaccine saved almost hundred and eighty thousand lives. and prevented about one point: five million hospitalizations when hospital rules are overrun and that's really important thing lobby for an early break here. Ok, so we can just get cookin. YO, uninterrupted and unmolested man The second embryonic, that's how good yeah a lobbying approved.

Ok, we'll be right back everyone until your power, the stuff works ready for this You know it's been a while. since we all had a good excuse to get guess it up in looking sharp, but those times are coming back, and you want to be ready for him when they do so when you need to look your best. I think it's time to turn the Indo China that right Do you ever shop online or visited assuring before you may not have had the best time? Personalizing your clothing, but that is all changing now with Indochina yeah, which is why Indo China offers completely custom fitted suits you, its casual work more but, as surprisingly affordable prices in every pieces made to your exact measurements in you can customize every day.

he'll indo. China was now open, its elected Nord stream stores, giving you even more ways to get great fitting personalized clothing. Fine, your nearest location at Indo, China that come and get this right. Now you can get fifty two. Where's off any purchase of three hundred and ninety nine dollars or more by using our code stuff, a check out. That's fifty bucks offer purchase of three hundred ninety nine dollars or more. At I n D, o c h, I n o dot com, promo code stuff. you One thing I love more than

Anything else is an outdoor fire and hanging out with my friends: oh yeah he's. Not only does it hits you up, it's a beautiful, it smells nice looks nice plus you could do far worse for roasting marshmallows than an open fire. You know I'm saying that right, and so we want to talk about solo styles, of course, because they make a smokeless fire pit where it is super easy to get that fire going and you're not gonna get smoking your face, which is the one problem with that outdoor fire yeah the point of having a fire is enjoying the fire not dislike getting started frantically or having to dodge the smoke. That's why solo stoves works so well, there smokeless in their easy delight, but a boom, but being you ve got your cosy fire this winter at right and this year you can shop, solo, selves, black Friday, sale early, get great deals on that solo, so far, be it from November, eleventh through November. Eighteen,

and get ten dollars off with promo code stuff, plus a lifetime warranty an free thirty they returns and to get that extra. Ten bucks off just go to the early bike, ready sale. It's always so that come from a good stuff, Everybody did you know that last year there was a victim of identity theft every one to three seconds. I did a criminal could be spending your money applying for loans in your name, damaging your credit or eating selling your personal info on the dark web yeah and, unfortunately, chemist certain threats to your identity by just checking bank statements or just monitoring your credit. The solution, lifelike identity theft, protection, the tree lifelike sees certain threats that you could miss if you're only monitoring your credit cards plus they're, going to alert you if they find something that could be suspicious yeah if you become a victim of identity theft. A U S, based identity, restoration, specialist dedicated to your case will work to fix it,

start to finish. No one can prevent all identity theft or monitor all transactions at all. Businesses, but lifelike by Norton can help protect your personal information. So you can keep what's yours at right. Any can save up to twenty five percent off your first year by going to lifelike dot com, slash stuff, that's life luck, dot com, stuff for twenty five percent of the funding, Don't Josh starting ok, so we should talk about like sing what a moron does. Thank you for swooping,

in reminding me that oh yeah, this article, the Euro, you get the history part. First, let's start there. That makes a lot like those escaping that now he's asking I was, but my vision is blurry em, so interested in this. ok, so we're Tom. I am already in a martini ashore for MESSENGER, RNA and messenger on a basically is a it it's a blueprint right. It translates copies a little strip of the blueprint, that's encoded in your entire genome in your dna, and it takes that little bit. We usually which codes for like approach inner peptide, which are really important things that are our body uses to do everything from contracting your muscles to making you feel hungry, like. Basically, everything comes down to a protein or peptide and the instructions for building each of those poor. teens and peptides are included in our dna. In its most

You are in a that, goes to the DNA says: okay, we need some more this protein, I'm here to make a copy. May I please make a copy here are some flowers? They said if I brought you some flowers you'd be cooler with this in the dna so proceed and the MRI enables people to put up and produces itself as a b and leaves the nucleus. This is really important. Mri nay, goes to the DNA. It makes a copy and then leads the nucleus and from that point, there are and is all about the site or plasma right so I kind of like the and have expanded upon the the wonderful metaphor you have of like a building site, and I guess I think we failed to mention that the amino, since in the body is: what's really carrying out the work right like making your eyes blue light

yeah. Well, the amino acids. There are the building blocks of proteins peptides a few arranged, a certain set of mean who asked is in a certain way. You ve got a Polly peptide and you got a protein right in our in this case, if we're talking about this is like a job site, did I say entering you said a man array, men raw. Well, that's the inner raised, like embedded in art. That's too so sad. I haven't said an hour. I once It sounds like it I'm here I'm going to die, So I m RNA just like Black Angus, don't gotta garee eggs into those good so in our cheese m. Rna in this case would be like the architect showing up the blueprint. wearing some like sensible, like she knows, but work birds, but they're really expensive work, but you can tell him: there's not a scuff autumn. Ok, and so it heads over to the work site, which is decided plasma. The cell outside the nucleus right

and then I think in this case, the ripe zooms would be the contractor sort of yes, because the contractor maybe translates these blueprints into a, marching orders for the law workers that are the amino acids yeah the I wasn't clears the sandwich off of like the drafting tape in spreads out their marinade blueprints, as are going to see we Geiger wipes his mouth, some crumbs away from his mouth and dumb, gets to work, taking that bill print taking that MESSENGER Rna and translating it in you, those amino acids they get constructed in just a certain way to produce a protein M are unable do it again? Do it again, do it again, let's keep going I'm feeling good. Let's keep this going for a little while that, right for a little while just happens, you know a certain number of times, not specific. It varies, but its limited and then that M are starts to break down nice going in shock,

You said a martini in the they concentrate and then is carried away from the cell and eventually out of the body through the lymph nodes in is disposed of. So, like all jobs of ITALY, the contractor will disappear on. You will know that was the TAT, they got you write it out. Well, the architect disappears earlier. I guess I guess so, but that you want the architect come back sort of ass, well, ass, his skin and come back here, you'll get another architect, there's always more and more in the body has always happy to produce more mri, nay, with sending out blueprints and instructions. It go make this protein right now. Man have really screwed up a thought: the contractor disappeared, a perfect would that it would have been pretty great and you still the joke. You never just wrong in case. You are wrong to scientifically, but the

about an hour. Vaccines vaccine is that researchers have figured out how to use this natural process to help us vaccinate ourselves against diseases, and they do that because we reached a point where we can, rather than having the the M produced in the nucleus of the selling going out into the sight of plasma vaccine research is produced, the MRI outside of the body and then injected, The body and then it goes into the site or plasma from our side of the cell and then from that point on. Everything else is follows the exact same, process. That is where we're out right now, and that is where you're you can start to feel your head opening up like a blue monotony in and out back yet, and I mean that, did it of itself is remarkable. That is it. They said. You know what this stuff can actually go into. A cell even though, and we'll get a little bit more into this, even though its like can be up to ten thou in times too big to permeate

that so we'll figure that part out right in and they did that's that's. You know, courtesy of the of the little fatty lipids, yeah at the vehicle that allows that to happen, but just the notion they thought like, and what have we can get the stuff to go from me. outside in yeah was remarkable. It really is- and it was just this contribution from hundreds of researchers- is building on one another's work and that finally led to the point where it like it went from, while the really cool idea to ok were actually preventing deaths in a pandemic. Thanks to these things now, right any another. A couple of ways to a few you can immunized a person like literal technique. using Am Rna, and it turns out that we are at an off its lucky or just enter divine intervention violation, type stuff. It turns out that the one that we that works really well and that were using The covert vaccine turned out to be sorted the cheapest in the easiest wine which me

means in vivo within the living. So in other words you just get it acted in your arm, as opposed to like envied that's the other way which is It's a lot longer. It's really com. created a lot more expensive, figured out how we can just do this with a shot in the arm, that is a conventional, am RNA, as opposed to some. They called self amplifying that we're not going sort of get into now. But it's a conventional in vivo shot that goes into your arm. Yeah, it's the most straightforward. It could possibly be at this point in our am RNA vaccine technology which, like you said, is rather gee you didn't have to be. That way could have, it could have been the most expensive and the most difficult and time consuming near and we'd be an by much different spot right. Yes for sure, so, tat kind of explain. How am RNA vaccines do their thing. It helps the kind of view is like a metaphor for like a a training session like when know your vaccinated against something,

you're. You're immune system is being trained to fight and invader, but it's like a training session that uses like blank round. So it's much safer, then then say: like you know, capturing one of those enemies, pushing minded giving everybody live ammunition. Things have given us in that not a military training session. I guess so sugar. I was thinking more Swat team, but sure so. You know we mention a couple of times as limpid nanoparticles that in case the MRI aid in that things are anywhere from a thousand ten thousand times too large, for what normally could pass the cells membrane, but that lipid coding basically opens that gate and says you know what they're with me You love me, I'm a little slippery fat, so bright and just just coming along inside the so with me and I'll shut the door behind us yeah, which is really southern cause. You know with the if any of the written word or called toll like receptors in the south,

which are always looking out for something out of the norm, notices Am you? What are you doing out here? You should be in there. What's going on everybody, hey come quick, you ve gotta problem and you would not be able to actually successfully vaccinate somebody cause you'd set up the alarm to early on there's something called interfere on that it actually does interfere with em rna from being transcribed, and so a great name it it's perfectly so fish caught em RNA out that interfere arnwood would come in and prevent I'm already from ever being transcribed into the viral protein. That's a big one that that lipid coding helps protect. So say now. We ve got the mri, Nay showing up in the site or play some again coming from outside the cell, but now it's in the sight of pleasant, everything's cool everything's normal and thinks he can proceed from there, tried, and it shows up with those blueprints rolled up under their arm. It's got the little work orders from from the big boss.

And since I resumes you're about to get a lot of work thrown your way. You gonna ok without you, gotta create all these different proteins. There were coded for and in this case where we want to stop a pandemic, so it's coded for this virus and we ve got just a tiny little bit of his viruses body and don't worry you're not gonna, get this person sicker anything because my friend John Carter me you made another metaphor of like a piano player traditionally. If you wanna play the piano, you're gonna use at least an arm, and probably one of your ears and traditionally but you really want both those arms in both those years. Yes, it like ended in a body to go along with it like just an ear and an arm can't play the piano right. So just a little bit of this, Iris isn't gonna make you sick know exactly solar or lay spread it to someone else. That's a big one and that's what and that's what the m.

In shows up coated for it's a little piece of the virus. That year, you want to immunize the person against, and it says, hey everybody, let's start making this Hey everyone! Hey we're here, come make this viral protein, which is called the antidote antigen, and so the body search doing that. His as it did know, the MRI was outside the seller was ever creek, it in a lab, and so it starts trains being the MRI, Nay and the viral protein start getting made, and the whole point to all If you want like a really good immune response, Chuck you want to trigger both of the two immune systems that humans have. You got the innate system and you have the adapted system adapted to systems. Yes, you get too because you vertebrate and if you can trigger them both too to a large degree, but not so big degree that you end up with the sidewalk keen storm that can accidently kill you. You ve got a good immunization, going. That's right

and we talked about with great wonder and marvel about the human bodies immune system before, but as fresher, we do have two of them. We have the innate, which is the first line of defence, is like sergeant slaughter. You know, foreign invaders come in and insurgents order just wants to kill you kill, kill, kill everything that comes in his in his little scope right and that's the innate system. Just neutralize everything the second it sees it be on the lookout for everything and if it looks weird, kill it and that's like if you get it the skin on your near a cut on your arm or something, and it smiled that inflammation around the cut is that in aid system and of its mild enough and it doesn't get complicated area thing that may be all you need for something like that sergeant slaughters. Are you me? That's all you need, but in case in with anything a little more sophisticated You're gonna want to engage that adaptive system as well yeah which, if the innate system is, is act

evaded on high enough alert. It's going to basically go tell the adaptive system like hey there's. This is what this is something more than just a cut on the knee thy great. We really need to pay attention to this, and the adaptive system is made up of specialised white blood cells and they basically are trained to take it. Look at this weird new foreign invader, which are called non self materials. Basically, anything that isn't part of you. It comes from outside your body called nonsense. in Sarajevo title. I think so too. I see maybe Phil Collins Nonsense! material yeah, but then it just be. The cover album witches it's a great name for standard. You know get so they look at this now, Self Material and they say okay, we gotta remember that, so they basically learn, learn to recognize it catalogue it and then figure out how to produce anti bodies that specifically attack this virus.

Or this antigen the little bit of the virus that that can be infectious and they it remembers it and so the next time, the end dinner. That virus comes in your body. Your body is ready because the innate system triggered the adapted system, which memorizing, catalogued, Annie bodies to fight he used to fight that virus. Yes, in its, it works great and it works fast there was a study that found that the anti producing cells can produce ten thousand antibodies our no no no per minute. No, no, ten thousand anybody's per second, so it literally just wants to flood that site with with reinforcements basically to kill all the stuff in a very smart strategic in pinpointed way. Yes, so you got your name system, your adapter system. You want to set up

off, and so we're going back into the sellen by now, in this whole time that we ve been talking the sell that too up there. I am RNA that was injected into you in the vaccine, has been making that viral protein, the antigen over and over again it's like I like this, I don't know what to do with it. I'm going to just going to start wearing it on the surface of my cell and the sellers and no any definite. It thinks that you know everything's going hunky, Dory, looks good on me like exactly, but luckily we have some kinds of immune cells as innate immune cells, who, on the look out for anything weird their total fascists, they dont truck any kind of a non conformity or anything out of the norm They look at this. This new say muscle, sell because that's what you get your via your vaccine injected into wearing all these weird viral approaches.

the said come with me, overwhelm that poor Sally, take him out back and basically disassemble them I love that. I wonder it makes you wonder like all these, or just doing the same thing, but like some of em, Go wait a minute like you, you are very suspicious. And you're coming with me, and I want to introduce you to my friend the adaptive system. like do they know which cells or is it just a random thing? Why you mean they know what sells you know the cells ago that are more suspicious by I guess what they're saying is like stop expressing yourself there. It is There were two men sort of you know why I gotta find it interesting that some of them are just doing their thing,

and then some of em, I mean they're the same kinds of cells known to know their different kinds of cells. Okay, there are different cells that are peak are suspicious, those whose you're an innate immune cells there constantly I look out for something weird and when you find something where they just kill it and all the other girls are just the other day. They're like Tommy. Don't look at me, I'm normal! I'm normal I've got. I've got no weird proteins on my surface. Look at them since now. Ok, so then those cells that take the poor muscle cell that's been creating as Varro Protein and thinks it looks pretty snazzy and is now being disassembled. They take some those Varro proteins to the adaptive immune system and that's where they say hey guys. Look at this. We don't know what this is, but we think it's a problem, so you might want to remember it and create some antibodies that you can deploy against it. If we ever see it again later and at that point after all of that happens, you are vaccine against that yeah and you know here's the thing that some other myths that people think that the single

inside your body and knows what's gonna happen in ten years in tenure, we will all have horns growing out of our heads because of this there's no one here Thence emirate M Rna leaves you it's very fragile, like we mention, and different studies have shown different results. somewhere in the neighbourhood of a few days to a couple of weeks is basically as long as That, in our in aid, is going to survive before it degrades and then leave body through the limp system, yeah under normal circumstances, it's just a few days, but they figured out how to make it a little stronger because you wanted in there a little longer, because the more that year, muscle cells, are producing this viral protein to the moon. or of Slash eight response and then hence the more of an adaptive response you gonna get, but no matter what they they do the emigrant is going to go away. It's going

follow all the normal processes for exiting the body. Those cells that produce that viral protein are going to be destroyed and it was viral proteins are going to be taken up and taken to the lymph nodes where they're shown to those t and b cells. Produce the antibodies against them all that is a totally normal process, and that is the point of vaccination has during this says. Maybe your innate immune response makes you feel, like you get the flu for a few. Like ours or half of a day, or Maybe your arm parts really bad that setting a response, but you're not going to get sick you're not actually going to have covered, because it's that live training with blanks tinge writing to treat to train your immune system. How to recognize us of it when sorry,

Kofi to virus comes along and says all see what's going on here, because all my God, oh no somehow this thing this this body's already been trained to attack me now I'm dead and gone, and I can't possibly in fact this person. That is the point. That's what's been done with them, or a knave accents here in I was about to describe this last part- is another miracle in this, but I think the grating, the hard work in research to describe it as a miracle. It is hard work in research is what led to the stuff. So the I guess, we'll call it a break through one of the other biggest breakthroughs is that day had to find the what you call the gold like zone that that perfect perfect amount. So this thing would work perfectly. So we talked about the site. Ok storms, you dont, want that you don't wanna over blow it and do too much. you had to dialogue back a little bit, but it can't be so weak that it doesn't even notice the advantages to begin with. It's got a notice, so it does as antibodies, so you have to find them

like zone in there and then there's the last bit of the fact that there is an basically an early warning system in the body that prevent M aid from being translated. If it thinks like it's not built well, if it's miss, if its misfortune it or something it can really wreck the body system. So it's on the look out for that stuff in it. It has to get past that early morning, sir, in order to make all this work anyway, and they did it all of those things yeah, it's pretty amazing, They made something this natural enough to full nature for a free, for all intents and purposes, your boss, is like. Oh, I made this m are in a cool. Let's listened, let's, let's start translating it, which is astounding and in Then everything just kind of follows: that process is perfectly in a really is like hats off to those people who made this stuff Vienna, hats off the end, and I think it, let's take a break UK. I think we did a pretty good job.

there ya, think it and we're gonna talk about how they make this stuff right after this a chuck did you know that energizes ultimately theme double batteries. Last up to twenty years in storage. I did not know that. Amazing, because I think we can all agree. Leaks are bad roof leaks are bad hand. Sanitize or links are bad secrets that leaker bad and battery leaks. The worst yeah mean when you by your batteries and have him story, you know one of sitting around leaking. You want them hanging tight until you're ready to use them, so they have full power. That's what energizes! Ultimately,

batteries are all about. The trade energized is different. They are designed to prevent damaging leaks. So when it comes to toys, digital cameras in your other valuable devices, you can feel confident. Knowing you have the long, lasting power and protection, you're gonna need from energize her so turned energize, our ultimate lithium, number one longest, lasting double a battery. When you have a simple question about your credit card, getting answer should be simple right, but then you call your credit card company You can't reach a real person. How can I assume you speak with a representative. I'm sorry, we don't have live representatives. What can act to a representative. Did you say representative? Yes, I'm sorry, there are no representative available. How can I help

at discover, they believe. Managing your credit card should be uncomplicated. That's why, when you call discover whether question about your credit card discover gives the option to speak with a real person based in the U S day or night, twenty four seven. They also give you the op define help by messaging them through the website or the mobile app, because Having the option to connect with a real life person beats dealing whether recorded message any day of the week. That's just nonsense and at discover they think their need to be a lot more of that single and give them a call, send them a message on online or connect with him on the app they look forward to. Speaking with you live, learn more at discover, dot com until now

Josh starting aright love. How you put this so much in this that going to read it verbatim UK. To put it Nutshell did so emperor simplified. It's basically wrong engineers. spell out the genetic code they want, the M Rna to carry the Abbe ingredients, they press enter in the computer, tell syllabic equipment what chemical reactions to carry out and for how long I mean that's kind of it. In a nutshell, The simplest like this. If you really need to tell your weird uncle it thanks giving how it works, you may just wanna start there and see what is reaction its he goes. They press enter. That's my greatest fear.

Haven't, you ever seen more games trade, but the circuit nice to start at the beginning though you have to understand what the genetic code of this virus you're trying to fight and again, thank you, human genes. Project for pushing and that along and once you have the genetic code You studied a virus. You can figure out what its Achilles heel is in the case of the covered vaccines, the two, one from Madonna. and then one from Bio and tech, foot and Pfizer can't forget, biotech basically they're the ones who actually came up with the template for this vaccine and Pfizer was like hey with partner. So it's it's wrong. Did this? the Pfizer vaccine, but by the way, just announced today that they approve mix and match. I heard that too, which is its awesome. I mean everybody loves variety to spite of life. Well, I'm still gonna get the modern it to begin with. I'm going get the maternal boost.

Variety, but I'm just gonna, keep it keep it in the family, others. My plan to I like a modern as well and by the way is so new and modern as such a new company, I think they were organised. Two thousand ten, that the covered vaccine that they make is the only product that these near the town knew all this stuff is it's crazy, but for the corona virus vaccines, the covered vaccines chuck, they figured out that this spike protein s protein is what it's called that that is the viruses Achilles heel. It's the thing that gives the corona virus that spiky appearance yeah, the crown and that is the thing that it uses to fuse to cells membrane and then basically coax it open up so that it can spilett viral cod it's in there and make more more viruses. So it's the weakest point of the virus that's what they figured out, how to target but to understand

that you have to know what the genome is, so that you can go in and say here's the part of the genetic code of the the Sars Covey to virus that makes that spike protein. Let's take this plug it into different, like a string of their marinade and then we'll have that I'm already that produces that spike protein, and we can use that in a vaccine and that's what they ve done. It some. It almost seems like a greek myth or something with with a crown cuz. I remember when we talked about the coronavirus in that fancy crown. Unlike look at my fancy crown- and it turns out it's that that fancy crown that's what's going to drag it down, numerous and vanities vanity. That's what it is replying a lot with human shouldn't right, it's exactly as the too close to the sun. So they identify that little crown, like you said, is the Achilles heel and they got a little bit of code, and

then the rest of this is this is sort of another one of the Big Breakthroughs Magna Carta miracle. They again they figured out how to do this. All outside of the human body because they got a hold of plasma, did plasma did not plans appeal. I assume plasma dna usually from equal. I, but don't let that freak you out. That turns out. It's really helpful in this case, and this axis like a template, it's like the working the working DNA that they used to figure all this stuff, standing in for the humans own dna and its in it's in the it's on that work site. It's in that site or plasma is like almost extra bonus. Dna that's outside the nucleus and so they're. Using that to stand, and for our own dna. So we could figure, we could figure out how to make this stuff work together. Yeah, it's almost like, if you are looking at a piano keyboard and a p piano key

was plasma, DNA and saying a coded for luminescence or something that if you went along and took out some of the keys and put indifferent keys the now that it's coded for an entirely different kind of protein, in this case that the antigen that you want that spike protein. But the point is it's like a structure, I keep you. In the piano metaphor. Indifferent thrilling way is an entirely happy with that, but it's the backbone. It's the thing that you use to hold the original code. because Remember M Rna likes to go to dna to make a copy of that little code, that string of a gene teasing season Ays, that's how it made in it that Have it happens in the body? That's how they do in the lab to and start that means you have to have dna, ok right, but here's the thing you can't just create that template and then that's it Now, being Bang Bonbon, Jovi gotta transcribed that

to the M Rna and think of nineteen eightys it Brookhaven National LAB is where they develop. This right, ingenious technique that use bacteria fires, which are these viral parasites. That- and this is where be cool. I kind of comes back in that infect bacteria like eco lie, and they have a really really efficient rna transcription engine, so they said well, it's just use that causes already really good at that yeah it, which is pretty cool, the other thing to a fear like, oh my god, equally plasma dna bacteria values that are viral parasites. They're using this, the others is like Frank and sign stuff. keep in mind there not harvesting like while the coal lie or wild bacteria forges like their building those things from scratch in the lab in there getting to the point, if they're not already there, whether

Are we only need this part of the plasma dna which, again by the way, does not create equal? I it creates an extra bit of something, or we only need this part of the bacterial fudge, and so they just make those parts that they need, or increasingly just ordered them from from lab supply. Companies online like that, the point that were at now, because again, these are all non living things that you can sterilised and there in some cases not just parts of non living things like plasma, dna or bacteria fudge. Yeah, I mean it's it's amazing. So they put this the plasma DNA template they take the bacteria version. They put it in soup kettle on the stove. They add a little chemical go juice. That says I get started and then the back door if says, wait a minute, I'm under what I'm good at I'm great it that transcription and so on, in its history, transcribing right now and I a transcribed that code in the play the DNA and I'm gonna produce item

of em rna strands. Like all does it doesn't sound like a lot? But if you have an average can run you you're gonna, get about two grams of em rna per leader, that's like seven to ten coffee beans. Advertise cough: being here and that in a few days- and you may think- like I thought he said, allied a couple grams is in a lot. These vaccines use I think, respectively Madonna and Pfizer a hundred and thirty micrograms per dose. So that too, AMS into producing anywhere from too two thousand six hundred thousand actual vaccine doses yeah and also do Your return Ma Am Rna which exists on the nano scale in your using ten coffee beans worth of that stuff in three days, their town, small, yes, very small, so they ve got tons of em RNA each time they run one of these batches and then

take the mri, nay that comes out and they purify it. They get rid of any left over nuclear materials from that transcription process clean up the slot like ours and then they surrounded with a livid nanoparticle. That packet of fats is gonna, help it get into the cell and protected on its wild journey through the body, and then they mix it with a few other things, I'm usually a few kinds of thumb salts, often too, to mimic the ph of the body, so that it at its accepted a lot more easily over these sugar to stabilize the whole thing, and that's about in not even about it. That's it like there there's some fat, there's the mri any salt in sugar and then that's what you have in your vaccine, whether it's the biotech Pfizer or the modern one, the track

we are on, says yeah, but what else is really in their say? That's it the salt in the sugar and when I just told you about Dumdum and he'll say hopefully, while that makes me hungry now, yes, The sounds delicious plenty of glory remnant. My mouth it there's no butter in that gathers lipids apart, so we're gonna finish up talking a little bit about what differentiates this from traditional vaccines. The biggest thing is that it's like we said before its built from scratch in a lab, outside the human body and that's very different. in its non living like we said, and other vaccines are called, viral vector vaccines and they either use like if you get a flu shot or something you told me about it, dead virus or alive one. That's been weakened, or proteins my viruses and it takes a lot time to produce these. It's not like, like this thing when it light speed, but

not in an unsafe way and in a truly astounding a way I know I was reading about the emergency, use authorization project process and, like the FDA, did not mess around like they. They. They definitely did double time too, to try get these things out the door cuz they needed to, but they did not cut corners on safety. From anything I saw it was a really safe process and it way, but it was still really fast, not because the FDA cut corner but because a more and a vast scenes are able to be created, really really fast, and so I think, Biotech Pfizer head emergence, use approval within eleven months eleven months of developing the vaccine. This second fastest, a vaccine had ever been developed before prior to em RNA vaccines as four years yeah.

I want to say a little bit something else about that Cosette. I think that's a big reason for vaccine hesitancy is the speed at which it was approved. And like there's, no way they knew what was going on. I read, about this over then not even for this dislike over the past year and how that price As usually works. Is it's it's really, the funding, like your funded, a certain amount, money. Is a company to get approval for studies and stuff like that and get funded that certain amount, and you can only work, then that amount of money. So your study is is only gonna, be of a certain sample size and they're, pretty big, and then you all set like a certain place in line with this vaccine, they had of sample size out of the gate that was humongous because the entire world was in getting infected with the star or not getting infected, but you know tons the people are getting effected the entire world was on watch and on guard so you had no problems with sample size. You added

problem with funding, and you had no problem with waiting in line Keziah said are at your immediately at the front of the line right, so it it didn't get approved because they just want to speed it through. really quickly got approved as it jumped the line tons of money behind it and it had a ton of people in the getting. You know thanks volunteering to get jabbed early on for the test, which produced a ton of data that like more later than usual yeah yeah, because they have more participants unusual. That was everything else. as well to do so. Frustrating now. Is it actually get more data? Then they usually It has got it a lot faster and in their people, still think that you know there's not enough information, it is because you didn't take his long. Yeah big is very frustrating because people are like. I am wary of that cause. It was so fast and it was so fast because it is one of the biggest advances in the house. Of medicine this happening before our very eyes, but rather the.

is being like all my God, what an amazing time to be alive. What using accomplishment. Humanity did a significant portion. People like now, I dont trusted they're. Trying to kill me your catalogued mere bill gates wants to keep tabs on on meat, because Bill Gates cares what I'm doing we met bill gates. He does couple done he does you're doing in its aid to break into, he does not care what you're doing and you know we mentioned before that we almost like we were waiting for this, like we had The M are in a vaccine sort of technology figured out and to a certain degree- we were just waiting for the Chinese. Government in the researchers to release that genetic code, yes, and once they did their like our. I hear it is it's open source. in every twenty twenty two and everyone's like great that's all we needed and we are ready to rock n roll, and I think you did you say it was twenty five days later years they produce their first successful batch

amazing. Thirty, nine days after that, the first phase of humans, miles were under way, which I mean it's just so fast, but the kind of go back to that point to chuck, because I think a lot of people are also suspicious about that like. Why were they just waiting for this pandemic? It's pretty suspicious the day there were people who, while at Bio Intact, am Medina, who already had like these templates ready. They were working on em RNA vaccines in it for a number of different fields, and then there are other groups who are specifically working on corona virus vaccines. Could we dealt with corona viruses before murders Middle EAST respiratory syndrome, Sars? The original Sars? Those are both corona viruses, both of them share their spike protein wit Right Sars Cove II to the gets a virus that

What causes covid? That's a coronavirus as well. They all have the spike protein, so they had spike protein template. So, like you said when chinese researchers posted the genome of the Sars Covid, two virus people are like cool. Let's take that plug it in and see what happens, and it worked why it was so fast that plugin play enough. Yeah I mean that's. Really situation because in the future, might be able to solve things like. HIV and rabies and me even certain kinds of cancer like it's it's a technology that can be I do a bunch of things and ready to go for it for this year, the cancer one it's it's I mean. That's just amazing, trickier stepped yes, but they're getting to the point where they can say. Ok, you got cancer command. We're gonna, take a sample of your tumor, arrogant study. It working figure out what its genome is. We're going to create a tailor, made vaccine to train your body to fight that cancer

and we're going to vaccinate you against your own personal cancer were a few years ago, From being able to do that kind of thing in it, and when that happens, if it, if it, if we can do it, we will have beaten cancer. That's that's the next thing. The MRI vaccines are about to do. It's amazing. It's a reason to applaud science, and you have a little bit more that I didn't fully understand, and thankfully you're gonna tell people about while the other shady sweeping I mean one of the other things. If I'm not mistaken, this, it seems like vaccine hesitant people are worried about. Is that a martini back? get em by themselves in your dna and alter it, and that's actually, the opera that is why I am RNA vaccines do because, like we said they come from outside of cell and they do their work in the site. please don't go anywhere near your nuclear sir interact with your dna. They don't need to. They ve already got what

would have needed from the dna, in that the MRI nascent shows up with the blueprints ready to be translated into the proteins right like they can't can't get into the nucleus right now, I'm As far as everybody knows they they can't or they don't. There's no reason for to others reason. They should and then, even if they did, that doesn't mean that they would be transcribe. Into your dna right, the actual wild Sars Clovy to virus doesn't even you that a lot of viruses actually go in there aren't any reverse transcriber your dna and then get your dna to produce more viruses that a lot of viruses infect you with the stars. Covid two virus is not like that skull, a positive sense rna virus, where it shows up and in much the same way that the vac in shows up with ready to go and more a name. The Sars Covey to virus shows up and says here some are unable to start making more of myself

and it has nothing to do with the the dna in the nucleus. It just works in the cytoplasm plasmas, while so there's, no he's to think or believe there's, no evidence that the Sars Covey to virus embeds itself in your dna- and I hate to say this, but even if it did at least percent of your dna. Human being is made up of ancient viruses DNA that has been injected into humanity over the eons and as much as forty eight percent of your dna is actually old. Viral dna that's just junk dna now, so it doesn't united that doesn't insert itself into your dna, even if it does it? Basically, you would be good at making years of corona viruses for awhile right. That's it! I love it so there you go that some are in a back scenes. Nice work, nice work. Do you two men? Thank you for doing this one. This is a great one of

and if you want to know more about em, are in a vaccine, then just start researching this plenteous stuff out there to explain this even further and since I suggest start researching that means of course, it's time for listening to me there's is a quick linen colleagues about the church about the sub of is a follow up good morning fellows. Having listened to your part, Yes, for several years, some of my favorites include how soap works and how slots work. I'm listening to the tale of the church of the sub genius episode as I type and I often google, the topic here enlightening lightning us with and when I search for Bob Dobbs, a recent twitter post from Bob Dobbs said this earthlings of earth, you will be put for the nineteen seventies. That is,

Hashtag Sabena assessed, hashtag stark. This hashtag to stay motivations and Chris remarked in Texas is hysterical. Lubber pot gas, my wife and I have great conversations Europe, sets all the time and again that is Chris from Arlington Texas, very nice things like Chris. There was a nice little pick me up. We love the nineteen. Seventy, so screw use of genius agreed chickens. I somebody said well, if you want to give us a pick me up like Chris Chris Rank like Chris did and you can send us an email to stuff podcast cast it. I hurt radio dot com, stuff, you should know, is the production of Iheart radio for more protests, Radio visit thy heart radioactive apple had passed We listened to your favorite shells

my name- is Jill a poor. I'm a historian at Harvard New York, a writer and host Vanunu called the evening rocket sold out Elon Musk and his strange brand of capitalism call it Muskingum, driven by earnings, but also by fantasies I'll take apart mosques, vision of the future by looking at the science fiction. He built it added in the science fiction. He left out so blast off with me on a journey into the history of the future. Listen to the evening rocket unhurt radio up apple pod casts overview. Get your pod casts high. I married veto of vocal cultural works with artists like Oriana Grundig, Sean Ben does John Legend. Have you ever wondered what life looks like for people who thing for a living well and my new podcast backstage past you'll get to find out we'll talk about each guess vocal journey from the very first day ever,

as to the challenges they face. Did they built their career listed backstage passed on the heart radio couple pod cats are wherever you get. Your bike casts the Mai. Could do that pod gas network is dedicated to celebrating elevating latin next stories and content creators and english Spanish as Spanish, well about representation and feature the hottest celebrities, influencers and voices with a variety of podcast focus on pop culture, music comedy much more. It's listening. Sperience for everyone. It's where who do that meets. Go money that list Michael due to podcast network on the hierarchy of or wherever you get, your blog