In this week's SYSK Select episode, about 30-40 percent of humans suffer from some sort of allergy. The big joke, though, is that every sufferer is the victim of mistaken identity. Allergies are the result of a hypersensitive immune system mistaking a harmless protein for a foreign invader.
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hey everybody, this chuck and welcomed this week's s. Why
Kay Select episode all about allergies,
the reason I picked this one is because, although I think I'm on record
Episode even is saying: allergies, don't tend to affect me there,
may me this year and I've had a rough time
with the pollen so can have gotten
about allergies again, and I thought maybe,
could learn a little something to enjoy
welcome to study, should now asking for external aid work into the Pakistan Josh Clark, nature of the reach of brain, particularly small, today's glasses checks on the period by the way that can bibles mine after making video content having an entire season. I tell you show that people still way above the other one. Yet it's not like this is now the radio days of nineteen forty. When you really didn't like worth Orson Welles a baby face there used to be added up back in the day. I think of them is like the
in citizen Kane early on in the EU is clean, shaven baby face drank,
Yes, I think so. So what he said ass, if existing- it's, not ok, good things were
how do I get a little another, whether I am but not because of allergies? You sure well, that's funny
that goes Emily was like you know. You may have some allergies bit as possible. Sometimes you think you're getting sick and it could just be allergies. Defiling, could
yeah well, she's, a super allergic to all sorts of stuff
just really bad allergies. It's not like food allergies, seasonal, yet seasonal point, doesnt nights, ragweed knowledge of venom yet- and I grew up here
I grew up with allergies. I think of mention this before
Asthma, in all kinds of stuff- and I just got out of it, because that fake healer susceptible
I got bit by bit. Rattlesnake earnings are good venom and works. Both ways actually does
is Anti Van and remember, and even if we do want and what must venomous, sir poisonous we have on the world. Yet there was a good one. It was the country of Australia. Rumor is a dangerous place. Well Chuck. I specifically remember one time when
We were at work and you were attacked by a b.
And I had to deliver a and at the pen, shot to your thoughts,
remember the whole gang was there the whole Ganda carded you off in an ambulance is really kind of dramatic viewers. Scary. By coming,
M p. I plead that day, so kind of everything balanced out
all's well that ends well but what's mind. Boggling is that you don't even have an allergy to bees.
So like what happened me well, I was just tv.
Visa, free travel, distinguishing reality from fiction these days, other people or to hedge
you had to be allergy, though, after winning this article, we view would know what was going on
yeah, and I think we have and cover that maybe Pakistan we covered like Anna.
Ethnic shock a little bit, but this is like whereby took her is allergies
the cellular basis of what constitutes an hour
how they created where they come from its pretty cool?
stump Emily this morning, as I thought I was being a smart guy and even though she has bad allergies as I could, but you don't even know what they really are. Oh yeah
yeah, it's an overreaction from your immune system to a person
the invader. Almost exactly like that. Now I felt really stupid like, though, to pay.
Invaded louder. Emily does love that she's, like call be smart guy and like follow me around the house, brow beating me, so
Absolutely right, I mean analogy- is basically a case of mistaken identity. As far as your immune systems concerned, you got all sorts of foreign invaders come in nature
the time pressure, and we haven't immune system to handle these things. But every once in a while
it depends. They think power boy that you are genetically unfulfilled. If you have allergies, oh, it's not a complete JANET
Yeah, like you, have a little bit of information missing your and our own system has a little bit of information missing and so, for example, that in the article they use the example of like the shrimp. You can eat shrimp and there may be a protein attached,
that your bodies like did he eat this or where did this come from or even attacked by shrimp exactly and they think probably that all allergies are triggered by proteins, but is a case of mistaken identity. So, let's talk about this. Let's get in the means.
From a little bit how how the immune system handles
You're. Otherwise, that's right,
Well, I guess we could start with something called a month, a site and did you find-
two things like t cells and be cells, those Olympus sites,
She says it. If that's how they determine whether we have HIV, I believe like if your tea so counters low, because ETA Visa immunodeficiency disorder
so there are both white blood cells and they are really important to the immune system, but they make mistakes. Sometimes,
and I love the way this who wrote this by the way Steve Beach, freelancer never heard of him. I thought
a job though, because he like
t cells to customs agents,
some say just a site: they go anywhere. They want your body in May,
the gate cells and, basically like monsieur papers,
where you going thing was a purpose of your visit
click, Arizona in your body here like this
up anywhere. They didn't like you, so they can make it anywhere. They can pass
membranes and blood vessels and just pop up in Asia, where you lived out yeah through important for them to visit the lymph nodes. It is
potent because that's where they go back and start producing antibodies, write that down
when they see something made
governor cell and they say, hold on a minute. Your papers are not in order
then there's trouble and they they launch. Basically, they start the attack at that point, and we haven't quite figure this out. Basically,
happens when a bee cell, especially King
owners and a foreign body which is called an antigen because they generate anti
is a trigger the generational anybody's in your body in your body, so that were Amgen comes from the dry, the the beast, basically
takes down all of its data yeah and then goes
up another lymph nodes and on that basis, that way
its altered. The newer plasma cell inserts churning out any bodies that are specifically tailored,
to counteract that antigen that foreign,
vader that had encountered this right,
Our body or bodies have five types,
anti bodies in their called amino glove begins:
I love that it's tough to get out for its great were their work. On my jeez and I d
is the one that's responsible for allergic reactions
yeah and the reason that the ones responsible for allergic reactions, as we understand it, is because I d ease amino, gobbling, ease, yeah right. There
TAT to mass cells,
and basil fills yes and those are two different types of
cells, Marcel astounded, connective tissue Basil Phil.
Is a type of white blood cell, but they
the common area both of em contained his demean? Yeah
and when they are hijacked by an idee antibody, they basically become little ticking time bombs. So something
when you, when you come in contact with an agent in your body, goes off the that White boy tell goes off, Sir
using antibodies? Yet the first moment of contact creates with called listen.
Teasing exposure right, yeah, it's it's
Scully a mistake. It
in the case of allergies, yeah because I mean like there's nothing inherently dangerous about ragweed pollen. My Europe
we can handle, be venom, church and Churchill Fisher right by its there's some protein in each of those.
Certain people's bodies, if they don't have the genetic code for their white blood cells
they owe you pass your fine, then there's that case.
Can identify, like you, said the track, so once you have that sensitized exposure, the first time your body comes across as protein, there's that mistaken identity start producing antibodies and those antibodies attack
in the case of ideas to Basle fills and myself cells.
And they start circulating, throw your body just waiting for the next time. It encounters their origin that has been specifically designed to interact with the tried and
what happens then it they say hey. I know you, you know
was to be here, I'm going to release something called his demean. Witches can be a great thing in your body.
Does that's what's gonna. Do you know that
your arsenal fighting this this invader, but it can be a bad thing to write. If too much
is released, as as we will see in a little while, yes, so when in when an anybody- and I d come
to an average. India is already
connected to a mass seller. Basil fell. Remember the other. Things are loaded with with history to their basically taken them along for the party right now. So when it connects it, it sends a signal to something called a compliment proteins I believe yet and those
lament proteins come on as they are called chain reaction we can start to fulfil and they start.
Working on unlocking on unlocking on at once,
a certain amount of them- have kind of walk together along into this and a body and gin mass cell basil, Phil Joe,
the Mass cellar, the battlefield.
and all of a sudden you of his demean floating through your body, that's right! It basically
destroys those original cells such that the history means just released yeah, and
Duly released- and this is called the allergic cascade, this is what we think of
though, you may have come in contact with shrimp,
in ten days later. You extra, I know either an allergic reaction,
what you got other yeah Euler takes. Maybe seventy ten days for that sensitize exposure from that time to that,
I'm you could have the allergic cascade, that's how long it takes whereby they produce the antibodies yet, but when that their allergic cascade is kicked off and the historian is really
that's when the symptoms that we associate with the type of of allergy come about
yeah, so like a few inhale it here,
You could membranes again, a flare up sure make it.
Lives hives, which are basically like his demeanor cause your blood vessels in that area, the leak which makes it swell that's a hive sneezing ways,
All that I could we right now, if you want, if you let me, but it would be really gross here and I want to speak, would say: oh man, Jack get us anywhere
yeah, but I'm sick and I've allergies ascended to hear whether you, like the Kellogg's, Think Battle Creek,
yeah diarrhoea little vomiting. Maybe here that's like you know. I think that
scale from least
action to most? If your vomiting, then you ve ingested
then that you're really allergic to yet you can become swollen, usually like the pie,
your body or the the type of reaction you have right like where, if you, if your skin
because of your arms whilst, yes, if you probably,
inhaler unjust. That probably came in contact with your skin, like a break in your skin
it depends on how you ingested in power
body react to. It could is different for
and right and severity, obviously, but speaking of severity, I can get really bad was talked about in the B episode. If this cascade of this allergic cascade,
is allowed to continue, and you have
The reaction to you have enough antibodies attached to mass cells, embezzled, felicity time of his dominions. Release yeah, you can be a picture,
we can go into its call, an electric shock you
where you can have an awful access, which is not quite as bad. It's a bit.
Reaction, but it's not the full blown shock. If you're in flood full blown shock mode than you did.
Die easily and within many
Even if you have what say like a peanut allergy and you ask
those peanuts unless you get that injection of Evan Efron, let's go
open those airways and restrict the blood vessels back to their normal levels than you could be. A goner
really soon by ethical. Very this call a systemic reaction where your whole system is involved in this and you, if you're since his demean, dilates the blood vessels, your blood pressure can drop near
It also causes swelling soul,
if you're Airways, swollen that tends to close off, which means asked a few brief here, you could stay
your brain and kidneys of oxygen- and you know organ
You can happen and I think what they say several hunter
will die in the United States alone, each year gap, because
We didn't cover this in the in the tv episode about bees. Were I deliver their efforts?
from penance saved your life. Here you remember at German, but apparently the
acts of the upper pan. Last ten to twenty minutes. You I didn't realize it was that short bs, so we should have had you outfit.
Take a whole bell to those things. I thought your decided to go when she has ever been shot. Patently not, I think it's just like
hey, let's stave off death until we can get you to a hospital, I think so too there, but you have to do
early enough so that it can, I can have the effect
counteracting allergic reaction, and you you,
fits longer than ten or twenty minutes to get to the hospital is power. My one pan, but even if
survive your brain in your kidneys,
started oxygen. You can suffer long term damage from going in and of life to Jacques, yet I would be a four wreak if I had this possibility
existing a mile. I fear I would have in any event in my car in my
when each room of my house near, I would not take any chances and water
like a peanut. Algae too can be so easy to come in contact with that. Yeah well
we'd mention that time on the plane. When there they said he gave an open
nuts on this right and we had people write in their idea. Do that's it. I could seriously
right, and I understand that with crazy to me as like. If you fight Delta built, give your peanuts all day, long
If someone says they're allergic, that's the point
So this is the death of white, nay, said I'm, so everyone no peanuts today, because with the death of southwest, show them in twelve ii
these elections are sincere music,
guy! Well, my peanuts! I hate, guess I'll, just eat, press pencils and biscuits cookies near dirt, dirt! Ok, aprons! We want to talk to you about the future of phone service because it is here- and it's called
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so I would say you have allergies or let's say you think,
to go in and find out for sure there couple,
Is that they can they can,
what this means is often honey
and run into a beehive. Now you,
were do what's called a scratch test.
And I ve never had one these and we said one and she also doesn't mean a therapy which will get too, but they
Now you were a different
our genes to like your backer, your arm and then they
You were the needle and they see what happens and
arms, swollen and read
say you know what I think you're allergic to ragweed, not because we just put someone your body and scratch that they can.
The new blood tests in search for specific antigens yeah, that's better for kids. I think yeah, because
they can cause, we just put someone your body and scratched. They can also do blood tests
their genes- are just stupid
the kids, I think, yeah because they can cause a sensitized event in a kid. If you expose them to it cause
here's the thing. Does that mean that it's impossible to die from your first beating
what is possible here and also because, if there has
As it event, how did you come in contact with
be venom other than to be stung. How would you become sensitized?
as looking all over the internet for us, and I think one of the things that kind of fellow doing additional research for this episode is that we have a pretty good
of how allergies work, but it's definitely not complete. Yeah yeah away when you're on the cellular level ensure there are still some mysteries near to be had yet further
it lays the psyche?
your question was how do they identify that's foreign invader and
I was happy to say they identify dinner
they re and how do they? How do they take down its information and then go back to the to the lymph nodes and start producing an adviser and they had a within ten impaired and they had a load off carded there they did a police gets here. That's the way. I see it, so you go
scratch they blood tests. They both work there, ok and then, if you,
If, if they say you know what you are mere allergic,
the something's Lindsey. There is basically three things they recommend. The first is to avoid that thing. Whatever it is sure ineffectual
MR peanuts than your pretty good shape, cassettes pretty easy to avoid most cases. New thing
have you ever had a shrimp allergies. Shrimp is pretty delicious. Nobody fifty it's it's
you to avoid them pollen, let's say: okay, his Poland's everywhere is right here in this. So if your allergic to Poland there's no avoiding any, I mean three cars that all the cars in the spring in the south are yellow.
Cars painting the streets run, yellow literally so
You would take medication, cortical sure you
our growth enough enough from pain. Depending on what you are allergic to you. You know that kind of thing
One is what you said. Emily was doing what I've done before too, which is a therapy Dennis. I think so,
I undertook the process of immunity therapy by myself
and it seems to have worked better said
doktor give you injections and in your life that tell me my Emily's experience wells
She does the standard amino therapy where she goes into to get her
would shots once a month, I think
Aren't you out honour on a low doses? It's like
we are weak. Dilution of these antigens right and aid
injected in her body and just build up over time to increase her her immune response. I guessed right
and over time. So this is what they think happens: overtime either the body possibly gets its
genetic information, Phil, then enough, so that its it's like
was my face red dress. This was actually a foreign invaders, just shrimp protein and
they believe that another and a body I e g, which acts
kind of like a blocking into body that represents an allergic reaction, starts to build up
as a result of immunity therapy there we should say I think him- you know, therapies
a fairly controversial. Is it I believe so big
its introducing. You know a potentially dangerous thing into a human being, and
It's not like, if you ask somebody of honey as a good immune therapy. Logically, it should make
if you use local honey, very, very local honey. It's going
tat some of the same Paul in that year
both to that your allergic to write in it and so on,
you eat it. When you ingested, it's like taking that low level- and it should be doing the same thing- is that you know taking
directions from the doktor chirpy it's more delicious here and in it takes a long time in Lisbon at it, for she was out of her back.
virtually no success. So,
so has been helping Earl, I think so because
though, has bad allergies, but there used to be wait. Worship it, but
but on the shots now for, like monsieur
the kitten and she's been on it again for like five years, Romania has been while so
I had one serious, it wasn't even serious, but it was in my own. Distinct allergic reaction was shrimp. Once
and I ate it and numerous like? Why are you read in like one of those red dots, all of you what's going on and I figured I am was,
I was having an allergic reaction to ship. They never had before right now.
Shrimp and I tried it the next day tried a little by the shrimp. Can I had a similar reaction says like something's going on well so
I decided that I was gonna, get myself over my shrimp allergy without overhead without Horoscope Right
ever had em shrimp chips, yes
their delicious on air delicious like little kind of potato chips, french fries therefrom forward because they have shrimp dust
unlike sexual powdered, shrimp, shrimp, does so
started, like varies eating. Little amount
jumped ship than over the overtime, only more whole bags of omega time? You know,
And finally, I get to the point where I could eat tramping it. I dont know, if that
really cured me or if there was just a fluke like maybe that shrimp, so local, typos, tramping airlines or something I got a shrimp. But am that's? That's my immunity.
This story. Well, you can it's written
gangbusters. So I got an idea, that's good dearly! Whenever I can election
to make up for lost time spent like three years two years without eating shrimp. So beware problems.
Tramp of the world's charges at guttural number you live well, you know how its caress most people do. I guess it
yeah, that is allergies and about the reason I quizzed Emily's, because I think a lot of people have allergies, don't either,
stand up a core concepts
and hopefully now you do, that it's a case, a mistake,
I do so asked me in your your dns dumb,
or incomplete. Ok, if
like this. You should go check out how allergies work you can type in the search for a house. The efforts that can't you can also
about an hour ago. I wrote about using honey for him. You know therapy. That's pretty interesting, probably like honey allergies, maybe would be to give principally in the search bar for thou. Innocence. First part Weiss, which means we're gonna have to
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Guys are useless near cast on men and women,
and how's your mind of a story. I thought you might like to hear my dad is an actor and way back in the 90s. He was in a film called in the name of the father, or do that
but they knew they lose rough. Britain is that is dead.
He said it starts Abraham, Lincoln or Daniel. They Louis
in the film he played in this. One of my favorite, like movies from
here, is by the IRA. Wasn't it yeah laid? It was about like wrongfully, imprisoned friends. Basically that day
spected to farmers and don't give me that there is a prison in
he played a prison guards who get set on fire by some pretty nasty in these services of fire to a guy,
in the guy. What happened
serve as a warning for any accurately decides their upper perform their instants the directorate side of my dad good
recent flailing and running with his arms on fire and then aslant professional with you, the more intense full body firesides. We like we said in the stunt person pockets like the fires thing you're always Rony arise going. What would you do in Europe? Are you stand there? Can someone put me out some people do
months to sit there? Well, that's different already one
wrapped up his arms covered them in jelly and set them ablaze? But what might add a failure realises that men do not wait for any one to say action result he stood there on fire.
For someone to say he could go whilst getting hotter and hotter with each hasn't. Second, unfortunately, director eventually realise what was happening and hastily yelled go
but by this time my dad was way too hot
kind of sidestepped into the shot waving his arms like a half baked ballerina. If you watch the scene carefully, you can actually see the shots. He was really on fire and
I'd, be genuine fear and panic and his eyes of you guys. I carry on making loans for as long as humanly possible. That is ready, turn out from hawks running nice in Vegas, Freddy Senior
since its junior was on fire.
Jim Sheridan was a director of suggestion was known ass, the girl, that's a pretty great, listen. There's given was the Disney Freddy Thirty
pretty turner outrunning one. Well, if you have a great story associated with something we talked about as
We want to hear you can tweak to us as well as to Pakistan, can join someplace. Put that comes less that you should know you can send an email to stuff had cast a discovery that come in check at our website that you should know guide for more on this, and thousands of other topics is. It has to have more exact com. I'm Katy correct, and I back with my new part, cast next question with Katy Current
question aims to make sense of our chaotic, complicated and ever changing world. One question: at a time
I look forward to figuring this all out together, listen to next question with Katy, correct on the eye heart, radio, app apple podcast or wherever you get your podcast.
Transcript generated on 2019-12-18.