« The Joe Rogan Experience

#901 - Dr. Rhonda Patrick

2017-01-19 | 🔗
Dr. Rhonda Patrick is a Ph.D in biomedical science and expert on nutritional health. Her podcasts and other videos can be found at FoundMyFitness.com
This is an unofficial transcript meant for reference. Accuracy is not guaranteed.
hey you fuckers what's up i say that with all due respect and love i am at levity live and oxnard on february 17th and 18th and it's almost sold out i think saturday night is totally sold out february 17th still has some tickets left ann i'm doing the ice house in pasadena on a bi weekly basis now so on wednesday nights and last night was awesome we had tom papa greg with simmons and tony hinchcliffe last week or two weeks before that he had russell peters bill burr and tom segura anw been doing these and it's fucking the ice house is one of my favorite places just because view well see all this comedy club in the world it's the it's it's like it's the perfect shape
like the perfect club it really it's an amazing place we never been there and you want to come out these wednesday night shows are at one thousand pm and you can get tickets from the ice house website but for the next couple months on booked up every other week wednesday so last night was ones or last night was the 18th so the next one would be the first february first and then one after that 15th so there's that march third i am with the golden pony tony hinchcliffe at the car theater at the mgm in las vegas that should be a gay old time in the flintstones way i'm trying to bring that back probably won't work right and then april 20th to four hundred and twenty shows first show sold out second show almost sold out and this is in portland or at the arlene schnitzer concert hall this is the four
twenty celebration and should be fucking great excited about that i got a lot of their stuff coming up too but i'll put that out later you know i'm saying this episode the podcast and all of 'em are brought to you by on it on it is a total human optimization website and that concept is pertinent to this conversation that happened today with the great doctor rhonda patrick if you have i've never been to on it you don't understand what on it is about i urge you to the first thing you do is go click on the on it academy link 'cause that pretty much defines what we're all about what we're all about is to to all human optimization and what we mean by that is we are attempting an that's our goal is provide people with all of the information that you need to get your life together to get to uh
demise your time here on planet earth whether it's through supplements whether it's through motivation whether it's through strength and conditioning program strength and conditioning equipment we provide you with all that stuff at on it dot com the audit academy link though is filled with hundreds of pages of free articles on dia on the science behind nutrition on different exercises different articles about motivation and we also have an actual audit academy which is in austin tx which is an amazing gem state of the art equipment awesome instruction and tenth planet jiu jitsu so go get yourself some of that use code word rogan and you'll save ten percent off any and all supplements like alpha brain which i don't do anything without an and i'm on it right now it i'm on it haha use a code word rogan save ten percent off any and all supplements and go there and check out all the cool shit we have including amazed
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supplysoletslift dot com slash rogan ly ft dot com slash rogan we did it we got through the ads my guess today is the great doctor rhonda patrick she's fucking amazing i love talking to her she want smart people i know and this was one of my favorite podcast that we've ever done so enjoy doctor rhonda patrick government logan experience join my day joe rogan podcast by night all day doctor rhonda patrick hello hello welcome back you got a big fat book of notes over there i do it's like something i use like before i'm giving a talk or something like that where i like to something about writing handwriting things like helps me remember yeah
they've shown that i do that before shows if you looked at my notebook and you think if you ever thought that i like actually wrote my notebook you think i'm a crazy person 'cause i'm writing this same thing over and over again like all work no play makes jack a dull boy it's just like before us set what i do is i just write out the key things that i wanted to work on and i'll write him out over and over again so like i'll have one hundred page notebook it's like one hundred pages of like half of it's the same stuff yeah and over again yeah i'm kind of the same way like i'll write out things like that are in more detail and then like you said like righteous just like a you well like it's different when you're giving a talk at least like in academia like a power point do you have a slide in the slide cues like a couple of minutes of talk so you got it helps you remember what you were going to talk about that help for comma i bet this is probably a good idea i should have a say slide show you know like that would actually be a really good idea for like particular points
we could show that you weren't lying like look this is a real thing you know right yeah you have like a reference that there's a couple of things and i'm talking about in my new set where i have to i have to reassure people that i'm not making this up because it's so ridiculous you know and one of them was this woman who prosed as a high school student she was a twenty zero police officers super attractive and she poses a high school student and convince a young boy to sell her marijuana and then arrested him so it was just a knicks apparently no was a sting operation wow when he was a regular kid he was an honor roll kid oh my god now he's a felon is a crazy yeah there it is teen falls in love undercover cop in marijuana sting gets arrested yeah so this is one of them i would love to be able to put that up and go see i'm not 'cause you could i guess you just make stuff up if you wanted to
but isn't that what comedians do they make stuff i mean you can a lot but if you made something up like hey there was a story in the news and just made it up that sounds great i guess who cares if it's funny yes come to laugh but yeah i guess you're right p people like comedians usually make up personal stories but sometimes there's they say it's true true and i'm like it's so outrageous is it really true like i don't know because it's just so funny you know like some of the stories that some of these comedians tell when i'm just like how can this be true they said it was true but it's much is that part of comedy can you do that definitely my friend dahmer air has a really funny joke about that he goes he goes he's a true story was hey how about you just make something up that's funny you know like it doesn't have to be true buddy brad then they say it's troop so it's kind of like messing with you 'cause the whole time they're doing their bit you're likely come here pretty much true 'cause that's fucking hilarious yeah sometimes it's true sometimes it's not i guess it depends depends on the person yeah i assume everything in your notebook is true well
i hope so you know the other thing that helps me like so this this helps you know writing it down it helps me but also there's the running running like helps so actually this was very interesting 'cause study just came out not long ago showing that if you so if you run before you're going to learn something and you want to like let's say you want to do something short and recall so you're going to go up on stage and say something you know say a skit or whatever and if you run right before that it improves the short term like memory so your short term recall if you run right before whatever it is you're quickly read or something and then you want to remember it but if you are learning something and then you run after you learn it and then like the next day you remember it so it's more of a longer term memory it improves that so it's like whether or not you're running before after you learn it effects the short term versus long term memory wow how did they work that out that's bizarre
well it wasn't like they were testing for that they just found it out through there they were just you know doing running before after they're probably looking at just to see how it affects shore in long term memory recall and they were surprised to find out this is a study that was done i can't remember where it was done now i tweeted about it not long ago 'cause it was like within this last month that it came out so you know it's like if you want to if you want to so like while i'm you know learning new material throughout the day and i go for in the evening and then the next day i'll be able to recall it better theoretically now i'm subject to the placebo affect sino this i'm like oh right that's a problem yeah don't run normally but i did a 5k on monday like i don't run at all but a buddy mine had a 5k race in vegas so i flew in for him and my friend cameron hanes and uh i ran it and it was surprisingly hard it was
with all the working out i do a blacks only three miles hope it's like three dot one or someone like how hard is that fucking hard easy yeah no so do you do any lake aerobic yeah between kickboxing jujitsu and i do elliptic machine and i do a lot of yoga but doing the i'm a trying to your three times a week i'm not always successful at getting there i got there last week three times a week but i don't run so i figured but all the stuff i do a mike i'll have i'll be fine nope not really so you didn't train at all you just kind of like on the fly just did this 5k i saw so you post something about this an isn't doesn't cameron isn't he like some kind of like crazy runner allow you to freak yeah he's preparing right now for the mower brace which is two hundred and thirty five or two hundred and thirty four miles something crazy like that jamies run so when jamie shakes his head like that you know it's really gross yeah that's
i mean he's a nut he did two hundred and five last year he did the bigfoot two hundred which is two hundred and five miles per plus it has something insane like fifty five thousand feet of elevation change over the course of the entire race 'cause your constant going up and down and up and down and at some point it's so steep and the it's an outdoor race over mount saint helens and sometimes that are and so brutal that the top speed is two miles an hour he's going to be like one of those like amazing super agers like like like that just very mentally are ponies in when he's older either there's not going be doesn't show like been shown like if you part of being super ager like being paradera means you're old but you're physically fit your mentally sharp and mentally sharp is really the key thing you know 'cause yeah we start losing brain mass at like the age of twenty and by the time if you can actually make it to
one hundred years old you lose like twenty percent of your brain mass so they found that one of the key to leg maintaining your brain mass is pushing past that comfortable zone physically so like exercise wise and also mentally just you know obviously like like learning new things in challenging yourself so you know so well working out you don't do this kind of like you know half assed thing you push yourself you have to really push yourself and that seems to be keef or becoming a super ager that's crazy that it works with your brain why exercise i mean exercise has profound effects on your brain i mean specifically for looking at you know aerobic aerobic exercise it's hard aerobic exercise as you said doing a 5k running three miles i mean you do you do a lot
training and yet that was still hard for you you know because doing that type of aerobic exercise is difficult studies have shown that even just like twenty to thirty minutes of aerobic exercise can healthy young man increase serum bdnf so which is brain derived neurotrophic factor this is a growth factor that is involved in growing new brain cells and in allowing the existing brain cells to survive so you know talking about combating brain atrophy we're talking about commenting that the fact that your brain is atrophying starting at the age of twenty that's the way to do it your brain starts to atrophy at twenty at twenty you start to lose brain mass oh my god i'm doomed i know it's really frightening twenty used do you want your peak at twenty nine but was so stupid at twenty i'm so much smarter than i was when i was twenty i agree i agree i'm still stupid i mean it's not necessarily like brain mass an intelligence i mean i don't know that
there is definite portland but but like when you start losing mass in your hip campus i mean that's memory be learning that part of the brain but there's just so many studies showing that exercise robik exercise and also you know it doesn't have to be aerobic you can do resistance training that sort of stuff also effects the brain as well but for me like i've been a runner since high school track i guess long a long time and for me you know i've done like a few races have done a marathon and i don't feel like marathons anything like i felt like that was just really rough you know like it was and i'll run three miles an i will fill challenge like if i push myself i can do that now i feel like doing that a couple times three times a week is plenty for me but when i run you know for me it's my i entered this like state of
like daydreaming sort of i get creative you know when i'm going on like a three mile run i'm just i start thinking about things if i have an important decision to make or something that's causing me some some some sort of anxiety i go for a run and i feel like i can address the issue better and what's interesting is that there have been studies that have shown that going for a run in specifically aerobic exercise it activates the part of your brain involved in executive fun in which helps you make decisions you know it's kind of like that over arcing part of your brain that like helps with all the planning long term planning all of that and so i always i do i feel like if i go for a run things bothering me from anxious i always feel better one hundred percent of the time like there's not a single time that i go for a run and i'm like damn i feel worse right i do that you know it's like i feel i feel crap i'm doing it on my oh this is all well i feel
like the human mind i mean this is all just theoretical in my own theories i think the human mind is designed to confront serious things like like predators and you know dangerous enemies and and we don't really get much of that in this life so when is dealing with stress i think the mind preparing for some things that don't exist so even if you can work things out logically there still remains like this residual effect of all these human reward systems that are kind of in place from the time we really did have to have all those those reactions in place to deal with you know dangerous invaders or be in all the horrible not conditions you know whatever they would be that we hardly ever experience anymore so like when i workout if i have anything is bother me or troubling me i think i get like a distorted perception of the danes
sure of it or the physical reality could be something real simple like i have an issue you at work that i have to deal with like maybe i have to make a decision or maybe you know i'm stress about something and i feel this no matter how much i work it out logically i still feel this physical like residual issue and that issue who only seems to be resolved for me 'cause i don't run with hitting the bag like for me it's a punch back like it's which is really hard to deal like when you when you do rounds like kickboxing rounds in a bag i have a timer and i could set it for three to five minutes well actually it will it allow you send it all the way down to one and then it has like intervals so it gives me like thirty seconds every thirty seconds of buzzard go off and it has two lights one light is yellow and one light is blue and so the yellow light i kind have a go at law six thousand and seventy percent and then the blue light i sprint so it's like sprint try to catch your breath sprint try to catch it
and i do that for seven eight rounds and when i do that i don't give fuck about anything after it's over i'm like who cares like it's amazing what it does 'cause my mind still has all the same data don't understand all whatever it is like it's whatever work related nonsense to understand all the issues about it and there all there's no new information but now the information is coming into my brain and it's going to this isn't a foreign invader these aren't vikings they're coming over in a fucking boat with a dragon's head at the front of it swinging swords this is just some nonsense whatever it is you know agent issue or manager issue or tax issue or whatever the fuck it is that seems so physically daunting before the exercise with an app words when that aspect of the problem is alleviated that stress it's almost like my our bodies are just
confused as to what these problems actually are i am like i love i love your your interpretation this 'cause it's exactly the way that i would like to talk about why we need this type of stress i actually just like you said i actually think that from an evolutionary like evolutionary perspective that we were meant to be stressed we were meant we were meant to be outside either hunting tilling the land for food to prepare food out boy barded by uv b radiation which is stressful we we design to have stress and what i mean by design find was we have genetic switches which are supposed to be turned on these genetic switches that are activated by stress are supposed to be turned off and just like you said we're building novel time now where we don't have to outside we don't have to
till the land we don't have to hunt for food we consider we can sit on the couch on her butt all day an order delivery or go to the grocery store and we don't have to eat foods with polyphenyl owls are flavonoids are things that are also slightly stressful yeah so this is kind of that concept before mrs but it's it's i like the way you would you be explained it because i really agree with you i think that humans were meant to be stressed exercises the former that stress and there's different various different types of of that and i and i think that we were supposed to switch on those those genetic switches those jeans that are helping us deal with stress so like you know like you said you have a problem and i i'm the same way with my run i'll have some something that's bothering me i have to deal with whatever it is i mean in my mind i blow it up it may not even be that big of a deal but i go for a run
with no new information with nothing new you know like i feel better and i think that's partly because as i'm switching on all these you know stress response pathways that help me deal with the stress better these anti inflammatory pathways just all this would really good you know these good genetic switches that are being switch put on so we had totally makes sense i think this new time that we live in a i just don't necessarily under think the body understands where the stress is coming from i think your body is a physical organism an nature is an absolutely brutal thing and it has been for us as well as for all these other animals forever but now for uh it's not really that brutal anymore and so all these mechanisms are in place to protect you and they don't get served and for me martial arts is always been like the best one to deal with weightlifting's good to like ugh kettlebell workout does it too but like the big ones for me are jitsu and kickboxing because jitsu
really really hard to do an it's also you are solving problems so i think you get to serves two purposes it's incredibly grueling as far as like this boring process of just rolling you know and competing with each other even in a friendly roll like with a that i really like and were laughing and we pan's you know every time someone gets tapped out or whatever it's so difficult like your your bodies next so hard and your mind is taxed because you're dealing with countering you're dealing with setting up moves you're dealing with your thinking several steps ahead and then you're adjusting those thoughts based on what this person that you're sparring with is doing to so people get real really really addicted to jujitsu for all the right reasons and one of the things that i found is that jiu jitsu people for the most part are way more mellow than most people would expect like way more chill about stuff like way
you're less likely to respond to something in a dumb or an imbalanced way because they whatever your body whatever these requirements are that we're addressing your body he has all that in jujitsu but without the real real violence you know i mean like the ones trying to kill you they're just trying to do this thing to you and you're trying to do that thing to them and those things mimic actual combo actual real life and death struggle in a friendly and it also as this camaraderie built into it too because you've kind understand that you're going through this incredibly intense things together i also understand that it takes a unique person to go through that and and get past all these psychological hurdles all these physiological hurdles and then you also are aware that this person understands like really clear is the kinship that you
i'll share in having this experience together and that's really that's really i kind of relate i mean not to the same degree like what you're what you're describing is on a whole other level but i and something similar when i'm when i'm out surfing you know it's i'm getting the physical exercise but i'm also like a tackling these fears of these big waves and getting under an drowning and getting tangled with my court you know there's like a million and every time i do it i always have that fear paddling out there but i get out there this guy surfers and we're all sitting out there and there is a sort of friendship that we develop out there 'cause we all love surfing and we've all like we we know it's like oh here comes the way we're you know helping each other like look this one on the outside paddle out you know so it's kind of like completely like different level from what you're describing with ju jitsu
yeah but still i kind of can relate a little bit you know i think you i don't know if it is a different level and allow why do people surf as well i think there's like a similar attraction to it 'cause also you're a monster dodger like you're out there in the monster soup yeah it's it's that's what that is it's crazy that i still haven't you know you'd think that after doing it for so many years that i would get over that fear but and so there so so powerful yeah i mean how can you get over the fear my friend shane dorian is a big wave surfer and he's been on the podcast for and he's a big time po hunter too and we talk all the time about this you know the he describes it is just it's so attractive like i want to try it but there's not enough hours in the day for maine there's not uh i get too addicted to things and it's just an i have a fucking real fear of sharks it's real
sharks are scary really scary or so but they're real they're out there oh jesus what is this jamie shane dorian wave oh my god my hands are sweating watching is out of his fucking mind totale he's a lid jet mania wow like that is how high would you say that wave is it's gotta be fifty feet right oh yeah yeah it's in hawaii is called jaws is the name of the way jaws oh my god look at the size of that is so insane that is so insane like losing my mind just when i see these guys big wave surfing like this my heart hurts i'm so anxious right now watching my god it's so insane that's more than fifty feet right i would say at the very peak of it it does look like it's more than a fifty foot face now when it comes down does it say there unload youtube thing what it come down on you i mean it if that if that
you got smashed like if you fell and that came down on human year you're probably fucked right that's the fear yeah i mean damn mean the biggest wave have ever served is like overhead you know it's like overtime and a half overheads are not even double overhead so that it was like i had a couple of scary moments where i was just tumbling during donut and i couldn't find which way was up or down you know i've had one time i was surfing out in this place i'm saying to go called sunset cliffs and it's a reef break and it's really hard to out there so you have to like time you have to jump out when the you know after the wave breaks and then you paddle out and there's all these kelp beds and i was surfing there this one time and this was back when i was really dumb and didn't wear a leash because it was like lee is you know i like to dance on my board and they get in my way and so i didn't really but i you know
big wave and i was writing it and i wiped out and i like got caught in the kelp oh and so it was like the you have this moment when you panic and that's really bad panicking when you're like in the water cause panic takes like your energy yeah and and i panicked and i was because i mean i thought it was going to die as miss kay kelp bed so i'm wrapping might see we yes i've had nightmares about it like it that's stuck with me that was like that was one of those moments that you know sort of traumatizing in a way in hello just to get out of the kelp i don't remember i don't remember because it was just i think the panic sort of i just lost track it seemed like forever to me i don't know how long it actually took and of course i lost my board like swimming and wow i got cut up on the reef yeah reefs are brutal rapes her brutal yeah i actually stick to uh
it breaks now but i don't like you said i don't even get to surf that much anymore because i just don't have time so p so that when they serve breaks that over those reefs like you just can't wipe out wipeout you're going to go right into all that jagged shit yeah it depends on where the reef is like like i was in the wave in kind of in more so i was closer to where the wreath was but yes you can it's it's dangerous that beginners should not ever go out on a reef and i've seen many beginners out there but it's yeah it's definitely more scratches and cuts pretty brutal but you have any shark encounters no the only sharks i've actually actually i shouldn't say that's not that's not actually accurate i don't have any scary shark encounters i served for a long time in la hoya and there's a breeding ground there for a leopard sharks which are not to be confused with tiger sharks tiger sharks to rip definitely scary leopard sharks are the ones that have
the spots on him and they're really harmless they're kind of like nurse sharks yeah they're not like really do like sand sharks just come around yeah yeah and they really cool to look at but i've never had i've never actually known anyone that serves in southern california that is you know with all the surfers that i've known that has had an encounter in southern california with a shark i do know people that i've encountered them in the bay area yeah the bear is a big breeding ground for great white i would never surf there really now i would never serve i would never serve there yeah the sharks yeah the sharks but there are it's all connected it's like don't go outside there's a bad neighborhood somewhere well they can move around i guess just in my head i've sort of like convincing myself that they're not they're not coming to seeing the there's a video of a drone flying over malibu where some guy takes a drill and he's flying over the malibu
surf and he's like the phone is like maybe a few one hundred yards away from some surfers and you see a big fucking great white just swimming along just swimming don't show me this video drone shark footage so here's these people they're all in this or they came and we're just southern california new big deal and when the and keeps going further and further out you see this fucking whopper shark that's not far away from these people will find it here and jamie will find it there's one right there where is this oh nothing just missing something nothing just a sharp conserved malibu before right there what the fuck damn it joe don't show me this you know you're smart woman you understand i do monster soup i try not to think about the sharks then well it's a gold look there's two of am interesting look that surfer and two sharks no big deal
yeah that's pretty scary yeah it's supposed to be scary just i don't know and now apparently catalina that whole area out part of catalina is a crazy shark fishing mecca where i have a friend of mine from texas and he try bold two catalina island and he said it the most savage stretch of water in all of north america he said is just infested with mako sharks and they go out there to catch mako sharks which are delicious mako sharks are really really good to eat too they taste swordfish they taste amazing are they dangerous like china will fuck you up don't bite you but the thing about sharks now it's because of you are so silly because of the awareness of shark fin soup you know because shark fin soup is the practice of acquiring shark fins is really brutal and not sustainable at all it's really horrific and a lot
of asian fisheries engage in these unsustainable practices where they'll scoop up thousands and thousands of sharks cut there things off and then throw them right back in the water so they waste most of the shark in order to get the fins for shark fish soup and because they're trying to raise awareness of this now people are getting really upset at anyone who catches sharks even if they catch sharks legally for food because sharks are not in dangered and is what is the more in anymore sense and tuna is in danger because to not all are in vastly diminished numbers than they were just a few decades ago if you talk to anyone who's a commercial fisherman or even a sport fishing like these guys that run these charter boats i'll tell you like you to catch way more tuna it used to be way more prevalent i think there was something they addressed in that jiro dreams of sushi movie as well as that the commercial fishing is just peru utilizing the tuna maria but yet everybody still eats tuna and they don't think twice about it because
his campaign against shar fin soup is made people like really upset at people that catch sharks to eat even people that eat meat it's like whoa so simplistic in like are protesting in like people just have it in their head that i heard that you're not supposed to eat sharks anymore like you catching sharks you fucking asshole like like that is the one thing that you know i mean if you want to talk about a fish to don't do no harm to human beings like sharks are on that list you know in this is this is scary guy damn animal if you could eat that i say kudos kudos to you because sharks are higher up on the food chain don't they have higher mercury levels it's good question because i know like swordfish like i would not eat swordfish really hell no no yeah there is like i wish i could remember the amount it's something like one hundred and fifty micro times per like four ounces or something so compared
not too wild atlantic salmon which has like four micrograms yeah swordfish so the ones that are really safe to eat that i know of are the wild lantic salmon while the last concert in atlantic wild alaskan salmon caught see white tuna is okay but the albacore tuna has a get more mercury i think it's like you know twice as much or something but i'm a little thinking that you know shark would be i on the mercury level that's interesting i'd like to find now because i know that people have had issues that eat a tremendous amount of sushi people that sushi like everyday i know they have had issues with mercury in the past i actually had an arsenic issue with sardines the sardines are bottom dwellers and i i used to eat sardines all the time i have love sardi yeah i love starting to and if
we can sardines too much i got some blood work done and the doctors like you some significant amounts of arsenic in your system am my being poisoned he's like no not that it's not like someone trying to kill you but it is like a dietary issue and then he asked me what i ate and i you know we went through all my food is like nothing else i got he goes without seafood i go oh yeah eat seafood lot of sardines like that's it i didn't sardines because it makes sense so i backed off i didn't eat sardines at all for three months came back the issue is completely resolved you know what besides sweat you sweat out a lot of these heavy metals like mercury arsenic garlic some of the bay mercaptans and garlic they key play binchy late mercury and help pull it in like extruded your body through urine so like when i
where i make salmon or fish which i actually do eat a lot of salmon it probably like two or three times a week i always have fresh garlic with it oh wow that's amazing and sam is outstanding too because it's so high in essential fatty acids articulates really good for you exactly it's really high in omega three fatty acids epa and dh a so and it's got a modest amount of vitamin d whenever i'm sick i eat giant cloves of garlic i'll just break it down to a point where it makes me feel horrible i have like a big glass of kombucha and i'll take like a lump of garlic and i'll break off like four or five cloves and i'll just take off the skin and chew those bitches down and chug it with bucha it's off sometimes it it's painful spicy slowing down like my system is like what in the fuck is this like i could feel it inside my body burning i love it i've done the same thing previously i mean i don't do that anymore but yeah
and garlic is very powerful antimicrobial compounds in it so i that you know makes perfect sense it's the last time i did it i went to take a knee yeah go down and e really yeah like i actually go down but what i did was i put both my arms on the counter and i went down like this for all because it was just burning going down i just was like what this is probably not even working i'm just being retarded getting back to some i was like pungent compounds that are in these these plants and that kind of gets back to what we were talking about with switching on those genetic switches that are to be switched on their men were supposed to eat these kinds of foods garlic you know broccoli cauliflower kale these things that have that pungent mustard you know that pungent
i mean these things are you know various different polyphenyl's in compounds one in particular i become obsessed with lately is sulforaphane and that's present in most of the cruciferous family like kale broccoli cabbage brussels sprouts bobby buck just you know that whole family of vegetables pretty much ate those vegetables a lot but i've become very obsessed with this this compound that is actually so for things not in the plant it gets form once you break the plant tissue once it's like chewed or crushed or blended or whatever chopped somehow because it's stored as a precursor and then why on the tissue gets you know chapter or whatever then it forms offer fan and that's part of its you know our medic respond it's it's plant response to try ward off in insects or whatever thing so that's that's why it forms
it actually when we ingest it it's a really really really good for us you know so the soul for frein in particular which is actually really really high and broccoli sprouts have you ever had brought these products yes i yeah so broccoli sprouts actually contain like a hundred times more of it than mature broccoli so it's like probably the best source of sulforaphane diete resource of sulforaphane out there i saw on your instagram that you make shakes with that right i do yeah i've become sort of convinced that it's very powerful anti aging and also powerful nutro pick in a way i guess i could say and i can elaborate but you know so i've been doing the shakes where you can sprout you
sprout your own sprouts at home for a relatively cheap you just buy some organic four units there but i am look like a weed dealer that's what about her that's what everyone says three dot five pounds of broccoli sprouts wink wink that's what they're calling it these kids believe it or not though if you freeze them so that was actually i'm freeze uh so those bags are going in the freezer when you freeze them because when you freeze the play the tissue also gets like broken it actually doubles in some cases you can up to double the amount of sulforaphane because it like has a longer time form this so you can have a more concentrated i learned that the hard way but what hardware let me just because it's so pungent and powerful that if you make a shake with it and you're doing like at first i was doing fresh shakes and then we started freezing them and that was making shakes that were you know from previously frozen sprouts and it's like i needed like half the dose we not to feel
feel the same thing or what do you feel ah ok so i guess i should probably you know it's kind of just like like when you drink coffee now you kind of just you feel a little papi and good you feel a little more alert sort of like that and it's the thing is is that it's it's been shown so there have been clinical studies in humans and this is very interesting because it's been shown like if you give it you give you know even just a small amount i think it was like between seven to thirty milligrams of sulfur in a day to young adults with autism it improved their for scores by like thirty four percent and artistic scores they they like there's a range of different you know
that are done to like measure different various brain functions but improve this and this you ought to stick you know he's autistic individuals by like thirty four percent the same was done in a pilot study for people with schizophrenia where it like improve their their sentence so they're just brain functions better wow yeah so and this is like pretty that the results were so powerful that the assistant at johns hopkins the study is not being repeated you know because it's like this is what is going on here like how is this affecting the brain and i think you know if you look at all the animal studies there's lots and lots of animal studies that have been done which are enough people aren't quite as convinced because it's like well how much of this relates to humans but it's been shown to be as good as effective as does the antidepressant prozac in alleviating depression in mice and they do all these battery of tests where they like stress the mice out making the depressed and social defeat in like
hanging by their tail it's actually just kind of gnarly but and then you know there's like you know a bunch of test they do to see if they're depressed and you give him you know your placebo you give him prozac where you give him the broccoli sprout extract and it performed just as well so it helps depression it's been shown to help with no general diseases all sorts of things but the point is i think that the reason it's actually affecting all these brain functions and why even you know you someone like me may notice a small fact from from eating them is because it has a very profound effect on inflammation and that is because as a mentioned it's it switches on one of those switches that was meant to be switched on a pathway called nrf two in our body that controls over two hundred genes and so first rain is the most potent naturally occurring compounds that we discovered yet that activates as
way so it's no other plant compound weather naturally occuring plant compound can activate this pathway as is potenti friend and enter up to is i mean it's been shown in multiple studies to be involved in delaying aging and a lot of that happens through lowering tons of different inflammatory jeans activating anti inflammatory jeans lowering oxa have stress all these glutathione related enzymes that helps with detoxifying compounds that were exposed to on a daily basis like carcinogens and things so i think that we're having a low level of this like inflammation stuff that were constant being supposed to and it affects the brain you know so if you're if you get a dose of this you you may notice a small effect now with someone that has autism or schizophrenia inflammation and oxidative stress have been shown in previous studies most previous studies to to play a role in in the etiology of those diseases so i think that's how it may be affecting the brain but it's not just
affecting the brain and probably one of the most well known functions of sulforaphane is that it's like a very powerful cancer preventative com sound so it's you know it's been shown to prevent cancer for example if you men that had prof get cancer when they were given sixty milligrams of sulforaphane a day for i think it was like a month i don't remember exactly how long but it lowered it's slow the doubling rate over to more biomarker called prostate specific antigen psa which is what is usually measured when men have prostate cancer you you measure the progress progression of it because it has a doubling rate a double every so often but it's slow that doubling rate by eighty six percent which is pretty pretty profound of course is lots and lots of associate of studies have shown christopher's vegetables you know if you eat more of them you have a lower risk of bladder ovarian prostate kidney just all sorts of cancers but there's the clinical trials i thinker what's wrong
really telling because they're you know you're giving someone this compound and it's lowering a tumor progressive progression marker by eighty six there's another study which is really interesting also and this is kind of like where really got me interested i'm not sure if other people are interested in it but you know where to two compounds from like pollution so like living in los angeles for example is probably definitely one of the places that you're going to be more exposed to some of these airborne carcinogens so benzene's one of them acrolein in the air reading a man you know we're getting to some degree we have it we have benzene in our system and it is a carcinogen it's been shown to cause cancer specifically linked to leukemia's smokers get a ton of it because it's in it's in cigarettes so cigarette smokers are like really loaded up with benzene but there was a study where people were given like
thirty milligrams of the sulforaphane and in the form of a broccoli sprout drink a day for like a week and starting on day one drinking this drink um they excrete it sixty one percent of the benzene like on day one hundred and sixty one percent of benzene which is coming out of their yarn like as you measured metabolites and it was wow that is amazing like getting rid of some of that stuff you know i you know 'cause i'm definitely want to get rid of dancing and all that stuff that i'm being exposed to so that they got my attention to because it was just so significant in a profound effect just after one day so that that was another sort of thing that got me really into it and then the aging stuff where you know it's been shown some inflammation has been identified as a key feature of aging taking sulforaphane has been shown to load
fleming three markers in people by like twenty percent c reactive protein other inflammatory markers courses like dozens of studies in animals that have been done but i'm sort of i think the human studies are more interesting talk about a subject new morale and then also it's been shown to affect the cardiovascular health because of the inflammation i think so typed diabetics that were given us some days i think it was something around forty milligrams as well so for roofing they were given this daily and for a month for four weeks and it low their triglycerides by twenty percent it lowered their atherogenic index which is like measuring you know that the dangerous type of ldl then sell the else or glycerides looking at all these things that lower that by fifty percent improve their blood sugar by like almost twenty percent so that's like thing that my mouth and try to get my mom on this and you know my mom she's she definitely he's got like high triglycerides you know thing you know so
i'm really convinced and then there's been studies in animals that's just shown that it like delays aging so i'm convinced that i think it's one of those things you get it in cal and i think that i've been getting a good dose of it i've been drinking smoothies pretty regularly since probably like two thousand and ten yeah probably six seven years and i do feel like it's like help age like help me age a little better i mean it could be completely in my mind but just kill this kill with healthy but i think that i've found something take it to another level where i think that i'm pretty convinced that if i continue taking this so far fain i think it will absolute affect the way age and i think it will affect my brain aging as well i mean it's been shown to at least in animal studies to affect brain aging traumatic brain injury i mean if you administer it after dramatic brain injury it improves outcome
improves like brain swelling and all that but like fifty percent you know just all sorts of non's it's just like i could go on it the video i did like a forty five minute video where i'm literally just talking about this for forty five minutes and then it went down youtube switch on youtube yeah i i did this this research took month many months and it's like a sixteen page article i wrote and i hope to get published i think i'm going to submit for publication is it just it was a lot of work and it happens anything in the literature as comprehensive covering every base like i just i try to cover everything that was a good study you know that was important so so and then i flew out to johns hopkins uh recently i was invited to give a talk there and i meant it just so happens that guy who discovered that first of all the guy who discovered so far fain is there but
he's much older i didn't meet with i met with some of the train with him who discovered that broccoli sprouts are the best source of silver for it so he made that discovery back in the nineties and i interviewed him and he just went on and on and on and talked about so far refrained like in a dish into like what i had already talked about on one of the videos i did and he had we had some really interesting stuff to talk about in terms of like you so in order to get this offer thing you have to the plant has to be crushed or chopped and that's because it has an enzyme in it called my rasaneh's and my ross and is heat sensitive so when you when you steam your broccoli when you boil your cal when you saute your kill any of that stuff unfortunately
your inactivating mar austin is and so you're not getting as much sulfur frame you're getting dramatically less dramatic almost non almost nonexistent the precursor the carafe in an is still in that plant so you're getting the precursor and we do have some bacteria some types of bipedal bacteria in our gut that contain the my rossanese enzyme highly very well from individual to individual but so you can can some of that to sulforaphane but it was interesting that he mentioned is you can actually sprinkle mustard powder like mustard powder you by after do you saute your kale or after you steam your vegetables or if you cook if you apply heat to any of your cruciferous vegetables afterwards you put the muscle padawan must powder it has active marasa knees in it and it's pretty the marasa knees in the mustard seed it is more heat stable so so you can actually
convert your precursor into the sulforaphane by adding the mustard powder and i was like that is a really great wow like thing to know because now i'm like 'cause i do cook a lot of my saute kale that i i steam my broccoli puts butter and salt pepper it's how i eat my broccoli so is there beautiful started in are there any compounds in cal that or broccoli or anything else that make them more bioavailable when you do come yeah i mean a lot of minerals and stuff in it like magnesium the calcium those things are at those things become more by it by available when you call come and you so you would get that benefit plus if you just cooked it right out of the musters right when the mustard seed powder you have to make sure it's like what i like to do is spray a little bit on my hand and lick lick it like it's got to give that have to have that bite if it doesn't have the bite it's like it's been too great
spit on the shelf for too long it's been an amazon shelves for too long whatever you know so yeah it has to have that like mustard bite to it could you just use regular must i don't think so now mustard seed the mustard seed yeah so that so that was a very useful like you know because the sulforaphane it's really good job i really i'm trying to like get people to i think the more people that get this offer no i think they're going to be healthier i think it can help prevent answer lower inflammation i'm just so many different good things so smokers for god sake your smoker they should be taking so for if they should be drinking those shakes i'm drinking drinking like every day you know 'cause they're getting so much benzene so two questions about this one where does someone get broccoli sprouts where where would you get that
also the thing is is that you can brought you can buy broccoli sprouts already sprouted out like whole foods are sprouts or whatever your local you know grocery store is most most of the grocery stores contain i have brought these products are seen off office brown's idea it's a very rare that you find broccoli sprouts isn't it there at whole foods there at sprouts but the problem here's the problem with buying sprouts they're very prone to to bacterial contamination coli the longer they sit on the shelf and a lot of times when you go into these grocery stores there sitting on the shelf and so they're probably likely little contaminated with like e coli then if you were to sprout them yourself and get them fresh so you can buy them but i think and they also charge like
this it's like five bucks for like a little like package of it you know it's like one shake yeah it's a one shake whereas you can like spend twenty dollars and get like a pound of seeds and so how do you grow it well there's lots of different methods you can you can use hemp like so previously we used to do these hemp handbags bags we just put this he's in the bag and you add some water you basically just keep adding water to them and let it drip and they sprout within like four days then we started this charmouth said we're now we have mason jars with a lid on top that has like little holes that are big enough for water to come out obviously but not for the seeds to come out and so you know so you get these jars and you add water let sit for like six hours and then dump it out and then you just after that you continually just add the water and but out now the water and turned out kind of leave it tilted so that the water isn't just like you don't want what are just sitting in there so that it's like growing bacteria and stuff
so you get like let me know till the water so i just want it wet is that we are yeah and it really just takes like four days and then you have sprouts the only thing is you but you do have to be you know clean like if you counters all dirty and your hands are dirty and all the dishware using dirty and then you're probably going to contaminate them so you have to like be a little fastidious about the way you sprout these things you know but i think once you're aware that then it's ok the other thing is and this something that i'm going to talk to the expert his names doctor jed fahey recently interviewed him podcast he he mentioned something to me that it caught my interest he said this seed itself the broccoli seed itself has the enzyme it has the precursor to sulforaphane and if you break or crush the seed or chew the seed then you're actually getting sulforaphane so you can actually
crush up the seed in like a coffee grinder or something and like take a shot of it but the thing is is there spend no research doing this method so all these studies that i just talked about in humans those were all done from like broccoli sprout powder extract from this sprouts powder extra exit so they devise a supplement great question so well the power extracts were mostly made by researchers in fact jed jed is supplied a lot of a lot of different universities with the with the extract himself but there are so supplement wise that's the other thing that he really sort of illuminated for me because because he's at actually been measuring this search supplements that are on the market and like if they actually have what they say they have and so because myerson is is so unstable it is hard to make a supplement with sulfa roofing
there is one supplement only one that i know of that actually has sulforaphane the actual active compound and that's called prosta fain and that's only available in free it's by the way i have no affiliation with any of these like supplement companies at all i'm just telling information it's only available in france it's only available in france and so and that so he actually tested that one and people that given prostafine the bioavailability of the proofing with seventy percent so seventy percent of it ended up like in their bloodstream there's another supplement called ava mccall ava mccall has glue carafe and and plus my renee's in it so it doesn't have the soul forever and has the two compounds that can form so for afraid of it hasn't together that has been tested and that was about forty percent by bio availability so about forty percent of it was you were actually getting sulforaphane forty percent of the time
and that was also tested there's no supplement and that is available in the us there's another supplement by called crucera i think and crucera only as the precursor no enzyme so totally relying on your gut bacteria and some people it's very variable so that only had like a ten percent bioavailability availability other than that those are the three supplements that he really could and this is in a study just published recently that he got behind i asked about a few others 'cause i had actually been taking there's another one called braka max by jaro and he kind of was like i asked him about it he was kind of lighting just some of what it says in there but not all you know the prob is is that these supplements i mean there's a lot of a lot times like he was telling me like geez like said
the ten times the supplements had like clover leaf in them when they're supposed to have like the cruciferous you know precursor graph in in so it's just like it's kind of disgusting how supplement company inc have somebody cook a supplement companies are you you know totally just putting all this cloverleaf and whatever and there was a study that came out a couple years ago on this like like seventy five percent of all these like herbal eken asia like all these you know compounds that are you know marketed for whatever don't actually even contain eken asia or whatever they say they contain it's really it's really kind of bad now it's a giant issue and if you are a company that sells that stuff a lot of times you're not even not even getting it directly from the source you know they're buying it from companies that supply it to them and a lot of times these companies are in china and places where the regulations are not that strict you can
right you can get just mean we had an issue with that when we first started making alpha brain where we would get stuff tested we get batches test and the batches of different individual ingredients would have stuff in it that they weren't supposed to have in it just because they mixing it all up in the same bins oh yeah that's true this also that yeah i mean there's just you got to find a reliable brand you know and i think you know thorn porn seems to be a pretty reliable one that i've seen multiple multiple different times where scientists are like yeah we've that it's more expense but they seem to be pretty reliable so it seems like the best method is a sprout your own broccoli sprouts yeah i think that's the best method and it seems like very cost effective to exactly it's cost effective you don't you don't have you know have extra cash to buy all these expensive supplements cause the all the ones i just mentioned that actually are effective and have what they say they're not cheap
so that those bags that you had in that instagram photo is that all sprouts that you made yourself yeah it does a mason jars are ticks sick that was six oh no it's not that bad yeah i mean they get really dense too they fill up inside the jar yeah yeah i have like uh picture somewhere on there they were there with the jars but i'm thinking i might just do a quick sprouting video like a like fiber six minute like i'm already going in my head about how i'm going to start sprouting awesome and they're good like you know you don't have to do i always sort of take it to the next well like i make my shake and it's like we're good on salads i mean you can sprinkle them on anything you know i re so i really like them on salads quite a bit so that's amazing now there you go oh wow there we go yeah those the yeah so so those are with mason jars that have holes already in them yeah yeah so you can actually
by this sprouting kit so these actually we found these are the old lids we were using we actually found better lids that have even other holes because some of the seeds were getting out of this but this came as a kit sprouting kit you can buy on amazon it has like a little wooden thing to set the mason jars in so they're like tilted and you can like drip the water out they came with those lids but then we did some experimentation and found other kids that are superior to those but how much maintenance is involved in making these like how often do you have to tend to these things oh it's just like after the first initial like six our water you know where you let them sit it's like twice today in the morning and evening dump water on them but you have to come out and my days it take to grow that that was about five days i think four five days so for i like me who goes away on weekends a lot i'd have to make sure that i am home for a stretch that makes sense you can so you could have harvard actually
here's the thing the longer you're letting them sprout so i was just trying to like maximize i want more dense you know 'cause i wanted to get as my bang for my buck you can actually you could have harvard is harvested though is probably like early like three days three days and actually the longer wait the more you have to be careful with contamination too so it's like it's better probably even to ha for some sooner freeze them so they're like you know no bacteria that way you're just you're safe and you just put him exit block storage bags yeah do you have a vacuum seal things and freezing no i should i do that with me yeah that's a good idea i mean that that wouldn't that would be a good idea to do wow that's that's really intense stuff the other question i that to have to talk to you about was when you're saying schizophrenia and how sophia fain can prevent or somehow or mitigate the of the effects of schizophrenia do you think that there
here's a possible correlation between a lot of these mental health diseases an a lack of proper nutrition oh absolutely i think that a lack of proper nutrition is a huge component of a lot of mental diseases in psychological diseases in general in fact inflammation is now it's really been identified as i caused sing a causal role and depression and that's something that you know so with that precious thing it's kind of a funny story and it's not that funny it's actually kind of eye opening but back in the so the cdc has like esther with about eleven percent of of americans are on some sort of antidepressant eleven percent so here's the story behind that that's so crazy it is and i know several people that
or on them or have taken them or you know you know whatever but the story behind that is kind of interesting because back in like the early 70s a lot of these clinical trials were being done on antidepressants with people that hide depression and at that time people that had depression that were involved in these trials where were people that were are severely depressed and hospitalise so they were so depressed that they had been hospitalised for depression i don't know many people have been hospitalized compression nowadays but so they were hospitalised for depression and then they were given either a placebo or anna depressant and a multiple trials you know fda had reviewed these trials seventy percent of the time the anti depressants or anti depressant worked in seventy percent of the patients compared to thirty percent of the patients were possible work right seventy percents pretty good you're comparing that to thirty percent we'll see about was like well that's applications that seem
to work right what then happened after those trials were done star in the 70s and like 80s is that the clinical dayag plastic manuals called the dsm at that time it was a dsm two they change all their diagnosis you know markers and symptoms for depression and they expanded it a great great deal and then called depression major depressive disorder so it became the sort of like broader you know disease quote on quote where it was like it's not just these people that are severely hospitalized it's people that are when you depressed and anxious and sad or what you know it's just basically you're you're getting a bigger group of people which is probably a great opportunity for for a pharmaceutical company but then
and when clinical trials were repeated on this new population of people so these are clinical trials that were done from like the 80s all way up until like the two thousand year two thousand when those were reviewed by the fda what was found was shocking was that only forty percent of people of not responding to responding to and depressants necessary eyes other you know norepinephrine reuptake inhibitors also whatever the standard of care is compared to thirty percent placebo so now you're talking about only temperature performing only tent this antidepressants performing only ten percent better than placebo it's like ok something so clearly it's not that the additive presidents don't ever work it's just that we are now over prescribing them to pee people that you know have this major depressive disorder and they're not king on people that weren't the initial
the people that were like severely depressed and hospitalized you know so it's like okay that's that's a big problem because there i mean their prescribed like i mean i just like i can't even believe it you know i just have so many personal stories people i know you know that have gone you know going some crisis and personal break add forest whatever also there giving you some crazy all of a sudden there giving some crazy drug and they change the personality the person and i'm just like please get off of this like you know it's not like and like i say it's not like they don't ever work it's just that you know i think once the clinical diagnostic booked change the whole like a procedure for diagnosing depression became major depressive order and disorder all of a sudden you're gay
people that are now like having just you know whatever stressful event in their life that's making them a little depressed the time which everyone's probably experienced are now being you know given this antidepressant when they don't really need it and there are effects that are not good with taking some of these you know at the present so there is a big effect on libido yeah and libido yeah i know a lot of people that have taken it with their sex drive just goes away yeah there's actually a gene that numb a gene called fism variation in a gene that that is linked to that so people that but haven't even more severe effect where they really don't they really have like sexual dysfunction in response to and it just shuts down yeah yeah it doesn't happen to everyone quite as much but there there's a percentage of people that really really fax and there's lots of other you know things i mean it's just it's changing your brain chemistry right and it's not exact it's an exact science no there's a lot of experimentation going on with it i had a friend of mine
and who had gone to several doctors and they had prescribed a bunch of different things to him and he was sick really depressed and eventually they gave up and he had to find a much better doctor that his care his whatever his insurance package would not pay for and once you from that doctor then the doctor is just more knowledgeable about potential do once i mean i don't know how many different ones there are but they got him on something that actually worked he's off it now now it took him awhile and then eventually got not be and then oddly enough which is an interesting thing is people always want to connect depression they want to say depression is a disease he's and they want to say it almost like you got herpes like you know i mean yeah it's like what you've got depression all were you need medicine and for him the one of the big factors in and fixing everything was his own success his own person
success and then he became more happy and then his medication helped he became more successful and then as he became eventually really successful he started to experience like a better quality of life he was happier he was more confident and then i slowly weaned himself off and now he has no need for them to mean that is so fascinating because so we're not talking about necessarily a disease like he does not have cancer it's not like that they cured him of a disease it's it was a blanket that was keeping him warm it was something that was allowing him to bridge the gap between an unhealthy mental state and a healthy mental state but a lot of that health had to do with his own life he still eats like shit i mean he's not like the healthiest guy he eats a lot of fucking candy but he's really healthy now as far as like his mind is very happy
yes not lying you know he's not faking it so to me it's always i mean when i've talked to friends that have had had really good results with anti depressants so i think there are some dark moments in people's lives where that can kind get them out of that but then part of me doesn't buy that that's the way to go 'cause part of me is like ok well did you exercise no did you take like real healthy foods no did you clean your life up no did you like what happened here and one of the things that a lot of these anti depressants do is they make you not feel bad about stuff like about anything like i had a friend was on zoloft and she said like she took it for a year and she's like i'm kind of lost a year of my life like i didn't give a fuck about anything during that year like anything can happen like on scary yeah but that not giving
perfect not not feeling bad you also you don't feel great either you don't feel like you don't feel like god it's a good time to be alive looking young healthy i can move all those thoughts don't sort of come into play it's like it dulls everything it dulls the highs and it dulls the lowe's and it keeps the pain away that's kind of interesting because believe it or not that's actually a symptom of depression i think it's called like hedonia or something where some it's not like really responsive to anything it's like you can't like you just can't like you know you know you can't like excite them or or like make them soup thanks i there's kind of like you know so that's actually kind of interesting that she was experience in that while on an antidepressant well the results very pretty wide totally yeah i i mean with the same drugs right yeah yeah that was that because it by university like what's causing that that you like you could take something and you would have a totally diff
reaction and i could take something and you know it would just be perfect you know i honestly don't think we actually know really why that is but what we do know is that there are i mean there are different we are different people and i've got different genes that are regulating how much serotonin i'm making how much dopamine i'm making how much i metabolising how quickly i metabolise sing it then you another and so when you like and keep in and this is this absolutely does affect how some of these drugs are you know when they're taken how how their with their biological fact is now you know why the white i don't know you know so it's it there's definitely like a a genetic variation that affects just the way our neurotransmitters are being fired away in the way they're being metabolised and so if you're if you're at sing a drug that's changing the way something is being mataba most already then it's you know it's going to affect people differently i think i think that's one reason
but honestly i don't know who knows just maybe like other you know situations as well other territory situations all these things probably play a role you know with inflammation i was talking about actually playing cause a role i mean they have actual in studies where normal the people are injected with either a placebo which is saline water salt water or their injected with something that our gut produces called endotoxin in our gut produces it when our immune cells in orgot attack the bacteria in our gut because endotoxin is actually a component of the bacterial cell membrane and that is released pawn information so when you're eating a terrible diet lots of refined sugar and that's that's actually been shown release endotoxin and it causes inflammatory response so when people are injected with endo talk listen or their injected with pro inflammatory cytokines
interferon gamma which we also make in our body when were inflamed people start to it normal healthy people start to experience feelings of pressure they start to feel depressed anxious social withdrawal people with placebo did not experience that i'm also they had elevated levels of other inflammatory biomarkers in their blood so it really like and this is just this is puzzle i mean we're talking about injecting an inflation inflammation all this in their experiencing these like depressive symptoms it was actually uhm people that were then given one of the omega three fatty acids epa there given actually a pretty high dose of it i think it was close to like two grams or something completely alleviated any of the symptoms of that so those people that we're getting the inflammatory cytokine or the antitoxin and the epa did not experience the symptoms that was really like information you know driven these symptoms that were not experiencing
we'll see about so that's kind of and there's been multiple studies showing this and that you know it's not just one sided multiple studies multiple studies again this is kind of like a new method people are using to explore how inflammation effects depression it also it's been shown the same sort of scenario where there's a placebo and they're injecting inflammatory cytokine doping levels lower in the brains of people that were injected with the the pro inflammatory cytokine but not the same water and also the reward path where in the brain is also decreased so you know again like i was mentioning you're not not that excitable your you don't you know it's kind of like and that and that was not that did not happen in the placebo group so this was not just an effect of being shot up with something you know so when when scientists have look at some some of the mechanisms and explored will how is it that inflammation is affecting dopamine in the brain how is it that it's you know affecting people's mood it's thought now there's
variety of mechanisms one is that you know these inflammatory cytokines they actually cross the blood brain barrier they get into the brain and they disrupt dopamine release they disrupted serotonin release it disrupt norepinephrine release you know they're disrupting mirror transmitters being released on the other thing is that there's been recently discovered that the lymphatic system is actually directly connected to the brain through the meninges and it was previously thought that was like cut off the brain was protected from the lymphatic system but it turns but we were wrong you know everything that we learn in textbooks for years and years in our science classes was not accurate actually we are lymphatic system is connected and what that means is that our immune system the chemicals inflammatory cytokines were producing you know from our mean cells are getting in the brain and disrupting you know is release in uh i think so really i really strong connection to imp
and in depression that's shown to be causal but when you think about it it's like well what causes inflammation ok well we can talk about the sugar stuff because that's been shown eating a terrible diet does but the other thing that causes it and it's what you mentioned that is a stressful event in someone's life now you know a breakup tragedy work relate stress social anxiety whatever it is anything that causes you to release cortisol stress hormones believe it or not those things actually affect inflammation in your gut so it's like a two way st here i think that previous that you and i have talked about another podcast like got microbiome bacteria you know you can take microbiome back to your from anxious mouse and transplanted into a non anxious mouse and make an anxious and vice versa right so there's like some sort of got brain axis through with something called the vagal nerve well it goes both
ways you can go from the brain down to the gut so it's been shown that like cortical release hormone which is a stress hormone you know get through the single nerve when you release it goes in the gut it activates been cells which then activate other proteins in the guide that chew up the called proteases the chew up the gut barrier and then you start release more influence you know inflammatory cells which then like getting check with bacteria more inflammation and then it goes back it's like this feedback loop so i think that's how stress it's also part of the mechanism how a stressful event any any sort of break up or tragedy those sorts of things also cause inflammation they cause inflammation in fact is it totally off topic but that's one reason why people should never go and like get like blood work done like like a day or two after some kind of like traumatic events so if you get fired
blood work so yeah like do not look at your blood or break up or whatever yeah 'cause they will like it will skew every anything wow everything well that's that's so amazing and when you discussed and when you lay all these facts out it make it seemed so irresponsible that ten percent of the people are on this drug eleven percent skews me around this drug or us it was you know whatever a category of these drugs instead of dealing with it i mean it seems like it's we're in a weird place when it comes to the holistic treatment of the human body where winner very weird place where we have all of this information now but it doesn't seem like it's being applied when comes to the average person who is suffering the average person who with the disease or depression which i guess you could call a disease and it just seems so insane that all we know that we're treating it only
is chemical pathway were only treating with a pill this pharmacy you know this pharma khalaj ikle solution to this which just seems so limits upsetting it's so upsetting it's very upsetting i'm like it's like a mission of mine you know i think you know i think the problem is multi fold do you know one is that you have to psyche trison their trained a certain way and people when their patients come in they expect that they're going to come they come in because they want a pill most of the time they do they come in because they don't want to deal with it and they want a pill and so you know that's kind of a problem because they need people need to understand that these pills are not the magic bullet i mean i just told you only forty percent people are responding these antidepressants that are standard of care compared to thirty percent they respond to placebo a sugar pill like that is ridiculous you know so i think i would lie
if there was some way to get a physician of usually there's psychiatrist that people go to for these sorts of pro forms to like push someone to say you have to go run so you're going to run six miles a week you're going to run you're going to do that that is going to help you like it's in fact it's been shown it's been shown a multiple studies that exercise improve depression and one of the ways that does it vary in interestingly is that aerobic exercise specifically has been shown that whole serotonin they were talking about inflammation inhibit release of serotonin will guess what inflammation text serotonin in another way the to serotonin serotonin tryptophan when you have inflammation so like i said emotional event causes inflammation doesn't have to be your sugar diet okay you what location can be caused by your cortisol release when you have that inflammation your body
thinks that it needs to fight off something but that's what it thinks it's like ok this i'm sick i've got foreign invader i need to kill it and so the tryptophan which usually is being transported in the brain and make serotonin which plays a role in how you feel or plays their own lots of brain functions then gets diverted into another pathway because your body's like wait a minute i don't need to feel good i need to the lot i need to survive any to live so it the trip to fan gets converted into this whole other pathway called kind uranian which helps with it basically immune cells need it to different immune cells needed to make different types of immune cells so your body is like ok that runs on this out there software i need more men sellable about but the problem is that the kind you're earning then gets converted into so now what you have is your depleting your brain it's our town right there right that's the first thing so if you're not sick and if you have chronic inflammation you're chronically stressed you're chronically eating a terrible diet
then you are going to constantly be diverting the serotonin you know the tryptophan in his other pathway you're going to be depleted uranium serotonin right so that's one thing this is a two fold prob and then that whole kind aronian thing gets converted into something called quinolinic acid which actually crosses over the blood brain barrier becomes a neurotoxin and also has been want to cause depression so not only are not getting serotonin you're getting this gnarly shit and your brain that's not supposed to be there an exercise it's been shown specifically aerobic exercise causes your muscle to soak up the con yearning actually another precursor to it so that it can't form quinolinic acid so it doesn't form the neurotoxin park part but you know exercise also caused you to make to makes tryptophan go into your brain you know alleviate some of the competition with branched chain amino acids like lucy and i solution so that's another way it's doing a million sprained ragnarok traffic factor we talked about at the beginning of the podcasts that also plays a role in depression helping prevent depression so
marriage neurogenesis all that stuff that helps growing new brain cells making new connections helps helps you deal with stress that's why you make it when you stress your body it seems like there could be some sort of a whole holistic approach like our clinic that looks at all of these factors looks at all these factors and prescribes instead of just prescribing a pill prescribed a very specific by an exercise routine and maybe even meditation may be giving something that the practices or or uh enhances mindfulness or promotes mindfulness someth and that allows you to manage the way you are viewing and taking in scenarios and scenes and events in your life and then pra missing them in a more healthy manner it seems like all these things would be is effective or maybe more effective than just a pill i agree with you and i'm hopeful for the future i think that the more
there's a lot of scientists to spatter starting this now i mean it's becoming very common to to look in the scientific literature and and see you know scientist researching inflammation in the role of information depression and the role exercise in helping treat it and the role of other you know dietary lifestyle factors in causing in treating depression so i think that you know i really am hopeful that in the near future that it like you said it's going to be a multi pronged approach where it's not just a magic pill and i'm not saying that's not all so going to be included in some you know i'm just so you know it's i think i think the diet lifestyle meditation exercise if we could just get that into like you know that the clinical world and if people were motivated enough to realize this will really help them like it really well people will be so much happier
i really i really think so so i'm people just don't want to fuck an exercise it's weird they would so much to go to a doctor and get a pill it's it's so strange it's a lot of people well it's this fear of discomfort people have this extreme feeling in their mind when it comes to their associations with exercise they want to avoid discomfort they feel like any type of exercise is just like something to be avoided that's not for me fuck that i don't want to sweat i don't want to strain and uh sometimes this association that they have is about the beginnings of getting in shape it's not about once you're actually fit because once you we fit exercise is something you look forward to it's an alleviation of stress it's it feels great like but i can't get a workout in i i look at my schedule i go oh shit i don't have any time for a workout which means i'm not going to get that good feeling and so instead of looking got it like oh i've gotta go grunt and sweat i'm
thinking i'm not going to feel good i'm not going to feel relaxed i'm not going to feel carefree and i'm not going to feel even appreciate if like my appreciation of things it gets enhanced greatly after exercise i just feel better i feel i can take things in for what they are rather than you know whenever wherever sensory data that i'm getting from any event is just one more distraction that gets in my way and in that so a lot of times how i look at things from over stressed or from working too much totally beautifully put because that that that's exactly like the least what's been shown for like narrow it imaging studies is that exercise does what you're talking about is the executive function you're talking about feeling good you without that sensory stuff which is the imac delights emotional center that's been shown to be decreased in activity after exercise where is the executive function is increased so it's it's it's just it's done is exactly in the right direction right you so you're yeah you're able to logically
think about this more and you feel good and it's like you're not that that era once that like you don't feel it as much that part of your brain is actually quieter after exercise meditation does a similar thing but if there was just a way to get this knowledge to pete for p understand people that are adverse to exercising you know if there was just some way and i'm really trying to fight the way because there are many people that i care about in my life that are that way and that feel depressed in or on some sort of you know antidepressant which doesn't really work for them still and so i'm trying to find a way i like how like i can tell them i'm having this conversation with you and you get it because you experience it you exercise you do you know you you eat healthy you experience these things but for someone that's never experienced it how do you communicate it it's so hard for people to start anything new it's hard for
able to start a pottery class that's not going to you know it's not going to be involved with any physical pain or any gas or any exhaustion there's no there's not that feeling that you get when you really tired you know the feeling that you get from me is particularly difficult doing boring stuff like an elliptical machine like elliptical seemed to me it's a good great workout it's awesome in from out of gym 'cause if i go to a gym like at a hotel and you know they have some bullshit weights and but they have an elliptical machine i go ok if this thing has a high setting i can get a real work in this but those times when you're tired and you don't want to do it there so fucking boring it's just gosh you have to listen to something you have to watch something like other stimuli has to come in in order to get you pumped up but i know this 'cause i've done it one thousand times for so who hasn't done it one thousand times you they get to that point like fuck
this i'm outta here oh my god let me get a donut you know give me a coffee i will go out and smoke a cigarette i feel better you know and it's so hard to get past that because we have all these connections in our mind when it comes to comfort comfort and stress comfort inn like our body for whatever reason most people their associations are to avoid anything that's uncomfortable but it's uh the logical because when you look at comfort and you look that success and progress and eventual the feelings of accomplishment and of getting past certain hurdles in terms of like how you feel about life a lot lot of those are connected to discomfort like discomfort is your friend it really is like discomfort and not being happy and content with certain situations in life or sir feelings in life there are massive
massive motivators and there are amazing at facility can change and yet are in sting is to avoid those and just sit on the couch and watch some fuckin reality show about due to make moonshine with our jaw open czar it is it's too much too much of that like stimuli read on to do anything and you can still like get yeah get that sensory information do you know the the need to act like to need to actually go out there and act is so strong it's such a it's it's an important thing but yet we resisted many people i know you don't i don't but so many people do i but i feel the thing you know i don't don't allow it to work but i feel that fuck this i want to workout i feel it all the time almost every time before i workout we have at least an inclination to blow it off i don't ever embrace it but it's there where is there with everybody no one is like completely
be one hundred percent healthy and without any resistance yeah i wonder if also because we were talking about this being a super ager i wonder if there is some association there we were looking at looking at how it's important to push bass pass that uncomfortable ness whether it's physical or mental and that's linked to being a super ager but what if it's just like the ability to make yourself do that is important to too it's not just the act that you're doing it's not just the strenuous exercise which is is obviously good we know that it's good from scion but what if it's just being able to like push yourself like maybe some people don't have that ability whatever reason or they just haven't tapped into it and uh because i'm really experienced i think that's it i think it's a learned thing you know if i take time off like i got sick recently and i couldn't work out for like a week or you know six days or so and the of the act of getting back into the gym i think in a lot of ways we
rely on momentum we rely on the momentum of past x this is where you're just conditioned to do that it's one of the things that you do and for me at least when i get when i get like really disciplined really i get really consistent with my workouts one of things that i feel i almost feel momentum i feel like there's like a push behind me like alright well you know like after i get out of the gym i have a really good workout on my cat now i'm doing it i'm doing all the time now and i'm looking forward to the next time and it makes that resistance much weaker and it fix my motivation in my discipline much stronger i think a lot of it is based on just the consistency you know it's one things i talked about recently on the podcast i said you know like blow something off it's not just not good blowing off an exercise that you planned is not just bad for you physically it's also bad mentale
because then that option is now available the option to fuck off is available and but you did it before and you're probably going to do it again and you'll get mediocre results not just in that aspect of your life but maybe in all aspects of your life 'cause i think that option to fuck off when you embrace it that is a pathway that you might choose when it comes to dealing with con clicked in your personal life dealing with business decisions dealing with court your decisions like an uncomfortable decision that you might be faced with you maybe you need to make a change as far as what your pathway is in life but you don't do it instead you fuck off and that the inclination to fuck off i think that gathers momentum as well the inclina to be disciplined that comes with phantom two and i think both things like you did you take a path the path of the healthy person are the path of the fuck off like both of them are available in whichever path you embrace total he totally i mean i think that the same thing go
it would like lying to i mean when you i think it's very bad well i like even if it's something that is really benign like what they call it a little tiny white look great that you know because then you start making these neural actions in your brain and you start to like it used to doing it like he was saying and and i think that it just kind of dawned on me as you were saying this that we the motivation in the momentum you're talking about i think that's the same way i think you're like building these new pathways is motivation pathways and that's really important for that momentum to do it again and again you know there's been there was some studies a few of them that have been done where you can take person and do that direct transcranial stimulation which i don't know much about but i remember these studies and like related certain part of the brain that's involved in motivation and you can motivate them to go to the gym so you motivate them to actually go workout
so that's in one of those electrodes they put on a specific area the outside of your head and then it's like a little nine volt batteries attached to it and it just zaps you little bit apps it saps you little bit and like activates a certain brain region that that brain region is activating specifically with this study i was talking about it actually is a couple of them were are involved in motivation and that's probably with you and i we already have those pathways activated because we're constantly forcing ourselves to go i mean i feel the same way there are times i'm like god i don't want to go for a run like so far if you do it god damn you feel great feel great and you know what you accomplish something so it's not only like you're feeling great from all the neural mecca things that are being activated and all the biochemistry that's going on but you have accomplished something you did you push past them and you didn't want to do when you feel good about doing that after magnetic stimulation therapy wilmington woman finds motivation enerji yeah there's uh
a radio lab about this radio lab podcast is called nine volt nirvana and it is pretty good i like i love it i love radio lab and it actually deals with the first story the opening store is amazing 'cause it deals with this woman who went to the it's like sniper training simulation video v go thing that they do where they they put you in front they give you like a fake gun and put you in front of a video screen and a scenario plays out and the scenario there's like a terrorist attack you have to take out the bad guys and they did it with her and she was twenty minutes long and she was terrible terrable she fucked it all up it was just like a disaster like she didn't respond correctly then they put these electrodes what would you exactly call them one of those things that cancel so they put these on her brain in the on the outside of her head and very specific areas and stimulated it and then recreate it
and in the recreation she was one hundred percent effective killed all the bad guys and she went through this twenty min thing and when it was over when they to older that it was over she thought they were fucking with her 'cause she thought it only two minutes like yeah like every kredible it's amazing the way she describes it is amazing it's amazing a little scary too just because i mean so i can you like program someone to do there's another study that was that was a published like two years ago same thing trans cranial direct stimulation and i but i liked him so non expert any this but i just remember this study because it was trying to investigate what part of the brain's fault in consciousness right and so she so that the study was designed in such a way where she was reading a book and they zapped are in a certain part of the brain and she
stopped reading the book this woman and like just looked at them like a zombie like no nothing no talk no and then they zapped her again and she started she picked up right where she left off no recollection at all of doing so this was like trying figure out if this person is faulty consciousness anyways that was a little sick with that's with the yeah that is a real concern right because one of the things about this transcranial direct stimulation of of the the brady allow podcast was that that they talked about how many people are out there just fucking experimenting where there's uh whole community online where people are talking about like experimenting with the voltages and experimenting with placement and one guy did something you've lost the sense of taste like much yeah
so people still buying these and like doing it like this yes well that you can go it's like you go to fucking radio lab the consequences of a world where anyone with twenty dollars and access to radioshack and make their own brain zapper yeah that is from radio lab from their their podcast page it's amazing because there's apparently this gigantic community of it like hold on a second go back up there and make that lg again the la a couple of years atdtdcs trance direct cranial stimulation has been all over the news researchers claim that juicing the brain with just two milla amps nine volt but think nine volt battery battery help with everything from learning languages to quitting smoking to overcoming depression and so they brought in a neuro scientist michael weiss and at wright state research institute into the studio tell them how it works really interesting very into you know i feel like in terms of like treating depression or helping
people get motivated to go to the gym it may really have relevance but it also might be like slapping a supercharger on an old chevy nova below the fucking engine on the thing you know it's true it's true i mean you don't really don't really know enough about what's going on i certainly when be experimenting with that right i'm in now let's do it you do it yeah i'm thinking about going to radio show up radioshack right after i get out of here not really but sore i mean it's just interesting it it's amazing that we are really some sort of a system and you can choose that's it stumble electricity here a little item in there a little broccoli spray here that's the weird thing about people one of the weirdest things about people is how very all we are depending upon what we put inside of us and we don't think of that way most of the time we think of ourselves as ourselves you know i'm sure you think of yourself is rhonda patrick but rhonda patch
rick relies on a bunch of fucking chemicals to be rhonda patrick right i mean there's a lot of stuff going on in there it's not it's not this one like this is a laptop you know i'm not adding shit to this thing like i could put programs in it and stuff but i mean this is that everything in here's kind of worked out processor there's a motherboard it's all all this junk is in place in the electricity plugs into the back and it's not really variable you know the hume body so fucking variable and pliable and malleable there's so many different things that you can do to make self better this conversation with a friend of mine who's not a physical fitness guy by and he's kind of an e liston nihilist i guess you're saying i never say that word i just read it i think it's analysis analysis and he's now is a little bit of a curmudgeon and he yeah what's the point you know like really what it what it what is the point you're always do walls martial arts and exercise i go okay if i could give you a pill and that
bill would turn you essentially into a super person like you do you share that you can't do now you could lift weights you can't what left he could beat people up you could do physical fitness fits feeds that you know what right now are totally insurmountable and outside the realm of possibility would you take that pill so simple and he goes no i wouldn't i go you wouldn't okay if i could give you a pill that would prevent you from being a decaying old man and you could stay in state you are right now would you take that he's like yeah i probably take that i go well that's how it feels like to me mother fucker like that's how it feels like to me like you're a decaying goldman yeah like he's not much i think he's a year older than me but he looks like he's fifty years old that means bodies all humped his you like you like scarlett pouch it doesn't have any muscle tone and i'm like dude all of that is just physical fitness like you're not broken like there's nothing
wrong with you but if you got on like a steady yoga routine and started doing some resistance training and started maybe swimming or something like that a year from now you have acomp slightly different body you know and so talking to me i'm like i've done it my whole life so like stuff that i can do stuff that you don't think is possible and to me it's like two times a week three times a week i do that stuff like this is not your body is like a race car that you can juice up yourself like you can add the fat tires you can add the improved suspension you can beef up the horsepower in the engine you do all that yourself or you could just choose to have this shitty body it's always falling apart on you right i mean you're you and i are both choosing to do as you know is we're both kind of obsessed with nutrition and aging and being you know optimal as we can in terms of our health but and ultimately what we are doing is delaying the aging process by switching on all these so
which is in like you know exercise and getting all the micronutrients and avoiding the refined sugar which is causing it location and all that stuff and it's really because that stuff is part of the aging process and it accelerates the aging process you know where i don't think people that don't do this stuff realize that it's like it's not just about looking good about aging it's about like being older and being fit and being mentally sharp and not being you know to generate and decrepit and how i mean how awful would that be to be like sixty which is a young man sixty is still young and to be like you know we're not yeah broken which is really common it's super calm especially for sedentary people exactly is entropy most sedentary people are people that also choose to eat terrible diets so it's like
not only are they sedentary they're also eating crappy food and not getting all the nutrients they need so it's just like this mega explosion dynamite of just bad yeah increasing information i think intelligent people like my friend he is intelligent and i think he connects vanity with those things anything's vanities for fools in a thanks it's it's a it's a trait that he finds is reprehensible he just doesn't like it you know he sees people that are you know ma'am in on what or maybe it's the flashy clothes maybe it's the you know the way they wear their hair whatever it is he thinks is preposterous he connects that with physical fitness mike man but it's your vehicle it's like well how you get through this life and it's it's how you think it's it's it's so many different things that are all connected into one super organism which is the life that you're living
i wouldn't i think everybody knows now i mean it's not something we grew up knowing but everybody knows now about your gut biome this is a a really huge factor in how you to exist as an organism or as it may be even an organism is the wrong word 'cause we're essentially ecosystems you know when we're in charge this weird consciousness that has all this resistance and has all the inclination towards comfort and fucking off and blowing things off is what is in charge of making all these things happen that keep this ecosystem healthy it's almost like if earth itself had like a shitty manager you know like there was a manager over a natural manager of earth that was like how god who cares if it rains oh god you know like let's you know i'm going to stop growing things i don't give a shit anymore it's all stupid anyway literally like that
killala life would do it's all going to die eventually i mean the sun only lasts seven billion years and you see that is the perspective a lot of people take with aging where it's like well you're going to you're going to age you can't stop aging and it's like yes you're right but that's not the point the point is to age better like that's the point the point is to increase your health man you know and that is we know is possible like that there's some there's some of these like centenarians and super centenarians i've seen that are like over one hundred years old and they're like riding bikes an racing and it's like their old they're very old are experiencing a very good quality of life yeah and they're experiencing a quality of life that these other people that don't exercise feel they physically feel their own body diminishing and they just feel it's inevitable it it is what it is you're wasting your time you're out there running around but we're not because this it's right now it's not like
no ones under the illusion they're going to live forever but you are enhancing the experience that you're currently involved in right now and who are alive you are alive you do experience this life but do you experience this life optimally is it is as enjoyable as it can be and we all know that there's a spectrum for that enjoyability like we've all had times in our life or it's not been so great in times in a life where everything came together like what a fucking great day woo like make more of those like you could make more of those and then the whole things better and i think when that whole thing is better it effects everybody you touch everybody it's around you everybody come in contact with and that in turn minutes also grandiose but in turn can affect the entire race of human beings i agree totally totally agree and i love the way you put it about like the feeling good it's not just about
you know staving off cancer or you know it's not just about what's going to happen two thousand and thirty years from now it's about now it's about not being depressed we know that you know it's about feeling better it's about being smarter it's about having more executive function having more long term planning less emotional a mid to let you know anxiety that is the bike right here right now that is happening that is so you know it's not just long term effects which you also are you know also affecting which is very good so it's like a win win you're not just affecting the future you're affecting right now how you feel how you perform you know it's yeah it's an important concept that i continue to try to get across to people and it also will optimize everything else you do whether it's creative pursuits whether it's relationships that you get into a lot of those things are predicated on how you feel as you enter them how you feel when you participate in them and you can enhance that you can enhance that an
there's a weird thing that people do when they want to pretend they're not trying to do better you know i'm fine everything is great like it's not that's not true you're putting out effort it's a matter of you you have a mindset or you have a connection in your brain with pooh hang out more effort and connecting that to discomfort and that connecting things to discover if you ever saw stephen press field has a book called the war of art brought up in this podcast a million times i ourself a copy of it or give it to you afterwards because i okay i bought like fit the copies of it my hand i handed out to people it's great and he's been on this podcast before in his book is essentially mostly about the creative pursuit and it's about resistance that people feel when you know you should write or you know you should paint or whatever you said sculpt whatever these things are that you you pursue and that there's this thing that comes up that tries to keep you from doing that this resistance and
like this is a battle that you will fight for the rest of your life but the key is to fight it not to give in don't give into that resistance to just to fight that resist and in doing so every day you do so you have won the battle for that day and you will continue to fight that battle an if you continue to fight that battle that same mine that you will win and this is a guy like up until the time he was forty years old was basically a loser isn't doing well it was like a failed writer and then he kind of just figured down and got his shit together and then wrote books about it now is like a really accomplished author and it's it's an amazing story he's a really cool guy too i had it on for a podcast and you know in his susie asom and the way he approaches it in this book is like it's a very pragmatic like you can see the steps and he he
lays it all out in a way that's very easy to digest awesome yeah i'd love to read it i mean i i i think that's something that's very important part of of of the mixed this is pushing past that resistance to you too very much sir you're right once you do it you get better at it next time too you still there but you do get better at it next time there's also a problem i think that what it comes up when you and i are doing these podcasts were there so much data there is so much to take in i mean we have done how many podcast now like six or seven six one lot and eh one of them is three hours of like what the how does she know all this in the snow books like that when i put it up on twitter you know the that you're gonna be here every like gay you know book out i mean that's like the number one response in the comments that's awesome yeah there's a lot of stuff that i i in
learning you know so something that like to learn about things that can make me better or things that can make other people better mentally physically aging and all that so i like to share that with with people i have you heard of this we're talking about an aging pill and it kind of came into my mind when you're talking about giving your friend that if you could take a pill that could you know play the way you age or make you live longer or better have you heard it nicotinamide right beside or nicotinamide mononucleotide not at all not at all no oh wow it's like it's kind of like i guess it's maybe it's not made its way into the popular media as much as i thought but it's definitely blown up in the science so there's so nicotinamide right beside an nickatina mononucleotide there like precursor forms to vitamin b3 and the body they get converted into something called nad an eh
ideas something that you absolutely have to which make energy have to have to make an entry like you can't oxidize fat fatty acid you can't ox raise glucose you can't make energy from any of the food you eat without any d because in my country and needed to make the energy so it's very important for your mitochondria function to make energy but also it's very important it's like the levels of any we always rise like when you're fasting in between meals so like you know between breakfast and lunch breakfast some dinner or whatever your nad levels go up like only after a meal and during the fasting state and also when you exercise so the the levels of energy will will will go up somewhat but on this so these are precursors to an eighty right i'm i'm sorry this 'cause this is kind of the studies that have been done all the mechanisms go back to this informing nad nad is something that decreases with age
it's something that you know it's just it's it's very important for aging anytime you're inflamed all the entity gets sucked and sucked up into that information because your energy to me now energy it requires energy to like have your immune cells be activated and fighting on whatever they think they're fighting off whether or not it's refined sugar or actual an infection but dna damage sucks it up so it's like you know it's basically a limiting factor in a lot of ways so this been all these studies over the past i don't know i'd say like six you there's probably now bieber six years where various scientists are have been feeding mice you know this side by side or nicotinamide mononucleotide and they're finding that you know for example if you feed them nicotinamide mononucleotide today's aging in their liver in their bones in their eyes their muscle so it's basic
like their tissues or aging better they haven't endurance they have better mitochondrial function and these are doses like human equivalent adoes to like twenty four milligrams per kilogram body weight per day which could be a lot if you weigh a lot but showing that it improves matic chondral function and nicotinamide i decide which gets converted into nicotinamide mononucleotide it's kind of confusing it just anyways lots of studies i'm not showing that it like if you give it to my said have some sort of mitochondrial defect in their muscles all atrophying being completely reverses that your muscles are like they're making lots of mitochondria and their improves muscle function and enhancing performance anyways like you get the idea like lots and lots of animal studies recently there's been a human clinical trial done with nicotinamide right beside an that to show that it's safe and that it actually does increase nad levels in in human blood which it does
even as low as one hundred milligrams dose a day and is this a supplement that big people can buy so so nicotinamide mononucleotide is not that's found like broccoli broccoli is really high and it cute merger really high in it cabbage is high in edamame but nicotine my tribe aside which gets converted into that which eventually makes its way to nad is it is a supplement so uh few scientists actually some big names is an aging filled the clinic warranty and a couple of others have started a supplement company called a lease can you give me that pad i forgot to put a pad over here i gotta write that down thank you yeah and so it's called a lease and it has nicotinamide him like the matt damon movie yeah elysium oh look at this they have it
so it has nicotinamide and by the way no affiliation i don't have any affiliation with any subway companies also a supplement company what is the company jamie think it's a company called the companies called alicia moore is the supplement at the supplements called aliciem but how do you spell the actual nicotinamide right i'm i'd an iac nick e i n a m i d e right beside our i b o s i d e yeah so the it's interesting it's also there's another company i think thorn makes makes one with it in it but born yeah thorn the thing it's interesting about the aliciem though that i found because i started looking in this like i've met lenny guarantee he's the guy ok who who who's lab the whole pathway that resveratrol axon was discovered that so nad
switch is on this whole like genetic pathway that's like anti aging and it does changes all these epigenetic factors okay without getting into all details in like boring people to death it's like it active it it's basically nad levels rise that acts as a switch this this is an ad levels so this is a supplement that's rising nad levels but what's interesting about elysium is that it has something in it called terra still been cheryl still being is found and in blueberries blueberries probably one of the best sources of it but what was so interesting i was trying to figure out like why are they putting trying to figure why putting child still being with the nicotinamide right beside because nicotinamide riverside is affecting any its effect contraband genesis with him it's been shown to increase mcconnell biogenesis like i said these mice mice you never were were performing like forty two percent better at different insurance activities after being supplemented with us so that's
same yeah it's but they're giving a lot like the like at thirty two to twenty four to thirty two milligrams per kilogram body weight would be the human equivalent so you know figure that out that's a lot that's probably like four grams a day or something like that right for like a hundred and sixty or eighty pound person something like that i don't know anyways the pterostilbene is interesting because as well in and of itself it's interesting because it's actually it's chemically similar to resveratrol and but it's four times more bioavailable than resveratrol and it actually has been can weird side by side in mouse studies to like different mouse studies that have looked at cognitive function and it's better at improving cognitive function in animals then re is largely because it's four times more bio available so anyways well i don't know if that's why they're doing it because it's not affecting the same pathway but then i came cross something really interesting and that is
it's still being actually has been shown again this is an animal study to increase the type bacteria in the gut that cause this is the conversion of certain compounds alagia tan things which are found in berries and some nuts but really high in pomegranate ellagic tan get converted into something called tarot still called you with an eight by your gut bacteria which what tarot still being is increasing that gut bacteria sotera stilbenes actually increasing the prod a year old within a from berry yes they were having this other compound uralla in a what that does is this has been shown also another studies it causes my defeat might have ag or my top ag which is the clearing away of damaged mitochondria so you basically clearing away damage my to consulate the eat themselves so fiji would be eating itself kind of like autopay g her atop a g as it's called which is a self
sort of a damage cell that gets cleared away eats itself that happens a lot during a fasting state well this my to fiji is doing it specifically for mitochondria and this is the reason why this is so cool and i'm going to credit not bore you be like i can go on and i said keep going i don't worry about that uh the reason this is so cool is because so you know mitochondria are very important for the way we age it's not just muscle function brain function the threading enerji for everything like period like your mitochondria decay you decay that's the way it is like period so their mitochondria as you are aging their decaying they're getting damage and all this stuff well they have this whole repair system where where you have lots of mitochondria inside one cell list we have one damage mitochondria unhealthy what they do is they fused together exchange all their content and fizz back apart so they're kind of repair each other so we have a healthy wanna damage one the healthy one kind of mixes with the unhealthy one and then you have two healthy ish ones right so
this is happening constantly inside every cell if you if you look at a mitochondria it's never like you never my see mitochondrion themselves are always like like a network like they look like vermicelli spaghetti because you're constantly doing this well if you clear away the damaged ones and you increase mitochondrial biogenesis with because in my driver side so not only are you getting rid of the damage to pool your now creating new ones that are like brand new healthy you young brimming young mitochondria like you had when you were a young person young child so now your pool that you're mixing with is like not mitochondrial biogenesis is good in and of itself because you're making you mitochondria but having damage one still around can still dilute the pull out you know it can still dilute so if you get clear out those damn which ones and you're making new ones it's kind of like boom you're going to get like young new mitochondria so i think that pasa
lee is another reason why they combine those i mean it's completely speculation i'm just but anyways you learn some cool about terra stampede you're within a yeah my mortgage is a very interesting thing you know exercise to some degree can increase it fasting does and what is fasting increases when you're fasting you try to sew nad levels rise uh you try to conserve some of you g in the way you do that is by eating different organ al's eating eating the cell itself which can then provide energy for other cells so you so usually what happens is fasting will selectively get rid of some of the damage cells are damaged mitochondria so that that happens during during a fasting so that makes sense when you yes so it's interesting though that the the body manages it so well that it goes after the damage once before i know for the healthy it's it's well there's lots of like molecular mechanisms that have been figured out why that is and that's because the damage one there might
control membrane potentials like different and it's just it's all this complicated stuff but it's like it all works out perfectly where it's like these these these enzymes that like targeted to to basically become undergo might've ag it's like recognizes certain one with lower membrane potential which happens to be more of a damage mitochondria and it's just kind of like it's kind of beautiful how it all works out that way ok i was going to say i completely like was going to say something else they lost my train of thought but yeah so anyways that the fact that you can like have new mitochondria is like pretty i mean that's kind of like the big thing with with aging that's been out for a long time is like young you might account
i know you're probably aware of the study but they injected old mice with the blood of young mice and they found that the old my started behaving more lively and then they did the reverse they injected the young mice with the blood of old mice in them no my struggled and and deteriorated and now there's some crazy new start up for was like eight grand they fill you up with the blood of young people yeah ok i'm glad you mentioned this 'cause i've been reading about it recently actually you know peter thiel the paypal yes he does that he's he's publicly talked about that he's he's on trump's board now isn't anyway i think so yeah one of the first people that trump hired which is fascinating so fascinating yeah yeah he does he's talked about how he gets blood in okay so here's what is he said about it
i don't remember exactly what just that i don't think he said anything about whether it's doing anything but i think you should mention showing up younger nothing like he's got a snapchat filter on well here the thing that was really interesting about this whole thing 'cause i've been following this field for awhile too 'cause i find it very interesting for multiple reasons one it's like it could be app all right i mean easily but there it is look at him looks young as fuck he's nine years old he wants inject himself with young people's blood or is doing it trump delegate and gawker bankrupt are oh yeah he's the guy who he he fine against hulk hogan's attack on gawker because gawker outed him as being they out him as gay or they attacked him and they did really shitty with him and you know he's a fucking billionaire so he went off and thank you for turning off your ad blocker enjoy the forbes add light experience fuck off
denton files for personal bankruptcy yeah he he went after that guy because of it yeah so we go back to the other only changed articles there so what he's doing given feels obsession with warding off death it comes as no surprise of silicon valley billionaire is interested in the least one radica we're doing it injecting himself with young person's blood wow inc exene published part of a year old interview with thiel and which the venture capitalist explains it he's interested in para bye closest wells called which includes the practice of getting transfusions of blood from a younger person as a means of improving health and potentially reversing aging said i'm looking in this stuff i think it's really interesting blah blah blah it's unclear whether the forty year old entrepreneur is currently receiving guarantee diaz reports that a thief
will capital employee actually the personal health director has a personal health director personal health director to peter thiel that's hilarious that's what you do when you're all baller i'm going to get a personal health directory is the same company ambrose well see this is the one that we were talking about the other day interesting so this is actually happening says thiel spends four one thousand dollars per quarter per quarter to get an infusion of blood from an eighteen year old based on research conducted at stanford on it extending the lives of mice so he's got one fuck an eighteen year old is vampire ring one kitty given him beets and broccoli sprouts and making him run up hills that's cray but you would have to hope that kids not doing math you know like he's got is eighteen year old keeping all these biomarkers is blood and what i'm changing yeah because you have to make sure i mean that's so we're going to farm off young people and
wow that is so crazy he's given six million dollars to bio medical genter ontologist gerontologist aubrey the gray that crazy fucker i had him on adam mommy yeah yeah he's interesting but he drinks yes boo this is like every night he was like three end strong at eleven in the morning when i walked into his office yeah that's what i was saying when i was hanging out with them he's like he he's based being all of he's putting all of his eggs in the basket of science he thinks that science and things like with peter thiel is doing is going to be able to mitigate all this stuff that he's doing yeah but am i if you're stuck in that like position where it's like ok they can delay the aging but like you're stuck like now ok we can't make you like eighteen but we can stop you from dying but you know so it's like that's possible so he's going to be stuck like not well he also doesn't exercise i've found him to be purple
i sing i really enjoyed talking to him but i found him to be quite perplexing because of the booze and because of the lack of exercise is big fucking crazy gandalf beard like let's go how would you do there's a lot going on here you might so there's a lot a lot of image here yes i disagreed a lot of nutrition of will hold on a second let me talk about that but and some say that the pay to participate study with potential to collect up to four point eight million from as many as six on a participate and mounts to a scam hi what's certain is it's based on some intriguing if inconclusive science car maisie and a thirty two year old princeton graduate and competitive rower said he was inspired by studies on mice that research its own together with their veins conjoined in a procedure called parabiosis ok that's what we're talking about that study about mice so what did you guys disagree with well is the role that nutrition plays an aging to eat anything is a big role now we didn't think of the big pussies boozing so yeah
losing is not working out i mean how can you ignore all the science on the the the positive benefits of exercise and nutrition there's lots a study showing that the diet lifestyle we now have a huge impact on on aging yeah you know for i mean we just one more thing about this parabiosis though because it's kind of people we're thinking that it was the young there was something in the young blood that was present to the g n f eleven not just on the screen that was actually enough eleven what is that right it's a growth factor eleven yeah so it was thought that this was what was responsible for read you dating tissues and growing new brain cells because that's what happened when you gave it to the older mice but then other studies started come out also out of stanford showing that in fact it may not be something that's in the young blood but something that's in the old blood that's actually causing the aging something called v cam one that starts to start to make as you're getting older and it like causes in
asian in the brain and like starts messing up things so there is a recent study that we just came out and show that if you like make an antibody against that became one and prevent it from like doing its action it's like you can stop that from happening so anyway is there a lot to be figured out is there an out of body that they're currently working on yeah trying to make some kind of some some something that you can take a day some solution agent it's going to be weird is going to be weird if you see like old people become young it's not going to be rid of people do get any older be kind of weird but like if i came ran into you like twenty years from now i'm like damn ronnie you exactly the same it would be cool but it wouldn't freak me out what would freak me out of arnold swarts anger started looking like it was when he was twenty again that would freak me out like if we start seeing the change in the process we start seeing things review course not just halt or slow down which we kind of have with like really healthy people like some people you know
people kind of defy aging at least to a certain extent like tom cruise is a perfect example i want to know what their fill that dude up with you know who else i think who i was thinking that defied ageing lie aging famous wise counter reeves i feel like the guys look the same for like a long yeah and he's in his 50s now yeah he looks great yeah he looks great i think he smokes too right yeah no yes yeah that's just show you some kind of like genetic there are there definitely are tom cruise one thousand nine hundred and eighty three two thousand and fourteen injecting him with some kind of young fluid you know i'm saying i mean look he's got fucking ungodly sums of money and that's part of part of the issue you know i mean they've date yeah you can definitely do things with money that that edge and make you look younger trying figure out
wordly wise and stuff hope he's doing surgery though no no well and one of the things that they think is what is that picture up above what's that one with the turn off one up there is that him working out up there see that shows aging so one of the right like he's got substantially less tone to his muscles but that could just be he's been busy it says the maverik days are over well go back what does it say is it from nineteen eighty six to write on the set yesterday so that's also that does not that much of a variability there that could easily be just using working out is hard when you're on a movie set your work in one thousand five hundred and sixteen hours a day sometimes especially these gigantic big bug budget blockbusters you're you know involved in these crazy stunts and all that stuff so interesting yeah but
you know back to this like diet aging thing that like our and i just read on i mean it's it's so it's so weird that someone that's he's familiar with aging literature would disagree you know with with some of the signs out there like there's been studies looking at for example people that have like one twelve ounce can of like sugar water or sugar soda some kind of like sugary drink a day they have if you look at the their telomeres and their white blood cells so telomeres are biomarkers for aging when you look at their team ruling their team ears are shorter compared to people that don't that soda every day and that corresponds to like four dot six years of biological aging i mean that's like someone that's the same exact ages you but has a team member that looks you know either five years older you know saying yeah it's brilliant all based off of like this refined sugar soda
here is a personal thing with him because he knows that he's not addressing that his own life maybe that's why he's decided to put up these blinders and ignore the science well i think also he's interested in extending lifespan too like massive point sugary soft drinks may be linked to accelerated dna aging study so he's like i said he's putting all of his eggs in the basket of science yeah women who knows mean there's it's kind of interesting that he is doing that though because he will concentrate like very heavily on that and again and we're talking about all this nutrition and exercise the benefits of it like there's so much to study there's so much that it may be
his maybe his desire to issue that and go straight to the science of it only and talk about genetic manipulation and all these other different abel's like maybe the maybe the something to that maybe you really can't spend enough time in both fields totally yeah i think that makes sense and i and i do think that there's hope for you know things like genetic engineering and stem cell therapies that will help tomb humans up eventually and that will make a big difference in have talk to you about my stem cell experiment now no ok i i have been getting stem cell shots i got them for an injured shoulder i had shoulder that i had a rotator cuff tear bicep tendon tear and labrum tear in my show then it was most likely had been dislocated before and i didn't know which is just to say
effects of years of doing difficult stuff with your body especially jiu jitsu cuz but you get to is all about joint manipulations and joint locks and chokes and grappling and there's a lot of snow out of much that your body goes for everybody i know that does to get to a certain point time either have to get some porn form of surgery or has some pretty significant injuries that they have to work around so hi he om went to a doctor there was like well we have to get surgery like this is gonna the if it and if not now sometime really soon because every time i work out if we get really sore and not have to ice it afterwards i get these shots and they're doing them from their extracting the stem cells from women's placenta and they take the stem cells and then they should come into the area where you have the injury and the results are fucking freakish you heal like wolverine i mean it's really bizarre and now this same shoulder that i had you know like a real
problem with worlds worried about needing surgery i do ninety pound presses with kettle bells with one shoulder and does not have no pain no pain no discount word not bothering me at all and it's unbelievable how much strength and function that the shoulder has now that's really cool and realize they were doing that with the simple some cells yeah until some cells are like kind of like a gold mine because they they parts possess a tap of stem cell called multipoint instance i which is able to form multiple different types of it cartilage cells that you the form cartilage cells that form bone even cells that form neurons so they're able to form lots of different types of cells and usually plants are just like thrown away i mean so it's kind of cool that there i guess there companies that are freezing them down and finding you know donors that match
yeah let me tell you the name of the company so people who are listening it's in my doctors name is doctor roddy mcgee and he's in las vegas and the company is um i'll have it listed here that's good i've gotten on my instagram on my pen ready here to you can't let me tell i won't let you down just give me a second i'll scroll through my instagram and i'll find him 'cause it wasn't that long ago that i was there but i posted something about it on instagram but i'm a i'm a giant believer in it and i've had some friends my friend john dudley who is an archer was experiencing tendonitis in one of his elbows for a long time i mean he had it and it was you know something that he had been working through for quite a few years and he had one stem cell shot and within two weeks the pain was completely gone yeah it's it's freaky what they're able to do
i'm fine i'm all about it i'm i'm stem cell therapies i mean that's something that i'm extremely excited about for the future but have you ever tried hydrolyze collagen powder or like bone broth yes i drink bone broth every morning okay awesome yeah so that's another thing like 'cause i i'm getting into the bone broth but i was doing hydra add hydrolyze collagen powder to like my coffee in the morning and also my smoothies and what does that do well since it just like it's got a lot of the same things as bone broth bone broth probably actually even better 'cause it has more stuff but it's been shown like an animal studies if you take the hydrolyzed collagen powder and radio label it so you can follow where it goes in an animal it goes right to like the cartilage bridge in the joints and ligaments i you is it like his help me healed like injured wrist you know obviously like my injuries are like way way less mag
students something that you're experiencing in your shoulder here it is total sports madison in vague iss that's the name of the company that that does the stem cell injections for that what about the company that you applied biologics it's called flow graft amniotic fluid therapy that's what they're calling it but it's total sports medicine in las vegas that's where i got the stem supplied site biologics is of the company that yes please the placenta yes complied biologics flow graft amniotic fluid therapy and my friend riding mcgee dr ride mcgee is at total sports madison in vegas he's awesome he's any such a knowledgeable guy too if you ever want to talk to my get you in contact with them and explain all the details he talks like you you too could fucking geek out to weather and confuse the shit out of anybody standing next to you well you know pretty soon they're actually there make stem cells from skin cells now yeah word that i know they did that with a woman they created a new bladder for her she had bladder cancer
and they created a completely new bladder from her skin cells in a you know laboratory environment and then replaced her her damage bladder that's amazing yeah i had only heard about the clinical say that what they did with i cells were like the woman and someone was had some sort of blindness and they were able to use skin cells from her own skin call it a clock them in becoming retinal cells but blatter is really cool too i mean so these these lots and lots of animal studies but every once in awhile there's like a new clinical study where they're just kind of piloting doing this and seeing the safety in humans and that is where i'm like i can't wait like yeah it's crazy them sound check for my brain where i know i'm shooting it right in my ear right in there it's going to be very bizarre when we get past healthy human state that's what i'm really not just concerned not concerned about rather but curious about like it's curious
not even a strong enough word but i feel like within our lifetimes maybe it's fifty years or whatever it's going to be they're going to be able to engineer a human body to perform and uh sherry e no you're aware of milestat inhibitors and the benefits on that they've they've they've shown that the accidental ones and they've done with like with pets and towels but then they started to do it on purpose for me nice and there the mice are living longer they're super mice there they are like way more muscular i think there like two to three times more muscular than the average mouse they look freakish when they kill them when they so then they skin them and they show the body of the mouse compared to with the muscle structure and can with the body of a natural mouse it's like what in the fuck are you doing here like this is this is like the hulk if you're making a tiny thing you know and your pudding all this extra muscle on it and for whatever reason it's living longer yeah that is that's the interesting part
that it's a living longer and we're trying to figure that out like what you know 'cause usually there is some sort of trade offer you like well let's see if we could in that jamie they saying the miles staton inhibitor studies they did on mice because their physical formance was extraordinary like they could do things that the other mice just could not do but on top of that they actually little bit longer yeah i see that's very interesting yeah i know they were doing it with like pigs two or something and i've seen some pigs are they done some sort i think they were doing gene engineering on them with the mouse at inhibitor but yeah so it's all very interesting they've done it with animals that you use i mean they're thinking that you could do it with animals that we use for food and they would just they would provide more meat that way right which is kind of interesting but what's matter what exactly i found a couple of different studies somewhere older than like ten years so i don't know
oh ok increases muscle mass and muscle fiber in aged mice but does not increase bone density or bone strength that could be a problem snap that's an old study my nine two thousand thirteen is the one i clicked on interesting maybe two thousand and thirteen is probably where i saw it but the some of those images just click on those images jamie because some of those images you could see they had the like go down there with mice carcasses right there you can see that prince in the size now that's not it was not necessarily it i think it's actually the one where you made was that hum well there's plenty to look at but yeah there it is you can see like the difference in the muscle size from the average switch is on the left versus the mile staten mouse miles down knockout mouse but look at
you're standing there that one mouse just looks like a giant ass powerlifter mouse these are strange times when it comes to this science really strange times i mean muscle mass is looking pretty with that's exactly what i saw how that's exactly i saw good lord to credible i mean but you've got like two levels of it you've got level you know a and level b you've got the natural mouse which is on the left what is this image what is this image titled jvc ok okay body building and miles staton and there's an image of three one is a control which is the average mouse the other one says dominant negative how does that word go at act rib act rib two rise and the other one is follow staten and in the call staten one it is just fucking lee haney of mice now let's add giant ass mouse it's ridiculous
is like double the size of the middle mouse which is double the size of the other i don't know what either of those pathways are or what they do but clearly they regulate muscle mass some things going on that would be kind of weird to like do an inch fiction and like all of a sudden you're like gaining lean muscle mass without like doing any doing anything yeah doesn't look like those mice are working out now be super weird yeah that would i don't know well that's why most conceptions about steroids you know people think that like you do steroids just get bigger and muscular now you actually have to work out what does a guy this is a mile oh this is bullshit this bullshit yeah this is just don't even click on that you take that fucking off that's law guys that these god damn supplement companies that do that that's really gross one of the things they do is they pay someone to get in really great shape so someone gets in really great shape like they'll give him steroids will pump them up and then they pay him to get fat so
they pay him to stop working out they get fat and then they change the way the lighting is like one of the things that you could see when you're dealing with fraudulent companies is these shirt off pics before and after wanna transformation is like in the the good picture there tan and the lighting is really good for accentuating muscle you know the with the with the shape of the muscles in the shadows and everything they look ripped and then the other one they like pasty and white and they pay these guys to get fat a friend of and they paid him to do it yeah these things right here like that guy on the right the app after is the fucking before and guy on the left before is they pay that guy to stop working out and give fat how do people live with themselves like doing that like i just don't it seems like people do so fraud there's a lot of monsters out there i think this is from bigger stronger faster i think this was actually taking like the same day oh why did some
well the sides and they do that they do that too for sure they definitely that too and uh our friend chris bell and mark bell who were in bigger stronger faster you know they they know a lot more about that than we do then there's a picture of him right above that that if you haven't seen that documentary i highly recommend it bigger stronger faster which talk it's about the supplement industry and use of steroids and all these different things but that's one of them yes one of the weird practices they do like if you look at any of those before and after pictures it's mostly what you're seeing mean less like a really ethical company and they hired someone to take their product and continue to workout but even then it's like when you show up before and after what was the guy doing before was a guy doing after how much is that his diet how much that is exercise like how do you know did you get it the test on his guys on steroids like what's happening here yeah i think we should just focus on
i can actually yeah yeah science in ways we know like we can increase muscle mass you know obviously you know weight lifting and to me to be on abu grabe when you when you brought up the science of nutrition and the factors you know the the the positive benefits of it what was his reaction and whatever so as as part of this is an older podcast that i did i can't remember what episode but it's it's been a year and a half at least i would say i can't remember his exact reaction i mean you can tell if you listen to the part i talk i talk a lot about we talk a lot about you know chris burns stem cell on a lot of these you know possible you know therapies that are being used that can potentially extend lifespan but there's a point in the podcast where nutrition comes up and you can tell it's a little awkward between the two of us because we can't have different viewpoints and i'm sort of not trying to
rude because look at their fucking wizard we were like so close in his office and he yeah anyways he's god god that beard is fucking awesome though god damn it i think i think his point was just that you can't you're not going to you're not going to extend lifespan by forty or fifty percent with diet and that's what he wants to do and that's fair but the point that i think it's it's one thing to say that and another thing to kind of disregard nutritional together you know 'cause that's 'cause that's just stupid nutrition plays a role in the way you age and so i think that should be you know it shouldn't be something that people should completely does for disregard and not and not think about and not and not even not think about it when they talk publicly talk it down like i don't like that like
like that's fine if you want to focus on technologies and and i agree with that i mean i'm i'm all about you know all these gene therapy technologies and crisper and you know in two three point stem cells in a huge huge fan of all that but i don't think that being a fan of that and and being excited about what the science in and what new technologies are are going to be able to bring us should you know make us talk about like kind of people any traction right watching the also a big factor is the way you feel and a big factor too i mean i assume he just doesn't just want to extend a shitty life right you to extend the life where you feel wonderful right right and well if your boobs in all the time like he is that guy booze is everyday i talk to me like we were drunk as fuck in new york i wanted that what is it two thousand and forty five of conference there's a conference in new york where all of
these nutty people who think you're going to be able to download your brain into a supercomputer and the year twenty forty five like this extended life conference and a lot a lot of it was run by this russian billionaire that i talk to which is a he was a very odd character he was building a robot that they were not satisfied with the results of this robot so the they never unearthed it they never unveiled it rather but these all these people is to three hundred and forty five conference in new york were all like this gathering of like these super geeks that are all in various ways trying to extend life and aubrey de grey was there as well and i met him at the bar and we just got fucking
with a hammer and we're talking to mike desire we extend life it's gonna feel they were just drinking again essere during the off you're causing massive information or any of that this is terrible are we doing but you know i mean it does or to like very contrary ways of existing yeah to look to extend life but yet to diminish the potential of the life your kerr currently experiencing but you know i guess he's having fun you know yeah i don't you know he was an interesting guy and i enjoyed talking to him but i don't want to talk about about but when i was very shocked when i walked into his office at literally eleven in the morning and he had already down two beers and he's on his third and i was just like i didn't i wasn't expecting
not right i wasn't i mean it was completely shocking to me and so god bless and now they're hammering it you know ag yeah who knows yeah yeah but i guess there's a lot of different approaches and i think he's at his approach is welcome it's interest it's in it's just as important you know that i have a guy like that that's kind of fucking up his body and still still after it like it's interesting right you know this like i was saying though that that thing that with him then i you know that the major difference is fifty focusing on nutrition and that's something that that i to get the message across that's right i want something you can do right now yeah so many could right now until an end in the meanwhile still telling people about awesome science coming out but until then lets you know yeah keep it let's keep it going they're not mutually exclusive they're not they're not makes a mutually exclusive
the other you know one of the things that we were talking about the muscle mass i started thinking about this time restricted eating have you heard about this at all time restricted eating a little bit like eating with and like a certain time period that correlates corresponds to like the day it has really profound effects on on muscle mass without any other factors that have an exercise or anything that's mean that's extremely interest interesting but this like times are to eating is it's very important for for healthy metabolism it's all also something i've been obsessed with since like probably early summer i've been doing it like just you know really fanatically making sure that i'm eating within like no more than twelve hour period i try to do like ten hours
so like when you wake up in the morning you have a cup of coffee or you know you eat even if a cup of black coffee the first thing you pour into your your system that's not water starts all these metabolic enzymes starts in your liver you know your guy starts he's these enzymes and those enzymes are on a clock because humans are diurnal creatures were were meant to be awake and working in active and thinking during the day and we sleep at night which is different from nocturnal creatures like some rinse and other animals that are you know sleep during the day an actor night so because we're meant we are active during the day were diurnal all these all our metabolism metabolism enzymes all the things are active during the day and things that activate them are light light exposure and also food intake and is in a biotic is also something so anything that gets metabolized like by your by your system by your liver whatever activates these enzymes and once they're activated there on this like
twelve hour clock where it's like ok so you're metabolising glucose fatty acids all these things you know well if you're eating within that twelve hour clock but when you go beyond that twelve hour clock that's when things start to go really wrong 'cause you're metabolism enzyme started shut down and are not doing things properly so you're not like insulin response if you're not even fatty acids and things like that just metabolism in general isn't not working as well you know after twelve hours and so that's kind of a big i opener i know there was a lot of people think they eat
well our time here like if you're a survey them but yeah i i don't eat more than twelve hours but there's actually a study done by a friend of mine who's a expert in this field he's at the salk institute is name is sergeant panda very good scientist i interviewed him on my podcast and he's you know done a lot of research on this this topic and he did a human study where he had like this app where people locked there for they took pictures of the food that they ate and it like you know since some database they hadn't had time stamp on it so they can you could see when the clock when they won their first cup of coffee or whatever was in the morning and then when they were eating and i turned out most people are actually eating in a fifteen hour clock so they were having a cup of coffee you know eight seven in the morning and they're you know they're eating it like nine nine hundred and ten ten right yeah so they're eating much later the thing
thing is is that like when you do that you start to gain more more fat you start to become more insulin sensitive and you start to like your muscle starts to waste regardless of what you eat regardless of what you eat so so i take that back so you if you eat healthy if you eat healthy so if you're eating a terrible diet a terrible diet that's and this has been shown in mice like lard that plus sugar those two together which is the actual of the bad combination glad you brought that up i'm going to make a note but keep calling those two are the bad combination so if you eat if you're eating that if you're feeling the mice that and you let them whenever they want so they can eat their nocturnal but i'm just call it day and their days actually night just know that that's true if they eating during the day and night they gain like you know tons of weight come fat become like you know type to die fettig fatty liver i mean there just mess they're breaking down like earlier than they should but if you eat
normal so if you're eating like a healthy diet that's not high fat high sugar you don't necessarily you're not necessarily going to gain more fat you don't you don't become type two diabetic and all that if you're not eating all the crap so you probably just going to be ok but if you take that same mouse who is eating a health diet and you make it eat within a time restricted window of at least twelve hours actually the best was nine to ten they gain way more muscle mass this is on a normal diet just way more muscle mass and if they ate within a nine hour window they had to like him really improved endurance that's something i've noticed in myself if i eat within a nine hour window and i go for a run next morning my insurance is like very noticeably improved to like extremely recently improved so do you have like a timer like how do you do you do you time yourself at the beginning of your day like when you first eat and then yeah so i
typically it will make so my friend kevin rose has an app that like it's called to hard what did he kevin rose has an app to everything i did yeah yeah i've had him on love that guy yeah he's awesome he's big ketogenic diet proponent as well yeah he doesn't actually do keto anymore because they expect after you got it blood work done and there's different you know jeans that people have that can affect the way they respond to that sort of diet most of the time people respond good but actually because he was on here just one long ago introducing zero a new app to help you fast so he has an app helps you do that that actually works really well personally what i do is i'm just kind of crazy about it and i just like remember that day so i'm like ok i had my first cup of coffee at eight hundred am but his app actually is really cool because it really helps you keep dragging in send you reminders so like helps you and it's a free app so powerful kevin rose anyways
really cool because you can just like literally these mice were gaining more muscle mass just not by doing anything but eating within this time restricted window and the the thing that was also very interesting about this was that you could cheat a couple of days a week so they could like let's say weekends when you have like social events in your like out drinking or whatever you can you can cheat two nights and still have the same benefits so that at least in my s we don't know if it's the same for humans sergeants doing trying to aggregate some data with humans he actually has an ongoing trial that you can sign up for it's called my circadian clock and it also an app on his phone the phone that you just basically all you do is like sign a consent form take pictures of your food and and like allow certain data if you no different than to stay there for them to collect and instead they're doing this clinical study with some humans from data that are aggregate
kind of get is fasting tracker right now yeah you can do it's different options for cabins fasting it's like their circadian option which is the one i'm talking about and then there's like people doing intermittent fasting and what's this acadian option that's the time restricted that certain which is basically circadian is the circadian clock you're on so that's what's this twenty four hour cycle day to day night cycle so eating within at least a twelve hour window is the twelve hour is the most you ever most so if you get up at eight hundred o'clock in the morning that's when you have your first cup of coffee that's when it starts not with food it starts with first cup of coffee 'cause that's i think a lot of people don't think that they think that they are still fasting they have a cup of coffee and then they go run that's the thing because coffee even if it's black so people think if they have black coffee their fasting and they go run but black fee is caffeine is zeno biotic is something that has to be metabolised by liver enzymes your gut processes it so anything
other than water exactly other than water and the same goes for like taking vitamin pills or drinking herbal tea late at night like the same the same thing goes even herbal tea herbal tea is also got herb stuff in it so non caffeinated herbal tea like yeah because those are xenobiotics camomille i mean that stuff's gotta be processed by your liver for your gut it's it's not it's not water right you know so i mean this is something that's kind of a big question in that as well if the fasting let's say you're you're eating with like nine hour window or ten hour window nine hours optimal nine hours is really but i found to be optimal for endurance in term the animal studies like ten hours also if they eating there healthy diet within ten hours they still had restore lean muscle mass they don't have to do anything else no extra exercising it just because what was happening is they were there basically can't
working better and there are also getting rid of fat easier so so it increased their lean muscle mass that's incredible because i eat late at night all the time we got comedian and that's probably probably eat after a show or so i came home last night at two hundred o'clock in the morning pigged out after a show i mean it was healthy food like kiefer pistachio nuts i buy those big jugs of shell pistachios so the shells roots i just eat like piles of pistachios 'cause i feel like i'm not eating anything bad that's good for you but this knowledge now knowing this i'm going to i'm cut that out now please let me know although i'm going to start right now yeah that's awesome i mean like i said you can cheat there was cheating at least in mice twice twice a week was ok two times a week good cheap and that's kind of cool because it's like a weekend right right so you have your social event it's hard to do with social events and stuff if you have like a something late and you kind of have to fast
call early in the morning all the way up and so you can do it later yeah you know what i mean but i do a lot of workouts fasted now and one of the things that to do is i get up in the morning without having anything and then i workout but i've been having coffee so i thought thought i was fasting you will see the thing is and this is kind of what i was talking with sachin about is that if you're fasting itself the fasting itself is having a positive effect on all these enzymes so maybe there's some sort of cancel station out it's not not it's not as good it's not as good i would say so just water we don't have actual empirical data on that saying ok well you know and that's that's option would like to look at and humans because it's like a big question if you are just fasting in in theory it's not you're starting all those clocks the clocks are caffeine starts to clocks that soon so then again you know like i said fasting changes your metabolism in a way to that makes it better so maybe it's not quite as bad
quite as babbitt nozzle exactly i like that that's perfect income yeah so shoot for nine hours that was like that nine hours is the best especially for insurance like enhancements like oh really so if you get up and you're at if you're up at eight hundred o'clock in the morning or seven hundred o'clock in the morning whatever it is yeah you almost have eat dinner like at five yeah that's the problem you have to you have to either fast in the morning or you have to eat early which is really hard for working people nine to five hours yeah i mean it's like you're eating breakfast before you go to work and less you're not right and that's kind of the problem people that are going you know switches manage apps humans yeah i see yeah we have it you know life is kind of different now but it's you know there are people that were talking about you they just take their breakfast to work and they wait till wait till like one thousand o'clock to eat or something like that yeah because also there's people that like to go to the gym after work and so there's more time it's like
get a race this clock i gotta eat but you know so really if you can start the clock later if that's possible for p they're working like that they don't have flexible hours then then it would be better to start the clock later and there's a lot of human data on this like just looking at like the associations between people that eat within you know an eleven hour period and fast for thirteen hours for example women that do that have already had breast cancer they reduced their breast cancer risk recurrence by like forty percent you know yeah because it lowers it causes insulin sensitivity it lowers like igf one levels and it's just like lowers all these like hormones and things that are known to promote cancer growth it's really a powerful thing and improves metabolism really improves metabolism and that's something that a couple of scientist that i've talked to that are at ucsd are looking at and
simply seeing that it seems to be really important obviously people doing shift work like nurses are kind of i mean that's the problem the other kind of fucked when you doing that late show stuff and they are there they have twice the cancer incidents likely yeah twice twice shift workers they are also much more likely to be type two diabetic because you're eating you're eating like when you at night you're in being you know get your metabolism all is all screwed up not only do are you like when you're eating after the twelve hour clock are not as insulin sensitive and so your blood glucose levels are higher so you confusing your clocks ok like it says okay i'm restarting now because it's late i'm getting my first signal in its after it's been after twelve hours and it confused it so when you go to sleep at two hundred in the morning and go to sleep and wake up the next morning i have your meal it's already going to have started that clock awhile ago so you won't be as insulin sensitive 'cause you earlier in the day or the more the more insulin sensitive you are so you know what
i so you kind of like confusing the clock it's like this yeah but i think important mechanism in system for people to understand and time restricted time restricted eating like i have really implemented that because i think that's something that also will affect the aging process i have talked to people like conferences i've given a talk out that have come up to me afterwards and they're they're talking about how they've been on a diet for two years and how it may be that the wait for first or type two diabetes been great but still there fasting blood glucose levels were still on the high end and you know even though they're no longer type two diabetic i mean which is really good and they say are you doing the time restricted eating with every eating within a nine hour window and it completely resolved it completely result it and it actually have multiple people tell me that an so saying is in the amazing thing is the increase in muscle the muscle is really the increase that the interesting part i would like to like talk to sachin more about that
have him do more experiments if possible because we didn't dive as much into that on the podcast and we chatted but he is such a phenomenal scientists and he's very proactive and into health and all this you know preventative madison and he's just a great great person working out of the salk institute in la jolla very procedures place to be is a lot of good scientists there did you do your podcast with him through skype or did you know i married down there your gas and yeah yeah i usually try to i like to meet with people when i when i interview them yeah so i i've noticed yeah so i you can't like i've done skype ones and they're just uh it's like there's a disconnect there's something missing yes it's nice for you because you actually have a studio and people come to your studio so right now now i'm i'm like going around to it two it's in you know if i'm at like a place from giving a talk and i'm like this great scientist there i'm going to ask people
how do you spell his name s a t c h i n sachin panda what a great name yeah actually his first name is such an tananda because he's indian so shortened it to sachin but is he's a really good person to talk to to like he's very you know just he speaks eloquently explain things but he's a little bit of an indian accent but you know it's just it's kind of like cute but his science has changed my life like oh yeah all of my you're creating in knowledge i've been following him for a few years like i've really looked up to him for if in fact i don't even know if i told him this but i was like interested in doing a postdoc with him in certain point like after i had finished my phd 'cause i thought he was back in twenty twelve when i graduated he was making these discoveries about late night eating and how it like how it makes you
more so you basically more insulin resistant how it's like screwing up brain section two all these things that i didn't even talk about and i got really interested in it because i know a lot of people that eat late at night and people that are having trouble losing weight date and all that they were eating late at night so wow that's amazing i'm going to listen to his podcast with you and or your podcast with another check that out that sounds awesome that be cool so the saturated fats here's what you wanted to do yeah i did because you actually sent me an article about that which i found was really fascinating is that there saturated fat is important it's how would you describe it as a precursor to hormones it's it's not just a pre
the hormones so saturated fat saturated fat increases ldl cholesterol ldl lebron's it proteins which carry cholesterol and fatty acids we always call it cholesterol the type of it it's a transporter of cholesterol but also transports fatty acids and other things but the thing is is you know the ldl oil is a very very important because every time you make a new cell in your body which is happening constantly you're always making you immune cells are making new kidney cells are making you liver cells i mean it's happening all the time i need to make a new cell you need ldl there to transport cholesterol and fatty acids because cell so membrane the cell itself the member and is made of it it has fatty acids in cholesterol and phospholipids and other things but so you need that cholesterol when you
images sell you know and you're repairing that damage cholesterol needs to be there so i mean you really really need cluster ldl cholesterol is very important for that for that reason and without it you're kind of screwed right i mean you can't like repair damage as well you're not going to make as many new cells so all these people avoiding saturated fats and cholesterol in their diet they're doing their doing literally doing their cell regeneration a disservice well i don't want to make that broad statements i don't know what else there in maybe they're getting other types of fatty acids that also help but yes p weather like on stands for example which is a very broad broadway of inhibiting like cholesterol synthesis bright like full stop that's why a lot of those people on staten's one of the major major side effects his muscle atrophy and muscle wasting you know 'cause your muscle
one of those cells you're constantly repairing damage and making muscle and's a big big problem huge problem with the staten staten users it also so a colleague of mine wrong crowds he's at the children's hospital in oakland he has been studying buttons and their effect on mitochondria and he was only me that it's like toxic to mitochondria and he's trying to figure out why it's like maybe that's partly why it some also causing muscle wasting so people don't consume saturated fats or they lower their radically lower the saturated fat in their diet how does their body produce new cell membranes well i mean you still you're making cholesterol in your
body and you're making it from there getting fatty acids in they're getting it from plants i mean plant sterile they're getting them from from other sources you know but it i think the problem with the with the saturated fat was is not so much that because people still get it to some degree i mean it's like what's on optimum yeah i mean i i don't know i can't attack i have to see like the person i think it it varies depending on what else they're eating but you know the price i think the problem was that saturated fat was deemed sized was demonized in a very corrupt way which is the the new york times article that was released which is a mind blower which detail and how the sugar industry had bribed scientists to rhel these data blaming saturated fat for heart disease and obesity and all these issues when i was in fact that was causing all that so they were literally
rigging the system and paying scientists and it was a horrible article because that property and these lies that they spread i believe it was in the 50s here it is how the sugar industry shifted the blame to fat and it's if you get a chance and you want to feel sick at what can be done with money watch or read that because it's just it's awful it is really awful and it was an internal sugar industry document that was discovered by a researcher at the university california san francisco and it was published said monday when this was out i believe it was a couple of months ago but it amazing it suggested that five decades of research into the role of nutrition heart disease including many of today's dietary recommendations may have been largely shaped by the sugar industry and propaganda and money they spent money to literally bribe scientist to release false data it's horrible it's really nasty but i mean
the thing is not that much money there years ago go back to it here they paid through the harvard scientist the equivalent of fifth three thousand dollars in today's dollars to publish a nineteen sixty seven review of search on sugar fat and heart disease studies using the review were hand picked by the sugar group article which is published in the prestigious new england journal of medicine mini why is the link between sugar and heart health and cast aspiration is on the role of saturated fat even though the info once pedaling revealed that documents dates back to nearly fifty years more research reports show that the food industry has continued to influence nutrition science this had such a negative light there were such negative consequences from this from from the demonization of saturated fat because people then obviously started eating more refined like
breakfast in the morning is that having eggs you're having like cereal but the real problem was the trans fats because trans fats can can have similar but our hygienist hydrogenated fats which you know you take like a a a minus saturated fat and high genetic you can have similar properties properties as saturated fat like butter how it's solid and then you know melts at a higher temperature but these transfats i mean i remember my mom had a big tub of margarine i mean we used margarine are mashed potatoes and everybody thought it was healthy and it was so i mean it's not just one i it was literally that's what's it causes heart disease because the trans fats like i said you take these fats into your new cells right because that's part of what you know fatty acids in cholesterol that's part of what you're doing with them in your body the transvestite taken up and the whole structure of its ski boot up so when this happens in the endothelial cells lining your blood vessels that make some real stiff real stiff and like i mean it's just like screws it up so trans fats are like
we have known about that like the fact that trans fats are playing a causal role in heart disease for like decades and the fda finally in two thousand and fifteen two thousand and fifteen ok finally banned them from the us and gave all the pennies that are still putting him in their process foods and lot of fast food companies use like crisco 'cause it's cheaper three years to get it off the market so we have until two hundred and thirty in eighteen jesus christ three years to get rid of poison that's after already like deck of knowing it's like you know the this is like it's like so bad so so bad for you anyways that's that's a whole that's one of them major repercussions and then obviously then you know people became scared of saturated fat and you know the thing
the thing with the sugar and this is kind of what you were initially nope hinting at is that a lot of there were there have been a lot of studies that have linked into that weren't corrupt you know by the sure that these were the early city but there have been studies a howling saturated fat intake to heart disease and and a lot of the studies were also because people were eating in addition a saturated fat they didn't correct for like refined sugar intake which is really what the problem is and that is now been shown in multiple studies so and this came down to actually being able to have new technology available that was able to then you know lda all is not there's not just one dl we now cholesterol in the body comes in all sizes and the the type the type that we are talking about the good type is a large point type and that's what saturated fat increases there's also it gets processed into smaller parts that are small dense ldl and that's what basically it can't get recycled back to the liver so
stays around the bloodstream and undergoes inflammatory transformations and sticks in the blood vessels causes all this problem right that's where we're fine sugar increases and that's been shown in clinical these so like healthy young men that were given twenty ounce is soda a day for three weeks to healthy young young man increased this increase their small dense ldl particles like massively increase or small dense ldl particles and also increase their flammatory markers c reactive protein by like almost one hundred percent which is like crazy so we're talking about like you know the refined sugar is what can make such but in fact dangerous is when you combine the two because the ldl gets processed into the small danson's refined sugar that does that so so so all dense ldl versus ldl yeah and so the thing is is that even now it's not standard of care adelegg measure all the particle size is it's like we've known about this for at least a decade now like so raw
kraus he is he's the guy who actually pioneered this asset and figured out how to to measure them the small dense ldl called ion mobility i say it's done in a quest labs to does it but you can also ask your physician you can ask your physician to measure the particle size but the thing this is that because it's not so thing that standard of care when you go into measure your ldl cholesterol and it's above a certain number positions are like freaking out and i couldn't stand but the reality is that you need to look at the small dense ldl that's what's actually get you know get put you at risk for heart disease and that's just not standard of care you have to like specifically asked for you know and so crazy that there's such a vast difference in the consequences for your health but yet it's not tested even well the knowledge is there well that's what i was saying with the transparent i mean the knowledge was there like i was talking to i like eighty eight year old mentor brucene and then we use like i remember
back in the 80s so we stayed away from that never gave margin my children like well you're a scientist like my mom wasn't you know like he is known about this for like when i was like in five you know he's known has known it for thirty fucking years since now at two thousand and fifteen is when you know there's always a lag between research and application of it but i mean i do not much of a i don't know what it takes to you know maybe these regulatory committees met this probably a lot more than i know that goes into like figuring out like how you make these regularly but it's only financially motivated that's what's disgusting about it they're giving these companies three years to get poison out of food that is what really upsets me i'm like ok finally finally have banned in the us but you're given three years like three years for people to profit off of reasoning for killing people yeah and not only do i know you should have a cancer recommendation or while warning to see what you have on cigarettes yeah and it's not even like you can go to like people we go to the
for market and will say no transfats on their food and all that but when they go to fast food or they go to some like restaurant where they're using crisco there not even going to know they're getting it i don't even telling you this is awesome totally damron budget this was great you blow my and every time this is amazing um there's a lot to study folks so go over this podcast thirty or forty times and i know i'm going to go over it few you found my fitness on twitter your podcast found my fitness yeah i have a podcast it's called found my fitness actually i just released the podcast today with doctor rolling grew it's who is the notorious psychedelic psilocybin researcher i met with him when i was at johns hopkins user outside of my realm but you should listen to it i will definitely do that and let's do it again soon it's been too long so much fun thank you so much i appreciate our folks sia bye thank you everybody for two
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the code word rogan and you will save ten percent off any and all supplements all right he did it folks we got through this one huh come out on which bad self the next podcast we will be doing we're going to do one tonight live from the mother fucking comedy store this will be a first we've never done this before and it should be really interesting so that is this evening going to do one live from the comedy store and will work that out tonight comic store now has a podcast studio fucking badass place that is goddamnit art folks that for today see you soon bye bye big kids one
Transcript generated on 2019-10-05.