Hello friends, welcome to the show this episode of the podcast is brought to you by my good friend bill birds, new Netflix, comedy special, which is out right now. It's called paper tiger and it's fucking awesome. I'm a married man with the kid, but I'll tell you this right now. If I've learned anything in five years of being ARI, is we're always working on me? I just think that myself, like what could my wife complained about my fucking crush everything picked up after myself, I like to think I'm a good dad. I worked my ass off to make a great fucking living crush. All of that All she has on me is who I am, is a person my daughter's yet to meet the real mate she's seen glimpses up daddy

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and if you have been meaning to wrap up your last will or living trust, but can't seem to find the time take a moment. Do the right thing: if your family, are you confused or have questions? Well, don't let that slow you down! Legalzoom is not a law firm, but their network of Indy Pendant attorneys in tax professionals can give you the advice that you need to make the right decisions. Save ten percent for Lynn, the time on the things that you have been meaning to do with Legalzoom, just go to Legalzoom dot com right now and use the code Rogan at checkout, Legalzoom or life meets legal. My guest today is a brilliant scientist. He's been on the past and I fucking love the episode and we have a new one that we just did, and I think it's even better he's amazing and he has a new book out called lifespan. Why we age and why we don't have to. This is one of the most informative podcast since you were ever going to run across when it comes to aging and some really fascinating new information, that's

available for you, your ears and eyes. Please give it up for David Sinclair the Joe Rogan experience trying my day, Joe Rogan podcast by night all day, why we age and why we don't have to I'm so happy. There are people like you there, because I don't want to age, I'm aging clearly, but uh not interested in it. I don't like it yeah. Well, I don't know anybody who does Joe Rogan thanks for having me back on actually going back. The first one was a smash hit. Man, people loved it all. My friends were very excited, but I question for you right off the bat regarding metformin. There was actually an article, I'm sure you saw it recently like within the last couple of days that was going around through all the mainstream papers. It was talking about how the use of metformin Dhea and what

something else as well, that was taking, but human human growth hormone, taking two years, two biological years off of people's lives in terms of their age, with your natural eight, with your actual I'm fifty two would make me fifty right, even forty, nine dot, five. According to the study for yeah, that was actor. That was a good study uh. You know it's only nine people, so we have to repeat this with a studs. What did you get like nine super athletes, or did you get like schmoes that don't exercise uh? As far as I know, these were just regular smiles, smiles yeah, which is good news schmoes. Like me, yes, good news, yeah, I mean that's what you want. You don't want, like some people, just respond, better they're super bodies. You know like a great thing about that. Ah, study is first of all, I was with the first uh. The main author on that paper, while it came out, was over in his well as part of my journey up. The great rift of Africa ended up in Israel anyway, the guy there ah see poor Beth is his name.

He and I, and a couple of other guys, they're trying to figure out not just why we age why we don't have to, but is aging truly reversible and that's what this study suggests is that it's not just about slowing down aging, but one day we could be eighty, but biologically thirty. Now, when we're talking about the biological age, how is that measure? This is measured by the length of the telomeres is measured by physical performance? Is it measured by a combination of these factors, it none of that something brand new. Most people don't know about it, so it's called the Horvath Clock and what Horvath and others have discovered is that if you read the dna- and you don't just look at the letters Actg, if you look at what's on the letter c size means called there're chemic modifications and those chemicals change as we get older in very linear and predictable ways, if you use a computer,

aye aye, you can say if I took your blood sample right now, I could read your dna look at those chemical groups on the seas, and I could say you are okay. Fifty two, you might be forty six according to that clock, oh and also I could predict when you're gonna die whoa. You thought right, yeah like a fortune, teller yeah, but the Good NEWS is well now that we know what's not just measuring aging. We actually think that clock is part of the aging process. We're learning how to reverse it too. Now. Is this just one modality? This combination of growth hormone? Is this one way of going about it Are there other ways of going about it? Growth, hormone, dh, EA, metformin, met foreman. Is there anything else? Well, that's the

First, that's of interest just those three things first, but I'm sure there's gonna be many more discovered. We've only had this whole death clock over the last few years in humans being used widely, but I think, as we use this clock, we're gonna figure out that whole bunch of stuff that we do and things that we can do and combine will not just slow aging but reverse it, and not just by two and one slash two years eventually and some of the technology that I talk about in my book, we think could turn the clock back by a decade or more whoa. Now what things are you talking about? That could possibly turn it back a decade or more well, sir, the, and who do I have to blow sorry yeah. You can point me yeah, you may have to do it a few times, but up the I, the amazing thing about where we are now today with agent and we're right on the cutting edge? So it's great to be able to share this with your listeners. Is this clock? It's ah changed on the dean right.

What I'm saying in my theory of ah of aging is that it's not the d n a that we lose that's the old theory. You know the old idea that antioxidants hurt the Diaz just throw that out for a while. Maybe, however, what I think is going on is that the DEA is getting modified and the cell can't read the DNA the way it used to. Okay, that's really important, and so the clock is not just a clock: it's not a clock on the wall. It's also. If you move the hands of the clock time changes, that's what I think is going on. We pause right here for a moment and explain what you were saying about antioxidants, oxidants, well, toxins have bean the biggest disappointment in the aging field. Doesn't stop forty million people every day, buying drinks with antioxidants in them, but antioxidants have, with very few exceptions, failed to extend the lifespan of any organism. But you are a proponent of Roseville

patrol. At least you used to be a. Are you still? I still take it on and we still study it in my lab, but what's he brought this up is really important is very true. Was originally thought to be an antioxidant and it is a mild anti oxidant, but the way it really works. We know this is a fact from my lab is that it stimulating the body's defenses against aging and disease, because it's binding to these enzymes that we work on called sirtuins, and these are the defenders of the body, and you were saying the. If I remember correctly, you take for his very trol, you take a powdered form actually bought exact, which you take and you mix it with your in the morning is a is a how you do it yep? What's the what's, the dose that you take well probably comes out to about a gram in a gram, okay, so someone's taking capsules. What pensive probably captures a two hundred and fifty milligrams that, because in the morning you know I'm still alive, so that's good. Thank you.

Do you? Is it important to take it with fats? Is a or you take it with yogurt yeah yeah, either high protein, which is a greek yogurt, suffices or fact, but water ill? It's like brick, dust want to solve and canceled this, but if I go massive whole milk, maybe would be ok, yeah, that's great, but it has to have something to bind to. Is that the deal for sure yeah in our studies in humans and in mice, if we didn't give them high fat food, it barely got in? There was five fold lists now. This study of metformin, dh, ea and human growth hormone does not include an immense right, so but N M N is also effective, uh. Well, let's delve in a little bit, please, if you read the paper and I have uh turns out, one of the effects of this treatment was the reduction in the levels off a protein.

We thirty eight cd, thirty eight resides on immune cells and it goes as we get older and what they found. One of the biggest effects of the treatment was the levels of this city. Thirty eight protein went down. So what is the CD thirty eight? This is the main enzyme in our bodies, the two grades in a d n, a d is required, for these are two and defenders to work. So one possibility is that and I'm sure it's complicated, but one way this could be working is by allowing body to make an a d and store it rather than degrading it as we get older, interesting, so would supplementing with any nmn, which is a form of any NAD correct, a precursor precursor. Would that enhance the effects? Do you believe like? If they try to do a new study it could could it could? Potentially each of these

missions cost ten thousand dollars for the treatment? So it's not easy to do these studies, ten thousand dollars for the entire t of the treatment and the treatment. Last. How long? I don't remember how long they treated the patients for, but I do know that it was cheap. That's why? Then I did nine, because I've at first I said to my friend, Steve Horvath, nine patients, you kidding me: what did you do a fifty went? Well, we don't have the money, that's the that's the problem anyway. My point really is that we need to test a lot of different combinations include and include this one right, the which is a little bit more risky toxic, but there are better molecules in development. The question is, what is the best nation and do you use it with exercise and fasting, or is it bad to combine them all together? We don't know yet that's a good question two that I wanted to ask you, because one of the things that came out of the podcast was input from some other people, that I know that our nutrition experts and performance experts that were skeptical about met for,

and they were saying that met foreman, although it may have an anti aging effect that actually decreases physical performance in athletes. Well, that there a study that shows that on virtual to actually really can prevent the great gains from X. So here's the solution that I think is worth trying a solution, and that is a theme that I have in my book and my my research, and that is, we don't want to be doing everything everyday. Necessarily, we want to pulse it. We want to shock the body and let it recover. We know that you can't just exercise, I mean some people who, being on this show run one hundred miles every every weekend, but generally you want to hit it hard and let it recover hit it hard leather coat. So what I am planning to do and actually started doing is on days that I'm exercising and recovering, I don't take metformin and the I'm just sitting around on a plane. I do and that way I think that my body can have the best of both worlds. So

when you are not exercising- and you take it, you feel like it doesn't have a hit when you are exercising and not taking it so somehow or another whatever performance hit. It has it's temporary yeah right well, this is all just theoretical it. It is we're right on the cutting edge of human knowledge. We don't actually know what the best thing is, but my best guess is that we want to allow the body to recover. So I don't take metformin those days rather than taking met foreman every day, like a diabetic. Would that what is what is the what's that hit like what is happening? What's the mechanism behind the performance it from taking that form? We don't know, but I can tell you the best explain so that I can give you some foreman is a derivative of a plant molecule, the french lilac. So it's not crazy molecule, it's pretty NASH,

but what it does is many things in the body. Scientists will quite annoyingly argue about it, for they have for the past forty years. So there's no correct answer, but what I think is going on is that metformin is interfering with the mitochondrial in the cell mitochondria, that we call the battery packs they're, basically making chemical energy, without that chemical energy would be dead in about twenty seconds. So we need that for life, that interrupts that energy production in the mitochondria, but you need the mitochondria to amplify after you've, exercised so they're they're antagonizing each other. So why does metformin work by inhibiting the mitochondria? The body gets a signal that it doesn't have enough chemical energy, it's not making enough so expands the number of mitochondria. These are ancient remnants of bacteria that entered ourselves cells and we have less. If we sit around and like we are now, and we have more free exercise and met foreman, Beitel

nobody's shit, we're running out of energy, the body responds in make more mitochondria just like exercise does, but I think, if you're taking metformin and exercising that inhibition is preventing the benefits somehow of what you get with exercise, perhaps preventing your house so like what? What did the study or what studies have been done and what did they reveal? I don't remember the precise details of the study it was. It was giving metformin everyday to people who were in a controlled exercise. I think was treadmill a week, but then what they measured was the mitochondrial benefit. Now that I think measured a bit of strength so confusing that there's a mitochondrial benefit, but a performance hit,

oh that actually met foreman prevented the mitochondria from amplifying up. Oh all, right. So then it must be ah interfering with the signal that you get from exercise whatever that is, we don't know exactly what that is. So you really have to be some sort of a guinea pig to try to fuck with the stuff toe go back and forth from taking it and exercising not taking it. Yeah, I'm sorry and I'm one of those guinea pigs and what do you no disrespect, but how hard you're working out not enough? yeah. If I could spend three hours a week in the gym, not bad. It's all in one day That's maintenance one day really one day, three hours yeah! That's it doing doing it that way, I'm I'm smart, but you're, so smart. That drives me crazy when smart people do dumb shit, add Peter hotels on the podcast he's a brilliant man from the University of Texas, he's

researcher in tropical diseases and is obsessed with diseases and the importance of vaccination. All these different things that he's talking about how he is diet is terrible, a junk food constantly jack in the box and shut up What, if I don't man you're so smart and you're, a guy who works on diseases? What's the number one cause of diseases yeah, I don't think that some of my colleagues eat the worst food. They study longevity crazy, it's crazy! It's like they can't help their impulses. It's like there's! So many people like that that are obsessed with various aspects of health and performance, but they just they just can't get well. I would out more if I had time, I'm usually working till midnight and after that I'm not really go to the gym. You do have an excuse. You have a crazy work schedule. You do have an excuse, yeah. Well, I'm on planes FEB. So I tried exercise on the plains pretty hard. Do you really want um? stretcher Mask Watts squats, so we think you're, crazy, yeah, it's gotta pee alot. Are you doing

hello in there or something you haven't done. Excites royal people think you're in there doing. Meth yeah dude something in there. So what do you do when you work out? Ah I lift weights for an hour. Um then do it orbital stretching and then then we do some hot and cold treatment. Okay, yeah remember we did the my therapy last time. Yes yeah! That was fantastic. I won't do it again today. If you get time, I do tastic meant I feel planning on doing today. I did hot yoga earlier so like to do yoga in the morning and then cryo after podcast podcast. So I like to mix it up right. Let's do I don't have a cryo handy at my place, but I do the sauna and then cult up, and you should wanna cry out set up there, not that expensive. You can get one. What about these infrared boxes? Are there any good? Oh for saunas, I do not know, but some people swear by them. Laird Hamilton, who were talking about by the way how good

coughing. It's fantastic Tomba, superfood coffee. Well, we'll get you more well uh. Oh Jeff is going off to pick up our Pablo Escobar Mug shot picture. I'm obsessed with monk shots for some strange reason: we've been collecting new mug shot. Pictures, we've got a giant, Pablo Escobar or it's very nice um the Laird Hamilton stuff is. Ah, that's got Americ. It's got. Ah coconut milk. It's organic coffee, I'm so addicted to it. I drink that stuff, like water yeah, I'm gonna have to myself so yeah, it's delicious. He said I mean you could just you don't need a machine either good makes it yourself. He has all the stuff you just poured into coffee. Yeah I mean he's a hero of mine for us. Doug he's fifty something as a thousand years old runs mountains. Fucking serves things tall. Is the empire state building he's very interesting. The last I saw him. I was watching something on Instagram. I saw him in a sauna with oven, mitts on riding a bike

like like one of those echo bikes like those rogue air assault, bikes riding one of those fucking things in a sauna doing his sauna routine. I did not like it. I was cranky a sign up to two hundred and twenty degrees, and I think I cooked my lungs a little bit, not bad, but people who listen to the podcast afterwards. My apologies because I was I was coughing like that for like four five episode and then I had decided okay. This is fucking stupid, like I don't think this is good for me right well, hormesis. What doesn't kill you makes you live longer, that's not exactly true! You can push it a little too far. Sometimes boos, Boos and kill you, but it definitely doesn't make you live longer. That is true. Have you drink hard every night till something? If you look at two people, one that drinks hard and their brother who drinks water and runs all the time boy that water drinking guy looks fucking fantastic, doesn't compare

well yeah, that's probably another one of my vices. I lay off the Argos yeah. Well, how much do you drink? I probably have one two a day when I'm on vacation, like you I over, do it. I just got back from vacation. It's my body's way out. Yeah. I get fat on vacation man. Last time I was on vacation. I was doing this house in my size, government, ITALY? I went hard. Does drinking wine every now is doing about a half a bottle of wine every night. I was eating pasta all day long, but I I'm on vacation. I just go fuck it and also kind gives me a little project when I come back. You know like all right now, it's time to get serious right right. Well, I was in Africa recently and I gotta tell you one of the when you, when you see Wildebeest, get attacked and and chewed on for forty five minutes by a crocodile, nothing better than now going back to the camp and having a beard to come down. So I do a lot of that. So when you were safari, how did you

are you in one of those open jeep deals lot of that we did also some hiking. We had mess. I leaders that would go out with a federal officer with a gun to protect us. Oh Christ. It was fun, it's so much so different than being in a g to walk among the cats. Oh yeah man, you got sure you're almost dead yeah, it's like you're right there you feel like you're alive. You know how you get feeling of what it was like to be an early human. I've never encountered anything other than bears in the woods that are terrifying. I've never seen a mountain line while like hunting voicing two Mount lines ever one was from my back porch in Colorado and one was in the street and Santa Barbara. I was driving and I saw one run across this great. I didn't realize it was a mountain line until I saw the tail is like oh shit, I thought it was a coyote or something. Then I saw that law, but while hunting, the only thing I've ever seen is a grizzly bear, so Grizzly bear once I've seen black bears

black bears. Unnerving grizzly bears are terrifying. They look at you like this. You could shoot him and I still can't just look right through you. They look like am I eating you? What's going on with you, I'm going to eat you like they're, trying black bears alike get out of here. Should I run in my the boss? Are you the boss, like they're, not sure Grizzly bears, are fucking sure the boy there is trying to figure out whether or not they should eat you right and actually one of, and you realize, when you're amongst these animals, it's a huge privilege for us to go for a walk without getting eaten. Yes, yeah. We don't think about it that way, because we're so used to being in parks and, oh I'm out nature the fuck you or you're, not really in nature here in some weird sort of nature, preserve that we've sort of set up inside societies right and people me about my work: oh, isn't what you Bing unnatural, fuck natural! What about our world is natural anyway, brushing your teeth is a natural either stupid right. What you're born with a toothbrush in your hand, shut up

right right? Well, I would blew over here what it at thirty thousand feet: drinking a cocktail surfing internet, not so natural, that's natural you're, getting headed by solar radiation boozing it up you're, also somehow or another, online, no way that anybody ever going to be to to explain to me that my puny can can understand yeah exactly exactly yeah. Don't give me the argument that aging is natural. Therefore, it's acceptable, don't buy any of those natural things, because everything on earth is natural, even chemicals, we're not getting them from the stars were not pulling them out of other dimensions like what you talking bout, it's all from earth. Every right, even police, ooh tickles, most of derived from plants in Africa, is hanging out with the butler tribe. These are the pygmies they used to be in the forest, and I had the chief take me through the first new showing me all the drugs they used to take theirs closest adeiny um. I think I'm saying it right. It was a leaf

used to chew on they'd smoke, a bit of weed they'd go a little dizzy. They'd crouched down after about fifteen minutes. They'd stand up and they felt invincible, they'd go kill. One of those elephants in the jungle is killed. Elephants, many elephants, smaller elephants, yeah, but now the counter smaller people right, told me. Without that you can't accept the worms. The worms were about this long. My buddy Justin Wren were a big supporter of fight for the forgotten charity. It's charity that might Justin Wren set up and they build wells for the pygmies in Congo and through this application called the cash app, and I personally don't need it to an. We also do in benefits for them we're doing a big benefit now like coming up soon. They will be announcing soon, but he goes over there all the time and he's had malaria three times and just recently has a wired, some unknown parasite. That is just devastating his health

trying to figure out what it is so he's gotta go through a battery of tests and they've got a. You know, examine him, but next he goes over. There apparently is going to bring his own food, but the fucking poor guys got malaria three times yeah. Well, it should be taking his Madison more often but uh, I don't know it recurs. Does it really help you can't get rid of it? Well, it become systemic right. It's horrific man and the way he describes it and he's a gorilla. I mean a fucking gorilla, he's a huge man. He fights for Bellator he's one of the heavyweight contenders contenders. So he's this, you know two hundred and fifty pounds start of a guy who goes over there and catches these horrific diseases and just like barely he survives and gets medication and comes back, but then, when you get sick, sometimes it'll kick back in again. This kick back and watch another reason you don't want to go back to natural way of life, but you're a good man John for us. To put a note,

the pygmies, I was just in a such a fucking angel when you talk to him, and you see his documentaries that he's put out in his films that they've done with water for now with his organization. Five for the forgotten, like you, can't help but help how gosh I was in on the you get inside of the volcano riffed on and the way they live was was just. It was shocking and out we're gonna help rebuild a school for them, but they need help and the right on the edge of civilization that the battle try. The pygmies are in the worse situation than anybody in there they're the lowest of the low there picked on racially. They kicked off their land. How to save the guerrillas in these elephants and what to do? They got everything they knew how to how live is gone and that crazy there kicked off their land to save animals right yeah. Well, give it there this there's no way out. You got to do that. Isn't there a way to not kill animals and have them all coexist? I guess you could have

kept them into groups of national parks, so you can't easily have humans living the National Park has posed. You could, but they they're trying to modernize them. So they put them on this small few acres of land which they're trying to learn how to farm and the way they subsist. It is through tourism. So I would recommend anyone who's interested, go, see them support them by a lot of stuff. I think he bought up one slash four of the village. They love that, but we're gonna go back and do something meaningful. That was awesome. That's awesome natural! So we're talking, we got laid off sidetracked, so you were in Africa, which is the most realistic environment every. If you want to really know what nature is all about, you were in the most realistic environment, all tooth fang and claw. It's like whatever survive survives and whatever doesn't becomes food and there's just this car instant cycle going on and you're walking around yeah. When you walk are you walking when you saw the crocodile eat, the wildebeest no you're in the jeep. I was in the jeep.

That, how does a jeep thing work? Why don't they just jump in the jeep? I don't understand that good question. I asked myself that, as they were walking by The guerrillas they've been habituated to humans. They they lit, we don't even see the jeep or the gorillas. Don't there, you know they're, not aggressive and less. They think you're a threat. They don't eat meat, they just eating plants all day, yeah there still pretty dangerous one swipe from a gorilla. Oh my god, great back back. It's interesting that the jeeps about around for so long. They they just go under the jeep there, that the gun was there yeah yeah. But it's as though the jeeps aren't there. You might have six jeeps looking. We saw some lines apart, a Impala right in front of us and going about their daily lives. You see it catch. It just missed that we saw them running away, who, God, if I saw them running in real life, I'd shit, my pants without running

words our camp, so we were running the other way. I heard a horrible story about these people, their own safari camp and this person to use the bathroom in the middle of the night. Apparently you know there's cabins and you have to leave the cabin to go to the bathroom and the cats went in the bathroom and got them and drag them out the kid. No that the way to go yeah, it's the hyenas, you gotta watch out for 'cause. They will actually eat you alive. Oh fuck yeah, but the look LT's, don't like the hyenas. They don't have respect any animal that eats another animal. While it's still screaming oh yeah, they don't give a fuck. They don't try to kill you. They just eat. Yeah that will do EAST had a broken leg. It got away from the crook, but it was it's. It's Bush made at that point yeah, but there were. There were people in the jeep, some other Americans cheering. It was like a sport for them. Oh no. I didn't appreciate fuck in America. It was a solemn moment. This animal going to die in there like woo no chasing. It must be meant right it. It was mixed, it was girls

would be super concerned. I think it was a few, but we're cheering yeah fuck him might have been, I think, guys, cheering but hard, but they were chasing this poor animal. It's half had been broken off and it was running on a broken leg and they were chasing it. The people were the jeep and the people in the back of the jeep yeah, my my kids with me that were screaming and crying it was. It was emotional and I want to see that yeah. I I ii, I've never seen anything take anything out in the real world it shocking. You know you can see it see it on BBC or whatever as much you want. When you see it live my friend Johnny Hamilton, he works at a ranch in Colorado, shot out to Johnny. He was far following the trail of this gigantic elk they'd. Seen all these footsteps and they seem mountain line footsteps and then, there was no more mountain line footsteps and then they followed it about

a hundred yards of shell or so, and they found the the cat on top of the elk it had jumped on the Elks back and killed. The elk is one hundred and fifty lb cat, a nine hundred pound Elk, a big bowl and it just leaped up on its back and just like in got a hold of its neck and neck at rags to the ground, but it wrote it for like a hundred yards. Yet the cross did this to to the wildebeest, so L, interesting. We saw a lot of those and what we learned was that the old elephants, because they've run out of the teeth the teeth were down and at some point they just can't chew anymore, so they have to find really soft stuff, eventually they die, and that gives rise to this legend that there's this great yard. For elephants, not a graveyard is just where the soft food is, but I was thinking if elephants had do, they could easily solve aging. They just get dentures and yeah. Why can't we just track them and give them some implants yeah? Well, they do it with all right and I think in the zoo. They might do something like that. I

right they do with dog, takes rebuild they're wearing out yeah. I've seen that before with people it's cool, it made sense that fix my daughters teeth, but I said to the dentist: I don't change, topping it, but it's funny. I said the dentist. Can you fix my t? If you just did my daughter went on no you're, almost fifty, we don't fix teeth at fifty. Do I feel like you're, on your way out exactly yeah, someone said that to me in terms of ah meniscus at a meniscus tear, and they said well when you're younger, you have more blood flow to your meniscus and we would just surgically repair it and hope it would fix, or perhaps today you stem cells, but mostly actually because of your age. It's not going to heal correctly and I'm like okay, I'm confused because you're talking about blood flow like blood flow like what is happening, that's different. I don't. I think this is like some old medicine. Nonsense, like is blood not flowing, I mean

well, it's flowing and someone with your fitness is flowing, probably as much as a thirty year old anyway. I'm in better shape than I was when I was thirty, I do more shit. I do more running. You know, I'm, like my mom got a lot of blood flowing around man. I'm I think they compare. Oh you to sedentary people for sure they do that's the problem with medicine. Is that it's tailored to the average person yeah. We got it fixed that scurry per analyzed tailored yeah, measured. I think if I wanted to go on Safari like that, like you did I'm I would. I would have to make sure that I wasn't around any chairing like that. I got caught. I would have to take sort of a solo trip and not have to be heavily armed right and then wearing armor, some sort of arm well, so that was intense in and a had a flamethrower yeah right there with me right right, fuck, those things man, you never see survivor. Man do you know survivors, yeah, sure, yeah less is a great guy, but he's committed to finding bigfoot. Now it's always doing these days right, yeah, but anyway, les

yes did an episode where he did Survivorman in Africa and the scenario create these fake soneros. You know just man made scenarios like what, if you were in a hot air balloon and the hot air balloon got a hole in it and crash landed in these lion infested territories. So he literally did that that's insane in the basket, so you had a few items in the basket and the the for the for the hot air balloon with him, too worn off the fucking lions. So here he is it's nice time in Africa and by the way he sell films, everything you know the reason why they came out with that other show with that who's that other dude, the other dude that that got busted sleeping in the holiday Inn you got going to the yeah Bear Grylls he was going to the four seasons at night is like this is how you could do it, but I'm not going to do it.

He would show you how to do it. You could sleep in an igloo, but meanwhile he would fucking. He was getting room service and eating steaks and shit yeah. That's what I do, but Les Stroud really does it. I mean he br a series of cameras, so this is him and last went and he s so that's a pretends that thing crash landed. So this is a scenario that he's created for himself. The reality is, he really is surrounded by lions, and so he has a limited amount of propane and he would fire out look at look, look. Look. He would fire up that thing, which is what you use to get in the hot air balloon and scare the shit out of lions. So through the night here you could hear that look at the fucking, zeroes and shit, so he'd hear it in the middle of the night and you have to fire that thing up everybody, the fuck away and then after an hour, so that like to fuck time fire it up again, and so he was out there sleeping in this basket. Trying,

yes, so crazy, he's so crazy, and he would also do these things where he would have virtually no food for seven eight days. You know and just really just get super super skinny and almost starved to death. That's the opposite of being Jeep he's got like a bottle water. I got a pocket knife. I got some rope like this is how you, but I gotta stick. What is that some sort of a machete type thing fucking, crazy yeah? We we went up in a balloon which was beautiful by boy. It's fun, isn't it! I did that in ITALY, recently wild anyone afraid of heights. Don't worry it's beautiful, but we had a truck underneath us with people with guns. Just in case that happened, that's good yeah, so they don't take along people this. Industry and keeping people alive. It wanted to stupid shit. Yeah right. You can imagine. Ah, sorry, the Serengeti burned down yet with some guy in a balloon. How many days writes how many days did you go there for we traveled for sixteen days, I took

My whole family, Marlatt brother, his kids. How old are the kids two nephews and my kids are one thousand six hundred and fourteen twelve perfect age for this, the they don't recommend you being under a certain age. If you're gonna take malaria, medication right, they'll do groups really I don't. I don't. I think twelve might be. Okay, if I think it's like under ten or something like that these now the stuff is heavy duty like did it fuck with you? Do you have crazy nightmares? I I took the one that doesn't give you nightmares, but my other siblings had that my father came so he's eighty, and that was actually the reason we went to his 80th birthday present wow, that's cool! What a cool present sixteen days it was. It was awesome, we went. What did you like? Tanzania is supposed to be gorgeous? Yes, Erin Getty was incredible. It was old good. I really liked hanging out with with human beings to their into

sting species should for sure yeah I enjoy humans. Yeah was the origins joining a cold and us we went to. We started an old divide court, which is where humans, the the original fossils, were found going back a few million years wow and started there and then just went through looking at the various animals. We saw the gorillas and we ended up. A few days ago I was in Jerusalem, looking at where we come. Oh wow, real origins, tour up the crack, that's exciting wow that is so cool. So what was the most unusual thing besides Jerusalem? Is that the most unusual? That's the most insane thing where all the religions are on top of each other touching raw and blessing this spring and humans are crazy. Anything well, I'm sure you've seen. I was in Germany once and therefore UFC and I was flipping through the channels of the television and there

was this live feed from MECCA, and this is pre Instagram I was on. Instagram definitely would have 'cause. I watched it for hours. I just sat there in my room drinking a cocktail with my feet up watching these people circle around this. What is that square shaped thing in the center of MECCA? If you was it, the religious object that I believe I think says something to do with an asteroid like there's. A piece of some find out that makes sense is important people, but the up the the watch, some people circle, they're all wearing the religious garb this islamic garb that they have to wear and they're all circling around this thing like for hours and hours and hours, and it's oddly appealing like part of you, wants to go. I recognize

signs that there's got to be a very strong sense of unity and community and everybody agreeing that we are all going to treat this. This is a sacred object, is a sacred place, we're gonna, wear sacred, close we're all gonna. Follow this this path, and this and we're all going to be together in this, like this, like super reinforced sense of community, that's actually ordained by God himself. What we'll need that feeling for me at science and the fossils, though, that I and my colleagues believe with the origins of our needs, an origin story here it is. How would you say that CUP Copa Kabar it's built around a sacred Blackstone, a meteorite, the Muslims believe was placed by Abraham and his mouth in the corner of the Kaaba, a symbol of God's covenant with Abraham and Ishmael and, by extension, with the muslim community itself yeah that

this, so it is actually a meteorite which how how incredible right, like a little bit of science and a little bit of religion, all wrapped up together this discovery. So this is what it looks like so you're watching this, the channel that watching in Germany again this is probably like more than ten years ago, twelve years ago, perhaps, and watching the circle around this, like religious spot, very, very captivating yeah, the one that I remember most from I think was Jerusalem. Yeah was people touching the store and where the crucifix was thought to be, and they were lined up for hours to just touch it for a few seconds. Meanwhile, the origin of humans, the fossils there's, maybe

three people hanging out? No one really cares. Admittedly, it is out of the way it's not in the middle of the Middle EAST, but still it struck me that humans are more focused on these icons of religion rather than where I believe we really came from Africa. Yeah I mean if you look at it and you see it, you touch, you feel it. It's the only sensible explanation I mean you can still have religion. That's fine, but you know don't tell me those fossils were put there by somebody. No, I mean obviously not, but it's it is that the idea that a human being came from some lower Hamid, which came originally from a shrew, is so so hard to follow like if you go on

way back to sixty five million years ago to the asteroid hitting the Yucatan and you're like wait. What happened? A j, a big rock smashed, killed everything except like these little rodent things and they just eventually evolved ever that's what I love about science. It's amazing! It's not only amazing, it's actually true yeah. We can prove it yeah I mean basically for all the fossil record. That's one of the funny thing. So many people go. Oh. What about the missing link? There's missing! There's holes in the fossil record! Well, just holes in your education, just not holes mean they go out to Australia, Pithecus, explain, Australia, Pithecus, explain, explain the various other human beings. You know explain, explain, Mo Flory insists explained the neanderthal explain. All these different is a whole slew of different fucking things that were human like what was that God's experiments was God fucking around

yeah that let's try to make him super short and wide and thick and heavy like a five foot. Seven two hundred pound person that's way stronger than a person to add those are no good. Listen, let's how tall are skinnier one but with bigger brains are hot right and let's have them brief. That's what we did. Let's bang am every bang. I don't know if it was marriage or rape, but something happened. I think most rape, mostly most breeding, was raped until about like five hundred years ago. I agree with you: do you know that too day there's a country? Is it Kurdistan? What is the country that twenty percent of all marriages, beginning kidnapping, so, there's a shame to the the female being kidnapped. She ultimately has to marry her captor find out. That's it the Kurdistan Kurd Kurdistan yeah. I have to say that Kurdistan, her good stand. I think

silence yeah one in five girls and women, kidnapped for marriage in Kurdistan? How fucking crazy? This is two thousand and nineteen religion, shame, but the fact that you could kidnap someone rape them and then they get shamed into marrying you. Well, I shocked in Jerusalem, I'm going to probably have a lot of hate mail for saying this, but it's a fact that when you go to the wailing wall, as I didn't put little note in the wall, which was great experience by the way there there is a space for men and women they separated, but the space for men is four five times bigger than the one for women good. I couldn't help myself yeah it's all this disparity anyway, so so a similar amount of women that are going to this wall and they're just jammed a smaller area. Yeah still, two thousand is this: some ordained is this some sort of a religious yeah, the orthodox, as partly behind that I checked it out. So there's a there's, an actual

scripture that says men are supposed to have. Oh gosh. I doubt that just ancient sexism, yeah and even the wall is just tradition, but anyway the history of humankind is trusting, and I did that because we right there, it was all the black spots. That's like holes grass that sick plant material, I think, is it yeah yeah the plants growing out of the world. Well, it is ok. They're, not black, were just looking at low resolution. That's the women side. That's them inside! Remember the scene in what is the World WAR Z when all those zombies

climb up the wall that pile on top of each other. Like do you see where wars ain't, the fucking great movie, I can say, is that there's a crazy scene, it's Brad Pitt Zombie Movie or, although all the zombies pile up on top of each other and make it to the top of the wall. You got it James. You pull it up, says uh, so they get to the wall and look at these fucking zombie people are climbing up yeah, you know it's, it's pretty gnarly man!

you never seen this movie I wanted to. Does the novels are supposed to be excellent? What the novels written by some famous guys, son who's, who wrote the novel, but does a great scenes like see? They're all piling on top of each other and their they just reckless. They they they have no concern for their their health or well being because there are, you know like the dead, so they're just making this human thing, and then the soldiers are shooting into the pile trying to knock him down to get over the top of the wall in the start, affecting people. It's pretty wild movie yeah, who wrote that movie is a wild movie Matt. This is what it's one of those zombie movies, where the zombies move fast, that this

slow zombie movies, which come on like that's. Why walking dead like, I feel like you could fuck those things up. I mean they can only last so long as they don't move fast like how are they surviving just kind of like shuffling towards you? I feel like if you just have ah big sword. You could just start hacking away yeah. So there are a zombie cells in the body and I make that segway 'cause people are going to say why the hell out we talk about aging. Well, we will. We are here forever MAX, Brooks the Son of Melbourne. There you go shout out to MAX Brooks and MEL Brooks. Sorry aging. Well, we don't have to zombie cells yeah. So what are they? But we don't talk about Africa and your trip Joe show. This is pretty exciting. It was your show too. Thank you when you're on it Jack grabs, Well something else. I recommend everybody go to Africa, not just to come back a different person, a better human being, but also to support them. They

need help over there when you were in the area where the older human, like fossils, were found. What's the feeling like when you're in this area, like you, you really are where the origins of human kind, or from I mean that has got to be a pretty profound feeling yet was spiritual. Unfortunately, the people who drove us there was saying hurry. How are you have to go see? Some zebras like this is more important than the zeros, but these are the people that are the guides yeah, that they don't know what was important to us for enough, but I would have loved to have spent whole day. There apparently they're, still fossils, sticking out of the walls of the Greeley yeah, so the reason that it should be allowed to do anything with them Donna. I don't know possible to contact university, or do you just like shut the fuck up? Well, actually, I probably shouldn't confess this on

I don't like me: don't do it bro the only letter, it's not so bad. Okay, you can actually find a whole bunch of stuff in Africa. That's interesting! If you look down other than out and my oldest daughter, all the store Alex. She looked out, Jesus scientist and so she sixteen year old scientist, she found a whole bunch of stone tools, not they're, not not in all gorge that sacred, but you know just on the the Serengeti or wherever did you get 'em analyzed not yet only found stone tools in the United States that they've brought back to sixteen thousand years ago, the oldest known, stone tools of any human being, and it's sort of the there's slowly but surely pushing back the dates of human civilization in America and one of more recent discoveries with stone tools that are from sixteen thousand years ago. So

people had made their way over here or it is on the system, no problem. I got this yeah, so you never saw it. I don't know if you saw it yet they said there's I don't know if they have video of it, but they said they saw this monkeys sharpening that's done before. It was actually breaking the glass with it monkey shadows. New glass with sharpen stone, impressive prison, break attempt, man, fuck, keeping monkeys in a cage that drives me so crazy. I hate it. I went. I took up pot edibles once like a real strong one that I went to the zoo. It was so depressing staring at the chimps have sat across and watch the champ cage. I'm like. Oh, my god. These things are in Hell. There is in prison even keeping little birds and cage little cages like this, but the monkeys are that's worse. Their whaling wailing. They had some some type of monkey. There was in a smaller cage, the champs it was

wailing wow. Just in Hell, yeah, it is it's brutal, actually that the stone tools are interesting because again getting to what's natural. What's natural for primates is to change their environment, take tools to yes, so what we're doing genetic genetic engineering? Well, I want to engineering, but we're using genetically understand why we, why we agent, while we don't have to it, is natural, of course, that's what we do all of even all of scientist natural. You could even argue that an Iphone in your pocket is natural sure humans have created it. They exist all over the world. I've argued that cities are natural. It's a completely normal thing for humans to do to create cities to say that cities are a natural well, why they everywhere, and why human beings make icing beehives are a natural to write a close yeah, a natural will be animal habitat mean animals like beavers, create beaver, dens and they're very uniform there,

similar everywhere they go exactly no yeah the other day. As someone said, humans tamed fire five hundred thousand years ago, and I said that can't be true five hundred thousand years ago. That's no too long ago. I checked it out, it's true, and these one even humans. These are pre human. I think probably one of the two species back we've been doing. This we've been changing their environment, using tools using fire for that long. The fire, when it's crazy right, because it's not just manipulating a physical thing, it's changing the state right, you're you're, doing something whether it's with flint and stuff. You know some something: the spark and some tender really creating changing the state of matter and will continue to do that. We'll continue to evolve and one of the the reasons that I wanted to see human origins is in my book. I talk about

natural life span went out a maximum one hundred and twenty two is the longest lived human that ostensibly eyes on record the. So without intervention we've reached our maximum, but why not now give us what evolution failed to give us? Okay? Why can't we be like all the species that are at the top of the game? Are there any factors when you look at the oldest people that are alive? Are there any common factors, actually not really that they do seem to have a collection of gene variants that predispose them to get to that long? Others, one called Fox three that if, if you don Eugene on, we can have a look twenty three me you've done it. I have we should look at it. I'm just tell um you need an a or ah a tea at a certain position. I've got one of them out of to my kids got ah two of my kids out of three have both so they, if they look after themselves, might have a better chance of living longer, but anyway

along with people, they tend to live a long time, no matter what they do. Often they smoke till ninety years old. Really, they quit at ninety, there's a few cases of that and they live another twelve years right right. Twenty two years right, you said one hundred and twenty two years old, that right, that's one, lady in France, but one of my friends his name is near bars like he was with me in Israel. He's got a story of when he asked the Centenarian Lady Lady that lived over one hundred that he knew. Why didn't you quit smoking and she said all four doctors. I went to me to quit. Smoking and they've all died. So go that's a Larry es she. What did she do for a living? Our junk comment? I forget the french les.

I don't remember what she did. I would imagine that would play a part like how stressful your occupation is and she had a great sense of humor that was probably part of it. She used to make jokes with reporters all the time. One was ah how many wrinkles do you have Jesus? I've only got one and I'm sitting on it. The uh, the other one, I think, is even better is a reporter. Who was young said you know you're one hundred and sixteen. I hope I see you next year. If your birthday she says, I don't see why not? You seem pretty healthy to me wow and she made it to one twenty two, You now have there been any anecdotal reports of people that live longer. Well, the food's Laura and people you know, I'm not biblical like not not unsubstantiated reports, because I had heard of there's some people that claim to have lived like ridiculously long, but they've never really figured out whether not it's accurate. Sure, there's there's a few of those, but even even Jon Kamen at twenty hundred twenty two there's a big

right now between US researchers, whether that's even true hello, really at it's a massive debate. I've got an inbox full of long angry emails from scientists. What's the evidence points to the contrary that too, so that the high part? This is that she her identity, was subsumed by her daughter to avoid paying taxes, oh and his photos of, and there is a blotch on one photo that matches the daughter. So there's a lot of forensics going on, and people want to subsume the grave and the french government's, not or french researches bring up the blood samples they don't. I don't want to know exactly so. It's probably shit now, probably one hundred years could it could be horseshit. I would say it does. Actually matter, God, Damn French, it doesn't matter. People have lived one hundred and seventeen and that's still pretty good. That's why you know if it's in that we can all live hood for that long he's going to complain. Would you like to get

when I'm old, old, old, old, old people and start doing work on him yeah to popham up with NAD, get him out of there? well my dad's experimenting on himself. So he's not one hundred yet but he's a house, you look well I wouldn't say it looks young, but his fitness is like a thirty year old and really these stronger than me, we tested out in the gym the other. No way that's embarrassing. He can lift more he's, fitter, we're going across the Serengeti and he was late in the charge. If you saw If you didn't see his face because he's got great hair and whatever physically put a bag on his head, you just you'd, say his thirty. The way moves people very where to put it back when you're done yeah. I shouldn't do that. Sorry, dad! You think he's thirty really well he's he's. Reinvigorated in life, so in my family we've got some ashkenazy bad genes. We tend to die young and my grandmother died. My grandmother is actually only fifteen years older than my dad and she died for years ago last, ten years of their life horrible. So we know, what's going to happen in my face

really, probably to all of us. So your mother, your grandmother, had your father when she was fifteen years old, right, whoa yeah back in ah the early days of world war, two she apparently was playing around with her boyfriend. She claims to be a virgin, but at that point, what something got somewhere that shouldn't have and was during high right. So I was raised by my grandmother. She was in her forties when I was a kid and she was the one that taught me to always stay young. Keep your adults ruin everything. That's probably why work on aging its ruin, everything how what was her advice like in in terms of like? Why? How do you avoid what adults are doing wrong? Well, you know she. She does growing up during the depression and world war, two

and then the communists came into Hungary and great give a lot of people thought she had. No, she had had no respect for humanity. So by the time I came along. First of all, she put all of our energy into to me and I'm I'm. I was a spoiled brat as a kid so that that was was helpful to me I think now is an adult. But, more importantly, she wanted me to do the best I could with my life. She said David, do what you can to make this world a better place. Make sure that you leave this place better than you found it and that's what I'm trying to do wow, what a profound advice for a grandchild, she was a rebel. She told me forget the rules kind of like you, I'm going my own way and we'll see how this goes. She she went to Australia. She said fuck, you repairman.

Here she went to Australia, the furthest place you could find from your never went back out. She went on Bondi Beach in Sydney in a bikini which was rebellious. Nor is she up take off the beach by by the police. Would you have to wear back then other full little british thing, dude daddy knees? Would it out down your knees? I think so, did they look like. Maybe it was a one piece, but he wanted to show your belly. That's what I think, but Is a rebel. She went to new guinea by a self in the 60s. What year was this where she was wearing a bikini? That would be fifty six. You couldn't wear a bikini in the fifties, wow how well okay, like those pin up girls right when you see them, they always had one piece suits on so imagine new guinea in the sixties. As a woman on a run up in the highlands, she claims to have eaten human flesh

who's. She spent most of the time drunk as well. Did you see that article that was yesterday where they were interviewing an Australian? Ah, ah a guy, it was a doctor or a scientist who's talking about climate change and he was saying that we have to start eating. Human bodies and that human bodies are very nutritious and that we just put them in the ground and I was reading it. I was like okay. Is this controlling like? What is he doing here? Is he completely insane person. But his advice was our pendants on me is ruining like in some places where there you know they're, stripping the rainforest to make room for cat raising. He was saying that we're getting rid of perfectly good meat. Every time we put someone in the ground well, we are, but but to suggest that it sounds insane to me

yeah, because it was we throw away half our food anyway, at least in this country. It was a mainstream publication that this guy was talking about, like the last thing you want? Encourages people getting used to eating people he's been watching World war, Z, maybe small ring yeah. I mean it's just one of those things but come on. I was I was going to say I'm just trying to get attention like this seems like such a or is it did he was he joking and it's hard to tell in text yeah well yeah I just not. Every Strahan is sensible. I found the article, but I don't see anything about insane. Wasting the human body is me and was one of more than several articles written on it. Maybe some extra complicated, but the idea was saying that people should eat meat and if they want to eat meat, they should eat human being because

well, maybe wanna waste animal rights activist might be just a nuclear ate. Your relatives, yeah yeah, but just last thing you want is people getting the taste of people. You know right now. I do do not need to go that far. Not yet speaking of the food supply, one of things people worry about if we all live longer, is we're gonna, run out of food and run out of space yeah. Ah, and one of things I address in the book is what really will happen if you do the cow relations, if you look at human history, that is not gonna happen out. I'm of the strong belief that we can engineer a way out of just about any problem, probably the the anything we can engineer our way out of this. If we get hit by a five mile wide meteorite, but everything else, I think we're going to be you, climate change, we're to be able to,

zero out of the well well, I did it. We can stop climate change at this point. That's definitely happening. You can see it all around, but will it wipe us out note it? Will it cost us trillions of dollars, yeah? And so I I don't think it's gonna be the end of us, but it's gonna be a challenge to to continue to to survive and and proliferate as a species in the face of all of those costly things and that's the biggest problem of climate change. Besides species losses, the expense in Europe there's only certain amount of human capital that we have to spend and we collect money, and that's one of the reasons that I'm excited about extending people's health and lifespan is that that'll save tens of trillions in the globe each year and that's my they can be put to combating global warming saving species. Besides, you know wonderful people who donate their their earnings as well, but really it

to solve the big problems in on the planet, one of them is to solve what we can do with a look frail elderly people that are coming right every year, more and more make a productive. Like my father, he could be in a nursing home like his mother, was, whereas now he's hiking in the jungles. Looking at watching gorillas with these five grandkids, how cool is that that's pretty cool know what kind of protocols he on pretty much same as me, although he does more exercise. So it's a the nation of any man met foreman and reserve troll, and what kind of exercise. I'm not sure if his protocol we're going to post that on on social media once we get, but I I know it involves a fair amount of aerobic exercise. He does op rolling and and walking up stairs so he managed to climb. I think it was forty stairs in fifteen forty flights of stairs in fifteen minutes which

an eighty year old, was quite forty flights of stairs in fifteen minutes holy shit yeah, the guise of phenomenon. What what has happened, though, is that his outlook on life has changed. He was depressed not not just because he was fearful of getting old and my mother was sick at the time, but now he's looking forward to another ten years of vigorous life traveling and it you know when you're healthy, you're happy. So when he was depressed, was he sedentary? No, no. He was depressed because, ah he was worried about his health. He figured he's going to be like all these other friends. Getting trail, can't can't walk losing your mind and it hasn't happened to him. So he just fuse. We went back and started a new career whoa. We talked about this last time, I believe what what's his new career again he's on a committee that evaluates clinical trials for ethics wow, which is what you want older people to do, use their wisdom, wisdom and knowledge to excited about something as well, something that's

simulates you and keeps you going and gives you something to be interested in and talk about, wasting human flesh. What a wasted is for someone with that knowledge to die prematurely. That's the more interesting thing to me about longevity is look, I'm so much wiser at fifty two then I was at forty two I just am. I make less mistakes amore, where just across the board, when I'm wiser forty two, then I was at thirty two and at twenty two I was basically a champ, so it's like, as time goes on. You understand how your interfacing, with the world you communicate with people. You know how to get. You know what you have to do and what the consequences are of not doing what you have to do in terms of being disciplined and being healthy and best meditation and making sure you

stand the consequences. Also of not doing the work that you're supposed to do in terms of like the way you feel about yourself, your self respect and the way you just feel about, like your sense of self satisfaction, it to me takes a big hit when I'm lazy takes a big hit. When I don't things done, and I don't expect everybody to do the same things that I do or have the same sort of work ethic or and now I'm going say, work ethics. That implies like some sort of of superiority, it's more of just the idea of what you to accomplish. Like your tasks. Everyone has their own idea of what, but if you enjoyed doing something and you're working towards something, I feel like. There's more purpose to life, you have more satisfaction in accomplishing tasks and that's one of things that's been highlighted when you read books on how

penis and studies on happiness, one of the things it seems to be most important is goal setting goal setting working towards those goals and achieving progress, but these are critical components to happiness for human being, so without them with is this aimless sort of drifting of life people for the most part? Obviously, everyone is different, but for the most part, people don't find satisfaction in just a nameless sort of drifting existence, yeah one hundred percent- I just turned fifty while I was in app or just before that you imagine being eighty and healthy that, like my dad or ninety or one hundred, this keeps getting better. Of course, of course, I'm so less stressed than I was in my 20s and 30s and one who's listening who's in their twenties and thinks that they are way better than a fifty year old. I can tell you from experience like Utah when I was in my 20s. I thought I knew everything, or at least I looked at myself as as a fifty year old, and I thought one old fart, yes yeah. It's now

like that at all, especially with today's health and fifty fifty olds are just like. They were like thirty year Old was there was no fifty two year olds. Like me, when I was twenty, they didn't exist, maybe Jack right well that it's been talked about. I think was in the new Yorker that this movie, cocoon- I don't know everyone seen it, but it's uh pretty interesting movie where these fifty sixty year olds are we given the fountain of youth and they still look old, but it was really post be quite funny to see these older people with gray, hair, jumping in the pool and acting thirty years old, but a fifty year old, isn't old anymore. Fifty rolls just getting going yeah, that's crazy about it. You know, I mean, if you see all movie stars from like the 1960s when they were like fifty, they looked like they were dead men. You know like we. We are.

We're looking at, I forgot what the movie was, but it was a movie where I was like how old was he when they made that movie it turned out. He was forty four, my deck, I looks one hundred years old looks like he's, never worked out. He probably smoke cigarettes all day, long, never exercises never drinks constantly. This looks like a dead man. It's crazy right, so so in the future. Ninety Wolf Mighty will feel like fifty info. When we were talking about layered earlier and layered, I think is fifty five years old and just as fucking fit as a human being can be and he's doing crazy shit. Where he's got this whole exercise routine that he does inside. Pool where he brings like seventy pound dumbbells and he carries, with one arm and swims across the pool in the other, do you know he does two handed dumbbell things: the bottom of the pool and leaps the surface catches a breath of air drops back down to the bottom again leaps, the surface? Why is carrying these dumbbells?

I mean just ruthless rigorous exercise at fifty five years old. Well, that they'll be a time when I can't really tell hold somebody is specially when we figure out how to reprogram the body to be young again yeah and let's see, can be such a such a great world when people with eighty years of experience can continue to run companies and and the teachers and educate the young people. Now that there's a bias, though against the elderly, you've always had this in society, and we have to overcome that. My dental was biased against me as a 50s and want to fix your teeth. You're dead, bro, not fixed, you know what the money screw it I'll pay for it just do it, so it's a twenty minute argument: do it do it twenty minutes? It was a lot. In fact the time ran out and she said fine I'll do one tooth just to check, because she was had all these reasons. Why I shouldn't it'll break off? I have to polish back your original teeth and I said: look I'm not going to get angry if it doesn't, just just try it and she did it and at first of all she said I have to eat crow offer it, and then my wife came a week later and she said man, your husbands, a pain in the ass,

but he's on to something and actually she's offering. This is a service now two people, our age, yes trying to make money. I guess I got it for it hasn't cracked off and I'm pretty happy with teeth that if it does fix it again right, why not it's everything and we should do yeah, but here's the problem with with some aspects of medicine when we're young, we don't get medicines that prevent us getting sick. One year old S, o drugs, like metformin you're, not gonna, give to a two thousand and thirty year old But when you get old, you don't get the medicines that they give the young when everyone should be treated equally. In my view, as long as we know it's safe for sure, you know there's the cost, but some of these treatments like made Forman, that's probably less than a dollar a day, a cup of coffee and might extend your life span. Where you get a cup of coffee for a buck. I get free coffee from here. You Laird, Hamilton, superfood machine click. Coffee is even more expensive than that yeah. It's the

limited idea of what you should or shouldn't do tow fix people as they get older. My friend got his a c l tourney any sixty and then said his doctor recommended he just rehab it and don't get it fixed on what that fucking talking about get it fixed man, you wanna have a bum knee just buckles on. So all the time go, get it fixed. Six months later it be done like you'll go through the rehab. Otherwise, six months later, you still have a shitty knee is like your call man, but I just get it fixed bite. The bullet go fix it right, but his doctor was like, where are come on Bruce come on. Bruce, let's be honest, where we're at the end of the movie, not two thousand and twenty anymore yeah, that's limited, limited thinking so frustrating to me. Yeah! I first encountered this one is twenty nine? Actually I don't twenty nine a rap they will they will no. Actually, this is the problem with the other end of the spectrum, which is, I was too young to get a medison that could help me when I get home.

Oh wow, cholesterol, medicine, the and I don't. I said: why do you want to get on this drug? I know you've got high cholesterol but you're. Only twenty nine come on. I said: look why wait till I get the disease to treat it put. You know now people use statens more, but in those days aren't statens very controversial though they are, they apparently have a huge health hit. Well, I haven't noticed and- and I have high cholesterol- and I think it's worth it but yeah. If, if there's nothing else wrong with you, you wouldn't take, but do you have arterial plaque? No, not yet clear, but shouldn't isn't, but isn't there some there's, there's doctors that are arguing that the idea of high cholesterol right, where it's LDL Hdl, with its good cholesterol, bad cholesterol. This, like this sort of uniform approach, people with high cholesterol, need to take something that lowers their cholesterol and

doctors that I've talked to are saying will not necessarily it all. You could be incredibly healthy, specially if you're not sedentary with with relatively high cholesterol. If everything balances itself out, if you have the appropriate ratio of HDL to LDL, do you have the appropriate ratio or is it out of whack? Now I do, but when was twenty nine, I was off the charts, but I had a blood that looked more like cream and that's where one of the things apparently were dietary cholesterol does make a hit. It does have a KN effect on people with a genetic predisposition to high cholesterol in certain ways right, correct, right, yeah right, but changing my diet had a big impact as well. What did you do that that was different? Ah, I went Maur uh. Well, I ate less. I lost weight that helped. Do you do um intermittent fasting yeah

as much as I can? One of the other guys that was on this tour of Israel with me is Volta longer and he's the arguably the world's expert on this. What a great name is he's an italian guy, Ghalta Longo Longo here, like the coffee so a guy call in when you got a real problem, yeah yeah well he's he's written a book and he is the probably words expert in human periodic, fasting for everyone who wants to know about what the best periodic fasting protocol is. There isn't one no yet we're right on the cusp. There haven't been enough studies, but there are a few types I go through them in my book so because we we won't have time to go through all of it, but there is a the what is at the eighteen four hours to go. If you can go skip breakfast have a late lunch. That's a good start! That's what I try to do every day. It's not always possible like when you're in Africa and they feeding you massive meals three times a day,

but the that's. What you wanted to be hungry for part of the day or you can go, more extreme and skip two days. What's the what's the benefit of being hungry great question- and this is what my lab and others figured out in the year two, your first few years of the twenty first century, we figured out that the genes that extend lifespan- these are two in genes- are activated by being hungry in part by raising an ad levels which we and a man will mimic. The effect of so being hungry actually raises your lifespan. Some sort of way right so caloric restriction is what we used to talk about a lot. If you restrict the calories of a rat, wasn't actually discovered back in the early twentieth century will make them live a

the thirty percent longer not in an old state, but it prevents them getting old, so the rest and get cancer heart disease and all these other good things, and that was the only thing that we knew up until about twenty years ago, even ten, probably up, and so we used to think you had. The house had to be hungry all the time and there was a still is a a society called the calorie restriction society and they were hungry all the time that very small meals, which is pretty tough. I tried that and gave up after a week, but this new paradigm is that you don't have to always be hungry similar to you. Don't always have to be on a treadmill. You can do it for a short time, make it intense, and then you can let your body recover and go back to a normal life for a little bit, and that's great news. That means that we can have the l cake and eat it.

So to speak, as long as the cake doesn't have a lot of sugar in it. Now, when you are on this protocol of restricted eating plus met foreman, when do you take what and when do you exercise and how do you balance it out like what I know what to do? What I use my body as a guy? You know now that I'm fifty, I have a pretty good like you, you know, you know how your body feels and reacts almost a measuring it. A rain that that matches my pulse in my sleep is that the aura yeah yeah, oh, you are a hipster, Isn't Kevin rose a part of that companies that yeah he says, yeah, okay, from dig, dig dot com, you don't know, dig know how? Dare you sorry, it's a good place to go, find cool ship, Digg, dot, com, shut out,

dig yeah! I go there every day because really interesting stories on the internet. You always finding cool, weird videos and just fascinating science stories. Human nature. Human interest stories sounds good. I had a watch what kind of watch you're using? Ah the apple watch? Okay, how does that measure by the way they just released Apple Watch five today, it's better you might want to get it. Was it do? What is the apple watch too yeah? We because it are well changes, songs and in my head, tells the time occasionally but yeah what's useful with it is ah pulse and activity mm, and if I haven't moved enough during the day, I've got a standing desk and that's ah being helpful. Toe make move around a little bit more, but mainly it's on also do occasional blood tests to make sure that my body's optimize

a cz best. I can personalized ah and use eolas measures. You read the data off your watch like how do you read it? What what application are you using? Oh, nothing special. Just on my phone have a look okay, so you just have a look. What your resting heart rate is how much activity see how far you're walking, how many towers you're burning that kind of deal, yeah, yeah, pretty simple and I'm I'm happy to say my resting heart rates really low, which means you know things are going okay. So far. For me, even though I don't do enough exercise, as you rightly point out, they might resting heart rate of forty six. That's very good! It really amazing for a guy that Bailey does exercise yeah. You must have good genetics. Well, obviously, do your dad's in phenomenal shape it eighty! No. We have terrible genetic, so house in such great shape at eighty. Well, we don't know, but but it could be, that been exercising and he's also been on this paradigm. So one of the this in affected, my at least of any man which is what we're taking, is improve blood flow

you get the benefits of exercise without having to exercise if your mouse and those mice they're running on a treadmill for fifty percent further, because the blood flow in the lactate was reduced. Really so maybe that's happening with that's incredible now. What is the difference between the effects of and a man and iv and a d which is very popular. There's people to take IV n a d, and I mean I've- never done it, but we we've talked about doing it many times and have it brought in here and sometimes people do it and they do it very quickly. We do it only takes ten minutes, but it hurts like hell, apparently gives you like stomach knots, feel terrible right? All right is not on it. I haven't admitted publicly that I've done it do it, but I, but I try everything once hope that microphone. I try everything once yeah

and ah so. Last time I was out here in L, a uh I gave it gave it a shot so to speak yeah. How was it uh? It was fine. It was fine. Now, let's get to the science in a minute, but what I found was so it was a shot in the butt with some NAD day. So why didn't they do it intravenously? I thought that was the move. They did intra muscular right right. This doctor is experimenting. Uh trees was yeah, it was. It was a friend of a friend, so I had say I got an idea. Came here yeah, but here's the thing it felt I had tingles in my legs. I felt a little different for a few minutes, maybe ten minutes, and then it went away uh, but the science we don't. We don't know yet we're still trying to figure out if that actually works or not. So instead, I'm taking the molecule that we've studied in my lab, which is taken as a

now. There are a lot of people that swear by the ivy version of any d and when they do it intravenously, apparently you feel phenomenal. There's quite a few people. I know my friend Kyle Kingsbury's done it several times and uh he's very big on the latest and the greatest of health craze is well. I know it's being used widely, especially down in Florida to treat addiction any day, interesting ivy and I get emails all the time which is best, but you know I'm a scientist I'm having made it school. So I have to always be based on facts and the fact is, we don't know if it works yet right. Anecdotes rennick do with my father's story: it's not a clinical trial right. We need to do more, but what interesting about this field. Is that because people have accessed information through podcast

cures and through the internet now that papers, you can go to what's called pub, Med, central and find papers, people educating themselves just like scientists used to and they can go to the doctor or go to the internet and try experiments on themselves now I don't condone that. I can I'm a researcher not a doctor, but I find it really interesting that were in a new phase of society where people can learn war in many cases than the doctors actually, no sure in particular comes to nutrition, because that's one of things that I found it's shocking when you talk to some doctors and you talk to them about nutrition, particularly supplementation and they'll, say tha he's like well, you can get everything from a good diet MIKE. Can you really? Can you really like how much time did you spend in school motherfucker like

how much time did you study nutrition? This is nonsense. Talk we can get everything from a good die. What's your good diet, tell me what a good diet is. What are you getting from that good diet, how you getting that vitamin b? Twelve in high doses? What do you know where you're getting your see where you're getting your d, three, what he be getting? Were you getting your essential fatty acids with so what's of the optimal level of central fatty acids and they don't have a fucking clue what they're talking about now they don't there's so many doctors that go through their entire medical. You know orthopedic surgeons or what have you they go to their entire medical school with, like maybe four or five hours of nutrition research. I have to be careful what I say I work at the medical school, but I do love. Doctors don't get me wrong, but we need them. We're not going to do surgery on ourselves right. Some doctors will listen to their patients and do research. Those are the great doctors that actually stay on top of things, but it's really god right. There already working one thousand two hundred and fourteen hours a day. So, let's be fair to doctors plus. I have

work within the insurance system. I understand that they're. The only problem that I have is when they say things like you get everything you need with a good doctor. You remember our three square meals, a day, yeah bullshit, to make sure you follow the food pyramid and eat a lot of grain right right now. Remember that well and donate eggs, don't drink milk awareness, eight margarine, yeah. However, it's white milk is a sketchy thing. Quite honestly, because you're do you drink, it is dead. Liquid I've been homogenized pasteurized and I find body reacts very differently to raw milk than it does to milk that has been processed or if anyone studied the microbiome that might be helpful to. But it just makes sense that it's got all the enzymes in it. It's all that's how the human being or a body any any animals will send. Naturally process is that milk yeah, I guess it's mostly sterile yeah but yeah

use whole milk. In my day, it's surprising right, 'cause, I'm trying to avoid calories, but the benefits in the taste and how I feel that yogurt I make myself out of whole milk that you make yogurt yeah one of wild man why'd you buy it you're, so short on time, what you doing in making making your own butter to you get with Turner's turners yeah. You know we all have our hobbies. One of my hobbies

no he's the problem. I got so hooked on this type of yogurt, which I first made for my son trying to help him. He has a a weight and eating issue. I was thinking that would help him about. I got addicted to the yoga, and so does everyone in my family now. So if I don't make the that they like, that, was the okay no no kidding. So how do you do it? It's really easy that you get packets, there's three different packets, remote and putting in whole milk, shake it and stick it in the the often on on defrost for a twenty four hours really on the any, and so what is the frosting? What temperature is that it rots thirty five celsius, whatever that is a one thousand nine hundred and ninety ninety five, so you're, using like a dutch oven or something found its regular often, but I mean in terms of the pan that you put away

what you mean: what's the bottle? Yes, I was just the at large, the messenger, okay and just heating it up with the probiotics inside of it yeah bacteria inside it. It just starts to coalesce yeah, and I have perfected it. The first few ones were we're not great, but now it works every time and actually the protocol on the internet said you have to boil it measure the temperature, get it all right, sterilize it and pour it straight in shake it. Stick it in it's fine, really, yeah! So far, huh did you ever get it analyzed! No bureau scientist. You want to send it a little cup of it to somebody. Go hey man. Take a look at this. What do you all right about? I don't know where I'm not worried at all. I'm just curious as to whether, like how potent, as you know, there's various levels of you know ask Dophilus that you're getting from from yogurt yeah. I research it before I started, and this is a a company that makes a your

that it that matches a healthy microbiome. The only one I'm aware of that's great and you use whole milk. You don't use raw milk right, but I don't have good access to raw milk. Would you get it back to Oakes Health Food store like sprouts or you know some. I found a try that yeah. I think they have it at Erawan. Maybe whole foods has it. It's like. It's really tricky because use it's not even legal in some places to have whole milk. In fact people been arrested and and dislike locked up for having whole milk. Yes, Google, Google, that, because pretty preposterous, when you think about how easy it is to buy whiskey right and then think about people buying a whole milk that whole milk is apparently for some people I mean you might have to something to do with skirting FDA regulations and things along those lines. It gets very complicated for sure, and then

those are the reason for homogenization and pasteurization is obviously health right. We're trying to protect people and also its shelf life stays on the shelf longer, but I've definitely bought it. Yeah, there's a small. What is it called a small group food group raw food club? They had, they were rated into two thousand all and for sharing raw milk for some. The latest raw milk crate in attack on food freedom, federal organize a sting operation against a tiny raw milk buying club and ignore more serious food safety concerns yeah like twinkies, I mean how hard is it look. You can, I'm sure, get food poisoning from spoiled milk right, but isn't spoiled milk yogurt, ultimately right. Well, the hit his what I do with food. If it stinks, I don't need it good, move, bro yeah, I think milk, you smell pretty quickly. If

it's going bad, this involved unwashed room temperature, eggs, the other count, unwashed room temperature, eggs, the storage method, Rassam members prefer, by the way, when we had chickens for these nasty coyotes and killed all my chickens, we would store Ark eggs at room temperature. We put him in a ball, we would wash the outside of the egg and put him in a bowl. They would sit on the counter and I was eating, all day long. Nothing happened, healthiest, fuck dump gallons of raw milk and fill the large flatbed with the seized food, including coconuts. We seize your fucking, coconuts, watermelons and Frozen Buffalo meat. What the like? What is this agents? Who, who are these assholes that are getting paid government money from our taxes to steal, frozen frozen meat.

Jesus Christ, Christopher Darden, who helped prosecute Oj Simpson, appeared at Stuarts, arraignment Justin. Time to lower his bail, alright, so Christopher Darden's out there helping people gross. Just I mean I don't think you should We should somehow or another find out whether there's a way to test. If this raw milk is fresh enough for people to eat, but if it is, people live on, farms have been drinking raw milk since the beginning of time. It's normal and healthy taste better. It's it's way easier for you to digest. Like I get a little weird when I drink like straight like if I have milk and cookies, which I live um, I don't know what made cookies and milk. I might be full of shit here now, I'm thinking about it, the cookies might be. What's messing with my stomach, I don't think so, because you get this feeling from the milk like uh. It's probably both now that I think about it's. Both.

Well, in France, you get the imposter iced cheese gas. I don't read out on Mark used to bring it back in his luggage. He would smuggle back for rock a lot. You know what that is. Yeah, it's like a dish that he would make with meat and cheese. Yeah, that's good! I don't hear the french dying in droves. They seem to be healthy as and then I was fat right yeah. Their brand is better. They have bread. That is not from the. If they're they're, they they don't have modern wheat. So the week they have is not engineered to have more complex glutens and higher yields like we do so we don't vibrate in my family. My wife makes it nice yeah so we are now yeah. Let us out

EAST is even wild. She I got that from Belgium. A friend of ours hung hung some meets. What is it some uh some stuff in a tree collected? The yeast brought it back to the: U S and really shared it with us caught it. I caught some east. Well, he puts him dough, wet dough up in a tree and left it there. For a few days and caught this wild yeast up in the belgian forest were apparently it only occurs. He claims, but we have the best bread at home. It's crunchy, you know you look back on it, you break it open. I mean I'm trying to avoid cops, and this is the hardest thing when you get home and the bread's just come out of the oven and why you're avoiding carbs uh? Well, I'm tryingto keep my blood glucose levels. Steady, not spike too much. That's pretty clear that that's not healthy and just eating a bunch of parade will be a good way to spike that one of things that I've heard about the French and Italians in general is that

the e their bread with either potter all of oil and that these healthy fats that you're getting along with the bread is one of the reasons why it doesn't have the same sort of health hit and then just the complex gluten. So you know the the engineered week that we have when you eat pasta in ITALY. It has a different effect in your body to it feels different yeah exactly so. There are a number of people that I know, maybe people you know to have put in glucose monitors on their arm to see what foods they react to. Writer Patrick's been doing this for a while, and actually I asked her what what about? What's the worst food you've seen in your body to spike glucose, she said grapes avoid grapes really here avoid grapes.

I wish I had known as to that so now it's your turn to the right. You think you're eating healthy when you're having some fruit. As I said what what was the biggest surprise, you said potatoes on so bad. Well, there is a thing that you could do with potatoes right. Will you be oil them and then cool them off and then reheat them and apparently has a profound effect on the way it impacts your blood sugar levels? That's far healthier when you there's some sort of process see if you could find out what that process was. Who explained that to us? Do you remember was it run, probably was ninety nine percent of my nutrition knowledge of your front to back Patrick, but but I believe it's something to do with the way the potato reacts to being boiled and then chilled and then reheated again something about it. So the starches are less available somehow somehow and has a much more

ah healthy effect on your blood glucose levels and doesn't spike you in the way that just a straight up, baked potato would be coming from Chris Kresser. Ah ha, even that's the other one percent of my nutrition knowledge, it's probably not even spy like sixty forty potatoes for gut health and weight loss. The potato hack says potato intervention of the short term tool check the reactivity of got to resistant starch reset the hedonic system create metabolic flexibility, resolve inflammatory conditions and provide the patient with an empowerment tool to increase the fat loss of their dietary. It's not meant as a stand alone, diet, but rather a dietary tool to decrease hunger, blah blah blah blah blah blah blah screw up there. So we can find out what the fuck that the potato hack is explanation. Poor potato has been maligned did did did did did did, did, did, did d'oh, here's an explanation, functional medicine Chris Kreisher on the Joe Rogan show ha right here that screw scroll up

magic of this plan leases clinical effect. Efficacy is the amount of resistant starch resistant starch is a type of starts that is indigestible to us, but needs our microbiome. When a potato is heated and then cooled, a significant amount of its starch is retro graded into resistant starch. This means that the effect on blood sugar is greatly dampened, potato can be even be reheated and it will still retain its resistant starch content, the nourishment to our gut biome and the subsequent metabolic benefit. Cannot be overstated. I've seen this be crucial in some pain agents who have stalled on a low, carb or Keto eating plan, but still have significant body left to lose. Historically resistant starch would have been

present in most roots, tubers unripe, bananas, plantains etc, but is often devoid in our current diets. Chris crash in the house. Yeah, well, you go so when I was in Africa, you reminded me: they eat a lot of blueberries, and so these colored foods are also good to eat. In this virtual comes on when yams dark things right: well, yeah, leafy visuals, but also fruits- that are very colored colorful. So why is that? Why is that I'm glad? First, the so we have this idea called Xena or nieces and a terrible name for something, that's quite simple, and that is that these molecules from plants are produced to make the plans healthier. These are stress response chemicals and, with few stress plans,

they turn colored turn on a uv. Lamp will put a plan in the sun, it'll turn reddish. You know those are stress chemicals to survive an I believe that we've evolved to sense. Those chemicals in our food Supply so were attracted to juicy red tomatoes, as opposed to pale tomatoes, but is the driver, I think we're attracted to it 'cause they're colorful, what our bodies get out of it is that these chemicals go into our bloodstream and they turn on our defenses against disease to survive. Why is that good? Why did that involve up with tensely of all its? I think, because when our food supply was stressed, we need to get ready for adversity because we probably

run out of food and, if you're, a bird or some other dumb animal, dumber, animal or even a yes. So how you gonna know if your food supplies gonna run out, you've got it, no it chemically. So these chemicals are a heads up that adversity is coming. So if you eat a lot of these chemicals through, say red wine, which is stress, grapes and other things like blueberries, these chemicals they're not probably not working mainly through antioxidant activity, they giving us this stress heads up, isn't there there's that's a controversial thing? The red wine thing correct like whether or not read on the actual compound of resveratrol we're getting our benefit from, because it's apparently a very small amount of resveratrol in red wine. Ah, yeah sure it's not really controversial, except when people exaggerate and say that it's all resveratrol resveratrol is a component of dozens of healthy molecules in red wine corset in which is good for a number of things. Um there's

whole bunch of polyphenyl's. They called and sorrows virtual is part of that cocktail. What is also the fermentation process, because we're talking about grapes themselves with the high sugar content actually being something we should avoid right, so don't eat the grapes, but but wine, if you don't have too much of it, will have a concentrated amount of these Xeno hermetic molecules like was virtual and corseted. This is an apparent in red wine. It's really only in red wine white wine sauce for chicks right all the healthy not resulted. Actually, that's a job for my friend buddy I'll, get in trouble, no, it's just for my friend, but he always loves white one of my top three checks. Bro, I'm joking folks, just jokes: don't get a touchy! Yes, sir, you don't need to so that when we treated mice with ours are troll, they were immune to the effects of high fat diet. Western died and we've traced this down to a single genetic pathway that we work.

These are two ends. I talked about these in a d responsive pathways really, so they were immune to eating shitty food like the negative aspects of eating shitty food, yeah that it was two thousand and three that's why it hit all the newspapers, because it was the first molecule that was safe and could mimic the effects of fasting or caloric restriction without actually having to be hungry wow and what kind of dosage. Given these mice uh was equivalent of um about two hundred and fifty million grams a day in a human. Ok, so is one slash four of what you recommend. People take I don't recommend people take anything but okay, what you take right, let's just say that yeah I'll recommendation, sorry folks, yeah, I'm take a high dose because of of look at human clinical data, and I think that a high dose may be required to have an even better effect on longevity. But the the results are very clear. When we open up these mice,

maybe I should have said that when we examine the highs carefully are up with them that put them to sleep for scientific purposes. It was clear that they, they were healthier. Now there was still fat. That was interesting. That was still facts. We figured the experiment work, but their arteries were clean. Their livers were like a healthy, lean young mouse, and when we looked at their metabolism it was like a younger mouse. So let me ask you this, then, because you're you take statins if you are fairly convinced, because the research of the positive benefits of resveratrol in healthy, aging and healthy metabolism and their arteries. Why you as you know that there are some negative effects of statins right. Well, if I had five lifetimes I'd, probably try that experiment! Okay, I don't want you just don't want to risk it. Yeah is there.

I mean, have you looked through the papers? There were the research papers on on statens and a little bit. There is some correlations without dementia and the brain doesn't a cholesterol so that that might be one of the problems is your dad on statens? Yes, really. We have a whole bunch of genes that predispose twenty three made said basically give up now, while it's pretty horrible out so yeah. If I make it to eighty, I'm doing pretty well interesting because some board game when he was alive arm he He had made a decision to take statins versus changes, diet. This is before you got any gear too, when he was traveling the world in the eating the finest foods and drinking wine to excess every night and join the shit out of it uh. You know we had a conversation about it's like I would rather eat well said: I'd rather eat well and take these drugs, because I know the side effects another dangerous.

So then we have a conversation. Maybe two years later he gets really into Jiu Jitsu. His wife at the time was into Jiu Jitsu, and you know she had convinced him to try it and he went and tried it on me. Idiot got hooked and he has already had a addictive background. You know first was heroin and you know some other unfortunate substances and then is cigarettes for a while. He quit that and then Ju Jitsu became his new addiction and he got ripped. I mean he really at. I think he started training at fifty eight or fifty nine started, and then, by the time I'm sixty two. You know like a full six pack. It was crazy to see like Michael look at you man. This is

nuts, I just an image of him, walking down the street, and I mean he has no shirt on and he's fucking shredded got off. All the Staten's got off. Everything's changed his whole, his issue with cholesterol, yeah good on him. Just through daily exercise yeah. I should try, it should yeah. A little bit ashamed that I haven't been able to get off the Staten's, but they just scare me mad. I'm just read too many things. Well, I could have gone off them when I was on a really lean diet. I I tried to stock in our diet from okay. Now a can oh, yes, oh just fish mostly and and tofu yeah how'd it go. I was great, but then I had kids. Oh you can't feed tofu two kids. Every day right, you can have separate food just for yourself, not gonna snow. Although I understand yeah well, your that's. The thing is like you are so limited by time. You know you said you have such a nit involved,

research schedule and life schedule and travel schedule, I'm a pretty average guy, I'm not militant about what I try my best every day to do what I can, but this Staten thing I just haven't, had the chance to do it but rose virtual. I don't think is sufficient to keep these cholesterol levels down. Also combination. So far when you first got on how long you been on stantons since twenty nine, oh wow, so you really have been on them for twenty one years, only that super high dose SA eighty milligrams, what's a normal dose ten who that's crazy, yeah. My doctor, one of the best of Harvard looked at my genetics and said you're fucked yeah. I got it all wrong genes, these tiny little life, a protein particles, the ones that oxidize. So the fact that my arteries apparently clean is is good good news for me. Well, that's good news, like I said, look good

thanks. Oh obviously, there's a lot of biodiversity when it comes to human beings and some things that are bad for others, bad for. Well, I'm not losing my mind yet still pretty functional when it starts slipping away. We're going to do. I ask you for your friends or what do you do you know? What am I going to do? What if your dad's want to tell you that could have mark right he's eighty five I'd ever changing my diapers yeah David yeah, the same question three times in a row the way it's going. That could definitely happen. Well. Do you get a lot of sleep? I do now now that I'm wondering, if yeah, in which a lot of sleep for you between six and seven hours, all let's get a date, Doctor Matthew Walker was a guy that I had in my podcast who studies sleep and he was fascinating and it changed my entire opinion about what's necessary,

there's a direct correlation between limited amounts of sleep and Alzheimer's direct correlation he's like it's one of the most established links that you can see between a disease and a. Uh. Yes, quoting it's an association. I I always want you know, I'm a scientist always have to be skeptical sure as to whether, if you're predisposed Alzheimer's, you have trouble sleeping, oh and you start taking Ambien now, people say well. Ambien and Alzheimer's are correlated well yeah that maybe it's the other way around yeah ambient scares the shit out of me. You don't take that do tiny bits. Oh that's, tough, nuts 'cause people take it and they save

things. They don't know what they're saying right. Well, the recommended dose at least it used to be for men is ten milligrams, which is massive. I nibble on it. I take maybe a milligram just to not off if I'm desperate with jet lag, but yet I peeked doctors- many, I know, say the ten milligrams is probably too high, but check with your doctor. Yeah well, Matthew Walker says stay the fuck away from that stuff period. He said you're not getting real sleep anyway. You're not going in through full sleep cycles you're, just drugging your brain into a state of unconsciousness, probably with ten milligrams. That makes sense for me because I'm monitoring it. I know that I'm getting good deep sleep. Have you try um other, like melatonin things on those lines, I show so not effective uh, not as much sometimes Milton with milligram of Ambien is necessary, but a big change for me has been just don't stay up, watching tv get the screens off with the glasses. They really help yeah the screens watching those God damn screens before you go to bed. I love doing it, though love

watching the tv show. Before I go to sleep, it's probably the worst time. Do it, though right yeah, it is it really I mean you can watch. The show is just put the yellow glasses on. Oh, you know blue light emitting yeah blocking glasses, one of my sponsors movement watches. They have, ah, that blue light emitting glasses. I need to get those are blocking or admitting block blocking blue like blocking yeah yeah, not admitting how could a glass of mint you know blocking in blue light emitting signals yeah. Well, you can have blue light emitting glasses too. That'd be good really well for the middle of winter or if you get depressed well, were you is no real middle of winter here buddy, where used it used to live too, not too far, yeah, it's it's pretty tragic. I want to kill myself that seasonal, affective disorder, sure yeah, yeah yeah working indoors? I don't see son for months well that girl play sky when it's everyday is gray over

again, you see no real sky for so long. It's so weird. Australia. For that reason, I get real If I come out to L A and this blue sky, you really feel different, oh for sure, there's a reason why this is a fucking one billion people out here. What is your strategy for mitigating the impact of seasonal, affective disorder. What I do I try to go outdoors and get some sun in my eyes, when I can take vitamin d offshore yeah. What about a different, I seems to help make a difference: yeah yeah, so your vitamin d to it's. It's questionable, whether it's as healthy as people thought it was. That said, I think it did at worse, doesn't hurt you. Some people do some lamps for that reason, build build going on tanning booth. For that reason, right they will actually found this season. I went to the sauna in the cold Chuck bath and that really helped a lot. I don't know if it's related, but ah

I needed to shock my body in the middle of winter. If you just sitting by a fire and barely moving around, I just felt like it was a sack of shit yeah, a lot of people get fat in the winter too. Let's another thing they just they get indoors, 'cause it sucks out and they never went up doing anything. And then you dealing you're with the depression of being a little bit heavier to offshore, and then you drinking by the fire. All that kind of stuff- but it's all about shock your body- get your body out of complacency and our lifestyle, everything we do everything we buy. Everything on tv, that's being advertised to make your life better, is shortening your lifespan by making it easier for our bodies to exist. You don't want that. You gotta stress it. What other things do you think that people should be do

doing on a daily basis that most folks aren't? Well, we covered a lot um, so there's the be hungry, get the exercise, there's all sorts of exercise which is good, but the main ones of stretching and running and ah lifting okay cold and hot we've talked about and then there's the supplements that mimic the benefits of those plus. Probably more things. That's my that's! My regimen there's some other little tidbits that I put in my book, which it's a laundry list of things that I found work for me, but those are the main things you've covered um. This is Alan's, probably pretty boring, but I'll say it again. Ah, wear sunscreen! For two reasons. I mean you look better anyway, not that probably young people care but will make a difference by the time your marriage, but also because dna damage

does h. You are. We think that it's breaking the chromosomes and that's the major driver of aging that son will do that X. Rays will do that, maybe even a port scanners. I certainly I'm not really a diversity of getting scammed. I thought the radio waves are that the millimeter and they've Dedham penetrate very deeply so they're, probably not too bad, but I've looked into it's about the same radiation as you get on the flight and given that I'm doing probably one million miles a year, I don't want to double the amount of exposure. So when you go through that radio scanner, then the more modern TSA scanners they give you the same amount of radiation as a flight, because flight gives you say, moderation radiation as multiple x rays right is it that other thing is that bad? I believe it ok. Well, let's look, let's find out much radiation. Do you get on a five hour

flight and isn't comparable to multiple x rays cause, I believe, that's what I read well. The x rays I can say definitively based on our research. Would aid you agent issues? What does he want to you? What's breaking your chromosome and causing that clock that I was talking about hear that biological clock to accelerate? Is there something you can do to mitigate that? If you know you have to get an x ray, should you do something right afterwards, it potentially potentially you could take and man which we've shown in mile in mice, protect them against the effects of radiation, and that's one of things. We've talked to NASA about forgetting to Mars and back safely. So when I'm on a flight, I takes a man. A man in the expectation that to boost my body's ability to prevent those changes to the clock, now is there a commercially available and the men that you would suggest if someone wants to purchase it somewhere? Ah well, so I don't divulge

many names and there's two reasons for that one is I've been tested them, so I actually literally don't know, but the other is that yeah I I wanna stay above the fray and understand not yet involved, but it, but there are. If people want to go Google and go look online, they can find commercially available and a man right so yeah a and I've got a number of pages in the book on that. So it's it's all laid out, but summary this all right here, ladies and gentlemen, looking that lifespan, why we age and why we don't have to you thanks! That's NPR voice! Yeah! You can donate. If you enjoy programming like this. Putting me to sleep, that's laid a van something happened with people. They thought to be intelligent. You have to talk

like you're, ready to put people to sleep it's time to get sleepy anyway, so the enemy in um. So there were people who is selling it on the internet. Just just to get the facts straight. I don't sell anything. I understand my name's all over the internet. If you see my name with a company, it's b s that beautiful that's good anyway, so the enemy- and there are companies that sell its mark it's of than another molecule. It related called in our or Nicotine Ahmad ride beside, which is also what the body can use to boost energy levels and that's a little cheaper and they both been shown in animals to be to boost the sort who owns and help those animals be healthier in old age in reverse some aspects of aging, like insurance, loss of insurance. That kind of thing protect the IP act hearing as well, so that we don't know if it works in humans. That, let's be honest, we don't know if these things work. But let's also be honest. We know what's gonna happen, if we don't do anything and that's not pretty

either, do you have any high hopes for things like crisper things where there's going to be genetic alterations and they are starting to do some experience? You have a big smile on your face right now, so I'll, let you talk tell me, what's up? Ah well uh, so I'm a geneticist, I'm just down the hall from George Church he's in my department at Harvard and I'm a big believer in crisper, in the sense that it will revolutionize medicine right now. Explain it to people who don't know which means so crisper is an acronym for basically a system that is from bacteria that they used to kill and destroy the dna of invading organ seems like a virus, but we can now use that system to cut and change our own genomes. It's basically a a d n, a cutting enzyme that doesn't cut randomly. You can give it a barcode in the form of

of what's called rna molecule that tells where that ends. I will cut in the genome. Let's say you, Joe Rogan, have ah a terrible gene. That's causing heart disease. We take this crisper system. We say he is what you need to go to cut. We can tell the enzyme to go and cut it put into your cells. It'll, go cut it and destroy that enzyme and delete it, and you can also use it to cut the gym and insert new pieces. So you can both subtract and add dna at will now not just randomly, but what's important is you can tell it where to go and that's the big breakthrough they're doing some experiments on human beings. I know there was something that they were doing believes somewhere in Asia. For remember correctly, I believe is China, where they had done some manipulation to people to help prevent AIDS and in the process

of doing so, they may have boosted intelligence or the potential for intelligence, which was so convoluted that my puny little brain can understand. The study I was how to go over the same paragraph like four or five times. Just try to figure out what the fuck they were saying. Am I making any sense you are, and that was a study that the top I don't believe has been published. But it's being reported right that he is his name. His last name is he. He took embryos, an engineer them to delete CCR five gene, which is required for HIV to infect cells. Now that was, we can squeeze most of a scientist thing, that that was reckless for the fact that first of all, HIV isn't a huge risk in China, one in one thousand chance of getting HIV. There are plenty of other things, other things they that you could do. That could be more helpful. Let's say why not mutate? What's called p s K nine to prevent heart disease, which would probably fifty percent to kill

the boys, a boy so anyway, it wasn't. The most risk benefit ratio, modification that that it's one thing but the other is we don't know what happens when you cut things in embryos? Does it have changes to the dna clock? to accelerate their aging didn't mess without the genes? Did it cut in other places and screw up those doing? We don't know that yet, And so that's why the scientific community had a negative reaction to it. But what's interesting is that scientific community and the press has pretty much gone quiet on this. Imagine if this happened, the Bush era we with have protestors, Allover the place to be outlawed, and that hasn't happened, and I think it's because we live in a world with a twenty four hour news cycle, but isn't that also because, it's being if it was during the Bush world, I mean where the protest would really take place if it was done here the thing about things that are done in China or overseas like huh, it's like it's so far away

like wow, let's keep an eye on him. Yeah, that's true! There is the fear that some countries going to engineer an army of supplements. I mean we have the technology to do that right now, yeah, we we believe we understand how to slow, aging other genes that predispose you to to long life. We could make offspring a family that would potentially live lot longer, but it's just something that can only be manipulated in embryos fetuses. No now we can do it in adults, actually does does it. There are drugs during development to actually correction attic diseases such as a vision loss. Really. Yes, my eyes are gone. I can barely read like print on a laptop. I I need glasses to read my laptop all right so so we just put up a study on line up on a cycle by walk I've. Anyone can go there and see it. Just Google, my name and Bio AKA B, I o r x. I v

reason that's interesting. Is that what we're showing is in mice at least we can reverse the age of the retina and restore the vision of old mice. What do I have to do? Ah? Well, I think after Bloom, if you want okay, come on man well in a lose your job, let you let a let me correct those kind of jokes. Sorry I have it. I was joking. I started it folks, it's not his fault, but so what? What would I mean? Is this going to be available to the general public any time in our lifetime trying my best we're hoping to do clinical trials starting in two years from now? Really, and what would you do in those critical trials? Are so we'd reprogram the eye to be young again, so we now know that there's a set of genes called reprogramming factors, also known as Yamanaka factors that are from named after this japanese fellow who won the Nobel Prize in two thousand and twelve. These factors are used all over the world, even probably in high schools

to re program. Skin cells are the cells to be what we call pluripotent stem cells, the cells that can be used to make new organs or your blood cells, but what people hadn't tried until recently was: can you do this in a living animal or you just gonna mess it up, and what we found out is that if you do it, where you mess up the animal and it'll die, but what we've shown for the first time in this paper is you can do it in a safe way and normally that reversed the clock, make the cells young and restore how they work and get back vision? And what's the method, ology right, good question, so that the current method is using a virus? That's on the market. These air called a v s. A dental associative viruses, you put them in the eye they're already patients getting this in on the market really spark therapeutics is an example of a company that is key, during genetic diseases, in the eye with viruses or in a new word,

most people don't know about it, wow. So what is the company again? Jamie would have the spark genetic spoke there. Jamie already got it look at Bam, Band Motherfucker, Jamie Vernon, the house, so these folks are already doing this to people. So is this for people that are sort of desperate and they'll try something experimental right, the desperate in the sense that there's no other choice, no other cure. Now curing genetic diseases. Someone was just treated and cured of sickle cell anemia, that's phenomenal, and that you know I learned that that comes from malaria right those the yeah that people were the resistance to malaria? Was that trait from people that evolved in the area where they would get malaria was also what led to people getting sickle cell correct correct, so that I learned that from Tiffany Hanish, by the way amazing Tiffany shut up Tiffany that luck's turning

tough. Is this something that someone like me to take right now, no not easily your doctor would need to prescribe it, and so, if he did prescribe it, I could literally get vision back well. This is not the same tech, oh gee, that I'm talking about it from my list is inherited. Retinal diseases, our commitment to our I r D's. This is gene replacement, not not reprogramming the body to be young, but it's the same virus that would you to correct aging, so they're using this for certain rep diseases or their correcting it. Now How is this bacteria fixing your vision, well, the viruses are just invited to get the jeans into the cells. That's all, and these are one benign viruses, they don't hurt you, but there are carrier- and it may be eventually will have other ways to do this, but right now the virus is the best way and in the mice to restore the vision we have this

the combination of these Yamanaka reprogramming genes. We put them into the eye uh and then we turn them on with a drug. In fact, the same drug that I took when I was in Africa called Doxycycline is the same drug we can feed to the mice, turns on the reprogramming genes for a few weeks restores their vision back to a young mouse, and then we just take away the doctor cycle and an antibiotic and the mice have the vision back and how long does it take for it starts deteriorating. We don't know yet, but I think that it's permanent, because the age of the cells has gone back, those a young eyes again, so you might have a whole full cycle from like twenty or ten Thio forty years old. Again, that's the future that you'll get a delivery of this virus. You'll take the antibiotic for a few weeks, be fully rejuvenated and the doctor says, come back in a couple of decades will fix you again. I will give you some antibiotic and a couple of decades, but then it gets really weird if you have, if you engineer your children

to have the system. If that ever happens, let's imagine it could. We could do this right now with technology, and you have people engineered to be able to be reversed in their age. Let's say they have an accident and their optic nerve gets damaged or they lose the hearing from a bomb or something that a spinal injury give him a on ivy of antibiotics and they become just like an embryo. They can rejuvenate that. Regrow their optic nerve, regrow their spine, fixed back back like new, the vision, do you think that we're going to see that in our lifetimes I mean? Is this something that you're going to see? That's gonna be available to the general public. Also, so I've got a new entrepreneur, a cz we discussed four, and also one of the companies that I've started is exactly that raised money to be able to make this virus we're making. It now takes a few one million dollars and will hopefully, with the FDA's approval injected into peoples eyes now. First, it won't just be

guys like you. First of all, we have to go into an area where it's FDA approval, which is a disease like Glaucoma, which is pressure in the eye or macular degeneration. That's our first goal, then, if it's safe, why not do old eyes? Wow, that's incredible! What about people with injuries yeah? Well, yet you could theoretically put it into the spinal cord or give it given ivy, but people with eye injuries, oh for sure, so one of the things we also did in this paper that we've put online is we pinched the optic nerve, and and what normally happens is it just a I mean nodes, don't grow back right and less your baby, mouse or baby human, but

he made those cells so young that the optic nerve grew back to the brain wow. First time, that's being able, I know a guy. Have it from fighting he's, got a detached, retina detached so bad that is vision in his right eyes, extremely poor shadow to Michael Biz being um. Do you think that that's something that inside of his lifetime, they could see something use of this technology that could regenerate his eye. Well, you know I get get a lot of emails, so I'm not really trying to over promise anything. What I, what I think is possible is that will be used for disease, a chronic disease, then it'll be used for injuries like like that, but fresh injuries. I think it's really likely the work better. If it's fresh, I don't know where this technology's going. I can imagine a lot. We can all imagine, ah, that you could get vision back and people walking again, but that's where this technology is going, we only, but so I described the discovery in the book

as a actually what what happened. While I was writing the book as well, making these discoveries- and I were remarkable- and so we I wrote them down in the book as we went along so people can see how it feels to be a scientist to make these discoveries of. But it's only been a year or less that we've known about this, so imagine fifty years from now what we can do, even ten, it's going to be a remarkable future. It's very exciting, now kind of a timeline. Are you anticipating for bringing this to? You know people with injuries. Uh well injuries already a study plan for spinal injury in mice, and that will probably know the results in the less than a year, and then we could you, as fast as the FDA, allows us go into a clinical trial. Now now is the same scenario applicable for people with spinal spinal injuries as vision like people that have a more recent spinal injury will be more likely candidates, then people that have had older spinal injuries, I think so

so that would just be my guess that it's easier to fix a recent recently damaged system. Anything in the body that's fresh, but I wouldn't rule out anything when we when we first discovered this, the experiment was to have a fresh injury, the pinching of the optic nerve. But then I said to my student: why don't you just try old mice and he said, come on old mice? You kidding me how's that going to work just try just try it, so he did it and in collaboration with another lab at Harvard, so that they're, the experts and so Bruce Cassandra's. His name so Bruce called me, professor at half and one thousand and thirty at night. I just got off a plane, he said David, you won't believe it. I didn't believe it. I just looked at the data, it freaking worked, old mice are seeing again. He said I want to go down to the FDA and tell him about it. 'cause right now I diseases. Typically, all you can, who is slow them down and he is actually reversal of loss function. Is this apply to injuries as well? Do you believe old injuries or just old macular degeneration? We haven't tried old injuries, but now we've done glaucoma

which is an old injury, okay. So, theoretically, what we could do is at least with the existing nerves. If they're still attached, we should be able to rejuvenate those and make them work better, because he has some vision, as I so yeah, so that's possible that that makes more sense, but very little very limited in what are yeah well, we'll have to see interesting, because you didn't think I was gonna work on the old mice. I did tested now crazy. Well, it would literally reversing a not just the effects of aging but aging itself. So if I gave you those written as for little redness, he go and you are scientist you could look at that retina and analyze. It molecularly measure its clock. And you'd say those are young young eyes, and you would know the difference now. Do you feel like this kind of Technology is also going to be applied to people skin 'cause. You know one of the things that for women it's devastating when they develop wrinkles, you know they fucking hate. It

get a few wrinkles, the kind of look distinguished you know, but man when women get wrinkles, they freak the fuck out. They don't like it yeah we gonna try it on on aging on the skin, though you know, when I talk about making people work again, potentially it's probably at a higher priority for sure, but I think it's feasible. So there's a lab at the Salk Institute, Juan Carlos Belmonte, who may win the noble prize for his work on this in two thousand sixteen and a couple of years since he's been showing that it doesn't just rejuvenate old mice. Please also rejuvenating the skin? If you put it on a a wound, that's in an old mouse that mouse with hill will heal better. Now that doesn't prove wrinkles, but it does prove the skin can be rejuvenated as well. So there could be possibly some sort of a treatment to skin. Maybe a re injuring like of you There's this thing that they do. I think it's called a vampire facial. Have you ever heard of that they take platelet rich plasma,

then they micro needle your entire face, and then they somehow another apply. This platelet rich plasma to the areas that have in micro needles, and it has some sort of an effect and increasing collagen and elasticity of the skin and tightening of the skin. We've heard of this I've heard it for hair loss. I didn't realize people get it all over their face, their losses, while they're doing that sounds painful. So to me it makes sense that it might work the plate. The p r p is, as it's called, is full of factors that we we we know some of these are rejuvenating in mice. You know this: the system where you can hook up an old mouse and a young mouse male circulation. Yes and you get rejuvenation, there are factors that many of which we haven't discovered or identified that exists that you can rejuvenate, and I would bet that they're working most likely through this reversal of the clock, and so one of the things we're doing in my lab, is taking what it called exosomes which exist

in these preparations and seeing if they reversed the clock, I have x shot into injuries for stem cell watchers. Yes, yes did work. That makes sense. Yeah I had a full length. Rotator, cuff tear, that's completely gone yeah, so maybe what's going on, is you free programmed your body there? Yes? Well, there's it's a weird thing zones and stem cells and there's a new product called Morton's jelly. That's also a very effective and potent because it's known a lot of papers on these things. It's all you know the research on is some of it's a little shaky, but the efficacy at least anecdotal efficacy is pretty substantial and I'm one of those pieces of anecdotal evidence have had launch a shot. So just whenever I get injured like shoot it up, yeah! Well, you listen is, may not know about exercise, so exosomes a little compartments that are pinched off from cells and put into the body and communicate between cells across

so your liver can communicate with your brain paroxysms and within the Chicago's. There are things that we just discovering little teens are in a ah and they're full of goodies and drug companies are being built on these exes arms. Yes, um glad you brought up the study of the old mice and the young mice, where they put the blood in the old mice and then the old my started behaving like young mice and the blood of the old mice, the young mice and the young. My start, behaving like they retired, because there's company in northern California, that's supposedly doing this with humans, where they're injecting people with the bull a lot of old people are young people, rather some sort of transfusion not anymore, not anymore, the out of business. Well, my understanding is the FDA sent Bill later uh. I said: stop it, that's it just a letter. It's all! Take,

oh yeah, you don't want to go to the mix down the street and change your name. Oh, I got another life with down street change. My name uh, I think that's risky. Is it the check to see if their companies under I do not remember the name of it? But I know I remember they were Roni's LI link to Peter Thiel and then Peter denied that is ever use that you know the billionaire founder of Paypal who I've met is a wonderful man. The. Erroneously, someone is some story linked that said that he's at getting it he's like actually shut the fuck up. No, I'm not don't say that I've never done it not doing it. So it was one of those things where there was a lot of legend to it. Because of these mice. Studies these my studies, get people super excited about. The idea that all you have to do is get young people's blood, so you get a bunch of young people with healthy these free drug free, donating their plasma, doing their blood for

amount of dollars a quart right. You have a blood boy, hooking up, yeah blood boy, hey man! When I was young, I needed some cash. I was healthy. Come on region that shit, you know, take quarter blood, I get it in a couple hours. I think it might work, it's just that we don't know the consequences and the FDA. His job is to protect us. Yeah have just like they're protecting us raw milk, bunch of pussies just recently shut down about a month ago. I missed the boat could have been in there man, but if you did that, that's something that you have to do on a routine basis right, it's not like something you do. One one shot, probably give you a little boost for short amount of time. Yeah! Well, that's! What's different about this reprogramming, you do it once you come back easily yeah. The eyeball thing is very enticing to me: is it's so weird watching my eyes deteriorate like slowly, but surely I'm watching it happen? It's really. It sucks and it's a sure, sign you get an older yeah age, related macular degeneration to seems pretty stand

set. My friend cam hanes that fucker he's fifty two year. So they could see lazily twenty eighteen vision of fifty two. It's crazy see anything. I drop my phone on the ground he's a guy. You got a crack. He saw it from like for a room where there was a crack. I'm trying to look at it in the lies like right there and I put reading glasses on like son of a bitch, How the fuck did you see that he saw it from like where you are like looking at the phone like? That is crazy. Well, let's keep in touch and we will. And yes, if we get this on the market, then I'll Huff yeah, yes turns out. He has started up again as recent pretty recently, but it's not being sold as young blood for plasma. Is this plasma just give it a shot? Bro, just no promises. You want to go in there with me right after we do the crowd there. Please blood, some young blood behind,

failed, anti aging blood clinic tries again we tried to ask him questions, but he was very vague good for you, Sir Duck and move do the old Mohammed Ali ROPE a dope? like print now would occur. Sir yeah, I hope he stays evasive, but I mean it's also like maybe it's nonsense? Maybe it's not Would you like to do studies on people that are doing that and find out? I mean well what they do is measure the clock now that we ass right rights. Yes, that would be interesting, but based on what we know about how it works with mice, you think it's likely that there is some effect. It's possible, it's possible. I, like I very cautious, you're real professor. I like that's right, you're the real deal. I'd like to keep my job di. You should stop making those blow job jokes.

Funny that that is actually controversial to friends. Catches joke. Is there anything else that you think is promising, that is on the horizon, or that's being discussed or theoretical at this point, yeah there's something that is really interesting and that's a cold analytics so settle. Itics are drugs that kill off sin isn't cells. So what is sin isn't cells? These are often called zombie cells and what I think is the World WAR Z. Yes, what is zombies this podcast? So so listen, souls we've known for decades exist in the body, but what was not clear was whether they cause aging. Now it's pretty clear from animal studies, at least, is that we get lots of these accumulating and that they do cause aging and one of the best experiments that was Donna from Mayo Clinic was to genetically delete. The senescence

is that accumulated in an old mouse and it became young again or at least it delayed its aging by Fitbit it Now, senescent cells are pretty rare. There is not a lot of them, but they cause havoc because they don't just sit there in the body, but they send out these inflammatory markers and they cause cancer. We think so you want to get rid of these just I want to mention that in the biological clock, when I was saying that the clock is part of the aging process, what we think is that, as we get older that and it's a total of more my book, so if people read it, they'll understand a lot more. What I'm saying, but this this call book is messing up the cell's ability to be what it used to be. What I mean by that, let's take a ride in your now. Your nerves are getting older, but your nerves, I think, are losing the ability to read the nerve jeans so they're, forgetting that their nerves, so they're starting to behave actually more like a skin cell and

a skin cell in your eyes, not gonna, really work very well, so that we call that epigenetic noise, epigenetic, aging reprogramming resets that uh. So ah, why is that interesting? We think that the ultimate problem for the cell when it loses its total identity or gets a long way towards that. Is it shuts itself down because it says fuck. I didn't even know what I am anymore: I'm not nervous element skin cell, a metal, liver cell, Sinise son s Means stop, dividing just sit there and tell the body come kill me so now, they're putting out these panic factors, there's a problem you get inflammation. The problem is that as we get older, the body is not very good at clearing out the cells, they sit there and make wreak havoc, get information. We think Beijing aging so getting back to center lyrics. These drugs are designed to be a pill injection into your joint to kill off the zombies.

All these and theoretically rejuvenate the tissue and, theoretically, that aspect of aging and that's another treatment like reprogramming. That could be a one shot delivery and take you back a decade wow and how far away are we from seeing those much closer? Actually there's a few companies there's one called unity, there's one that I'm involved with in full disclosure, called's analytic therapeutics in Europe, and there are at least unity is in clinical trials right now for US arthritis really. Now what about the company in Europe, uh, pre, clinical, still mouse wow, so we're looking at like a decade from the general public or well for unity. They hope not usually when you're in a phase two study which there in it's a few years away if it works wow, it's such a cool time to see all this medical, innovation and

scientific innovation, but my head, spinning disk spur and then the reprogramming, which is new stuff. This is stuff that we dreamed off for thousands of years, and you know I don't think it's a dead end and it may not be as uh. You know we're not gonna go back to being twenty anytime soon. That said, I think we've we've had a major breakthrough. The equivalent I like to use is we figured out how to fly where the Wright Brothers right sisters we've got got include. Netflix is now my daughter will tell right non nonbinary people yeah, so my change, your name by the way to Xander she was Madeline. She didn't think that was appropriate. Why she's a tough chick she's a day and some black color sheet. I don't think she doesn't want to be identified as one of the other interesting she sixteen is. She changed it at eleven wow she's, a tough girl.

You know in my family we tend to be rebels and unfortunately, it passed along I'm getting every bring back, fortunately or unfortunately. Well, I guess I'll be proud of raising her last few years have been pretty annoying at home. I'm can't say anything out: the PR police she's, that's hilarious, the peace, police or pr do I say, I'm med pc. What was I saying about my daughter? Oh about the name change. As I talk about a name change, I don't know you tell me Jaimes, remember. Different now we got a million people screaming at us yeah. Well, you were talking about so many exciting things on the horizon, true and so that it's head spinning and so much is happening in our lifetime- that I thought was just imaginary or for the future. Now question is: are we going to reap all the benefits of this or we're going to be the lost generation to lead a normal human lifespan? And I don't think we are.

I think that we already have things we can do in our daily lives. Lifestyle end in molecules. You can take that give us a very good chance of living beyond. What's naturally, this is amazing that such it's, it's so exciting, and the last time you hear was about a year ago, somewhere in that range yeah yeah I mean and think about how many new things you have to discuss now versus. Then it's really interest man and I'm so happy that people like you that are out there doing this it just it's so just so exciting and it's so it makes I'm very happy to know you're out there. Thank you so thank you and your book people can find out all this stuff in detail, much more detailed and get the two one slash two hour, conversation lifespan, why we age and why we don't have to David a Sinclair Phd. Thank you brother. Always The time will do it again next year, deal yes by everybody. Thank you. Everyone for tuning into the show and thank you to our sponsors. They

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