« The Joe Rogan Experience

#901 - Dr. Rhonda Patrick

2017-01-19 | 🔗
Dr. Rhonda Patrick is a Ph.D in biomedical science and expert on nutritional health. Her podcasts and other videos can be found at FoundMyFitness.com
This is an unofficial transcript meant for reference. Accuracy is not guaranteed.
Hey you fuckers. What's up, I say that with all due respect and love, I am at levity, live and Oxnard on February, 17th and 18th, and it's almost sold out. I think Saturday night is totally sold out February. 17Th still has some tickets left Ann, I'm doing the ice House in Pasadena on a bi weekly basis. Now so on Wednesday nights and last night was awesome. We had Tom Papa Greg with Simmons and Tony Hinchcliffe last week or two weeks before that he had Russell Peters bill. Burr and Tom Segura Anw been doing these and it's fucking. The ice house is one of my favorite places just because view well see all this comedy club in the world. It's the it's! It's like it's the perfect shape
like the perfect club. It really it's an amazing place. We never been there and you want to come out. These Wednesday night shows are at one thousand pm and you can get tickets from the ICE House website, but for the next couple months on booked up every other week, Wednesday, so last night was ones or last night was the 18th, so the next one would be the first February first and then one after that 15th. So, there's that March. Third, I am with the golden pony, Tony Hinchcliffe at the car theater at the MGM in LAS Vegas. That should be a gay old time in the Flintstones way. I'm trying to bring that back. Probably won't work right and then April 20th to four hundred and twenty shows first show sold out second show almost sold out, and this is in Portland or at the Arlene Schnitzer Concert Hall. This is the four
twenty celebration and should be fucking great excited about that. I got a lot of their stuff coming up too, but I'll put that out later. You know, I'm saying, this episode, the podcast and all of 'em are brought to you by on it on. It is a total human optimization website, and that concept is pertinent to this conversation that happened today with the great doctor, Rhonda Patrick, if you have I've never been to on it. You don't understand what on it is about. I urge you to the first thing you do is: go click on the on it academy, link 'cause that pretty much defines what we're all about. What we're all about is to to all human optimization and what we mean by that is, we are attempting an that's. Our goal is provide people with all of the information that you need to get your life together to get to uh
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supplysoletslift dot com, Slash, Rogan, LY, ft dot com, Slash Rogan, we did it. We got through the ads. My guess today is the great doctor, Rhonda Patrick she's, fucking amazing. I love talking to her. She want smart people. I know and this was one of my favorite podcast- that we've ever done so enjoy Doctor Rhonda, Patrick government, Logan experience join my day, Joe Rogan podcast by night all day, Doctor Rhonda, Patrick hello, hello. Welcome back. You got a big fat book of notes over there. I do it's like, something I use like before I'm giving a talk or something like that where I like to something about writing handwriting things like helps me remember: yeah
they've, shown that I do that before shows. If you looked at my notebook and you think if you ever thought that I like actually wrote my notebook, you think I'm a crazy person 'cause. I'm writing this same thing over and over again, like all work, no play makes Jack a dull boy, it's just like before us set. What I do is I just write out the key things that I wanted to work on and I'll write him out over and over again, so, like I'll, have one hundred page notebook, it's like one hundred pages of like half of it's the same stuff, yeah and over again yeah, I'm kind of the same way like I'll write out things. Like that, are in more detail and then, like you, said, like righteous. Just like a you well like it's different when you're giving a talk, at least like in academia. Like a power point, Do you have a slide in the slide cues like a couple of minutes of talk, so you got it helps you remember what you were going to talk about that help for comma I bet this is probably a good idea- I should have a say slide show you know like that, would actually be a really good idea for like particular points.
We could show that you weren't lying like look. This is a real thing. You know right yeah. You have like a reference that there's a couple of things and I'm talking about in my new set where I have to. I have to reassure people that I'm not making this up, because it's so ridiculous. You know- and One of them was this woman who prosed as a high school student. She was a twenty zero police officers super attractive and she poses a high school student and convince a young boy to sell her marijuana and then arrested him. So it was just a Knicks. Apparently no was a sting operation wow when he was a regular kid. He was an honor roll kid. Oh my god, now he's a felon is a crazy yeah there. It is teen falls in love, Undercover cop in marijuana sting gets arrested, yeah. So this is one of them. I would love to be able to put that up. And go see, I'm not 'cause! You could. I guess you just make stuff up if you wanted to
but isn't that what comedians do they make stuff? I mean you can a lot, but if you made something up like hey, there was a story in the news and just made it up. That sounds great. I guess who cares if it's funny, Yes, come to laugh but yeah, I guess you're right p, people like comedians usually make up personal stories, but sometimes there's they say it's true: true and I'm like it's so outrageous. Is it really true like I don't know, because it's just so funny. You know like some of the stories that some of these comedians tell when I'm just like. How can this be true? They said it was true, but it's much is that part of comedy. Can you do that? Definitely, my friend Dahmer AIR has a really funny joke about that. He goes he goes he's. A true story was hey. How about you just make something up. That's funny. You know like it doesn't have to be true, Buddy Brad. Then they say it's. Troop, so it's kind of like messing with you 'cause the whole time they're doing their bit. You're likely come here pretty much true 'cause, that's fucking hilarious yeah! Sometimes it's true. Sometimes it's not. I guess it depends, depends on the person yeah. I assume everything in your notebook is true. Well
I hope so, you know the other thing that helps me like. So this this helps. You know, writing it down It helps me, but also there's the running running like helps. So actually this was very interesting. 'cause study just came out not long ago showing that if you so, if you run before you're going to learn something- and you want to like- let's say you want to do something short- and recall so you're going to go up on stage and say something you know say a skit or whatever, and if you run right before that it improves the short term like memory. So your short term recall if you run right before, whatever it is you're quickly read. Or something, and then you want to remember it. But if you are learning something and then you run after you learn it and then, like the next day, you remember it. So it's more of a longer term memory. It improves that. So it's like whether or not you're running before after you learn it effects the short term versus long term memory wow. How did they work that out? That's bizarre.
Well, it wasn't like they were testing for that. They just found it out through there. They were just You know doing running before after they're, probably looking at just to see how it affects shore in long term memory recall and they were surprised to find out. This is a study that was done. I can't remember where it was done now. I tweeted about it not long ago 'cause. It was like within this last month that it came out. So you know it's like if you want to. If you want to so like, while I'm you know, learning new material throughout the day and I go for in the evening and then the next day I'll be able to recall it better. Theoretically, now I'm subject to the placebo affect sino this, I'm like oh right, that's a problem yeah don't run normally, but I did a 5k on Monday, like I don't run at all, but a buddy mine had a 5k race in Vegas, so I flew in for him and my friend Cameron, Hanes and uh. I ran it and it was surprisingly hard. It was
with all the working out. I do a blacks, only three miles. Hope it's like three dot one or someone like how hard is that fucking hard? easy yeah. No, so do you do any lake aerobic yeah between kickboxing, jujitsu and I do elliptic machine and I do a lot of yoga but doing the I'm a trying to your three times a week, I'm not always successful at getting there. I got there last week three times a week, but I don't run so I figured but all the stuff I do a MIKE I'll have I'll be fine, nope, not really so you didn't train at all you just kind of like on the fly. Just did this 5k, I saw So you post something about this. An isn't, doesn't Cameron, isn't he like some kind of like crazy runner, allow you to freak yeah he's preparing right now for the mower brace, which is two hundred and thirty five or two hundred and thirty four miles something crazy like that Jamies run so when Jamie shakes his head, like that, you know it's really gross yeah, that's
I mean, he's a nut. He did two hundred and five last year he did the Bigfoot two hundred, which is two hundred and five miles per plus it has something insane like fifty five thousand feet of elevation change over the course of the entire race, 'cause, your constant going up and down and up and down, and at some point It's so steep and the it's an outdoor race over Mount Saint Helens and sometimes that are and so brutal that the top speed is two miles an hour he's going to be like one of those like amazing. Super agers like like, like that just very mentally, are ponies in when he's older, either there's not going be, doesn't show, like been shown like if you part of being super ager like being paradera means you're old, but you're physically fit your mentally sharp and mentally sharp is really the key thing you know, 'cause yeah. We start losing brain mass at like the age of twenty and by the time, if you can actually make it to
one hundred years old, you lose like twenty percent of your brain mass, so they found that one of the key to leg. Maintaining your brain mass is pushing past that comfortable zone physically. So, like exercise wise and also mentally. Just you know, obviously like like learning new things in challenging yourself, so you know so well, working out you don't do this kind of? Like you know, half assed thing you push yourself, you have to really push yourself and that seems to be Keef. Or becoming a super ager, that's crazy, that it works with your brain. Why exercise, I mean exercise has profound effects on your brain. I mean specifically for looking at you know aerobic aerobic exercise. It's hard aerobic exercise. As you said, doing a 5k running three miles, I mean you, do you do a lot
training, and yet that was still hard for you. You know, because doing that type of aerobic exercise is difficult. Studies have shown that even just like twenty to thirty minutes of aerobic exercise can healthy young man increase serum Bdnf so which is brain derived neurotrophic factor. This is a growth factor that is involved in growing new brain cells. And in allowing the existing brain cells to survive. So you know talking about combating brain atrophy We're talking about commenting that the fact that your brain is atrophying starting at the age of twenty, That's the way to do it. Your brain starts to atrophy at twenty. At twenty you start to lose brain mass, oh my god, I'm doomed. I know it's really frightening. Twenty used. Do you want your peak at twenty nine, but was so stupid at twenty, I'm so much smarter than I was when I was twenty. I agree. I agree, I'm still stupid. I mean it's not necessarily like brain mass, an intelligence I mean. I don't know that,
There is definite Portland but but like when you start losing mass in your hip campus. I mean that's memory, be learning that part of the brain. But there's just so many studies showing that exercise. Robik, exercise and also you know it doesn't have to be aerobic. You can do resistance, training that sort of stuff also effects the brain as well but for me, like I've, been a runner since high school track. I guess long a long time and for me you know I've done like a few races have done a marathon and I don't feel like marathons. Anything like I felt like. That was just really rough. You know like it was and I'll run three miles an. I will fill challenge like. If I push myself, I can do that. Now. I feel like doing that a couple times three times a week is plenty for me, but when I run you know for me. It's my I entered this like state of
like daydreaming sort of I get creative, you know when I'm going on, like a three mile run. I'm just I start thinking about things. If I have an important decision to make or something that's causing me some some some sort of anxiety. I go for a run, and I feel like I can address the issue better and what's interesting is that there have been studies that have shown that going for a run in specifically aerobic exercise, it activates the part of your brain involved in executive fun in which helps you make decisions. You know it's kind of like that over arcing part of your brain that like helps with all the planning, long term planning. All of that, and so I always I do I feel like if I go for a run things bothering me from anxious. I always feel better one hundred percent of the time like there's not a single time that I go for a run and I'm like damn. I feel worse right, I do that. You know it's like. I feel I feel crap, I'm doing it on my oh, this is all well. I feel
like the human mind, I mean this is all just theoretical. In my own theories, I think the human mind is designed to confront serious things like like predators, and you know dangerous enemies and- and we don't really get much of that in this life. So when, is dealing with stress, I think the mind preparing for some things that don't exist. So, even if you can work things out logically, there still remains like this residual effect of all these human reward systems that are kind of in place from the time we really did have to have all those those reactions in place to deal with. You know dangerous invaders or be in all the horrible, not conditions you know whatever they would be, that we hardly ever experience anymore so like when I workout. If I Have anything is bother me or troubling me. I think I get like a distorted perception of the Danes
sure of it or the physical reality could be something real simple like I have an issue. You at work that I have to deal with like. Maybe I have to make a decision, or maybe you know, I'm stress about something, and I feel this no matter how much I work it out. Logically, I still feel this physical, like residual issue and that issue who only seems to be resolved for me 'cause, I don't run with hitting the bag like for me. It's a punch back like it's, which is really hard to deal like when you when you do rounds like kickboxing rounds in a bag. I have a timer and I could set it for three to five minutes. Well, actually it Will it allow you send it all the way down to one and then it has like intervals? So it gives me like thirty seconds, every thirty seconds of buzzard go off and it has two lights. One light is yellow and one light is blue and so the yellow light. I kind have a go at law: six thousand and seventy percent, and then the blue light. I sprint so it's like, Sprint, try to catch your breath, sprint, try to catch it,
and I do that for seven eight rounds and when I do that, I don't give fuck about anything after it's over I'm like who cares like it's amazing what it does, 'cause my mind still has all the same data don't understand all whatever it is like it's, whatever work related nonsense, to understand all the issues about it and there. All there's, no new information, but now The information is coming into my brain and it's going to this isn't a foreign invader. These aren't vikings they're coming over in a fucking boat with a dragon's head at the front of it swinging swords This is just some nonsense. Whatever it is, you know agent issue or manager, issue or tax issue, or whatever the fuck it is, that seems so physically daunting before the exercise with an app. Words when that aspect of the problem is alleviated. That stress. It's almost like my our bodies are just.
Confused as to what these problems actually are. I am like I love. I love your your interpretation, this 'cause, it's exactly The way that I would like to talk about why we need this type of stress I actually just like you said. I actually think that, from an evolutionary like evolutionary perspective that we were meant to be stressed. We were meant we were meant to be outside either hunting tilling the land for food, to prepare food out boy barded by Uv B radiation, which is stressful. We we design, to have stress and what I mean by design find. Was we have genetic switches which are supposed to be turned on these genetic switches that are activated by stress are supposed to be turned off. And just like you said we're building novel time now, where we don't have to outside, we don't have to
till the land we don't have to hunt for food. We consider We can sit on the couch on her butt all day, an order, delivery or go to the grocery store and we don't have to eat foods with polyphenyl Owls are flavonoids are things that are also slightly stressful yeah, so this is kind of that concept before MRS, but it's it's, I like the way you would you be explained it because I really agree with you. I think that humans were meant to be stressed. Exercises the former that stress and there's different various different types of of that and I and I think that we were supposed to switch on those those genetic switches. Those jeans that are helping us deal with stress so, like you know, like you, said, you have a problem and I I'm the same way with my run. I'll have some something that's bothering me I have to deal with whatever it is. I mean in my mind I blow it up. It may not even be that big of a deal, but I go for a run
with no new information with nothing new. You know like, I feel better, and I think that's partly because as I'm. Switching on all these, you know stress response pathways that help me deal with the stress better. These anti inflammatory pathways. Just all this would really good. You know these good genetic switches that are being switch put on, so we had totally makes sense. I think this new time that we live in a I just, don't necessarily under think the body understands where the stress is coming from. I think your body is a physical organism. An nature is an absolutely brutal thing and it has been for us as well as for all these other animals forever, but now for uh. It's not really that brutal anymore, and so all these mechanisms are in place to protect you and they don't get served and for me martial arts is always been like the best one to deal with weightlifting's good to like ugh Kettlebell workout. Does it too, but like the big ones, for me are jitsu and kickboxing, because Jitsu
really really hard to do an it's. Also, you are solving problems, so I think you get to serves two purposes. It's incredibly grueling as far as like this boring process of just rolling you know and competing with each other, even in a friendly roll like with a that I really like and were laughing and we, pan's. You know every time someone gets tapped out or whatever it's so difficult like your your bodies, next so hard and your mind is taxed because you're dealing with countering you're dealing with setting up moves, you're dealing with your thinking, several steps ahead and then you're adjusting those thoughts based on what this person that you're sparring with is doing to. So people get real, really really addicted to Jujitsu. For all the right reasons, and one of the things that I found is that Jiu Jitsu people for the most part are way more mellow than most people would expect like way more chill about stuff like way,
you're less likely to respond to something in a dumb or an imbalanced way, because they, whatever your body whatever these requirements, are that we're addressing your body He has all that in Jujitsu, but without the real real violence. You know I mean like the ones trying to kill you, they're, just trying to do this thing to you and you're trying to do that thing to them and those things mimic, actual combo, actual real life and death struggle in a friendly, and it also as this camaraderie built into it too, because you've kind understand that you're going through this incredibly intense things together. I also understand that it takes a unique person to go through that and and get past all these psychological hurdles, all these physiological hurdles. And then you also are aware that this person understands like really clear, is the kinship that you
I'll share in having this experience together, and that's really that's really I kind of relate. I mean not to the same degree like what you're what you're describing is on a whole other level. But I and something similar when I'm when I'm out surfing. You know it's I'm getting the physical exercise, but I'm also like a tackling these fears of these big waves and getting under an drowning and getting tangled with my court. You know, there's like a million and every time I do it. I always have that fear paddling out there, but I get out there this guy surfers and we're all sitting out there and there is a sort of friendship that we develop out there 'cause. We all love surfing and we've all like. We we know it's like. Oh here comes the way, we're you know, helping each other like look this one on the outside paddle out. You know so it's kind of like completely like different level from what you're describing with Ju Jitsu
yeah, but still I kind of, can relate a little bit. You know, I think you I don't know if it is a different level and allow why do people surf as well? I think there's like a similar attraction to it. 'cause also you're a monster dodger like you're out there in the monster soup yeah it's it's that's what that is. It's crazy that I still haven't. You know you'd, think that after doing it for so many years that I would get over that fear, but and so there so so powerful yeah I mean how can you get over the fear, my friend Shane. Dorian is a big wave surfer and he's been on the podcast for and he's a big time, Po Hunter too, and we talk all the time about this. You know the he describes, it is just it's so attractive like I want to try it, but there's not enough hours in the day for Maine. There's not uh. I get too addicted to things, and it's just an. I have a fucking real fear of sharks, it's real
Sharks are scary, really scary or so, but they're real they're out there, oh Jesus. What is this Jamie Shane Dorian wave. Oh, my god, my hands are sweating. Watching is out of his fucking mind, Totale, he's a lid. Jet mania wow like that is How high would you say that wave is it's gotta, be fifty feet right. Oh yeah, yeah it's in Hawaii is called Jaws. Is the name of the way jaws? Oh, my god, look at the size of that is so insane that is so insane like losing my mind. Just when I see these guys big wave surfing like this, my heart hurts I'm so anxious right now watching my god. It's so insane. That's more than fifty feet right, I would say at the very peak of it it does look like it's more than a fifty foot face now when it comes down, does it say there unload Youtube thing what it come, down on you. I mean it. If that, if that
you got smashed like if you fell and that came down on human year, you're, probably fucked right, that's the fear. Yeah I mean damn mean the biggest wave have ever served is like overhead, you know it's like overtime and a half overheads are not even double overhead, so that it was like. I had a couple of scary moments where I was just tumbling during donut and I couldn't find which way was up or down. You know. I've had one time I was surfing out in this place, I'm saying to go called sunset cliffs and it's a reef break and it's really hard to, out there, so you have to like time you have to jump out when the you know after the wave breaks and then you paddle out and there's all these kelp beds, and I was surfing there this one time- and this was back when I was really dumb and didn't wear a leash because it was like Lee is you know I like to dance on my board and they get in my way, and so I didn't really, but I you know
Big wave and I was writing it and I wiped out- and I like got caught in the kelp, oh, and so it was like the you have this moment when you panic and that's really bad panicking when you're like in the water cause panic takes like your energy yeah and- and I panicked- and I was because I mean I thought it was going to die as Miss Kay kelp bed. So I'm wrapping might see we. Yes, I've had nightmares about it like it. That's stuck with me that was like that was one of those moments that you know sort of traumatizing in a way in hello, just to get out of the kelp. I don't remember I don't remember because it was just. I think, the panic sort of I just lost track. It seemed like forever to me. I don't know how long it actually took and, of course I lost my board like swimming and wow. I got cut up on the reef. Yeah reefs are brutal rapes, her brutal yeah. I actually stick to uh
it breaks now, but I don't like you said I don't even get to surf that much anymore, because I just don't have time so p so that when they serve breaks that over, those reefs like you just can't wipe out, wipeout you're going to go right into all that jagged shit yeah, it depends on where the reef is like. Like I was in the wave in kind of in more so I was closer to where the wreath was. But, yes, you can it's it's dangerous that beginners should not ever go out on a reef and I've seen many beginners out there, but it's yeah. It's definitely more scratches and cuts pretty brutal, but you have any shark encounters. No, the only sharks. I've! Actually, actually I shouldn't say: that's not that's not actually accurate. I don't have any scary shark encounters. I served for a long time in La Hoya and there's a breeding ground there for a leopard sharks which are not to be confused with Tiger Sharks tiger sharks to rip definitely scary. Leopard sharks are the ones that have
the spots on him and they're really harmless they're kind of like nurse sharks, yeah they're not like really do like sand sharks, just come around yeah yeah and they really cool to look at, but I've never had I've never actually known anyone that serves in southern California. That is, you know with all the surfers that I've known that has had an encounter in southern California with a shark I do know people that I've encountered them in the Bay area. Yeah. The bear is a big breeding ground for great white. I would never surf there really. Now I would never serve. I would never serve there. Yeah the sharks yeah the sharks, but there are it's all connected. It's like don't go outside! There's a bad neighborhood somewhere! Well, They can move around. I guess just in my head, I've sort of like convincing myself that they're not they're not coming to seeing the there's a video of a drone flying over Malibu, where some guy takes a drill, and he's flying over the Malibu.
Surf and he's like the Phone is like maybe a few one hundred yards away from some surfers and you see a big fucking, great white. Just swimming along just swimming. Don't show me this video drone shark footage, so here's these people they're all in this or they came and we're just southern California New Big Deal and when the and keeps going further and further out. You see this fucking whopper shark. That's not far away from these people will find it here and Jamie will find it there's one right there. Where is this? Oh, nothing, just missing something, nothing, just a sharp conserved malibu before right there, what the fuck Damn it Joe. Don't show me this. You know you're, smart woman, you understand, I do monster soup. I try not to think about the sharks, then well, it's a gold look there's two of am interesting. Look that surfer and two sharks. No big deal
yeah, that's pretty scary! Yeah! It's supposed to be scary! Just I don't know and now apparently Catalina that whole area out part of Catalina is a crazy shark fishing mecca where I have a friend of mine from Texas and he try bold, two Catalina island and he said it. The most savage stretch of water in all of North America, he said is just infested with mako sharks and they go out there to catch mako. Sharks which are delicious mako sharks are really really good to eat too. They taste swordfish, they taste amazing. Are they dangerous, like China? Will fuck you up, don't bite you, but the thing about sharks now it's because of You are so silly because of the awareness of shark fin soup. You know because shark fin soup is the practice of acquiring shark fins, is really brutal and not sustainable at all. It's really horrific and a lot
of asian fisheries, engage in these unsustainable practices where they'll scoop up thousands and thousands of sharks cut there. Things off and then throw them right back in the water, so they waste most of the shark in order to get the fins for shark fish, soup and because they're trying to raise awareness of this now people are getting really upset at anyone who catches sharks, even if they catch sharks legally for food, because sharks are not in. Dangered and is what is the more in anymore sense and tuna is in danger because to not all are in vastly diminished numbers than they were just a few decades ago. If you talk to anyone, who's, a commercial fisherman or even a sport fishing like these guys that run these charter boats, I'll tell you like you to catch way more tuna. It used to be way more prevalent. I think there was something they addressed in that Jiro dreams of sushi movie, as well as that. The commercial fishing is just Peru, utilizing the tuna Maria, but yet everybody still eats tuna and they don't think twice about it, because
his campaign against Shar fin soup is made people like really upset at people that catch sharks to eat, even people that eat meat. It's like whoa so simplistic in like are protesting in like people just have it in their head that I heard that you're not supposed to eat sharks anymore, like you, catching sharks. You fucking asshole like like. That is the one thing that you know I mean if you want to talk about a fish to don't do no harm to human beings like sharks are on that list. You know in this is this is scary, guy, damn animal. If you could eat that, I say kudos kudos to you, because sharks are higher up on the food chain. Don't they have higher mercury levels? It's good question because I know like swordfish like I would not eat swordfish, really hell. No, no yeah! there is like? I wish I could remember the amount it's something like one hundred and fifty micro times per like four ounces, or something so compared
not too wild Atlantic salmon, which has like four micrograms, yeah swordfish, so the ones that are really safe to eat that I know of are the wild Lantic salmon. While the last concert in Atlantic Wild alaskan Salmon caught see white tuna is okay, but the albacore tuna has a get more mercury. I think it's like you know twice as much or something, but I'm a little thinking that you know shark would be I on the mercury level. That's interesting. I'd like to find now, because I know that people have had issues that eat a tremendous amount of sushi people that sushi like everyday. I know they have had issues with mercury in the past. I actually had an arsenic issue with sardines the sardines are bottom dwellers and I I used to eat sardines all the time. I have love Sardi yeah I love starting to, and if
we can sardines too much, I got some blood work done and the doctors, like you, some significant amounts of arsenic in your system am my being poisoned. He's like no, not that it's not like someone trying to kill you, but it is like a dietary issue, and then he asked me what I ate and I You know we went through all my food is like nothing else. I got he goes without seafood. I go oh yeah eat seafood lot of sardines like that's it. I didn't sardines because it makes sense. So I backed off, I didn't eat sardines at all for three months came back. The issue is completely resolved. You know what, besides sweat, you sweat out a lot of these heavy metals like mercury, arsenic, garlic, some of the Bay Mercaptans and garlic, they key play Binchy late mercury and help pull it in like extruded, your body through urine so like when I
where I make salmon or fish, which I actually do eat a lot of salmon it probably like two or three times a week. I always have fresh garlic with it, oh wow, that's amazing and SAM is outstanding too, because it's so high in essential fatty acids articulates really good for you exactly It's really high in omega three fatty acids, EPA and DH a so, and it's got a modest amount of vitamin d. Whenever I'm sick, I eat giant cloves of garlic, I'll just break it down to a point where it makes me feel horrible. I have like a big glass of Kombucha and I'll take like a lump of garlic and I'll break off like four or five cloves and I'll just take off the skin and chew those bitches down and chug it with Bucha it's off. Sometimes it it's painful, spicy, slowing down, like my system, is like what in the fuck is this like? I could feel it inside my body burning. I love it. I've done the same thing previously I mean I don't do that anymore, but yeah,
and garlic is very powerful antimicrobial compounds in it. So I that you know makes perfect sense. It's. The last time I did it, I went to take a knee yeah go down and e really yeah. Like I actually go down, but what I did was I put both my arms on the counter and I went down like this for all. Because it was just burning going down. I just was like what this is: probably not even working, I'm just being retarded getting back to some I was like pungent compounds that are in these these plants and that kind of gets back to what we were talking about with switching on those genetic switches that are to be switched on. Their men were supposed to eat these kinds of foods. Garlic. You know broccoli, cauliflower kale these things that have that pungent mustard. You know that pungent
I mean these things. Are you know various different polyphenyl's in compounds, one in particular I become obsessed with lately, is Sulforaphane and that's present in most of the cruciferous family, like Kale, Broccoli, cabbage Brussels sprouts. Bobby Buck just you know that whole family of vegetables pretty much ate those vegetables a lot. But I've become very obsessed with this. This compound that is actually So for things not in the plant, it gets form once you break the plant tissue once it's like chewed or crushed or blended or whatever chopped somehow, because it's stored as a precursor and then why on the tissue, gets you know chapter or whatever. Then it forms offer fan and that's part of its. You know our medic respond. It's it's plant response to try, ward off in insects or whatever thing. So, that's that's why it forms
it. Actually, when we ingest it, it's a really really really good for us. You know so the soul for Frein in particular, which is actually really really high and broccoli sprouts. Have you ever had brought these products yes, I yeah, so broccoli sprouts actually contain like a hundred times more of it than mature broccoli. So it's like probably the best source of Sulforaphane Diete, resource of Sulforaphane out there, I saw on your instagram that you make shakes with that right. I do yeah I've become sort of convinced that it's very powerful, anti aging and also powerful. Nutro pick in a way. I guess I could say- and I can elaborate, but you know so- I've been doing the shakes where you can sprout you
sprout your own sprouts at home for a relatively cheap. You just buy some organic four units there, but I am look like a weed dealer. That's what about her! That's what everyone says: three dot five pounds of broccoli sprouts, wink wink! That's what they're calling it these kids believe it or not, though, if you freeze them so that was actually I'm freeze uh, so those bags are going in the freezer when you freeze them, because when you freeze the play the tissue also gets like broken. It actually doubles. In some cases you can up to double the amount of sulforaphane because it like has a longer time. Form this. So you can have a more concentrated. I learned that the hard way but what hardware? Let me just because it's so pungent and powerful that if you make a shake with it and you're doing like at first, I was doing fresh shakes and then we started freezing them and that was making shakes that, were you know from previously frozen sprouts, and it's like I needed like half the dose, we not to feel
feel the same thing. Or what do you feel? Ah Ok, so I guess I should probably you know it's kind of just like like when you drink coffee. Now you kind of just you feel a little papi and good. You feel a little more alert sort of like that and it's the thing is, is that it's it's been shown so there have been clinical studies in humans, and this is very interesting because it's been shown like, if you give it, you give, you know, even just a small amount. I think it was like between seven to thirty milligrams of sulfur in a day to young adults with autism, it improved their for scores by like thirty four percent and artistic scores. They they like there's a range of different. You know
that are done to like measure different various brain functions, but improve this, and this you ought to stick. You know he's autistic individuals by like thirty four percent. The same was done in a pilot study for people with schizophrenia where it like improve their their sentence, so they're, just brain functions, better wow yeah so- and this is like pretty, that the results were so powerful that the assistant at Johns Hopkins, the study is not being repeated. You know because it's like this is what is going on here like how is this affecting the brain, and I think you know if you look at all the animal studies, there's lots and lots of animal studies that have been done, which are enough. People aren't quite as convinced because it's like well how much of this relates to humans. But it's been shown to be as good as effective, as does the antidepressant prozac in alleviating depression in mice, and they do all these battery of tests where they like stress the mice out making the depressed and social defeat in like
hanging by their tail. It's actually just kind of gnarly. But and then you know, there's, like you know a bunch of test. They do to see if they're depressed- and you give him you know your placebo, you give him Prozac, where you give him the broccoli sprout extract and it performed just as well, so it helps depression. It's been shown to help with no general diseases, all sorts of things, but the point is, I think that the reason it's actually affecting all these brain functions and why even you know you, someone like me, may notice a small fact from from eating them is because it has a very profound effect on inflammation, and that is because, as a mentioned it's it switches on one of those switches that was meant to be switched on. A pathway called Nrf two in our body that controls over two hundred genes, and so first rain, is the most potent naturally occurring compounds that we discovered yet that activates as
way. So it's no other plant compound weather, naturally occuring plant compound, can activate this pathway, as is potenti friend and enter up to is. I mean it's been shown in multiple studies to be involved in delaying aging and a lot of that happens through lowering tons of different inflammatory jeans, activating anti inflammatory jeans lowering Oxa have stress all these glutathione related enzymes that helps with detoxifying compounds that were exposed to on a daily basis like carcinogens and things. So I think that we're having a low level of this like inflammation stuff that were constant being supposed to and it affects the brain you know. So, if you're, if you get a dose of this, you, you may notice a small effect now with someone that has autism or schizophrenia inflammation and oxidative stress have been shown in previous studies, most previous studies to to play a role in in the etiology of those diseases. So I think that's how it may be affecting the brain, but it's not just
affecting the brain and probably one of the most well known functions of Sulforaphane, is that it's like a very powerful cancer. Preventative com sound. So it's you know it's been shown to prevent cancer, for example, if you men that had prof get cancer when they were given sixty milligrams of Sulforaphane a day, for I think it was like a month. I don't remember exactly how long but it lowered it's slow. The doubling rate over to more biomarker called prostate, specific antigen PSA, which is what is usually measured when men have prostate cancer. You, you measure the progress progression of it because it has a doubling rate, a double every so often, but it's slow that doubling rate by eighty six percent, which is pretty pretty profound, of course, is lots and lots of associate of studies have shown Christopher's vegetables. You know if you eat more of them. You have a lower risk of bladder, ovarian, prostate kidney, just all sorts of cancers, but there's the clinical trials. I thinker. What's wrong
really telling because they're, you know you're giving someone this compound, and it's lowering a tumor progressive progression marker by eighty six there's. Another study which is really interesting also- and this is kind of like where really got me interested, I'm not sure if other people are interested in it, but you know where to two compounds from like pollution, so like living in LOS Angeles, for example, is probably definitely one of the places that you're going to be more exposed to some of these airborne carcinogens, so benzene's, one of them, acrolein in the air, reading a man, you know we're getting to some degree. We have it. We have benzene in our system, and it is a carcinogen. It's been shown to cause cancer specifically linked to leukemia's, smokers, get a ton of it because it's in it's in cigarettes, so cigarette smokers are like really loaded up with benzene, but there was a study where people were given like
thirty milligrams of the Sulforaphane and in the form of a broccoli sprout drink a day for like a week, and starting on day, one drinking this drink, um they excrete it sixty one percent of the benzene like on day, one hundred and sixty one percent of benzene, which is coming out of their yarn, like as you measured metabolites, and it was wow. That is amazing, like getting rid of some of that stuff. You know I you know, 'cause. I'm definitely want to get rid of dancing and all that stuff that I'm being exposed to so that They got my attention to because it was just so significant in a profound effect just after one day, so that that was another sort of thing that got me really into it, and then the aging stuff, where You know it's been shown. Some inflammation has been identified as a key feature of aging taking Sulforaphane has been shown to load
Fleming three markers in people, by like twenty percent C reactive protein, other inflammatory markers courses like dozens of studies in animals that have been done. But I'm sort of, I think the human studies are more interesting. Talk about a subject. New morale. And then also it's been shown to affect the cardiovascular health because of the inflammation, I think so, typed diabetics that were given us. Some days. I think it was something around forty milligrams as well, so for roofing they were given this, daily and for a month for four weeks and it low their triglycerides by twenty percent. It lowered their atherogenic index, which is like measuring. You know that the dangerous type of ldl then sell the else or glycerides looking at all these things that lower that by fifty percent improve their blood sugar by like almost twenty percent. So that's like thing that my mouth and try to get my mom on this- and you know my mom she's. She definitely he's got like high triglycerides. You know thing, you know so
I'm really convinced and then there's been studies in animals. That's just shown that it like delays aging. So I'm convinced that I think it's one of those things you get it in cal and I think that I've been getting a good dose of it. I've been drinking smoothies pretty regularly, since probably like two thousand and ten yeah, probably six seven years, and I do feel like it's like help age like help me age, a little better. I mean it could be completely in my mind, but just kill this kill with healthy, but I think that I've found something take it to another level where I think that I'm pretty convinced that if I continue taking this so far fain, I think it will absolute affect the way age, and I think it will affect my brain aging as well. I mean it's been shown to at least in animal studies, to affect brain aging traumatic, brain injury. I mean if you administer it after dramatic brain injury, it improves outcome.
Improves like brain swelling and all that, but like fifty percent, you know just all sorts of non's. It's just like. I could go on it The video I did like a forty five minute video, where I'm literally just talking about this for forty five minutes, and then it went down Youtube Switch on Youtube yeah. I I did this this research took month. Many months and it's like a sixteen page article. I wrote and I hope to get published. I think I'm going to submit for publication. Is it just. It was a lot of work and it happens anything in the literature as comprehensive, covering every base like I just I try to cover everything that was a good study. You know that was important So so and then I flew out to Johns Hopkins uh recently I was invited to give a talk. There and I meant it just so happens- that guy, who discovered that first of all, the guy who discovered so far Fain is there, but
he's much older I didn't meet with. I met with some of the train with him who discovered that broccoli sprouts are the best source of silver for it. So he made that discovery back in the nineties and I interviewed him and he just went on and on and on and talked about so far refrained like in a dish, into like what I had already talked about on one of the videos I did and he had We had some really interesting stuff to talk about in terms of like you. So in order to get this offer thing you have to the plant. Has to be crushed or chopped and that's because it has an enzyme in it called my Rasaneh's and my Ross and is heat sensitive. So when you, when you steam, your broccoli, when you boil your cal when you saute your kill any of that stuff. Unfortunately,
your inactivating, MAR Austin, is and so you're not getting as much sulfur frame you're getting dramatically less dramatic, almost non almost nonexistent, the precursor the carafe in an is still in that plant, so you're getting the precursor, and we do have some bacteria, some types of bipedal bacteria in our gut that contain the my rossanese enzyme, highly very well, from individual to individual. But so you can can some of that to sulforaphane. But it was interesting that he mentioned is you can actually sprinkle mustard powder like mustard powder you by after? Do you saute your kale or after you steam your vegetables or if you cook, if you apply heat to any of your cruciferous vegetables afterwards, you put the muscle. Padawan must powder, it has active Marasa knees in it and it's pretty the marasa knees in the mustard seed, it is more heat stable. So so you can actually-
convert your precursor into the sulforaphane by adding the mustard powder- and I was like that is a really great wow like thing to know Because now I'm like 'cause, I do cook a lot of my saute kale that I I steam my broccoli puts butter and salt pepper. It's how I eat my broccoli. So is there beautiful? started in. Are there any compounds in cal that or broccoli or anything else that make them more bioavailable when you do come? yeah, I mean a lot of minerals and stuff in it like magnesium, the calcium. Those things are at those things become more by it by available when you call come and you so, you would get that benefit plus if you just cooked it right out of the musters right when the mustard seed powder, you have to make sure it's like what I like to do is spray a little bit on my hand and lick lick it like it's got to give that have to have that bite if it doesn't have the bite. It's like it's been too great.
Spit on the shelf. For too long it's been an Amazon shelves for too long whatever you know so yeah it has to have that like mustard bite to it. Could you just use regular? Must I don't think so now mustard seed, the mustard seed yeah so that So that was a very useful like you know, because the sulforaphane it's really good job. I really I'm trying to like get people to. I think the more people that get this offer no. I think they're going to be healthier. I think it can help prevent. Answer lower inflammation, I'm just so many different good things so smokers, for God sake your smoker. They should be taking so for if they should be drinking those shakes, I'm drinking drinking like every day you know, 'cause they're, getting so much benzene. So two questions about this, one. Where does someone get broccoli sprouts? Where? Where would you get that
Also, the thing is: is that you can brought you can buy broccoli sprouts, already sprouted out, like whole foods are sprouts or whatever your local. You know, grocery store is most most of the grocery stores contain. I have brought these products are seen off office Brown's idea, it's a very rare that you find broccoli sprouts, isn't it there at whole foods there at sprouts, but the problem? Here's the problem with buying sprouts they're, very prone to to bacterial contamination coli? The longer they sit on the shelf and a lot of times when you go into these grocery stores? There sitting on the shelf and so they're probably likely little contaminated with like e coli. Then if you were to sprout them yourself and get them fresh, so you can buy them, but I think- and they also charge like
this: it's like five bucks for like a little like package of it. You know it's like one shake yeah, it's a one shake, whereas you can like spend twenty dollars and get like a pound of seeds, and so how do you grow? It Well, there's lots of different methods: you can. You can use hemp like so previously we used to do these hemp handbags bags. We just put this he's in the bag- and you add some water, you. Basically, just keep adding water to them and let it drip and they sprout within like four days, then we started this Charmouth said we're. Now we have Mason jars with a lid on top that has like little holes that are big enough for water to come out, obviously, but not for the seeds to come out, and so you know so you get these jars and you add water. Let sit for like six hours and then dump it out, and then you just after that, you continually just add the water and but out now the water and turned out kind of leave it tilted so that the water isn't just like you, don't want what are just sitting in there so that it's like growing bacteria and stuff.
So you get like, let me know till the water, so I just want it wet. Is that we are yeah and it really just takes like four days and then you have sprouts. The only thing is you, but you do have to be. You know clean like if you counters all dirty and your hands are dirty and all the dishware using dirty and then you're probably going to contaminate them. So you have to like be a little fastidious about the way you sprout these things. You know, but I think once you're aware that then it's ok, the other thing is, and this something that I'm going to talk to the expert. His names doctor, Jed Fahey, recently interviewed him podcast he, he mentioned something to me that it caught my interest. He said this seed itself, the broccoli seed itself has The enzyme it has the precursor to sulforaphane and if you break or crush the seed or chew the seed, then you're actually getting sulforaphane, so you can actually,
crush up the seed in like a coffee, grinder or something and like take a shot of it. But the thing is is there spend no research doing this method so all these studies that I just talked about in humans, those were all done from like broccoli, sprout powder extract from this sprouts powder extra exit so: they devise a supplement, great question. So well. The power extracts were mostly made by researchers. In fact, Jed Jed is supplied a lot of a lot of different universities with the with the extract himself, but there are so supplement wise. That's the other thing that he really sort of illuminated for me because, because he's at actually been measuring this search, supplements that are on the market and like if they actually have what they say they have, and so because Myerson is, is so unstable, it is hard to make a supplement with sulfa roofing
There is one supplement, only one that I know of that actually has sulforaphane the actual active compound and that's called Prosta Fain and that's only available in free it's by the way. I have no affiliation with any of these. Like supplement companies at all, I'm just telling information it's only available in France, it's only available in France and so and that so he actually tested that one and people that given prostafine the bioavailability of the proofing with seventy percent. So seventy percent of it ended up like in their bloodstream there's another supplement called AVA Mccall AVA Mccall has glue, carafe and and plus my Renee's in it. So it doesn't have the soul forever and has the two compounds that can form so for afraid of it hasn't together, that has been tested, and that was about forty percent by bio availability, so about forty percent of it was. You were actually getting sulforaphane, forty percent of the time
and that was also tested, there's no supplement and that is available in the US. There's another supplement by called Crucera, I think, and Crucera only as the precursor no enzyme, so totally relying on your gut bacteria and some people, it's very variable, so that only had like a ten percent bioavailability availability other than that those are the three supplements that he really could, and this is in a study just published recently that he got behind. I asked about a few others 'cause I had actually been taking there's another one called Braka MAX by Jaro, and he kind of was like I asked him about it. He was kind of lighting just some of what it says in there. But not all you know the prob is is that these supplements? I mean there's a lot of a lot times like he was telling me like geez. Like said
the ten times, the supplements had like clover leaf in them when they're supposed to have like the cruciferous. You know precursor graph in in so it's just like it's kind of disgusting. How supplement Company INC? Have somebody cook a supplement? Companies are you, you know totally just putting all this cloverleaf and whatever, and there was a study that came out a couple years ago on this, like, like seventy five percent of all these, like herbal, Eken Asia, like all these, you know, compounds that are you know, marketed for whatever don't actually even contain Eken Asia or whatever they say they contain it's. Really, it's really kind of bad Now it's a giant issue and if you are a company that sells that stuff a lot of times you're, not even not even getting it directly from the source, you know they're buying it from companies that supply it to them and a lot of times. These companies are in China and places where the regulations are not that strict. You can
right. You can get just mean. We had an issue with that when we first started making alpha brain where we would get stuff tested, we get batches test and the batches of different individual ingredients would have stuff in it that they weren't supposed to have in it just because they mixing it all up in the same bins. Oh yeah, that's true! This also that yeah. I mean there's just you got to find a reliable brand. You know- and I think you know thorn, porn seems to be a pretty reliable one, that I've seen multiple, multiple different times where scientists are like yeah, we've that it's more expense but they seem to be pretty reliable. So it seems like the best method, is a sprout your own broccoli sprouts yeah. I think that's the best method and it seems like very cost effective to exactly it's cost. Effective. You, don't you don't have. You know, have extra cash to buy all these expensive supplements cause the all the ones I just mentioned that actually are effective and have what they say: they're, not cheap,
so that those bags that you had in that Instagram photo is that all sprouts that you made yourself yeah, it does a Mason. Jars are ticks sick. That was six. Oh no! It's not that bad yeah! I mean they get really dense too. They fill up inside the jar yeah yeah. I have like uh picture somewhere on there. They were there with the jars, but I'm thinking I might just do a quick sprouting video like a like fiber six minute like I'm already going in my head about how I'm going to start sprouting awesome and they're good. Like you know, you don't have to do. I always sort of take it to the next well, like I make my shake and it's like, we're good on salads. I mean you can sprinkle them on anything. You know I re so I really like them on salads quite a bit. So that's amazing. Now there. You go oh wow there we go yeah, those the yeah, so so those are with Mason jars that have holes already in them, yeah yeah, so you can actually
by this sprouting kit. So these actually we found these are the old lids. We were using. We actually found better lids that have even other holes, because some of the seeds were getting out of this, but this came as a kit sprouting kit. You can buy on Amazon. It has like a little wooden thing to set the Mason jars in so they're like tilted, and you can like drip the water out, They came with those lids, but then we did some experimentation and found other kids that are superior to those, but how much maintenance is involved in making these like? How often do you have to tend to these things? Oh, it's just like. After the first initial, like six, our water, You know where you let them sit. It's like twice today in the morning and evening dump water on them, but you have to come out and my days it take to grow that that was about five days. I think four five days so for I like me who goes away on weekends. A lot I'd have to make sure that I am home for a stretch. That makes sense you can so you could have Harvard actually
here's the thing the longer you're letting them sprout. So I was just trying to like maximize. I want more dense. You know 'cause. I wanted to get as my bang for my buck, you can. Actually you could have Harvard is harvested, though, is probably like early like three days three days and actually the longer wait, the more you have to be careful with contamination too. So it's like it's better, probably even to ha. For some sooner freeze them so they're, like you know, no bacteria that way, you're just you're safe and you just put him exit block storage bags. Yeah, do you have a vacuum seal things and freezing? no. I should I do that with me. Yeah, that's a good idea. I mean that that wouldn't that would be a good idea to do wow That's! That's really intense stuff. The other question I that to have to talk to you about was when you're, saying schizophrenia and how Sophia Fain can prevent or somehow or mitigate the of the effects of schizophrenia. Do you think that there
here's a possible correlation between a lot of these mental health diseases. An a lack of proper nutrition. Oh absolutely, I think that a lack of proper nutrition is a huge component of a lot of mental diseases in psychological diseases in general? In fact, inflammation is now it's really been identified as I caused sing, a causal role and depression, and that's something that you know so with that precious thing, it's kind of a funny story, and it's not that funny. It's actually kind of eye opening, but. Back in the so the CDC has like Esther with about eleven percent of of Americans, are on some sort of antidepressant. Eleven percent So here's the story behind that, that's so crazy. It is- and I know several people that
or on them or have taken them- or you know you know whatever, but the story behind that. Is kind of interesting because back in like the early 70s a lot of these clinical trials were being done on antidepressants with people that hide depression and at that time people that had depression that were involved in these trials. Where were people that were are severely depressed and Hospitalise, so they were so depressed that they had been hospitalised for depression. I don't know many people have been hospitalized compression nowadays, but so they were hospitalised for depression and then they were given either a placebo or Anna Depressant and a multiple trials. You know FDA had reviewed these trials, seventy percent of the time the anti depressants or anti depressant worked in? Seventy percent of the patients compared to thirty percent of the patients were possible work right. Seventy percents, pretty good you're, comparing that to thirty percent, we'll see about was like well, that's applications that seem
to work right. What then happened after those trials were done? Star in the 70s and like 80s, is that the clinical Dayag plastic manuals called the DSM at that time. It was a DSM two they change, all their diagnosis. You know markers and symptoms for depression and they expanded it a great great deal and then called depression, major depressive, disorder, so it became the sort of like broader. You know. Disease quote on quote where it was like it's not just these people that are severely hospitalized. It's people that are when you depressed and anxious and sad or what you know. It's just basically you're you're, getting a bigger group of people, which is probably a great opportunity for for a pharmaceutical company, but then
and when clinical trials were repeated on this new population of people, so these are clinical trials that were done from like the 80s all way up until, like the two thousand year, two thousand, when those were reviewed by the FDA, what was found was shocking was that only forty percent of people of not responding to responding to and depressants necessary eyes? Other you know norepinephrine reuptake inhibitors, also whatever the standard of care is compared to thirty percent placebo. So now, you're talking about only temperature performing only tent. This antidepressants performing only ten percent better than placebo. It's like ok, something so clearly it's not that the additive presidents don't ever work. It's just that we are now over prescribing them to pee people that you know have this major depressive disorder and they're, not king on people that weren't the initial
the people that were like severely depressed and hospitalized. You know so it's like okay, that's that's a big problem, because there I mean their prescribed. Like I mean I just like, I can't even believe it. You know. I just have so many personal stories, people. I know you know that have gone. You know going some crisis and personal break. Add forest whatever also there giving you some crazy, all of a sudden there giving some crazy drug and they change the personality. The person and I'm just like please get off of this. Like you know, it's not like and, like I say it's not like they don't ever work, it's just that. You know, I think, once the clinical diagnostic booked change the whole like a procedure for diagnosing depression, became major depressive order and disorder all of a sudden you're gay
people that are now like having just you know, whatever stressful event in their life, that's making them a little depressed. The time which everyone's probably experienced are now being you know, given this antidepressant, when they don't really need it and there are effects that are not good with taking some of these. You know at the present So there is a big effect on libido, yeah and Libido yeah. I know a lot of people that have taken it with their sex drive just goes away. Yeah there's actually a gene that numb a gene called. Fism variation in a gene that that is linked to that. So people that but haven't even more severe effect where they really don't. They really have like sexual dysfunction in response to, and it just shuts down yeah yeah it doesn't happen to everyone quite as much, but there there's a percentage of people that really really fax and there's lots of other. You know things, I mean it's just it's changing your brain chemistry, right and it's not exact. It's an exact science. No there's a lot of experimentation going on with it. I had a friend of mine
and who had gone to several doctors and they had prescribed a bunch of different things to him and he was sick really depressed and eventually they gave up and he had to find a much better doctor that his care, his whatever his insurance package, would not pay for, and once you from that doctor, then the doctor is just more knowledgeable about potential. Do once I mean I don't know how many different ones there are, but they got him on something that actually worked he's off it now, now it took him awhile and then eventually got not be, and then, oddly enough, which is an interesting thing, is people always want to connect depression? They want to say, depression is a disease he's and they want to say it almost like you got Herpes like you know, I mean yeah, it's like what you've got depression all were you need medicine and for him the one of the big factors in and fixing everything was his own success, his own person
success and then he became more happy and then his medication helped he became more successful and then, as he became eventually really successful. He started to experience like a better quality of life. He was happier he was more confident and then I slowly weaned himself off and now he has no need for them to mean that is so fascinating, because so we're not talking about. Necessarily a disease like he does not have cancer. It's not like that. They cured him of a disease. It's it was a blanket. That was keeping him warm It was something that was allowing him to bridge the gap between an unhealthy mental state and a healthy mental state. But a lot of that health had to do with his own life. He still eats like shit. I mean he's not like the healthiest guy. He eats a lot of fucking candy, but he's really healthy now, as far as like his mind, is very happy,
yes, not lying. You know he's not faking it. So to me it's always I mean when I've talked to friends that have had had really good results with anti depressants. So I think there are some dark moments in people's lives where that can kind get them out of that. But then part of me doesn't buy that that's the way to go. 'cause part of me is like ok. Well did you exercise? No, did you take like real healthy foods? No, did you clean your life up? No, did you like what happened here and one of the things that a lot of these anti depressants do. Is they make you not feel bad about stuff like about anything like I had a friend, was on Zoloft and she said like she took it for a year and she's, like I'm kind of lost a year of my life, like, I didn't give a fuck about anything during that year, like anything, can happen like on scary yeah, but that not giving
perfect not not feeling bad. You also, you don't feel great either you don't feel like you don't feel like God, it's a good time to be alive. Looking young healthy, I can move all those thoughts, don't sort of come into play. It's like it dulls everything. It dulls the highs and it dulls the Lowe's, and it keeps the pain away. That's kind of interesting because believe it or not that's actually a symptom of depression. I think it's called like Hedonia or something where some it's not like really responsive to anything. It's like you can't, like you, just can't like You know, you know you can't like excite them or or like make them soup thanks. I there's kind of like you know, so that's actually kind of interesting that she was experience in that, while on an antidepressant well the results very pretty wide, totally yeah, I I mean with the same drugs right, yeah yeah. That was that, because it by university like what's causing that that you like you, could take something and you would have a totally diff.
Reaction and I could take something, and you know it would just be perfect you know I honestly don't think we actually know really why that is. But what we do know is that there are. I mean there are different. We are different people and I've got different genes that are regulating how much serotonin I'm making how much dopamine I'm making how much I metabolising how quickly I metabolise sing it. Then you another, and so when you like and keep in- and this is, this absolutely does affect how some of these drugs are. You know when they're taken how how their with their biological fact is. Now. You know why the white- I don't know you know so it's it. There's, definitely like a a genetic variation, that affects just the way our neurotransmitters are being fired away in the way they're being metabolised, and so, if you're, if you're at sing a drug. That's changing the way something is being mataba. Most already, then it's you know it's going to affect people differently. I think I think that's one reason
But honestly, I don't know who knows just maybe, like other you know situations as well other territory situations. All these things probably play a role. You know with inflammation. I was talking about actually playing cause a role I mean they have actual in studies where normal the people are injected with either a placebo which is saline water, salt, water or their injected with something that our gut produces called endotoxin in our gut produces it when our immune cells in Orgot attack the bacteria in our gut, because endotoxin is actually a component of the bacterial cell membrane and that is released. Pawn information. So when you're eating a terrible diet, lots of refined sugar- and that's That'S- actually been shown release endotoxin and it causes inflammatory response. So when people are injected with endo talk, listen or their injected with pro inflammatory, cytokines
Interferon Gamma, which we also make in our body when were inflamed, people start to it. Normal healthy people start to experience, feelings of pressure- they start to feel depressed. Anxious social withdrawal. People with placebo did not experience that I'm also- they had elevated levels of other inflammatory biomarkers in their blood, so it really like- and this is just this- is puzzle. I mean we're talking about injecting an inflation inflammation all this in their experiencing these. Like depressive symptoms. It was actually uhm people that were then given one of the omega three Fatty acids EPA there given actually a pretty high dose of it. I think it was close to like two grams or something completely alleviated any of the symptoms of that. So those people that we're getting the inflammatory, cytokine or the antitoxin and the EPA did not experience the symptoms. That was really like information. You know driven these symptoms that were not experiencing
we'll see about so that's kind of, and there's been multiple studies showing this and that you know it's not just one sided, multiple studies, multiple studies again, this is kind of like a new method. People are using to explore how inflammation effects depression. It also it's been shown the same sort of scenario where there's a placebo and they're, injecting inflammatory cytokine doping, levels lower in the brains of people that were injected with the the pro inflammatory cytokine, but not the same water, and also the reward path where in the brain is also decreased. So you know again like I was mentioning you're, not not that excitable, your you don't you know it's kind of like and that and that was not, that did not happen in the placebo group, so this was not just an effect of being shot up with something you know so when when scientists have look at some. Some of the mechanisms and explored will: how is it that inflammation is affecting dopamine in the brain? How is it that it's you know affecting people's mood? It's thought now. There's
variety of mechanisms. One is that you know these inflammatory cytokines. They actually cross the blood brain barrier they get into the brain and they disrupt dopamine release they disrupted serotonin release it disrupt norepinephrine release. You know, they're disrupting, mirror transmitters being released on. The other thing is that There's been recently discovered that the lymphatic system is actually directly connected to the brain through the meninges, and it was previously thought that was like cut off. The brain was protected from the lymphatic system, but it turns, but we were wrong. You know everything that we learn in textbooks for years and years in our science classes was not accurate. Actually, we are lymphatic system is connected, and what that means is that our immune system, the chemicals inflammatory cytokines, were producing you know from our mean cells are getting in the brain and disrupting you know, is release in uh. I think so. Really I really strong connection to imp,
and in depression, that's shown to be causal, but when you think about it, it's like well what causes inflammation? Ok. Well, we can talk about the sugar stuff because that's been shown eating a terrible diet does but the other thing that causes it and it's what you mentioned. That is a stressful event in someone's life. Now you know a breakup tragedy. Work relate stress, social anxiety, whatever it is anything that causes you to release cortisol stress hormones, believe it or not, those things actually affect inflammation in your gut. So it's like a two way ST here. I think that, previous that you and I have talked about another podcast like got microbiome bacteria. You know you can take microbiome back to your from anxious mouse and transplanted into a non anxious mouse and make an anxious, and vice versa right. So there's like some sort of got brain axis through with something called the vagal nerve. Well, it goes both
ways you can go from the brain down to the gut, so it's been shown that, like cortical release hormone, which is a stress hormone. You know, get through the, single nerve. When you release it goes in the gut it activates been cells which then activate other proteins in the guide that chew up the called proteases, the chew up the gut barrier. And then you start release more influence. You know inflammatory cells, which then like getting check with bacteria more inflammation, and then it goes back. It's like this feedback loop, so I think that's how stress? It's also part of the mechanism, how a stressful event any any sort of break up or tragedy. Those sorts of things also cause inflammation. They cause inflammation in fact Is it totally off topic, but that's one reason why people should never go and like get like blood work done like like a day or two after some kind of like traumatic events. So if you get fired
blood work, so yeah like do not look at your blood or break up or whatever yeah 'cause. They will like it will skew every anything wow everything well, that's that's so amazing, and when you discussed and when you lay all these facts out, it make it seemed so irresponsible that ten percent of the people are on this drug. Eleven percent skews me around this drug or us it was. You know whatever a category of these drugs instead of dealing with it. I mean it seems like it's we're in a weird place when it comes to the holistic treatment of the human body where, winner very weird place, where we have all of this information now, but it doesn't seem like it's being applied. When comes to the average person who is suffering the average person who, with the disease or depression, which I guess you could call a disease. And it just seems so insane that all we know that we're treating it only
is chemical pathway were only treating with a pill this pharmacy. You know this Pharma, Khalaj Ikle solution to this, which just seems so limits upsetting it's so upsetting. It's very upsetting I'm like it's like a mission of mine. You know, I think you know I think, the problem is multi fold. Do you know one is that you have to psyche Trison their trained a certain way and people when their patients come in. They expect that they're going to come. They come in because they want a pill most of the time they do. They come in because they don't want to deal with it and they want a pill, and so you know that's kind of a problem because they need people need to understand that these pills are not the magic bullet. I mean. I just told you only forty percent people are responding. These antidepressants that are standard of care compared to thirty percent. They respond to placebo a sugar pill like that is ridiculous. You know, so I think I would lie
if there was some way to get a physician of usually there's psychiatrist, that people go to for these sorts of pro forms to like push someone to say you have to go run so you're going to run six miles a week, you're going to run you're going to do that. That is going to help you like it's. In fact, it's been shown, it's been shown a multiple studies that exercise improve depression and one of the ways that does it vary in interestingly, is that aerobic exercise specifically has been shown that whole serotonin they were talking about inflammation inhibit, release of serotonin will guess what inflammation text serotonin in another way, the to serotonin, serotonin tryptophan when you have inflammation so, like I said emotional event, causes inflammation, doesn't have to be your sugar diet. Okay, you! What location can be caused by your cortisol release when you have that inflammation your body
thinks that it needs to fight off something. But that's what it thinks it's like. Ok, this I'm sick, I've got. Foreign invader? I need to kill it and so the tryptophan, which usually is being transported in the brain and make serotonin, which plays a role in how you feel or plays their own lots of brain functions then gets diverted into another pathway, because your body's like wait a minute. I don't need to feel good. I need to the lot. I need to survive any to live so it the trip to fan, gets converted into this whole other pathway called Kind Uranian which helps with it basically immune cells need it to different immune cells needed to make different types of immune cells. So your body is like ok that runs on this out there. Software. I need more men sellable about, but the problem is that the kind you're earning then gets converted into so now. What you have is your depleting your brain, it's our town right there right, that's the first thing. So if you're, not sick and if you have chronic inflammation, you're chronically stressed you're chronically eating, a terrible diet
Then you are going to constantly be diverting the serotonin. You know the tryptophan in his other pathway, you're going to be depleted uranium serotonin right. So that's one thing: this is a two fold prob and then that whole kind aronian thing gets converted into something called Quinolinic acid, which actually crosses over the blood brain barrier, becomes a neurotoxin and also has been want to cause depression, so not only are not getting serotonin you're getting this gnarly shit and your brain, that's not supposed to be there an exercise. It's been shown specifically aerobic exercise, causes, your muscle to soak up the con yearning actually another precursor to it, so that it can't form Quinolinic acid. So it doesn't form the neurotoxin park part, but you know exercise also caused you to make to makes tryptophan go into your brain. You know alleviate some of the competition with branched chain amino acids like Lucy and I solution. So that's another way. It's doing a million. Sprained Ragnarok traffic factor. We talked about at the beginning of the podcasts that also plays a role in depression, helping prevent depression so
marriage, neurogenesis, all that stuff that helps growing new brain cells. Making new connections helps helps you deal with stress. That's why you make it when you stress your body, it seems like there could be some sort of a whole holistic approach, like our clinic that looks at all. Of these factors looks at all These factors and prescribes, instead of just prescribing a pill, prescribed a very specific by an exercise routine and maybe even meditation may be giving something that the practices or or uh enhances, mindfulness or promotes mindfulness someth and that allows you to manage the way you are viewing and taking in scenarios and scenes and events in your life and then Pra. Missing them in a more healthy manner. It seems like all these things would be, is effective or maybe more effective than just a pill. I agree with you and I'm hopeful for the future. I think that the more
there's a lot of scientists to spatter starting this now I mean it's becoming very common to to look in the scientific literature and and see you know, scientist researching inflammation in the role of information, depression and the role exercise in helping treat it and the role of other. You know dietary lifestyle factors in causing in treating depression. So I think that you know. I really am hopeful that in the near future that it, like you, said it's going to be a multi pronged approach, where it's not just a magic pill and I'm not saying that's not all so going to be included in some, you know I'm just so you know it's. I think I think the diet lifestyle meditation exercise if we could just get that into like you know that the clinical world, and if people were motivated enough to realize this will really help them like it really well, people will be so much happier
I really, I really think so. So I'm people just don't want to fuck an exercise. It's weird. They would so much to go to a doctor and get a pill. It's it's. So strange, it's a lot of people. Well, it's this fear of discomfort. People have this extreme feeling in their mind when it comes to their associations with exercise, they want to avoid discomfort. They feel like any type of exercise is just like something to be avoided. That's not for me fuck that I don't want to sweat. I don't want to strain and uh. Sometimes this association that they have is about the beginnings of getting in shape. It's not about once you're actually fit, because once you we fit exercise is something you look forward to it's an alleviation of stress. It's it feels great like, but I can't get a workout in. I I look at my schedule. I go oh shit. I don't have any time for a workout, which means I'm not going to get that good feeling, and so, instead of looking got it like, oh I've gotta go grunt and sweat, I'm
thinking, I'm not going to feel good, I'm not going to feel relaxed, I'm not going to feel carefree and I'm not going to feel even appreciate. If, like my appreciation of things, it gets enhanced greatly after exercise. I just feel better. I feel I can take things in for what they are, rather than you know, whenever wherever sensory data that I'm getting from any event is just one more distraction that gets in my way and in that so a lot of times how I look at things from over stressed or from working too much totally beautifully. Put, because that that that's exactly like the least what's been shown for like narrow it imaging studies, is that exercise does what you're talking about? Is the executive function you're talking about feeling good you without that sensory stuff, which is the Imac delights? Emotional center? That's been shown to be decreased in activity after exercise, where is the executive? Function is increased, so it's it's it's just it's done is exactly in the right direction. Right you so you're, yeah you're able to logically
think about this more and you feel good and it's like you're, not that that era- once that, like you, don't feel it as much that part of your brain is actually quieter after exercise, meditation does a similar thing, but if there was just a way to get this knowledge to PETE for P, understand people that are adverse to exercising. You know if there was just some way and I'm really trying to fight. The way, because there are many people that I care about in my life that are that way and that feel depressed in or on some sort of you know antidepressant, which doesn't really work for them still, and so I'm trying to find a way I like how like I can tell them I'm having this conversation with you and you get it because you experience it, you exercise you do you know you, you eat healthy. You experience these things, but for someone that's never experienced it. How do you communicate it? It's so hard for people to start anything new, it's hard for
able to start a pottery class. That's not going to you know it's not going to be involved with any physical pain or any gas or any exhaustion. There's no there's not that feeling that you get. When you really tired. You know the feeling that you get from me is particularly difficult. Doing boring stuff like an elliptical machine like elliptical seemed to me, it's a good, great workout. It's awesome in from out of gym 'cause. If I go to a gym, like at a hotel, and you know they have some bullshit weights and but they have an elliptical machine. I go ok if this thing has a high setting. I can get a real work in this, but those times when you're tired and you don't want to do it there, so fucking boring it's just gosh, you have to listen to something you have to watch something like other stimuli has to come in in order to get you pumped up, but I know this 'cause. I've done it one thousand times for so who hasn't done it one thousand times you they get to that point like fuck
this, I'm outta here, oh my god, let me get a donut. You know give me a coffee. I will go out and smoke a cigarette. I feel better. You know- and it's so hard to get past- that because we have all these connections in our mind when it comes to comfort, comfort and stress comfort, Inn like our body, for whatever reason most people, their associations are to avoid anything, that's uncomfortable, but it's uh the logical, because when you look at comfort and you look that success and progress and eventual the feelings of accomplishment and of getting past certain hurdles in terms of like how you feel about life, a lot lot of those are connected to discomfort. Like discomfort is your friend, it really is like discomfort, and not being happy and content with certain situations in life or sir feelings in life, there are massive
massive motivators and there are amazing at facility. Can change and yet are in sting is to avoid those and just sit on the couch and watch some fuckin reality show about due to make moonshine with our jaw open, czar. It is it's too much too much of that. Like stimuli read on to do anything and you can still like get yeah get that sensory information. Do you know the the need to act like to need to actually go out there and act is so strong? It's such a it's it's an important thing, but yet we resisted many people. I know you, don't I don't, but so many people do I, but I feel the thing you know I don't don't allow it to work, but I feel that fuck this I want to workout I feel it all the time. Almost every time before I workout, we have at least an inclination to blow it off. I don't ever embrace it, but it's there Where is there with everybody? No one is like completely
be one hundred percent healthy and without any resistance yeah. I wonder if also because we were talking about this being a super ager. I wonder if there is some, association there, we were looking at looking at how it's important to push bass pass, that uncomfortable ness, whether it's physical or mental, and that's linked to being a super ager. But what if it's just like the ability to make yourself do that is important to too it's, not just the act that you're doing it's not just the strenuous exercise, which is is obviously good. We know that it's good from scion, but what, if it's just being able to like push yourself like? Maybe some people don't have that ability? whatever reason or they just haven't tapped into it and uh, because I'm really experienced. I think, that's it. I think it's a learned thing. You know, If I take time off like I got sick recently, and I couldn't work out for like a week or you know six days or so, and the of the act of getting back into the gym, I think in a lot of ways we
rely on momentum. We rely on the momentum of past x. This is where you're just conditioned to do that, it's one of the things that you do and for me at least when I get when I get like really disciplined really. I get really consistent with my workouts one of things that I feel I almost feel momentum. I feel like there's like a push behind me like alright. Well, you know like after I get out of the gym. I have a really good workout on my cat. Now, I'm doing it I'm doing all the time now and I'm looking forward to the next time and it makes that resistance much weaker and it fix my motivation in my discipline, much stronger, I think a lot of it is based on just the consistency. You know it's one things I talked about recently on the podcast. I said you know like blow something off: it's not just not good blowing off an exercise that you planned is not just bad for you physically. It's also bad mentale,
because then that option is now available. The option to fuck off is available and but you did it before, and you're probably going to do it again and you'll get mediocre results, not just in that aspect of your life, but maybe in all aspects of your life 'cause. I think that option to fuck off when you embrace it. That is a pathway that you might choose when it comes to dealing with con, clicked in your personal life dealing with business decisions dealing with court your decisions like an uncomfortable decision that you might be faced with you. Maybe you need to make a change as far as what your pathway is in life, but you don't do it instead, you fuck off and that the inclination to fuck off. I think that gathers momentum as well the inclina to be disciplined that comes with phantom two and I think both things like you did you take a path. The path of the healthy person are the path of the fuck off like both of them are available in whichever path you embrace total. He totally I mean, I think, that the same thing go
it would like lying to I mean when you, I think it's very bad. Well, I like, even if it's something that is really benign like what they call it a little tiny white, look great that you know, because then you start making these neural actions in your brain and you start to like it used to doing it like he was saying and- and I think that it just kind of dawned on me, as you were saying this- that we, the motivation in the momentum you're talking about. I think that's the same way. I think you're like building these new pathways, is motivation pathways and that's really important for that momentum. To do it again and again, you know: there's been there was some studies, a few of them that have been done, where you can take person and do that direct transcranial stimulation, which I don't know much about. But I remember these studies and, like related certain part of the brain, that's involved in motivation and you can motivate them to go to the gym. So you motivate them to actually go workout.
So that's in one of those electrodes they put on a specific area, the outside of your head and then, It's like a little nine volt batteries attached to it and it just zaps you little bit, apps it saps you little bit and like activates, a certain brain region that that brain region is activating specifically with this study I was talking about it actually is a couple of them were, are involved in motivation and that's probably with you and I we already have those pathways activated because we're constantly forcing ourselves to go. I mean I feel the same way. There are times I'm like God. I don't want to go for a run like so far if you do it god damn you feel great feel great, and you know what you accomplish something. So it's not only like you're feeling great from all the neural mecca, things that are being activated and all the biochemistry that's going on, but you have accomplished something you did you push past them and you didn't want to do when you feel good about doing that. After magnetic stimulation therapy, Wilmington woman finds motivation, Enerji yeah, there's uh.
A radio lab about this radio lab podcast is called nine volt Nirvana and it is pretty good I like I love it. I love radio lab and it actually deals with the first story. The opening store is amazing, 'cause. It deals with this woman who went to the it's like sniper. Training simulation, video v, go thing that they do where they they put you in front. They give you like a fake gun and put you in front of a video screen and a scenario plays out and the scenario there's like a terrorist attack. You have to take out the bad guys and they did it with her and she was twenty minutes long and she was terrible terrable. She fucked it all up. It was just like a disaster like she didn't respond correctly. Then they put these electrodes. What would you exactly call them one of those things that cancel So they put these on her brain in the on the outside of her head and very specific areas and stimulated it and then recreate it
and in the recreation she was one hundred percent effective. Killed all the bad guys and she went through this twenty min thing and when it was over when they to older that it was over, she thought they were fucking with her 'cause. She thought it only two minutes like yeah, like every kredible, it's amazing the way she describes. It is amazing, it's amazing, a little scary too. Just because I mean so I can you like program, someone to do there's another study that was, that was a published like two years ago same thing: Trans Cranial direct stimulation, and I, but I liked him so non expert any this, but I just remember this study because it was trying to investigate what part of the brain's fault in consciousness right, and so she so that the study was designed in such a way where she was reading a book and they zapped are in a certain part of the brain and she
stopped reading the book. This woman and, like just looked at them like a zombie like no nothing, no talk no, and then they zapped her again and she started. She picked up right where she left off no recollection at all of doing so. This was like trying figure out if this person is faulty consciousness, anyways, that was a little sick with that's with the yeah. That is a real concern right, because one of the things about this transcranial direct stimulation of of the the Brady allow podcast was that that they talked about how many people are out there. Just fucking experimenting where there's uh whole community online, where people are talking about like experimenting with the voltages and experimenting with placement and one guy did something. You've lost the sense of taste like much yeah.
So people still buying these, and like doing it like this, yes, well that you can go, it's like you go to fucking radio lab the consequences of a world where anyone with twenty dollars and access to Radioshack and make their own brain zapper yeah. That is, from radio lab from their their podcast page. It's amazing because there's apparently this gigantic community of it like hold on a second go back up there and make that lg again. The la a couple of years. Atdtdcs trance direct cranial stimulation has been all over the news. Researchers claim that juicing the brain with just two Milla amps nine volt, but think nine volt battery battery. Help with everything from learning languages, to quitting smoking, to overcoming depression and so They brought in a Neuro scientist Michael Weiss and at Wright State Research Institute into the studio, tell them how it works really interesting very into, You know I feel like in terms of like treating depression or helping
people get motivated to go to the gym. It may really have relevance. But it also might be like slapping a supercharger on an old Chevy Nova below the fucking engine. On the thing you know it's true it's true, I mean you, don't really don't really know enough about. What's going on. I certainly when be experimenting with that right. I'm in now. Let's do it, you do it yeah, I'm thinking about going to radio show up Radioshack right after I get out of here, not really, but sore I mean it's just interesting it. It's amazing that we are really some sort of a system and you can choose. That's it stumble electricity here, a little item in there a little broccoli spray here. That's the weird thing about people. One of the weirdest things about people is how very all we are depending upon what we put inside of us and we don't think of that way. Most of the time we think of ourselves as ourselves, you know, I'm sure you think of yourself is Rhonda, Patrick, but Rhonda Patch
Rick relies on a bunch of fucking chemicals to be Rhonda, Patrick right, I mean there's a lot of stuff going on in there. It's not it's not this one, like this is a laptop. You know, I'm not adding shit to this thing like I could put programs in it and stuff. But I mean this is that everything in Here's kind of worked out. Processor there's a motherboard. It's all all this junk is in place in the electricity plugs into the back, and it's not really variable. You know the Hume, body, so fucking variable and pliable and malleable there's so many different things that you can do to make self better this conversation with a friend of mine who's not a physical fitness guy. By and he's kind of an e Liston nihilist, I guess you're saying I never say that word. I just read it. I think it's analysis, analysis and he's Now is a little bit of a curmudgeon and he yeah. What's the point, you know like really what it what it, what is the point? You're always do, walls, martial, arts and exercise. I go okay, if I could give you a pill and that
bill would turn you essentially into a super person like you. Do you share that you can't do now. You could lift weights, you can't what left he could beat people up. You could do physical fitness fits feeds that you know what right now are totally insurmountable and outside the realm of possibility. Would you take that pill? So simple and he goes no. I wouldn't I go you wouldn't. Okay, if I could give you a pill that would prevent you from being a decaying old man and you could stay in state, you are right now. Would you take that he's like yeah? I probably take that I go well, that's how it feels like to me. Mother, fucker, like that's how it feels like to me like you're, a decaying goldman yeah, like he's not much, I think he's a year older than me, but he looks like he's fifty years old. That means bodies all humped. His you like you like Scarlett Pouch. It doesn't have any muscle tone and I'm like dude. All of that is just physical fitness like you're not broken like there's nothing
wrong with you, but if you got on like a steady yoga routine and started doing some resistance, training and started maybe swimming or something like that a year from now, you have acomp. Slightly different body, you know, and so talking to me, I'm like I've done it. My whole life so like stuff that I can do stuff that you don't think is possible and to me it's like two times a week three times a week, I do that stuff like this is not your body is like a race car that you can juice up yourself like you, can add the fat tires. You can add the improved suspension. You can beef up the horsepower in the engine. You do all that yourself or you could just choose to have this shitty body, it's always falling. Apart on you right, I mean you're You- and I are both choosing to do as you know, is we're both kind of obsessed with nutrition and aging and being you know optimal, as we can in terms of our health, but and ultimately, what we are doing is delaying the aging process by switching on all these. So
which is in, like you know, exercise and getting all the micronutrients and avoiding the refined sugar which is causing it location and all that stuff, and it's really because that stuff is part of the aging process and it accelerates the aging process. You know where I don't think people that don't do this stuff realize that it's like it's not just about looking good about aging, it's about like being older and being fit and being mentally sharp and not being you know, to generate and decrepit and how I mean how awful would that be to be like sixty, which is a young man. Sixty is still young and to be like. You know we're not yeah broken, which is really common. It's super calm, especially for sedentary people. Exactly is entropy most sedentary people are people that also choose to eat terrible diets. So it's like.
Not only are they sedentary they're, also eating crappy food and not getting all the nutrients they need. So it's just like this mega explosion, dynamite of just bad yeah, increasing information. I think intelligent people like my friend he is intelligent and I think he connects vanity with those things anything's vanities for fools. In a thanks. It's it's a it's, a trait that he finds is reprehensible. He just doesn't like it. You know he sees people that are you know ma'am in on what or maybe it's the flashy clothes. Maybe it's the you know the way they wear their hair. Whatever it is, he thinks is preposterous. He connects that with physical fitness MIKE Man, but it's your vehicle. It's like well how you get through this life and it's it's how you think it's it's. It's so many different things that are all connected into one super organism, which is the life that you're living
I wouldn't! I think everybody knows now. I mean it's not something we grew up knowing, but everybody knows now about your gut biome. This is a a really huge factor in how you to exist as an organism or, as it may be, even an organism is the wrong word: 'cause, we're essentially ecosystems. You know when we're in charge this weird consciousness. That has all this resistance and has all the inclination towards comfort and fucking off and blowing things off is what is in charge of making all these things happen that keep this ecosystem healthy. It's almost like. If earth itself had like a shitty manager, you know like there was a manager over a natural manager of earth that was like how God who cares if it rains? Oh God. You know like, let's you know, I'm going to stop growing things. I don't give a shit anymore, it's all stupid anyway, literally like that
Killala life would do it's all going to die. Eventually I mean the sun only lasts seven billion years, and you see that is the perspective. A lot of people take with aging, where it's like well you're, going to you're going to age, you can't stop aging and it's like yes, you're right, but that's not the point. The point is to age better. Like that's the point, the point is to increase your health man. You know- and that is we know, is possible like that. There's some there's some of these, like centenarians and super centenarians. I've seen that are like over one hundred years old and they're, like riding bikes, an racing and It's like their old they're, very old, are experiencing a very good quality of life, yeah and they're, experiencing a quality of life that these other people that don't exercise feel they physically feel their own. Body diminishing, and they just feel it's inevitable it. It is what it is. You're wasting your time, you're out there running around, but we're not because this it's right now, it's not like
no ones under the illusion, they're going to live forever, but you are enhancing the experience that you're currently involved in right now and who are alive. You are alive, you do experience this life, but do you experience this life optimally? Is it is, as enjoyable as it can be, and we all know that there's a spectrum for that enjoyability, like we've all had times in our life, or it's not been so great in times in a life where everything came together like what a fucking great day woo like make more of those like you, could make more of those and then the whole things better, and I think when that whole thing is better, it effects everybody. You touch, everybody it's around. You everybody come in contact with and that in turn, minutes also grandiose, but in turn can affect the entire race of human beings. I agree totally totally agree and I love the way you put it about like the feeling good. It's not just about
you know staving off cancer or you know it's not just about. What's going to happen, two thousand and thirty years from now it's about now, it's about not being depressed. We know that you know it's about feeling better. It's about being smarter, it's about having more executive function having more long term planning. Less emotional, a mid to let you know anxiety. That is the bike right here right now that is happening. That is so. You know it's not just long term effects, which you also are you know also affecting, which is very good, so it's like a win win you're, not just affecting the future you're affecting right now how you feel how you perform. You know it's yeah, it's an important concept that I continue to try to get across to people, and it also will optimize everything else. You do whether it's creative pursuits, whether it's relationships that you get into a lot of, those things are predicated on, how you feel as you enter them, how you feel when you participate in them, and you can enhance that you can enhance that an
there's a weird thing that people do when they want to pretend they're not trying to do better. You know I'm fine. Everything is great like it's not that's, not true, you're, putting out effort. It's a matter of you. You have a mindset or you have a connection in your brain with Pooh, hang out more effort and connecting that to discomfort and that connecting things to discover, if you ever saw Stephen Press field, has a book called the war of art brought up in this podcast a million times. I ourself a copy of it or give it to you afterwards, because I okay I bought like Fit, the copies of it my hand I handed out to people it's great and he's been on this podcast before in his book, is essentially mostly about the creative pursuit, and it's about resistance that people feel when you know you should write or you know you should paint or whatever you said sculpt whatever these things are that you you pursue and that there's this thing that comes up that tries to keep you from doing that, this resistance, and
like. This is a battle that you will fight for the rest of your life, but the key is to fight it not to give in don't give into that resistance to just to fight that resist and in doing so, every day you do so. You have won the battle for that day, and you will continue to fight that battle. An if you continue to fight that battle that same mine that you will win- and this is a guy like up until the time he was forty years old was basically a loser, isn't doing well, it was like a failed writer and then he kind of just figured down and got his shit together and then wrote books about it. Now is like a really accomplished author and it's it's an amazing story he's a really cool guy too. I had it on for a podcast, and you know in his Susie Asom and the way he approaches it in this book is like it's a very pragmatic, like you can see the steps and he he
lays it all out in a way, that's very easy to digest. Awesome, yeah, I'd love to read it. I mean I I I think that's something that's very important part of of of the mixed This is pushing past that resistance to you too, very much, sir you're right once you do it, you get better at it next time too, you still there, but you do get better at it. Next time, there's also a problem. I think that what it comes up when you and I are doing these podcasts- were there so much data. There is so much to take. In I mean we have done how many podcast now like six or seven six one lot and eh One of them is three hours of like what the. How does she know all this in the snow books like that when I put it up on Twitter, you know the that you're gonna, be here every like gay. You know book out. I mean that's like the number one response in the comments. That's awesome, yeah, there's a lot of stuff that I I in
learning you know so something that like to learn about things that can make me better or things that can make other people better mentally physically aging, and all that. So I like to share that with with people. I have you heard of this we're talking about an aging pill and it kind of came into my mind when you're talking about giving your friend that if you could take a pill that could you know, play the way you age or make you live longer or better. Have you heard it nicotinamide right beside or nicotinamide Mononucleotide, not at all, not at all? No, oh wow! It's like it's kind of like! I guess it's! Maybe it's not made its way into the popular media as much as I thought, but it's definitely blown up in the science, so there's so nicotinamide right beside an Nickatina mononucleotide there like precursor forms to vitamin b3, and the body they get converted into something called NAD, an eh
ideas, something that you absolutely have to which make energy have to have to make an entry like you can't oxidize fat, fatty acid. You can't ox raise glucose. You can't make energy from any of the food you eat without any d, because in my country and needed to make the energy. So it's very important for your mitochondria function to make energy, but also it's very important. It's like the levels of any We always rise like when you're fasting in between meals. So, like you know, between breakfast and lunch, breakfast some dinner or whatever your nad levels go up like only after a meal and during the fasting state, and also when you exercise so the the levels of energy will will will go up somewhat, but on this. So these are precursors to an eighty right. I'm I'm sorry this. 'cause. This is kind of the studies that have been done. All the mechanisms go back to this informing NAD Nad is something that decreases with age
it's something that you know it's just it's it's very important for aging, anytime, you're inflamed all the entity gets sucked and sucked up into that information, because your energy to me now energy, it requires energy to like, have your immune cells be activated and fighting on. Whatever they think they're fighting off, whether or not it's refined sugar or actual an infection, but dna damage sucks it up. So it's like you know it's basically a limiting factor in a lot of ways. So this been all these studies over the past, I don't know I'd say like six, you, There's probably now Bieber six years where various scientists are have been feeding mice. You know this side by side or nicotinamide, Mononucleotide and they're. Finding that you know, for example, if you feed them, Nicotinamide Mononucleotide today's aging in their liver in their bones in their eyes their muscle. So it's basic
like their tissues or aging better, they haven't, endurance. They have better mitochondrial function, and these are doses like human equivalent adoes to like twenty four milligrams per kilogram body weight per day, which could be a lot if you weigh a lot, but showing that it improves Matic, Chondral function and Nicotinamide I decide which gets converted into Nicotinamide Mononucleotide, it's kind of confusing it. Just anyways lots of studies. I'm not showing that it like, if you give it to my said, have some sort of mitochondrial defect in their muscles, all atrophying being completely reverses that your muscles are like they're, making lots of mitochondria and their improves muscle function and enhancing performance. Anyways, like you, get the idea like lots and lots of animal studies. Recently, there's been a human clinical trial done with nicotinamide right beside an that to show that it's safe and that it actually does increase NAD levels in in human blood, which it does
even as low as one hundred milligrams dose a day, and is this a supplement that big people can buy so so nicotinamide Mononucleotide is not that's found. Like broccoli. Broccoli is really high and it cute Merger really high in it cabbage is high in edamame, but nicotine, my tribe aside, which gets converted into that which eventually makes its way to NAD is it is a supplement so uh few scientists. Actually some big names, is an aging filled. The clinic warranty and a couple of others have started a supplement company called a lease Can you give me that pad? I forgot to put a pad over here. I gotta write that down. Thank you, yeah, and so it's called a lease, and it has nicotinamide him like the Matt Damon Movie yeah. Elysium. Oh look at this. They have it.
So it has nicotinamide and by the way, no affiliation. I don't have any affiliation with any subway companies, also a supplement company. What is the company Jamie think? It's a company called the companies called Alicia Moore is the supplement at the supplements called Aliciem. But how do you spell the actual nicotinamide right, I'm I'd an Iac Nick, e? I n a m. I d e right beside our I b o s. I d e yeah so the it's interesting. It's also there's another company I think Thorn makes makes one with it in it, but born yeah thorn the thing It's interesting about the Aliciem, though, that I found, because I started looking in This, like I've met Lenny guarantee he's the guy. Ok who who who's lab the whole pathway that resveratrol Axon was discovered that so nad
switch is on this whole, like genetic pathway, that's like anti aging and it does changes all these epigenetic factors, okay, without getting into all details in like boring people to death, it's like it active it. It's basically nad levels rise that acts as a switch. This this is an ad levels. So this is a supplement. That's rising nad levels, but what's interesting about Elysium is that it has something in it. Called terra still been Cheryl still being is found. And in blueberries blueberries, probably one of the best sources of it, but What was so interesting? I was trying to figure out like why? Are they putting trying to figure why putting child still being with the nicotinamide right beside, because Nicotinamide Riverside is affecting any its effect, contraband genesis with him? It's been shown to increase Mcconnell Biogenesis, like I said these mice, mice, you never were, were performing like forty two percent, better at different insurance activities after being supplemented with us. So that's
same yeah, it's but they're, giving a lot like the like at thirty two to twenty four to thirty two milligrams per kilogram body weight would be the human equivalent. So you know figure that out that's a lot, that's probably like four grams a day or something like that right for like a hundred and sixty or eighty pound person. Something like that. I don't know anyways. The pterostilbene is interesting because as well in and of itself. It's interesting because it's actually it's chemically similar to resveratrol and but it's four. Times more bioavailable than resveratrol and it actually has been- can weird side by side in mouse studies to like different mouse studies that have looked at cognitive function and it's better at improving cognitive function in animals, then re is largely because it's four times more bio available, so anyways. Well, I don't know if that's why they're doing it, because it's not affecting the same pathway, but then I came cross something really interesting, and that is
it's still being actually has been shown again. This is an animal study to increase the type. Bacteria in the gut that cause This is the conversion of certain compounds. Alagia TAN, things which are found in berries and some nuts, but really high in Pomegranate ellagic TAN. Get converted into something called TAROT, still called you with an eight by your gut bacteria, which What TAROT still being is increasing that gut bacteria, Sotera Stilbenes, actually increasing the prod a year old within a from berry Yes, they were having this other compound, uralla ' in a what that does is. This has been shown also another studies it causes my defeat might have AG or my top AG, which is the clearing away of damaged mitochondria. So you, basically, clearing away damage my to consulate the eat themselves, so Fiji would be eating itself kind of like autopay G, her atop, a g as it's called, which is a self.
Sort of a damage cell that gets cleared away, eats itself. That happens a lot during a fasting state. Well, this My to Fiji is doing it specifically for mitochondria, and this is the reason why this is so cool and I'm going to credit not bore you be like, I can go on and I said, keep going. I don't worry about that. Uh the reason this is so cool is because so you know, mitochondria are very important for the way we age, it's not just muscle, function, brain function, the threading enerji for everything like period like your mitochondria decay, you decay, that's the way. It is like period so their mitochondria, as you are aging, their decaying they're, getting damage and all this stuff. Well, they have this whole repair system where, where you have lots of mitochondria inside one cell list, we have one damage mitochondria unhealthy. What they do is they fused together exchange all their content and fizz back apart, so they're kind of repair each other. So we have a healthy wanna damage, one the healthy one kind of mixes with the unhealthy one, and then you have two healthy, ish ones, right so
this is happening constantly inside every cell. If you, if you look at a mitochondria, it's never like you. Never my see. Mitochondrion themselves are always like, like a network like they look like vermicelli spaghetti, because you're constantly doing this. Well, if you clear away the damaged ones and you increase mitochondrial biogenesis with because in my driver side so not only are you getting rid of the damage to pool your now creating new ones that are like brand new healthy? You young brimming young mitochondria, like you had when you were a young person, young child, so now your pool that you're mixing with is like not mitochondrial. Biogenesis is good in and of itself, because you're making you mitochondria, But- having damage one still around can still dilute the pull out. You know it can still dilute. So if you get clear out those damn which ones and you're making new ones it's kind of like boom you're going to get like young new mitochondria, so I think that PASA,
Lee is another reason why they combine those. I mean it's completely: speculation, I'm just but anyways. You learn. Some cool about terra stampede you're within a yeah. My mortgage is a very interesting thing. You know, exercise to some degree can increase it. Fasting does and what is fasting increases when you're fasting, you try to sew NAD levels rise. Uh you try to conserve some of you G in the way you do, that is by eating different organ AL's eating eating the cell itself, which can then provide energy for other cells. So you so usually what happens is fasting will selectively get rid of some of the damage cells are damaged mitochondria so that that happens during during a fasting. So that makes sense when you yes. So it's interesting, though, that the the body manages it so well that it goes after the damage once before. I know for the healthy it's it's well, there's lots of like molecular mechanisms that have been figured out why that is, and that's because the damage one there might
control, membrane potentials like different, and it's just it's all this complicated stuff, but it's like it all works out perfectly where it's like these these these enzymes that, like targeted to to basically become undergo might've AG. It's like recognizes certain one with lower membrane potential, which happens to be more of a damage mitochondria, and it's just kind of like it's kind of beautiful how it all works out that way. Ok, I was going to say I completely like was going to say something else. They lost my train of thought, but yeah, so anyways that the fact that you can like have new mitochondria is like pretty. I mean that's kind of like the big thing. With with aging that's been out for a long time is like young, you might account,
I know you're, probably aware of the study, but they injected old mice with the blood of young mice, and they found that the old my started behaving more lively and then they did the reverse. They injected the young mice with the blood of old mice in them. No, my struggled and and deteriorated and now there's some crazy new start up for was like eight grand. They fill you up, with the blood of young people, yeah. Ok, I'm glad you mentioned this. 'cause I've been reading about it recently. Actually you know Peter Thiel, the Paypal. Yes, he does that he's he's publicly talked about that he's he's on Trump's board now isn't anyway, I think so. Yeah one of the first people that Trump hired, which is fascinating, so fascinating, yeah yeah. He does he's talked about how he gets blood in okay, so here's what is he said about it,
I don't remember exactly what just that. I don't think he said anything about whether it's doing anything, but I think you should mention showing up younger nothing. Like he's got a snapchat filter on well here, the thing that was really interesting about this whole thing. 'cause I've been following this field for awhile, too 'cause. I find it very interesting for multiple reasons. One it's like it could be app. All right, I mean easily, but there it is look at him, looks young as fuck he's nine years old, He wants inject himself with young people's blood or is doing it Trump delegate and Gawker. Bankrupt are oh yeah, he's the guy who he he fine against Hulk Hogan's attack on Gawker, because Gawker outed him as being they out him as gay or they attacked him, and they did really shitty with him, and you know, he's a fucking billionaire. So he went off and thank you for turning off your ad blocker enjoy the Forbes add light experience, fuck off
Denton files for personal bankruptcy yeah. He he went after that guy because of it yeah. So we go back to the other. Only changed articles there so What he's doing given feels obsession with warding off death? It comes as no surprise of Silicon Valley. Billionaire is interested in the least one Radica, we're doing it, injecting himself with young person's blood wow INC exene published part of a year old interview with Thiel and which the venture capitalist explains it he's interested in Para, bye, Closest Wells called, which includes the practice of getting transfusions of blood from a younger person as a means of improving health and potentially reversing aging said I'm looking in this stuff. I think it's really interesting blah blah blah. It's unclear whether the forty year, old entrepreneur is currently receiving guarantee Diaz reports that a thief
will capital employee? Actually, the personal health director has a personal health director personal health director to Peter Thiel. That's hilarious! That's what you do when you're all baller, I'm going to get a personal health directory is the same company Ambrose well see. This is the one that we were talking about the other day interesting. So this is actually happening. Says. Thiel spends four one thousand dollars per quarter per quarter to get an infusion of blood. From an eighteen year old, based on research conducted at Stanford on it, Extending the lives of mice. So he's got one fuck an eighteen year. Old is vampire ring one kitty, given him beets and broccoli sprouts and making him run up hills, that's Cray, but you would have to hope that kids not doing math. You know like he's: got is eighteen year old, keeping all these biomarkers is blood and what I'm changing yeah, because you have to make sure I mean that's so we're going to farm off young people and
wow. That is so crazy. He's, given six million dollars to Bio Medical, Genter, ontologist, gerontologist Aubrey the gray that crazy fucker. I had him on Adam Mommy, yeah yeah, he's interesting, but he drinks, yes, boo This is like every night. He was like three end strong at eleven in the morning when I walked into his office yeah. That's what I was saying when I was hanging out with them he's like he he's based being all of he's putting all of his eggs in the basket of science. He thinks that science and things like with Peter Thiel is doing is going to be able to mitigate all this stuff that he's doing yeah, but am I? if you're stuck in that, like position where it's like: ok, they can delay the aging, but like you're stuck like now, ok, we can't make you like eighteen, but we can stop you from dying, but you know so it's like that's possible, so he's going to be stuck like not well, he also doesn't exercise. I've found him to be purple
I sing I really enjoyed talking to him, but I found him to be quite perplexing because of the booze and because of the lack of exercise is big. Fucking, crazy, Gandalf Beard like let's go How would you do there's a lot going on here? You might so there's a lot a lot of image here. Yes, I disagreed a lot of nutrition of will hold on a second. Let me talk about that, but and some say that the pay to participate study with potential to collect up to four point, eight million from as many as six on a participate and mounts to a scam hi. What's certain is it's based on some intriguing? If inconclusive science, car Maisie and a thirty two year old, Princeton Graduate and competitive rower said he was inspired by studies on mice that research, its own, together with their veins, conjoined in a procedure called parabiosis. Ok, that's what we're talking about that study about mice. So what did you guys disagree with? Well is the role that nutrition plays an aging to eat anything. Is a big role. Now we didn't think of the big pussies boozing, so yeah
losing is not working out. I mean. How can you ignore all the science on the the the positive benefits of exercise and nutrition? There's lots a study showing that the diet lifestyle we now have a huge impact on on aging yeah. You know, for I mean we just one more thing about this parabiosis, though, because it's kind of people we're thinking that it was the young. There was something in the young blood that was present to the G N, F, eleven, not just on the screen. That was actually enough eleven. What is that right? It's a growth factor eleven yeah, so it was thought that this was what was responsible for read you dating tissues and growing new brain cells. Because that's what happened when you gave it to the older mice, but then other studies started come out also out of Stanford, showing that in fact, it may not be something that's in the young blood, but something that's in the old blood. That's actually causing the aging something called v cam one. That starts to start to make as you're getting older, and it like causes in
Asian in the brain and, like starts messing up things. So there is a recent study that we just came out and show that if you like make an antibody against that became one and prevent it from like doing its action. It's like you can stop that from happening. So anyway, is there a lot to be figured out. Is there an out of body that they're currently working on yeah, trying to make some kind of some some something that you can take a day some solution agent, it's going to be weird, is going to be weird, if you see like old people, become young, it's not going to be rid of people. Do get any older, be kind of weird but like if I came ran into you like twenty years from now, I'm like damn Ronnie you exactly the same. It would be cool, but it wouldn't freak me out. What would freak me out of Arnold Swarts, anger started looking like it was when he was twenty again. That would freak me out like if we start seeing the change in the process. We start seeing things review course not just halt or slow down which we kind of have with like really healthy people. Like some people, you know
people kind of defy aging, at least to a certain extent like Tom Cruise is a perfect example. I want to know what their fill that dude up with you know, who else I think who I was thinking that defied ageing lie aging, famous wise counter Reeves, I feel, like the guys, look the same for like a long. Yeah and he's in his 50s now yeah he looks great yeah. He looks great. I think he smokes too right yeah. No, yes, yeah! That's just show you, some kind of like genetic there are. There definitely are Tom Cruise one thousand nine hundred and eighty three two thousand and fourteen injecting him with some kind of young fluid. You know, I'm saying I mean look, he's got fucking, ungodly sums of money and that's part of part of the issue. You know I mean they've date yeah. You can definitely do things with money that that edge and make you look younger, trying figure out
wordly, wise and stuff hope he's doing surgery, though no no well and one of the things that they think is what is that picture up above? What's that one with the turn off one up there is that him working out up there, see that shows aging. So one of the right, like he's, got substantially less tone to his muscles, but that could just be he's been busy. It says the Maverik days are over well go back, what does it say? Is it from nineteen eighty six to write on the set yesterday? So that's also that does not that much of a variability there that could easily be just using working out is hard. When you're on a movie set your work in one thousand, five hundred and sixteen hours a day, sometimes especially these gigantic big bug. Budget blockbusters you're. You know involved in these crazy stunts and all that stuff. So interesting yeah. But
you know back to this. Like diet, aging thing that, like our and I just read on, I mean it's it's so it's so weird that someone, that's he's familiar with aging literature would disagree. You know with with some of the signs out there like there's been studies looking at, for example, people that have like one twelve ounce can of like sugar, water or sugar soda, some kind of like sugary drink a day they have. If you look at the their telomeres and their white blood cells, so telomeres are biomarkers for aging. When you look at their team ruling Their team ears are shorter compared to people that don't that soda every day, and that corresponds to like four dot six years of biological aging, I mean that's like someone, that's the same exact ages, you but has a team member that looks you know either five years older, you know saying yeah, it's brilliant all based off of like this refined sugar soda
here is a personal thing with him, because he knows that he's not addressing that his own life. Maybe that's why he's decided to put up these blinders and ignore the science? Well, I think also he's interested in extending lifespan too, like massive point. Sugary soft drinks may be linked to accelerated DNA aging study. So he's like I said, he's putting all of his eggs in the basket of science, yeah women, who knows mean there's it's kind of interesting, that he is doing that, though, because he will concentrate like very heavily on that and again and we're talking about all this nutrition and exercise the benefits of it. Like there's so much to study, there's so much that it may be
his maybe his desire to issue that and go straight to the science of it only and talk about genetic manipulation and all these other different Abel's, like maybe the maybe the something to that. Maybe you really can't spend enough time in both fields, totally yeah. I think that makes sense, and I and I do think that there's hope for you know things like genetic engineering and stem cell therapies. That will help tomb humans up eventually, and that will make a big difference in have talk to you about my stem cell experiment. Now, no, ok, I, I have been getting stem cell shots. I got them for an injured shoulder. I had shoulder that. I had a rotator cuff tear bicep, tendon, tear and labrum tear in my show, then it was most likely had been dislocated before and I didn't know which is just to say
effects of years of doing difficult stuff with your body, especially Jiu, Jitsu cuz, but you get to is all about joint manipulations and joint locks and chokes and grappling and there's a lot of snow out of much that your body goes for everybody. I know that does to get to a certain point time either have to get some porn, form of surgery or has some pretty significant injuries that they have to work around so hi he OM, went to a doctor. There was like well, we have to get surgery like this is gonna the if it and if not now, sometime really soon, because every time I work out, if we get really sore and not have to ice it afterwards, I get these shots and they're doing them from their extracting the stem cells from women's placenta, and they take the stem cells, and then they should come into the area where you have the injury and the results are fucking freakish. You heal like Wolverine. I mean it's really bizarre and Now this same shoulder that I had you know like a real
problem with worlds worried about needing surgery. I do ninety pound presses with kettle bells with one shoulder and does not have no pain, no pain, no discount word not bothering me at all, and it's unbelievable how much strength and function that the shoulder has now that's really cool and realize they were doing that with the simple some cells yeah. Until some cells are like kind of like a gold mine, because they they parts possess a tap of stem cell called multipoint instance I, which is able to form multiple different types of it, cartilage cells that you the form cartilage cells that form bone, even cells, that form neurons, so they're, able to form lots of different types of cells and usually plants, are just like thrown away, I mean so it's kind of cool that there I guess there, companies that are freezing them down and finding you know, donors that match
yeah. Let me tell you the name of the company, so people who are listening- it's in my doctors name is doctor, Roddy, Mcgee and he's in LAS Vegas, and the company is um I'll. Have it listed here, that's good. I've gotten on my instagram on my pen, ready here to you, can't. Let me tell I won't let you down just give me a second I'll scroll through my instagram and I'll find him 'cause. It wasn't that long ago that I was there, but I posted something about it on Instagram but I'm a I'm a giant believer in it, and I've had some friends. My friend John Dudley, who is an archer, was experiencing Tendonitis in one of his elbows. For a long time I mean he had it and it was. You know something that he had been working through for quite a few years and he had one stem cell shot and within two weeks the pain was completely gone. Yeah, it's it's freaky. What they're able to do
I'm fine, I'm all about it! I'm I'm stem cell therapies. I mean that's something that I'm extremely excited about for the future, but have you ever tried hydrolyze, collagen powder or like bone broth? Yes, I drink, bone broth every morning? okay, awesome yeah. So that's another thing like 'cause I I'm getting into the bone broth. But I was doing hydra, add hydrolyze collagen powder to like my coffee in the morning and also my smoothies, and what does that do? Well, since it just like it's got a lot of the same things as bone broth, bone broth, probably actually even better 'cause. It has more stuff, but it's been shown like an animal studies. If you take the hydrolyzed collagen powder and- radio label it, so you can follow where it goes in an animal. It goes right to like the cartilage, bridge in the joints and ligaments. I you Is it like his help me healed like injured wrist? You know, obviously, like my injuries are like way way, less mag
students, something that you're experiencing in your shoulder here. It is total sports Madison in vague ISS. That's the name of the company that that does the stem cell injections for that. What about the company that you applied biologics? It's called flow graft amniotic fluid therapy. That's what they're calling it, but it's total sports medicine in LAS Vegas. That's where I got the stem supplied site. Biologics is of the company that yes, please, the placenta, yes complied biologics flow, graft, amniotic, fluid therapy and my friend riding Mcgee Dr Ride Mcgee is at total sports Madison in Vegas. He's awesome he's any such a knowledgeable guy too. If you ever want to talk to my get you in contact with them and explain all the details, he talks like you, you too could fucking Geek out to Weather and confuse the shit out of anybody standing next to you. Well, you know pretty soon they're. Actually, there make stem cells from skin cells now yeah word that I know they did that with a woman they created a new bladder for her. She had bladder cancer
and they created a completely new bladder from her skin cells. In a you know, laboratory environment and then replaced her her damage bladder. That's amazing, yeah! I had only heard about the clinical say that what they did with I cells were like the woman and someone was had some sort of blindness and they were able to use skin cells from her own skin. Call it a clock them in becoming retinal cells, but Blatter is really cool too. I mean so these these lots and lots of animal studies, but every once in awhile, there's like a new clinical study where they're just kind of piloting doing this and seeing the safety in humans. And that is where I'm like- I can't wait like yeah. It's crazy them sound check for my brain, where I know I'm shooting it right in my ear right in there, it's going to be very bizarre when we get past healthy human state. That's what I'm really not just concerned not concerned about rather but curious about like it's curious.
Not even a strong enough word, but I feel like within our lifetimes. Maybe it's fifty years or whatever it's going to be. They're going to be able to engineer a human body to perform and uh Sherry e, no you're, aware of Milestat inhibitors and the benefits on that they've they've they've shown that the accidental ones and they've done with like with pets and towels, but then they started to do it on purpose. For me, nice and there the mice are living longer. They're super mice there they are like way more muscular. I think there like two to three times more muscular than the average mouse. They look freakish when they kill them when they So then they skin them and they show the body of the mouse compared to with the muscle structure and can with the body of a natural mouse. It's like what in the fuck are you doing here like this is. This is like the hulk if you're making a tiny thing you know and your pudding, all this extra muscle on it and for whatever reason it's living longer yeah. That is that's the interesting part
that it's a living longer and we're trying to figure that out like what you know 'cause. Usually there is some sort of trade offer you like. Well, let's see if we could in that Jamie they saying the MILES Staton, inhibitor studies they did on mice, because their physical formance was extraordinary like they could do things that the other mice just could not do, but on top of that they actually little bit longer. Yeah, I see that's very interesting yeah. I know they were doing it with like pigs, two or something and I've seen some pigs. Are they done some sort? I think they were doing gene engineering on them with the mouse at inhibitor, but yeah so it's all very interesting they've done it with animals that you use. I mean they're thinking that you could do it with animals that we use for food and they would just they would provide more meat that way right, which is kind of interesting. But what's matter what exactly? I found a couple of different studies somewhere older than like ten years, so I don't know
Oh ok increases muscle, mass and muscle fiber in aged mice, but does not increase bone density or bone strength. That could be a problem snap that's an old study, My nine two thousand thirteen is the one I clicked on interesting. Maybe two thousand and thirteen is probably where I saw it, but the some of those images just click on those images Jamie, because some of those images you could see they had the like, go down there with mice, carcasses right there. You can see that prince in the size. Now, that's not, it was not necessarily it. I think it's actually, the one where you made was that hum. Well, there's plenty to look at but yeah there it is. You can see like the difference in the muscle size from the average switch is on the left versus the mile Staten mouse. Miles down knockout mouse, but look at
you're standing there that one mouse just looks like a giant ass, powerlifter mouse. These are strange times when it comes to this science really strange times I mean muscle mass, is looking pretty with that's exactly what I saw, how that's exactly I saw good Lord to credible, I mean but you've got like two levels of it. You've got level, you know a and level b. You've got the natural mouse which is on the left. What is this image? What is this image? Titled, Jvc, ok, okay body building and MILES Staton and there's an image of three one is a control which is the average mouse? The other one says: dominant negative. How does that word? Go at act, Rib ACT, rib, two rise and the other one is follow, Staten and in the call Staten one. It is just fucking Lee Haney of mice. Now, let's add giant ass mouse, it's ridiculous!
is like double the size of the middle mouse, which is double the size of the other. I don't know what either of those pathways are or what they do but Clearly they regulate muscle mass some things going on. That would be kind of weird to like do an inch fiction and, like all of a sudden you're like gaining lean muscle mass without, like doing any doing anything, yeah doesn't look like those mice are working out now. Be super, weird yeah. That would I don't know. Well that's why most conceptions about steroids. You know people think that, like you do steroids just get bigger and muscular. Now you actually have to work out what does a guy this is a mile. Oh, this is bullshit, this bullshit yeah. This is just don't even click on that you take that fucking off that's law. Guys that these God Damn supplement companies that do that. That's really gross one of the things they do is they pay someone to get in really great shape, so someone gets in really great shape like they'll, give him steroids, will pump them up, and then they pay him to get fat so
They pay him to stop working out, they get fat and then they change the way. The lighting is like one of the things that you could see when you're dealing with fraudulent companies is these shirt off pics. Before and after Wanna transformation is like in the the good picture there tan and the lighting is really good for accentuating muscle. You know the with the with the shape of the muscles in the shadows and everything they look ripped and then the other one they like pasty and white, and they pay these guys to get fat. A friend of and they paid him to do it yeah these things right here like that guy on the right, the app after is the fucking before and guy on the left before. Is they pay that guy to stop working out, and give fat? How do people live with themselves like doing that? Like I just don't, it seems like people do so, fraud there's a lot of monsters out there. I think this is from bigger, stronger, faster. I think this was actually taking like the same day. Oh, why did some
well the sides and they do that they do that too. For sure they definitely. That too and uh our friend Chris Bell and Mark Bell who were in bigger, stronger, faster? You know they. They know a lot more about that than we do then there's a picture of him right above that that, if you haven't seen that documentary, I highly recommend it bigger, stronger, faster, which talk. It's about the supplement, industry and use of steroids and all these different things, but that's one of them. Yes, one of the weird practices they do like If you look at any of those before and after pictures, it's mostly what you're seeing mean less like a really ethical company and they hired someone to take their product and continue to workout, but even then it's like when you show up before and after what was the guy doing before was a guy doing after how much is that his diet? How much that is exercise like how do you know? Did you get it the test on his guys on steroids like what's happening here, yeah, I think we should just focus on.
I can actually yeah yeah science in ways we know like we can increase muscle mass. You know. Obviously you know weight lifting and to me to be on Abu Grabe when you, when you brought up the science of nutrition and the factors you know the the the positive benefits of it. What was his reaction and whatever so as as part of this, is an older podcast that I did. I can't remember what episode, but it's it's been a year and a half at least I would say I can't remember his exact reaction I mean you can tell if you listen to the part. I talk. I talk a lot about. We talk a lot about. You know Chris Burns stem cell on a lot of these. You know possible, you know therapies that are being used that can potentially extend lifespan, but there's a point in the podcast where nutrition comes up and you can tell it's a little awkward between the two of us, because we can't have different viewpoints and I'm sort of not trying to
rude because look at their fucking wizard. We were like so close in his office and he yeah anyways, he's. God, God that beard is fucking awesome, though God damn it. I think I think his point was just that you can't you're not going to you're not going to extend lifespan by forty or fifty percent with diet and that's what he wants to do and that's fair, but the point that I think it's it's one thing to say that and another thing to kind of disregard nutritional together you know 'cause, that's 'cause, that's just stupid. Nutrition plays a role in the way you age, and so I think that should be You know it shouldn't be something that people should completely does for disregard and not and not think about and not and not even not think about it when they talk publicly talk it down like I don't like that like
like. That's fine, if you want to focus on technologies, and- and I agree with that- I mean I'm- I'm all about you know all these gene therapy, technologies and crisper- and you know in two three point: stem cells in a huge, huge fan of all that. But I don't think that being a fan of that and and being excited about what the science in and what new technologies are, are going to be able to bring us. Should you know, make us talk about like kind of people, any traction right watching the also a big factor is The way you feel and a big factor too, I mean, I assume he just doesn't just want to extend a shitty life right you to extend the life where you feel wonderful, right, right and well, if your boobs in all the time like he is that guy booze is everyday. I talk to me like we were drunk as fuck in New York. I wanted that. What is it? Two thousand and forty five of conference there's a conference in New York where all of
these nutty people who think you're going to be able to download your brain into a supercomputer and the year twenty forty five, like this extended life conference, and a lot. A lot of it was run by this russian billionaire that I talk to, which is a he was a very odd character. He was building a robot that they were not satisfied with the results of this robot, so the they never unearthed it. They never unveiled it rather. But these all these people is to three hundred and forty five conference in New York were all like this gathering of like these super geeks that are all in various ways, trying to extend life and Aubrey De Grey. Was there as well, and I met him at the bar and we just got fucking
with a hammer and we're talking to MIKE desire. We extend life, it's gonna feel they were just drinking again Essere during the off you're, causing massive information, or any of that this is terrible. Are we doing? But you know I mean it does or to like very contrary ways of existing yeah, to look to extend life, but yet to diminish the potential of the life your Kerr currently experiencing. But you know, I guess, he's having fun you know yeah, I don't you know he was an interesting guy and I enjoyed talking to him, but I don't want to talk about about, but when I was very shocked when I walked into his office at literally, eleven in the morning and he had already down two beers and he's on his third, and I was just like I didn't. I wasn't expecting
not right, I wasn't I mean it was completely shocking to me, and so God bless and now they're hammering it. You know AG yeah who knows yeah yeah, but I guess there's a lot of different approaches and I think he's at his approach is welcome it's interest it's in it's just as important. You know that I have a guy like that: that's kind of fucking up his body and still still after it like it's interesting right. You know this like. I was saying, though, that that thing that with him, then I you know that the major difference is fifty focusing on nutrition and that's something that that I to get the message across that's right. I want something you can do right now, yeah, so many could right now until an end in the meanwhile still telling people about awesome science coming out, but until then lets you know, yeah keep it. Let's keep it going, they're, not mutually exclusive they're, not they're not makes a mutually exclusive,
the other. You know one of the things that we were talking about, the muscle mass I started thinking about this time. Restricted eating. Have you heard about this at all time, restricted eating a little bit like eating with and like a certain time period that correlates corresponds to like the day. It has really profound effects on on muscle mass without any other factors that have an exercise or anything that's mean. That's extremely interest interesting, but this, like times are to eating, is it's very important for for healthy metabolism. It's all also something I've been obsessed with since, like probably early summer I've been doing it like just you know, really fanatically making sure that I'm eating within, like no more than twelve hour period. I try to do like ten hours
so like when you wake up in the morning. You have a cup of coffee or you know you eat, even if a cup of black coffee, the first thing you pour into your your system- that's not water starts. All these metabolic enzymes starts in your liver. You know your guy starts he's these enzymes and those enzymes are on a clock because humans are diurnal, creatures were were meant to be awake and working in active and thinking during the day, and we sleep at night, which is different from nocturnal creatures like some rinse and other animals that are, you, know sleep during the day, an actor night so because we're meant we are active during the day were diurnal all these all our metabolism, metabolism, enzymes. All the things are active during the day and things that activate them are light. Light exposure and also food intake and is in a biotic, is also something so anything that gets metabolized like by your by your system by your liver, whatever activates these enzymes and once they're activated there on this, like
twelve hour clock where it's like, ok, so you're metabolising, glucose fatty acids, all these things you know well, if you're eating within that twelve hour clock. But when you go beyond that twelve hour clock, that's when things start to go really wrong, 'cause, you're, metabolism enzyme started shut down and are not doing things properly. So you're not like insulin response, if you're, not even fatty acids, and things like that, just metabolism in general isn't not working as well. You know after twelve hours, and so that's kind of a big I opener. I know there was a lot of people think they eat
well, our time here like if you're a survey them but yeah. I I don't eat more than twelve hours, but there's actually a study done by a friend of mine who's. A expert in this field, he's at the Salk Institute is name is sergeant panda, very good scientist. I interviewed him on my podcast and he's you know done a lot of research on this this topic and he did a human study where he had like this app where people locked there for they took pictures of the food that they ate and it like you know since some database, they hadn't had time stamp on it. So they can. You could see when the clock, when they won their first cup of coffee or whatever was in the morning and then when they were eating and I turned out most people are actually eating in a fifteen hour clock, so they were having a cup of coffee. You know eight seven in the morning and they're you know they're eating it like nine, nine hundred and ten. Ten right, yeah, so they're eating much later. The thing
thing is. Is that like, when you do that you start to gain more more fat? You start to become more insulin sensitive and you start to like your muscle, starts to waste, regardless of what you eat, regardless of what you eat. So so I take that back So you, if you eat healthy, if you eat healthy, so if you're eating a terrible diet, a terrible diet- That'S- and this has been shown in mice like lard- that plus sugar- those two together, which is the actual of the bad combination, glad you brought that up. I'm going to make a note, but keep calling those two are the bad combination. So if you eat, if you're eating that, if you're feeling the mice that and you let them whenever they want, so they can eat their nocturnal, but I'm just call it day and their days actually night just know that that's true, if they eating during the day and night, they gain like you know, tons of weight come fat become, like you know, type to die, Fettig Fatty liver. I mean there just mess they're breaking down like earlier than they should, but if you eat
normal, so if you're eating like a healthy diet, that's not high fat, high sugar you don't necessarily you're, not necessarily going to gain more fat. You don't you don't become type two diabetic and all that if you're not eating all the crap, so you probably just going to be ok, but if you take that same mouse who is eating a health diet and you make it eat within a time restricted window of at least twelve hours. Actually the best was nine to ten. They gain way more muscle mass. This is on a normal diet, just way more muscle, mass and if they ate within a nine hour window, they had to like him, really improved endurance. That's something I've noticed in myself. If I eat within a nine hour window, and I go for a run next morning, my insurance is like very noticeably improved to like extremely recently improved. So do you have like a timer like? How do you do you? Do you time yourself at the beginning of your day like when you first eat, and then yeah so I
Typically, it will make so my friend Kevin rose has an app that, like it's called to hard. What did he Kevin rose, has an app to everything I did yeah yeah I've had him on love that guy yeah he's awesome, he's big ketogenic diet, proponent as well yeah. He doesn't actually do Keto anymore because they expect after you got it, blood work done and there's different. You know jeans that people have that can affect the way they respond to that sort of diet. Most of the time people respond good, but actually because he was on here just one long ago, introducing zero a new app to help you fast. So he has an app helps. You do that that actually works really well. Personally, what I do is I'm just kind of crazy about it, and I just like remember that day, so I'm like ok, I had my first cup of coffee at eight hundred am, but his app actually is really cool because it really helps you keep dragging in send you reminders so like helps you and it's a free app, so powerful Kevin rose, anyways
really cool because you can just like literally these mice were gaining more muscle mass, just not by doing anything but eating within this time restricted window and the the thing that was also very interesting about this was that you could cheat a couple of days a week, so they could like, let's say, weekends, when you have like social events in your like out drinking or whatever you can, you can cheat two nights and still have the same benefits so that at least in my s we don't know if it's the same for humans, sergeants doing trying to aggregate some data with humans. He actually has an ongoing trial that you can sign up, for it's called my circadian clock and it also an app on his phone. The phone that you just basically all you do is like sign a consent, form take pictures of your food and and like allow certain data, if you no different than to stay there for them to collect and instead they're doing this clinical study with some humans from data that are aggregate
kind of get is fasting tracker right now, yeah, you can do it's different options for cabins fasting. It's like their circadian option, which is the one I'm talking about, and then there's like people doing intermittent fasting, and what's this acadian option, that's the time restricted. That certain, which is basically circadian, is the circadian clock you're on? So that's. What's this twenty four hour cycle day to day night cycle, so eating within at least a twelve hour window is The twelve hour is the most you ever most. So if you get up at eight hundred o'clock in the morning, that's when you have your first cup of coffee. That's when it starts not with food. It starts with first cup of coffee 'cause. That's, I think, a lot of people don't think that they think that they are still fasting. They have a cup of coffee and then they go run. That's the thing, because coffee, even if it's black, so people, think if they have black coffee their fasting and they go run but black, fee is caffeine, is Zeno. Biotic is something that has to be metabolised by liver enzymes. Your gut processes, it so anything
other than water exactly other than water, and the same goes for like taking vitamin pills or drinking herbal tea late at night, like the same, the same thing goes even herbal tea. Herbal tea is also got herb stuff in it. So non caffeinated herbal tea like yeah, because those are Xenobiotics Camomille, I mean that stuff's gotta be processed by your liver for your gut. It's it's not it's, not water right, you know so I mean this is something that's kind of a big question in that as well. If the fasting, let's say, you're you're eating with like nine hour window or ten hour window nine hours, optimal, nine hours is really, but I found to be optimal for endurance in term the animal studies like ten hours. Also, if they eating there healthy diet within ten hours, they still had restore lean muscle mass. They don't have to do anything else, no extra exercising it just because what was happening is they were there, basically can't
working better and there are also getting rid of fat easier. So so it increased their lean muscle mass, that's incredible, because I eat late at night all the time we got comedian and that's probably probably eat after a show, or so I came home last night at two hundred o'clock in the morning pigged out after a show I mean it was healthy food like Kiefer, pistachio nuts, I buy those big jugs of shell, pistachios, so the shells roots I just eat like piles of pistachios 'cause. I feel like I'm not eating anything bad, that's good for you. But this knowledge. Now, knowing this I'm going to I'm cut that out now, please, let me know although I'm going to start right now, yeah, that's awesome. I mean, like I said you can cheat. There was cheating at least in mice. Twice twice a week was ok two times a week, good cheap and that's kind of cool, because it's like a weekend right right, so you have your social event, it's hard to do with social events and stuff. If you have like a something late and you kind of have to fast
call early in the morning all the way up, and so you can do it later yeah. You know what I mean, but I do a lot of workouts fasted now and one of the things that to do. Is I get up in the morning without having anything, and then I workout, but I've been having coffee. So I thought thought I was fasting. You will see the thing is- and this is kind of what I was talking with Sachin About- is that if you're fasting itself, the fasting itself is having a positive effect on all these enzymes. So maybe there's some sort of cancel station out it's not not it's not as good it's not as good, I would say so, just water, we don't have actual empirical data on that saying. Ok, well, you know, and that's that's option would like to look at and humans, because it's like a big question, if you are just fasting in in theory, it's not you're, starting all those clocks. The clocks are caffeine, starts to clocks that soon. So then again, you know, like I said, fasting changes, your metabolism in a way to that, makes it better. So maybe it's not quite as bad,
quite as Babbitt nozzle exactly I like that, that's perfect income yeah so shoot for nine hours. That was like that nine hours is the best, especially for insurance like enhancements like, oh really. So if you get up and you're at if you're up at eight hundred o'clock in the morning or seven hundred o'clock in the morning, whatever it is yeah, you almost have eat dinner like at five yeah that's the problem you have to you have to either fast in the morning or you have to eat early, which is really hard for working people. Nine to five hours. Yeah I mean it's like you're eating breakfast before you go to work and less you're, not right and that's kind of the problem, people that are going. You know, switches manage apps humans. Yeah, I see yeah, we have it. You know life is kind of different now, but it's you know. There are people that were talking about you. They just take their breakfast to work and they wait till wait till like one thousand o'clock to eat or something like that yeah, because also there's people that like to go to the gym after work and so there's more time. It's like
get a race. This clock I gotta eat, but you know so really. If you can start the clock later, if that's possible for p they're working like that, they don't have flexible hours, then then it would be better to start the clock later and there's a lot of human data on this, like just looking at, like the associations between people that eat within you know, an eleven hour period and fast for thirteen hours, for example, women that do that have already had breast cancer. They reduced their breast cancer risk recurrence by like forty percent you know yeah, because it lowers it causes insulin sensitivity. It lowers like Igf one levels, and it's just like lowers all these like hormones and things that are known to promote cancer growth. It's really a powerful thing and improves metabolism. Really improves metabolism and that's something that a couple of scientist that I've talked to that are at UCSD are looking at and
simply seeing that it seems to be really important. Obviously, people doing shift work like nurses are kind of. I mean that's the problem, the other kind of fucked, when you doing that late show stuff and they are there. They have twice the cancer incidents likely yeah twice twice, shift workers. They are also much more likely to be type two diabetic because you're eating you're eating like when you at night, you're in being, you know, get your metabolism all is all screwed up. Not only do are you like, when you're eating? After the twelve hour clock are not as insulin sensitive, and so your blood glucose levels are higher, so you confusing your clocks. Ok, like it says: okay, I'm restarting now, because it's late, I'm getting my first signal in its after it's been after twelve hours and it confused it. So when you go to sleep at two hundred in the morning and go to sleep and wake up the next morning, I have your meal. It's already going to have started that clock awhile ago, so you won't be as insulin, sensitive, 'cause you earlier in the day or the more the more insulin sensitive you are, so you know what
I so you kind of like confusing the clock. It's like this yeah, but I think important mechanism in system for people to understand and time restricted time restricted eating like. I have really implemented that because I think that's something that also will affect the aging process. I have talked to people like ' conferences, I've, given a talk out that have come up to me afterwards and they're they're talking about how they've been on a diet for two years and how it may be that the wait for first or type two diabetes been great, but still there fasting blood glucose levels were still on the high end, and you know, even though they're no longer type two diabetic I mean, which is really good and they say Are you doing the time restricted eating with every eating within a nine hour window and it completely resolved? It completely result it and it actually have multiple people tell me that an so saying is in the amazing thing: is the increase in muscle the muscle is really the increase that the interesting part I would like to like talk to Sachin more about that.
Have him do more experiments if possible, because we didn't dive as much into that on the podcast and we chatted, but he is such a phenomenal scientists and he's very proactive and into health, and all this you know preventative Madison and he's just a great great person. Working out of the Salk Institute in La Jolla. Very procedures. Place to be is a lot of good scientists. There did you do your podcast with him through Skype, or did you know I married down there, your gas and yeah yeah? I usually try to I like to meet with people when I, when I interview them yeah, so I I've noticed yeah. So I you can't like I've done Skype ones and they're just uh. It's like there's a disconnect, there's something missing. Yes, it's nice for you because you actually have a studio and people come to your studio. So right now Now, I'm I'm like going around to it two it's in you know, if I'm at like a place from giving a talk, and I'm like this great scientist there I'm going to ask people
How do you spell his name s? A t c h, I N Sachin Panda what a great name yeah. Actually his first name is such an tananda, because he's indian so shortened it to Sachin, but is he's a really good person to talk to to? like he's. Very you know, just he speaks eloquently, explain things but he's a little bit of an indian accent, but you know it's just it's kind of like cute, but his science has changed my life, like oh yeah, all of my you're creating in knowledge. I've been following him for a few years, like I've really looked up to him for if, in fact, I don't even know if I told him this, but I was like interested in doing a postdoc with him in certain point like after I had finished my phd 'cause, I thought he was back in twenty twelve when I graduated he was making these discoveries about late night eating and how it like how it makes you
more. So you basically more insulin resistant how it's like screwing up brain section, two, all these things that I didn't even talk about and I got really interested in it because I know a lot of people that eat late at night and people that are having trouble losing weight date and all that they were eating late at night. So wow, that's amazing! I'm going to listen to his podcast with you and or your podcast with another check that out. That sounds awesome that be cool, so the saturated fats, here's what you wanted to do. Yeah. I did because you actually sent me an article about that which I found was really fascinating. Is that there saturated fat, is important. It's. How would you describe it as a precursor to hormones? It's it's, not just a pre,
the hormones so saturated fat, saturated fat increases, ldl, cholesterol, LDL Lebron's, it proteins which carry cholesterol and fatty acids. We always call it cholesterol, the type of it it's a transporter of cholesterol, but also transports fatty acids and other things. But the thing is, is you know the ldl? Oil is a very, very important, because every time you make a new cell in your body, which is happening constantly you're, always making you immune cells, are making new kidney cells are making you liver cells. I mean it's happening all the time. I need to make a new cell, you need ldl there to transport, cholesterol and fatty acids, because cell so membrane the cell itself, the member and is made of it. It has fatty acids in cholesterol and phospholipids and other things, but so you need that cholesterol. When you,
images sell you know and you're repairing that damage cholesterol needs to be there. So I mean you really really need cluster ldl. Cholesterol is very important for that. For that reason, and without it you're kind of screwed right I mean you can't like repair damage as well: you're not going to make as many new cells. So all these people, avoiding saturated fats and cholesterol in their diet, they're doing their doing literally doing their cell regeneration a disservice. Well, I don't want to make that broad statements. I don't know what else there in maybe they're getting other types of fatty acids that also help. But yes, p, weather like on stands, for example, which is a very broad. Broadway of inhibiting, like cholesterol, synthesis bright like full. Stop! That's why a lot of those people- on Staten's, one of the major major side effects, his muscle, atrophy and muscle wasting. You know, 'cause your muscle,
one of those cells, you're, constantly repairing damage and making muscle and's a big big problem, huge problem with the Staten Staten users. It also So a colleague of mine, wrong crowds he's at the children's hospital in Oakland. He has been studying buttons and their effect on mitochondria, and he was only me that it's like toxic to mitochondria and he's trying to figure out why it's like, maybe that's partly, why it some also causing muscle wasting so people don't consume saturated fats or they lower their radically lower the saturated fat in their diet. How does their body produce new cell membranes. Well I mean you still you're, making cholesterol in your
body and you're, making it from there getting fatty acids in they're getting it from plants? I mean plant, sterile they're, getting them from from other sources. You know, but it I think the problem with the with the saturated fat was is not so much that, because people still get it to some degree, I mean it's like: what's on optimum yeah I mean I I don't know I can't attack. I have to see like the person I think it. It varies depending on what else they're eating, but you know the price. I think the problem was that saturated fat was deemed sized was demonized in a very corrupt way, which is the the New York Times article that was released, which is a mind blower, which detail and how the sugar industry had bribed scientists to Rhel these data, blaming saturated fat for heart, disease and obesity, and all these issues when I was in fact that was causing all that. So they were literally
rigging the system and paying scientists, and it was a horrible article because that property and these lies that they spread. I believe it was in the 50s here. It is how the sugar industry shifted the blame to fat, and it's, if you, get a chance and you want to feel sick at what can be done with money watch or read that, because it's just it's awful, it is really awful and it was an internal sugar industry document that was discovered by a researcher at the university California, San Francisco, and it was published, said Monday when this was out. I believe it was a couple of months ago, but it amazing it suggested that five decades of research into the role of nutrition heart disease, including many of today's dietary recommendations, may have been largely shaped by the sugar industry and propaganda and money. They spent money to literally bribe scientist to release false data. It's horrible, it's really nasty, but I mean-
the thing is not that much money there years ago, go back to it here. They paid through the Harvard scientist the equivalent of fifth three thousand dollars in today's dollars, to publish a nineteen. Sixty seven review of search on sugar, fat and heart disease studies using the review were hand picked by the sugar group article which is published in the prestigious New England Journal of Medicine Mini. Why is the link between sugar and heart health and cast aspiration is on the role of saturated fat, even though the info once pedaling revealed that documents dates back to nearly fifty years, more research reports show that the food industry has continued to influence nutrition science. This had such a negative light. There were such negative consequences from this from from the demonization of saturated fat, because people then obviously started eating more refined, like
breakfast in the morning is that having eggs you're having like cereal, but the real problem was the Trans fats, because Trans fats can can have similar, but our hygienist hydrogenated fats, which you know you take like a a a minus saturated fat and high genetic. You can have similar properties properties as saturated fat like butter, how it's solid and then you know, melts at a higher temperature, but these transfats I mean I remember my mom had a big tub of margarine. I mean we used, margarine are mashed potatoes and everybody thought it was healthy and it was so I mean it's not just one I it was literally that's. What's it causes heart disease because the Trans fats, like I said you, take these fats into your new cells right because that's part of what you know fatty acids in cholesterol, that's part of what you're doing with them in your body, the transvestite taken up and the whole structure of its ski boot up. So when this happens in the endothelial cells lining your blood vessels that make some real stiff, real stiff and, like I mean it's just like screws it up, so trans fats are like
we have known about that, like the fact that Trans fats are playing a causal role in heart disease for like decades and the FDA. Finally, in two thousand and fifteen, two thousand and fifteen ok finally banned them from the US and gave all the pennies that are still putting him in their process. Foods and lot of fast food companies use like Crisco 'cause, it's cheaper three years to get it off the market, so we have until two hundred and thirty. In eighteen Jesus Christ three years to get rid of poison, that's after already like deck of knowing it's like. You know the this is like it's like, so bad, so so bad for you anyways. That's that's a whole, that's one of them major repercussions and then obviously then you know people became scared of saturated fat and you know the thing
the thing with the sugar- and this is kind of what you were initially nope hinting at- is that a lot of there were. There have been a lot of studies that have linked into that weren't corrupt. You know by the sure that these were the early city, but there have been studies, a howling, saturated fat intake to heart disease and, and a lot of the studies were also because people were eating. In addition, a saturated fat they didn't correct. For like refined sugar intake, which is really what the problem is, and that is now been shown in multiple studies. So and this came down to actually being able to have new technology available that was able to. Then you know LDA all is not there's not just one, Dl, we now cholesterol in the body comes in all sizes and the the type the type that we are talking about. The good type is a large point type and that's what saturated fat increases there's also it gets processed into smaller parts that are small, dense, ldl and that's what? Basically, it can't get recycled back to the liver, so
stays around the bloodstream and undergoes inflammatory transformations and sticks in the blood vessels causes all this problem right. That's where we're fine sugar increases and that's been shown in clinical. These so like healthy young men that were given twenty ounce is soda a day for three weeks to, healthy young young man increased this increase, their small, dense, ldl particles like massively increase or small, dense ldl particles and also increase their flammatory markers C reactive protein by like almost one hundred percent, which is like crazy, so we're talking about like you know, the refined sugar is what can make such but in fact dangerous is when you combine the two, because the ldl gets processed into the small Danson's refined sugar. That does that. So so so all dense, ldl versus LDL, yeah, and so the thing is, is that even now it's not standard of care adelegg measure all the particle size. Is it's like we've known about this for at least a decade now, like so raw
Kraus, he is he's the guy who actually pioneered this asset and figured out how to to measure them. The small, dense, LDL called ion mobility. I say it's done in a quest labs to does it, but you can also ask your physician. You can ask your physician to measure the particle size, but the thing this. Is that because it's not so thing that standard of care when you go into, measure, your ldl cholesterol and it's above a certain number positions are like freaking out and I couldn't stand, but the reality is that you need to look at the small, dense, ldl, that's what's actually get, you know, get put you at risk for heart disease and that's just not standard of care you have to like specifically asked for you know and so crazy that there's such a vast difference in the consequences for your health, but yet it's not tested even well the knowledge is there? Well, that's what I was saying with the transparent. I mean the knowledge was there like. I was talking to I like eighty eight year old mentor, Brucene, and then we use like, I remember,
back in the 80s, so we stayed away from that. Never gave margin. My children like well you're, a scientist like my mom wasn't. You know like he is known about this for like when I was like in five. You know, he's known, has known it for thirty fucking years since now, at two thousand and fifteen is when you know there's always a lag between research and application of it. But I mean I do not much of a. I don't know what it takes to you know. Maybe these regulatory committees met this, probably a lot more than I know that goes into, like figuring out like how you make these regularly, but it's only financially motivated. That's what's disgusting about it, they're giving these companies three years to get poison out of food. That is what really upsets me. I'm like ok, finally finally have banned in the US, but you're, given three years like three years for people to profit off of reasoning for killing people yeah, and not only do I know you should have a cancer recommendation or while warning to see what you have on cigarettes yeah and it's not even like you can go to like people. We go to the
for market and will say no transfats on their food and all that, but when they go to fast food or they go to some like restaurant, where they're using Crisco there not even going to know they're getting it, I don't even telling you this is awesome totally damron budget. This was great you blow my and every time this is amazing. Um, there's a lot to study folks. So go over this podcast thirty or forty times, and I know, I'm going to go over it few. You found my fitness on Twitter, your podcast, found my fitness yeah. I have a podcast. It's called found, my fitness Actually I just released the podcast today with doctor rolling, grew It's who is the notorious psychedelic Psilocybin researcher. I met with him when I was at Johns Hopkins user outside of my realm, but you should listen to it I will definitely do that and let's do it again soon. It's been too long, so much fun. Thank you so much. I appreciate our folks sia bye. Thank you. Everybody for two.
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The code word Rogan and you will save ten percent off any and all supplements. All right. He did it folks, we got through this. One huh come out on which bad self the next podcast we will be doing we're going to do. One tonight live from the mother. Fucking comedy store This will be a first we've never done this before, and it should be really interesting. So that is this evening going to do. One live from the comedy store and will work that out tonight. Comic store now has a podcast studio, fucking badass place that is goddamnit art, folks, that for today. See you soon bye, bye, big kids one
Transcript generated on 2019-10-05.